ZA200610242B - Pharmaceutical compositions for the treatment of disease and/or symptoms in arthritis - Google Patents

Pharmaceutical compositions for the treatment of disease and/or symptoms in arthritis Download PDF

Info

Publication number
ZA200610242B
ZA200610242B ZA200610242A ZA200610242A ZA200610242B ZA 200610242 B ZA200610242 B ZA 200610242B ZA 200610242 A ZA200610242 A ZA 200610242A ZA 200610242 A ZA200610242 A ZA 200610242A ZA 200610242 B ZA200610242 B ZA 200610242B
Authority
ZA
South Africa
Prior art keywords
cannabinoids
combination
thc
cannabinoid
cbd
Prior art date
Application number
ZA200610242A
Other languages
English (en)
Inventor
Robson Philip
Guy Geoffrey
Original Assignee
Gw Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gw Pharma Ltd filed Critical Gw Pharma Ltd
Publication of ZA200610242B publication Critical patent/ZA200610242B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA200610242A 2004-06-08 2006-12-06 Pharmaceutical compositions for the treatment of disease and/or symptoms in arthritis ZA200610242B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0412753A GB2414933B (en) 2004-06-08 2004-06-08 Cannabinoid compositions for the treatment of disease and/or symptoms in arthritis

Publications (1)

Publication Number Publication Date
ZA200610242B true ZA200610242B (en) 2008-05-28

Family

ID=32696849

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610242A ZA200610242B (en) 2004-06-08 2006-12-06 Pharmaceutical compositions for the treatment of disease and/or symptoms in arthritis

Country Status (15)

Country Link
US (3) US20080139667A1 (hu)
EP (1) EP1765314B1 (hu)
JP (2) JP4920588B2 (hu)
KR (1) KR20070039499A (hu)
CN (1) CN1976690B (hu)
AU (1) AU2005251505B2 (hu)
CA (1) CA2568997C (hu)
ES (1) ES2735229T3 (hu)
GB (1) GB2414933B (hu)
HU (1) HUE046110T2 (hu)
MX (1) MXPA06014057A (hu)
PL (1) PL1765314T3 (hu)
PT (1) PT1765314T (hu)
WO (1) WO2005120478A1 (hu)
ZA (1) ZA200610242B (hu)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
NZ601567A (en) 2005-09-29 2013-03-28 Albany Molecular Res Inc Process for production of delta-9-tetrahydrocannabinol
GB2432312A (en) * 2005-11-01 2007-05-23 Gw Pharma Ltd Pharmaceutical compositions for the treatment of pain
GB2438682A (en) * 2006-06-01 2007-12-05 Gw Pharma Ltd New use for cannabinoids
GB2439393B (en) * 2006-06-23 2011-05-11 Gw Pharma Ltd Cannabinoids for use in the treatment of neuropathic pain
GB2448535A (en) * 2007-04-19 2008-10-22 Gw Pharma Ltd New use for cannabinoid-containing plant extracts
US9084771B2 (en) 2007-05-17 2015-07-21 Sutter West Bay Hospitals Methods and compositions for treating cancer
GB2450753B (en) * 2007-07-06 2012-07-18 Gw Pharma Ltd New Pharmaceutical formulation
GB2459637B (en) * 2008-01-21 2012-06-06 Gw Pharma Ltd New use for cannabinoids
PT2280687T (pt) 2008-03-26 2019-06-04 Stichting Sanammad Composições de goma de mascar compreendendo canabinóides
GB2471987B (en) 2008-06-04 2012-02-22 Gw Pharma Ltd Anti-tumoural effects of cannabinoid combinations
EP2424568A1 (en) * 2009-04-29 2012-03-07 University Of Kentucky Research Foundation Cannabinoid-containing compositions and methods for their use
JP2013520208A (ja) * 2010-02-24 2013-06-06 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 自己免疫疾患の診断、予後判定、及び処置法
GB2478595B (en) 2010-03-12 2018-04-04 Gw Pharma Ltd Phytocannabinoids in the treatment of glioma
US8445034B1 (en) 2010-11-02 2013-05-21 Albert L Coles, Jr. Systems and methods for producing organic cannabis tincture
GB2524689B (en) 2011-05-20 2016-01-27 Gw Pharma Ltd Cannabinoids for use in the treatment of neuropathic pain
GB2516814B (en) 2013-06-19 2016-08-31 Otsuka Pharma Co Ltd Use of phytocannabinoids for increasing radiosensitivity in the treatment of cancer
US10016360B1 (en) * 2013-07-26 2018-07-10 Steven Elbogen Compositions, uses and methods for making them
US9333229B2 (en) * 2013-10-16 2016-05-10 William Bjorncrantz Winterized crude cannabis extracts and methods of preparation and use
JP6673895B2 (ja) 2014-03-21 2020-03-25 エスティー アンド ティー インターナショナル,インコーポレイティド アサ属抽出方法及び組成物
US9186386B2 (en) 2014-04-17 2015-11-17 Gary J. Speier Pharmaceutical composition and method of manufacturing
US9044390B1 (en) 2014-04-17 2015-06-02 Gary J. Speier Pharmaceutical composition and method of manufacturing
GB2530001B (en) 2014-06-17 2019-01-16 Gw Pharma Ltd Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy
FR3022457B1 (fr) * 2014-06-23 2017-09-01 Assist Publique - Hopitaux De Paris Utilisation de cannabis pour le traitement de l'achalasie
US11541003B1 (en) * 2014-07-28 2023-01-03 Steven Elbogen Compositions, uses and methods for making them
CN107205960A (zh) 2014-10-21 2017-09-26 联合大麻公司 大麻提取物及其制备和使用方法
WO2017203529A1 (en) * 2016-05-24 2017-11-30 Bol Pharma Ltd. Compositions comprising cannabidiol and hyaluronic acid for treating inflammatory joint diseases
GB2539472A (en) 2015-06-17 2016-12-21 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
WO2016205923A1 (en) * 2015-06-25 2016-12-29 Compressed Perforated Puck Technologies Inc. Ingestible plant source pill and method
US9827322B2 (en) * 2015-07-24 2017-11-28 Bao Tran Medication dispensing system
SG11201809688RA (en) 2016-05-04 2018-11-29 Inmed Pharmaceuticals Inc Use of topical formulations of cannabinoids in the treatment of epidermolysis bullosa and related connective tissue disorders
US10499584B2 (en) 2016-05-27 2019-12-10 New West Genetics Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles
CN105997985A (zh) * 2016-06-14 2016-10-12 云南瑞酚生物科技有限公司 一种大麻提取物在制备治疗痛风药物中的应用
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
AU2017424129B2 (en) * 2017-07-18 2021-12-09 Deyi Pharmarmaceutical Ltd. Application of cannabidiol in treatment of pulmonary hypertension
US11612581B2 (en) 2017-08-09 2023-03-28 Cannibite Bvba Cannabis and derivatives thereof for the treatment of pain and inflammation related with dental pulp and bone regeneration related to dental jaw bone defects
CA3072849A1 (en) * 2017-08-14 2019-02-21 Zynerba Pharmaceuticals, Inc. Methods of treatment of osteoarthritis with transdermal cannabidiol gel
CN109498606A (zh) * 2017-09-15 2019-03-22 汉义生物科技(北京)有限公司 一种含有大麻二酚和/或次大麻二酚的组合物及其在治疗痛经中的应用
WO2019056123A1 (en) * 2017-09-22 2019-03-28 Inmed Pharmaceuticals Inc. TOPICAL FORMULATIONS OF CANNABINOIDS AND THEIR USE IN THE TREATMENT OF PAIN
CA3089994A1 (en) 2018-01-31 2019-08-08 Canopy Holdings, LLC Hemp powder
GB201806953D0 (en) * 2018-04-27 2018-06-13 Gw Res Ltd Cannabidiol Preparations
WO2019210401A1 (en) * 2018-05-01 2019-11-07 Willinsky Michael Novel anti-inflammatory, analgesic, anti-depressant cannabinoid and methods related to manufacture of same
WO2019237156A1 (en) * 2018-06-15 2019-12-19 CannPal Animal Therapeutics Limited Cannabinoid composition and methods of treatment using the same
JP2021532171A (ja) * 2018-07-02 2021-11-25 コンパニオン サイエンシズ リミテッド ライアビリティ カンパニー カンナビジオールの組み合わせ組成物
EP3820452A1 (en) * 2018-07-09 2021-05-19 Volker Berl Stabilized formulations of cannabinoid compositions
WO2020060761A2 (en) * 2018-09-04 2020-03-26 Skodda Anja Pet food formulation with cannabinoids
US11504416B2 (en) * 2018-09-04 2022-11-22 Paw Power, Inc. Formulation with cannabinoids
US11254633B2 (en) 2018-10-05 2022-02-22 Jonas Alcirdas Navickas Cannabis thin layer decarboxylation
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
JP2022509008A (ja) * 2018-11-12 2022-01-20 漢義生物科技(北京)有限公司 カンナビノイド化合物の神経皮膚炎の治療における応用
NL2022614B1 (en) 2019-02-21 2020-08-31 Patrick Alexander Unger Pharmaceutical, phyto-cannabinoid based compositions
NL2022615B1 (en) 2019-02-21 2020-08-31 Patrick Alexander Unger Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight
US20220331406A1 (en) * 2019-09-30 2022-10-20 Lonza Consumer Health Inc. Cannabinoid Product for Improving Musculoskeletal Health
US12016829B2 (en) 2019-10-11 2024-06-25 Pike Therapeutics Inc. Pharmaceutical composition and method for treating seizure disorders
AU2021259495A1 (en) * 2020-04-20 2022-10-27 Pike Therapeutics, Inc. Transdermal and/or topical pharmaceutical formulations comprising cannabidiol and/or tetrahydrocannabinol for the treatment of chronic pain
MX2023001129A (es) 2020-07-28 2023-03-27 Impello Biosciences Inc Metodos y composiciones para alterar metabolitos secundarios en plantas.
JPWO2022085622A1 (hu) 2020-10-23 2022-04-28
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
CN112755055B (zh) * 2020-12-31 2022-12-13 吉林省农业科学院 植物乳杆菌na136与大麻二酚单体联合在制备治疗类风湿性关节炎产品中的应用
US12029720B2 (en) 2021-04-29 2024-07-09 Tilray Brands, Inc. Cannabidiol-dominant formulations, methods of manufacturing, and uses thereof
EP4098254A1 (en) * 2021-06-04 2022-12-07 Assistance Publique, Hopitaux De Paris Cannabidiol for use in the treatment of pain resulting from an indoleamine 2,3-dioxygenase-1 (ido1) related disease
ES2962999T3 (es) 2021-07-30 2024-03-22 Cannamedical Pharma Gmbh Parche transmucoso que comprende un cannabinoide y/o un opiáceo
WO2024160792A1 (en) 2023-01-30 2024-08-08 Cannamedical Pharma Gmbh Improved transmucosal patch comprising a cannabinoid and/or an opioid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100886668B1 (ko) * 2001-02-14 2009-03-04 지더블유 파마 리미티드 약학적 제제
GB2377633A (en) * 2001-05-11 2003-01-22 Gw Pharmaceuticals Ltd Pharmaceutical compositions comprising the cannabinoids THC and CBD
CH695661A5 (de) * 2001-03-06 2006-07-31 Forsch Hiscia Ver Fuer Krebsfo Pharmazeutische Zusammensetzung.
SI1542657T1 (sl) * 2002-08-14 2012-04-30 Gw Pharma Ltd Kanabinoidne kapljevite formulacije za sluzniäśno administracijo
US6946150B2 (en) * 2002-08-14 2005-09-20 Gw Pharma Limited Pharmaceutical formulation
GB2394894B (en) * 2002-11-04 2005-08-31 G W Pharma Ltd New use for pharmaceutical composition

Also Published As

Publication number Publication date
MXPA06014057A (es) 2007-03-15
HUE046110T2 (hu) 2020-02-28
CA2568997C (en) 2012-12-04
CN1976690A (zh) 2007-06-06
AU2005251505B2 (en) 2011-03-31
AU2005251505A1 (en) 2005-12-22
JP4920588B2 (ja) 2012-04-18
JP2008501770A (ja) 2008-01-24
GB2414933B (en) 2009-07-15
US20160361290A1 (en) 2016-12-15
ES2735229T3 (es) 2019-12-17
GB0412753D0 (en) 2004-07-07
JP2012051925A (ja) 2012-03-15
US20080139667A1 (en) 2008-06-12
CA2568997A1 (en) 2005-12-22
KR20070039499A (ko) 2007-04-12
PT1765314T (pt) 2019-07-23
EP1765314A1 (en) 2007-03-28
CN1976690B (zh) 2011-05-25
EP1765314B1 (en) 2019-05-01
GB2414933A (en) 2005-12-14
WO2005120478A1 (en) 2005-12-22
PL1765314T3 (pl) 2020-03-31
US20200206184A1 (en) 2020-07-02

Similar Documents

Publication Publication Date Title
US20200206184A1 (en) Pharmaceutical compositions for the treatment of disease and/or symptoms in arthritis
US7968594B2 (en) Pharmaceutical compositions for the treatment of pain
US20190224140A1 (en) Cannabinoids for use in the treatment of neuropathic pain
EP2182940B1 (en) Use of tetrahydrocannabinol and/or cannabidiol for the treatment of inflammatory bowel disease
WO2007052013A1 (en) A combination of cannabinoids for the treatment of peripheral neurophatic pain
AU2018330807A1 (en) Compositions comprising a cannabinoid and spilanthol
WO2007042811A1 (en) Pharmaceutical compositions for the treatment of chronic obstructive pulmonary disease
US20200254038A1 (en) Pharmaceutical compositions containing cannabis, uses thereof and methods for improving sleep quality
KR20230156378A (ko) 터미날리아 케불라 조성물을 사용한 등통증을 완화시키는 방법