ZA200608306B - Fused ring azadecalin glucocorticoid receptor modulators - Google Patents
Fused ring azadecalin glucocorticoid receptor modulatorsInfo
- Publication number
- ZA200608306B ZA200608306B ZA200608306A ZA200608306A ZA200608306B ZA 200608306 B ZA200608306 B ZA 200608306B ZA 200608306 A ZA200608306 A ZA 200608306A ZA 200608306 A ZA200608306 A ZA 200608306A ZA 200608306 B ZA200608306 B ZA 200608306B
- Authority
- ZA
- South Africa
- Prior art keywords
- fused ring
- receptor modulators
- glucocorticoid receptor
- ring azadecalin
- azadecalin glucocorticoid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55183604P | 2004-03-09 | 2004-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200608306B true ZA200608306B (en) | 2009-02-25 |
Family
ID=34961932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200608306A ZA200608306B (en) | 2004-03-09 | 2006-10-05 | Fused ring azadecalin glucocorticoid receptor modulators |
Country Status (18)
Country | Link |
---|---|
US (4) | US7928237B2 (zh) |
EP (1) | EP1735308B1 (zh) |
JP (1) | JP4931794B2 (zh) |
KR (1) | KR101185281B1 (zh) |
CN (1) | CN101027301B (zh) |
AT (1) | ATE407934T1 (zh) |
AU (1) | AU2005222421B2 (zh) |
CA (1) | CA2558899C (zh) |
CY (1) | CY1108621T1 (zh) |
DE (1) | DE602005009687D1 (zh) |
DK (1) | DK1735308T3 (zh) |
ES (1) | ES2313317T3 (zh) |
HK (1) | HK1104813A1 (zh) |
IL (1) | IL177982A (zh) |
NZ (1) | NZ550362A (zh) |
PT (1) | PT1735308E (zh) |
WO (1) | WO2005087769A1 (zh) |
ZA (1) | ZA200608306B (zh) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005222421B2 (en) * | 2004-03-09 | 2010-09-23 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
TWI410422B (zh) * | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
US20100261693A1 (en) | 2007-10-17 | 2010-10-14 | Ulmann Andre | Method for treating cushing's syndrome |
CA2742964C (en) * | 2008-11-07 | 2020-07-07 | University Of Sheffield | Medicament and method of diagnosis |
AU2010247766B2 (en) * | 2009-05-12 | 2015-05-21 | Corcept Therapeutics, Inc. | Solid forms and process for preparing |
EP2493303A4 (en) * | 2009-10-30 | 2013-06-26 | Merck Sharp & Dohme | 2- [1-PHENYL-5-HYDROXY-4A-SUBSTITUTED HEXAHYDROCYCLOPENTA [F] INDAZOL-5-YL] ETHYLPHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS |
EP2524057B1 (en) * | 2010-01-15 | 2016-03-30 | Rigel Pharmaceuticals, Inc. | Screening assay employing dex and gdf8 |
AU2011293193A1 (en) * | 2010-08-27 | 2013-02-14 | Corcept Therapeutics, Inc. | Pyridyl-amine fused azadecalin modulators |
AU2012204232A1 (en) * | 2011-01-07 | 2013-06-27 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
US9006568B2 (en) * | 2012-02-15 | 2015-04-14 | Phillips 66 Company | Synthesis of photovoltaic conjugated polymers |
WO2013130420A1 (en) * | 2012-02-27 | 2013-09-06 | Corcept Therapeutics, Inc. | Phenyl heterocycloalkyl glucocorticoid receptor modulators |
PL3338781T3 (pl) | 2012-05-25 | 2020-03-31 | Corcept Therapeutics Incorporated | Modulatory receptorów glukokortykoidowych typu azadekaliny skondensowanej z heteroaryloketonem |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
WO2014088795A1 (en) | 2012-12-03 | 2014-06-12 | Phillips 66 Company | Benzo [1,2-b:4,5-b'] dithiophene-thienothiophene based conjugated polymers |
WO2015077537A1 (en) * | 2013-11-25 | 2015-05-28 | Corcept Therapeutics, Inc. | Heteroaryl-ether fused azadecalin glucocorticoid receptor modulators |
EP3848027B1 (en) * | 2013-11-25 | 2023-04-05 | Corcept Therapeutics Incorporated | Octahydro fused azadecalin glucocorticoid receptor modulators |
EP3265127B1 (en) * | 2015-03-02 | 2024-02-21 | Corcept Therapeutics, Inc. | Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor |
MX2017011885A (es) | 2015-03-30 | 2018-02-19 | Corcept Therapeutics Inc | Uso de antagonistas de receptores de glucocorticoides en combinacion con glucocorticoides para tratar la insuficiencia adrenal. |
ES2865334T3 (es) | 2015-08-13 | 2021-10-15 | Corcept Therapeutics Inc | Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH |
US9905769B2 (en) | 2015-10-01 | 2018-02-27 | Phillips 66 Company | Process of manufacturing an electron transport material |
US9911919B2 (en) | 2015-10-01 | 2018-03-06 | Phillips 66 Company | Process of manufacturing an electron transport material |
WO2017058406A1 (en) | 2015-10-01 | 2017-04-06 | Phillips 66 Company | Formation of films for organic photovoltaics |
US10418555B2 (en) | 2015-10-01 | 2019-09-17 | Phillips 66 Company | Formation of films for organic photovoltaics |
US10312448B2 (en) | 2015-10-01 | 2019-06-04 | Phillips 66 Company | Process of manufacturing an electron transport material |
KR102197526B1 (ko) | 2016-01-19 | 2020-12-31 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이소성 쿠싱 증후군의 감별 진단 |
IL297201A (en) | 2016-03-01 | 2022-12-01 | Corcept Therapeutics Inc | Use of glucocorticoid receptor modulators to increase the activity of checkpoint inhibitors |
US9943505B2 (en) * | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
CN110475558A (zh) | 2017-03-09 | 2019-11-19 | 科赛普特治疗学股份有限公司 | 糖皮质激素受体调节剂在儿茶酚胺分泌型肿瘤治疗中的应用 |
EP3600282A4 (en) | 2017-03-31 | 2020-08-19 | Corcept Therapeutics, Inc. | GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF COLD CANCER |
CA3065555A1 (en) | 2017-06-20 | 2018-12-27 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
KR102657097B1 (ko) | 2018-12-19 | 2024-04-15 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 헤테로아릴-케톤 융합 아자데칼린 화합물인 렐라코릴란트를 함유하는 약학적 제제 |
US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
KR20210118971A (ko) | 2019-02-22 | 2021-10-01 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 헤테로아릴-케톤 융합 아자데칼린 글루코코르티코이드 수용체 조절제인 렐라코릴란트의 치료 용도 |
CA3158112A1 (en) | 2019-10-16 | 2021-04-22 | Corcept Therapeutics Incorporated | Method of normalizing the neutrophil to lymphocyte ratio in cancer patients with a selective glucocorticoid receptor antagonist |
EP4072556A4 (en) | 2019-12-11 | 2024-01-03 | Corcept Therapeutics Incorporated | METHOD FOR TREATING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN WITH MIRICORILANT |
EP4076470A4 (en) | 2019-12-21 | 2023-11-22 | Corcept Therapeutics Incorporated | DIFFERENTIAL TREATMENT AND DIAGNOSIS BETWEEN ACTH-DEPENDENT CUSHING SYNDROME AND ACTH-INDEPENDENT CUSHING SYNDROME |
CN115397418A (zh) * | 2020-02-10 | 2022-11-25 | 科赛普特治疗学股份有限公司 | 使用选择性糖皮质激素受体调节剂刺激抗肿瘤反应的方法 |
EP4168402A4 (en) | 2020-06-22 | 2024-07-31 | Corcept Therapeutics Inc | QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS |
WO2022134033A1 (en) * | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
CN116829556A (zh) * | 2021-02-03 | 2023-09-29 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
WO2024006773A1 (en) * | 2022-06-28 | 2024-01-04 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
WO2024178196A1 (en) * | 2023-02-24 | 2024-08-29 | Corcept Therapeutics Incorporated | Methods of preparing intermediates of heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8828669D0 (en) | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
WO1999045925A1 (en) * | 1998-03-10 | 1999-09-16 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
GB9911053D0 (en) * | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
US6831093B2 (en) * | 2002-01-22 | 2004-12-14 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
AU2005222421B2 (en) * | 2004-03-09 | 2010-09-23 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
AU2010247766B2 (en) * | 2009-05-12 | 2015-05-21 | Corcept Therapeutics, Inc. | Solid forms and process for preparing |
-
2005
- 2005-03-09 AU AU2005222421A patent/AU2005222421B2/en not_active Ceased
- 2005-03-09 JP JP2007503030A patent/JP4931794B2/ja active Active
- 2005-03-09 CN CN2005800114815A patent/CN101027301B/zh active Active
- 2005-03-09 AT AT05725295T patent/ATE407934T1/de active
- 2005-03-09 NZ NZ550362A patent/NZ550362A/en not_active IP Right Cessation
- 2005-03-09 DE DE602005009687T patent/DE602005009687D1/de active Active
- 2005-03-09 KR KR1020067020988A patent/KR101185281B1/ko active IP Right Grant
- 2005-03-09 DK DK05725295T patent/DK1735308T3/da active
- 2005-03-09 PT PT05725295T patent/PT1735308E/pt unknown
- 2005-03-09 US US10/591,884 patent/US7928237B2/en active Active
- 2005-03-09 WO PCT/US2005/008049 patent/WO2005087769A1/en active Application Filing
- 2005-03-09 ES ES05725295T patent/ES2313317T3/es active Active
- 2005-03-09 EP EP05725295A patent/EP1735308B1/en active Active
- 2005-03-09 CA CA2558899A patent/CA2558899C/en active Active
-
2006
- 2006-09-10 IL IL177982A patent/IL177982A/en active IP Right Grant
- 2006-10-05 ZA ZA200608306A patent/ZA200608306B/xx unknown
-
2007
- 2007-06-27 HK HK07106903.6A patent/HK1104813A1/xx unknown
-
2008
- 2008-12-05 CY CY20081101413T patent/CY1108621T1/el unknown
-
2011
- 2011-03-11 US US13/046,529 patent/US20110166110A1/en not_active Abandoned
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2012
- 2012-05-21 US US13/476,776 patent/US8557839B2/en active Active
-
2013
- 2013-09-12 US US14/025,459 patent/US20140179671A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1735308B1 (en) | 2008-09-10 |
US20110166110A1 (en) | 2011-07-07 |
IL177982A (en) | 2012-09-24 |
NZ550362A (en) | 2010-06-25 |
KR101185281B1 (ko) | 2012-09-21 |
CN101027301A (zh) | 2007-08-29 |
US20140179671A1 (en) | 2014-06-26 |
CN101027301B (zh) | 2011-06-29 |
ATE407934T1 (de) | 2008-09-15 |
JP2007528417A (ja) | 2007-10-11 |
WO2005087769A1 (en) | 2005-09-22 |
CA2558899A1 (en) | 2005-09-22 |
CA2558899C (en) | 2013-02-05 |
IL177982A0 (en) | 2006-12-31 |
US7928237B2 (en) | 2011-04-19 |
US8557839B2 (en) | 2013-10-15 |
CY1108621T1 (el) | 2014-04-09 |
DE602005009687D1 (de) | 2008-10-23 |
PT1735308E (pt) | 2008-12-02 |
ES2313317T3 (es) | 2009-03-01 |
EP1735308A1 (en) | 2006-12-27 |
AU2005222421A1 (en) | 2005-09-22 |
AU2005222421B2 (en) | 2010-09-23 |
KR20070029684A (ko) | 2007-03-14 |
US20070281928A1 (en) | 2007-12-06 |
DK1735308T3 (da) | 2009-01-19 |
JP4931794B2 (ja) | 2012-05-16 |
US20120225856A1 (en) | 2012-09-06 |
HK1104813A1 (en) | 2008-01-25 |
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