ZA200610644B - Oligonucleotides for cancer diagnosis - Google Patents
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- ZA200610644B ZA200610644B ZA200610644A ZA200610644A ZA200610644B ZA 200610644 B ZA200610644 B ZA 200610644B ZA 200610644 A ZA200610644 A ZA 200610644A ZA 200610644 A ZA200610644 A ZA 200610644A ZA 200610644 B ZA200610644 B ZA 200610644B
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| US10140708B2 (en) * | 2016-01-21 | 2018-11-27 | Riverside Research Institute | Method for gestational age estimation and embryonic mutant detection |
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Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981783A (en) * | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5871928A (en) * | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| JP2802125B2 (ja) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | 核酸の検出方法 |
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| US5658786A (en) | 1992-03-04 | 1997-08-19 | Synaptic Pharmaceutical Corporation | DNA encoding rat taurine transporter and uses thereof |
| US6114114A (en) | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
| US5633137A (en) * | 1992-12-01 | 1997-05-27 | The University Of South Florida | Method for measuring specific gene expression: transcriptional activity per gene dose |
| US5677125A (en) * | 1994-01-14 | 1997-10-14 | Vanderbilt University | Method of detection and diagnosis of pre-invasive cancer |
| US5830645A (en) * | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
| AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| EP0937159A4 (en) | 1996-02-08 | 2004-10-20 | Affymetrix Inc | SPECIATION OF MICROORGANISMS FROM MICROPLATES AND CHARACTERIZATION OF THE PHENOTYPES THEREOF |
| WO1998008083A1 (en) | 1996-08-20 | 1998-02-26 | Motorola Inc. | Method and apparatus for detecting predetermined molecular structures in a sample |
| US6235474B1 (en) | 1996-12-30 | 2001-05-22 | The Johns Hopkins University | Methods and kits for diagnosing and determination of the predisposition for diseases |
| US6190857B1 (en) * | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
| NO972006D0 (no) * | 1997-04-30 | 1997-04-30 | Forskningsparken I Aas As | Ny metode for diagnose av sykdommer |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| AU9071098A (en) | 1997-07-29 | 1999-02-22 | Lambert C. J. Dorssers | Breast cancer resistance genes, methods for their detection and uses thereof |
| US6607879B1 (en) * | 1998-02-09 | 2003-08-19 | Incyte Corporation | Compositions for the detection of blood cell and immunological response gene expression |
| US6174680B1 (en) * | 1998-12-30 | 2001-01-16 | Dana-Farber Cancer Institute, Inc. | Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof |
| CA2318789C (en) | 1998-02-25 | 2011-05-10 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Cellular arrays for rapid molecular profiling |
| US6004755A (en) * | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| JP2002524091A (ja) | 1998-08-21 | 2002-08-06 | ナックスコー・インコーポレイテッド | 架橋可能な固定化核酸を用いるアッセイ |
| US20090233276A1 (en) * | 1998-09-22 | 2009-09-17 | Oncomedx, Inc. | Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions |
| US6593084B2 (en) | 1998-10-13 | 2003-07-15 | Robert E. Bird | Carcinogen assay |
| WO2000022172A1 (en) | 1998-10-13 | 2000-04-20 | Clontech Laboratories, Inc. | Nucleic acid arrays |
| WO2000024940A1 (en) | 1998-10-28 | 2000-05-04 | Vysis, Inc. | Cellular arrays and methods of detecting and using genetic disorder markers |
| WO2000026412A1 (en) | 1998-11-02 | 2000-05-11 | Kenneth Loren Beattie | Nucleic acid analysis using sequence-targeted tandem hybridization |
| US20040265869A1 (en) * | 1999-01-06 | 2004-12-30 | Chondrogene Limited | Method for the detection of type II diabetes related gene transcripts in blood |
| US20040241728A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of lung disease related gene transcripts in blood |
| US7473528B2 (en) * | 1999-01-06 | 2009-01-06 | Genenews Inc. | Method for the detection of Chagas disease related gene transcripts in blood |
| US20040265868A1 (en) * | 1999-01-06 | 2004-12-30 | Chondrogene Limited | Method for the detection of depression related gene transcripts in blood |
| US20050042630A1 (en) * | 1999-01-06 | 2005-02-24 | Chondrogene Limited | Method for the detection of asthma related gene transcripts in blood |
| US20040241727A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of schizophrenia related gene transcripts in blood |
| AU1853600A (en) * | 1999-01-06 | 2000-07-24 | Choong-Chin Liew | Method for the detection of gene transcripts in blood and uses thereof |
| US20050123938A1 (en) | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| US20040248169A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of obesity related gene transcripts in blood |
| US20040248170A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of hyperlipidemia related gene transcripts in blood |
| US20050003394A1 (en) * | 1999-01-06 | 2005-01-06 | Chondrogene Limited | Method for the detection of rheumatoid arthritis related gene transcripts in blood |
| US20040241726A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of allergies related gene transcripts in blood |
| DE19937187A1 (de) * | 1999-08-06 | 2001-03-01 | Qiagen Gmbh | Automatisierte Proteinreinigung im Multiwellformat durch Vakuumfiltration |
| AU2001277172A1 (en) * | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-trans protein and related reagents and methods of use thereof |
| US7108969B1 (en) * | 2000-09-08 | 2006-09-19 | Affymetrix, Inc. | Methods for detecting and diagnosing oral cancer |
| AU2002218000A1 (en) * | 2000-11-01 | 2002-05-15 | Genomic Solutions, Inc. | Compositions and systems for identifying and comparing expressed genes (mrnas) in eukaryotic organisms |
| WO2002059367A2 (en) | 2000-11-30 | 2002-08-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis |
| CN1636139A (zh) | 2001-01-12 | 2005-07-06 | 耶鲁大学 | 癌症病人的生物液体中存活素的检测 |
| US20020132274A1 (en) * | 2001-01-17 | 2002-09-19 | Nevalainen Marja T. | Diagnostic and monitorings methods for cancer |
| AU2002253878A1 (en) * | 2001-01-25 | 2002-08-06 | Gene Logic, Inc. | Gene expression profiles in breast tissue |
| CA2439504A1 (en) | 2001-02-28 | 2002-09-12 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
| WO2002088750A2 (en) * | 2001-05-02 | 2002-11-07 | Oxford Glycosciences (Uk) Ltd | Proteins, genes and their use for diagnosis and treatment of breast cancer |
| US20020169560A1 (en) * | 2001-05-12 | 2002-11-14 | X-Mine | Analysis mechanism for genetic data |
| US7335467B2 (en) * | 2001-05-15 | 2008-02-26 | Ludwig Institute For Cancer Research | Breast cancer antigens |
| US20030036077A1 (en) * | 2001-05-31 | 2003-02-20 | Chronix Biomedical | Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers |
| US7297480B2 (en) * | 2001-06-28 | 2007-11-20 | Dermtech International | Method for detection of melanoma |
| US20030099973A1 (en) * | 2001-07-18 | 2003-05-29 | University Of Louisville Research Foundation, Inc. | E-GeneChip online web service for data mining bioinformatics |
| US7229774B2 (en) * | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US7622260B2 (en) * | 2001-09-05 | 2009-11-24 | The Brigham And Women's Hospital, Inc. | Diagnostic and prognostic tests |
| CA2466483A1 (en) * | 2001-11-07 | 2003-07-03 | John D. Shaughnessy | Diagnosis prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| US20030232350A1 (en) * | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20030225526A1 (en) * | 2001-11-14 | 2003-12-04 | Golub Todd R. | Molecular cancer diagnosis using tumor gene expression signature |
| US20040241653A1 (en) * | 2001-12-31 | 2004-12-02 | Elena Feinstein | Methods for identifying marker genes for cancer |
| US20030195431A1 (en) * | 2002-04-10 | 2003-10-16 | Sukhatme Vikas P. | Observation of effects of body fluids on indicator cells for disease diagnosis |
| AU2003239544A1 (en) * | 2002-05-24 | 2003-12-12 | Tularik Inc. | Amplification and overexpression of oncogenes |
| CA2496885A1 (en) * | 2002-08-30 | 2004-03-11 | Oncotherapy Science, Inc. | Method of diagnosing colon and gastric cancers |
| WO2004024892A2 (en) | 2002-09-12 | 2004-03-25 | Chondrogene Inc. | Identification of sequences particularly useful for the diagnosis and identification of therapeutic targets for osteoarthritis |
| US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| GB0227238D0 (en) * | 2002-11-21 | 2002-12-31 | Diagenic As | Product and method |
| US7910550B2 (en) * | 2004-04-16 | 2011-03-22 | Stc.Unm | Human kunitz-type inhibitor with enhanced antifibrinolytic activity |
| WO2006048262A2 (en) * | 2004-11-04 | 2006-05-11 | Roche Diagnostics Gmbh | Classification of acute myeloid leukemia |
| US20070178503A1 (en) * | 2005-12-19 | 2007-08-02 | Feng Jiang | In-situ genomic DNA chip for detection of cancer |
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2004
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| AU2005250219B2 (en) | 2011-01-20 |
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| JP5060945B2 (ja) | 2012-10-31 |
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| AU2005250219A1 (en) | 2005-12-15 |
| US20120295800A1 (en) | 2012-11-22 |
| CA2568889A1 (en) | 2005-12-15 |
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| NZ551797A (en) | 2010-03-26 |
| GB0412301D0 (en) | 2004-07-07 |
| CN101027410A (zh) | 2007-08-29 |
| NO20065939L (no) | 2007-02-08 |
| EP1766056A1 (en) | 2007-03-28 |
| DK1766056T3 (da) | 2011-03-14 |
| DE602005025633D1 (enExample) | 2011-02-10 |
| JP2008501332A (ja) | 2008-01-24 |
| ES2358910T3 (es) | 2011-05-16 |
| WO2005118851A1 (en) | 2005-12-15 |
| SI1766056T1 (sl) | 2011-05-31 |
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