ZA200607425B - Dihydrotetrabenazines and pharmaceutical compositions containing them - Google Patents
Dihydrotetrabenazines and pharmaceutical compositions containing themInfo
- Publication number
- ZA200607425B ZA200607425B ZA200607425A ZA200607425A ZA200607425B ZA 200607425 B ZA200607425 B ZA 200607425B ZA 200607425 A ZA200607425 A ZA 200607425A ZA 200607425 A ZA200607425 A ZA 200607425A ZA 200607425 B ZA200607425 B ZA 200607425B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- dihydrotetrabenazine
- dihydrotetrabenazines
- novel isomers
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- WEQLWGNDNRARGE-DJIMGWMZSA-N (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol Chemical class C1CN2C[C@@H](CC(C)C)[C@H](O)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-DJIMGWMZSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010058504 Ballismus Diseases 0.000 abstract 1
- 206010008748 Chorea Diseases 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000000269 Hyperkinesis Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0403037A GB2410947B (en) | 2004-02-11 | 2004-02-11 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200607425B true ZA200607425B (en) | 2008-02-27 |
Family
ID=32011732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200607425A ZA200607425B (en) | 2004-02-11 | 2005-02-11 | Dihydrotetrabenazines and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080108645A1 (ru) |
| EP (1) | EP1716145B1 (ru) |
| JP (1) | JP2007522193A (ru) |
| CN (1) | CN100591680C (ru) |
| AT (1) | ATE406370T1 (ru) |
| AU (1) | AU2005213525B2 (ru) |
| CA (1) | CA2555815A1 (ru) |
| CY (1) | CY1108592T1 (ru) |
| DE (1) | DE602005009327D1 (ru) |
| DK (1) | DK1716145T3 (ru) |
| ES (1) | ES2313292T3 (ru) |
| GB (1) | GB2410947B (ru) |
| HK (1) | HK1098138A1 (ru) |
| HR (1) | HRP20080564T3 (ru) |
| MX (1) | MXPA06009164A (ru) |
| NZ (1) | NZ549105A (ru) |
| PL (1) | PL1716145T3 (ru) |
| PT (1) | PT1716145E (ru) |
| RS (1) | RS50660B (ru) |
| RU (1) | RU2365590C2 (ru) |
| SI (1) | SI1716145T1 (ru) |
| WO (1) | WO2005077946A1 (ru) |
| ZA (1) | ZA200607425B (ru) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843590B1 (fr) | 2002-08-14 | 2007-10-05 | Prestwick Scient Capital Inc | Derives de l'acide r(+)-2-amino-3-hydroxypropanoique a action glycinergique |
| GB0514501D0 (en) | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| AU2006277753B2 (en) * | 2005-08-06 | 2011-11-10 | Biovail Laboratories International (Barbados) Srl | 3, hb cis dihydrotetrabanezine for the treatment of schizophrenia and other psychoses |
| EP2012833B1 (en) * | 2006-05-02 | 2014-10-29 | The Trustees Of The University Of Pennsylvania | Radiolabeled dihydrotrabenazine derivatives and their use as imaging agents |
| PT2081929E (pt) | 2006-11-08 | 2013-04-15 | Neurocrine Biosciences Inc | Compostos de 3-isobutil-9,10-dimetoxi- 1,3,4,6,7,11b-hexahidro-2h-pirido[2,1-a]isoquinolin- 2-ol substituídos e métodos com estes relacionados |
| EP2214721A2 (en) * | 2007-10-25 | 2010-08-11 | General Electric Company | Fluorinated dihydrotetrabenazine ether imaging agents and probes |
| US7897769B2 (en) | 2007-10-25 | 2011-03-01 | General Electric Company | Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes |
| US7897770B2 (en) | 2007-10-25 | 2011-03-01 | General Electric Company | Fluorinated dihydrotetrabenazine ether imaging agents and probes |
| GB0721669D0 (en) * | 2007-11-02 | 2007-12-12 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US7902364B2 (en) | 2007-11-29 | 2011-03-08 | General Electric Company | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| US8053578B2 (en) | 2007-11-29 | 2011-11-08 | General Electric Company | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| US7910738B2 (en) | 2007-11-29 | 2011-03-22 | General Electric Company | Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| EP2220085B1 (en) * | 2007-12-07 | 2014-02-12 | General Electric Company | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
| US8013161B1 (en) | 2007-12-07 | 2011-09-06 | General Electric Company | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
| US7919622B2 (en) | 2007-12-07 | 2011-04-05 | Kande Kankanamalage Dayarathna Amarasinghe | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| US20120208773A1 (en) * | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| BRPI0913457B8 (pt) | 2008-09-18 | 2021-08-31 | Auspex Pharmaceutical Inc | Composto e composição farmacêutica |
| CA2771539A1 (en) | 2009-08-12 | 2011-02-17 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenzine |
| EP2576552A4 (en) * | 2010-06-01 | 2013-11-13 | Aupex Pharmaceutical Inc | BENZOQUINOLONE INHIBITORS OF VMAT2 |
| CN102285984B (zh) * | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| EP2897615A4 (en) | 2012-09-18 | 2016-04-27 | Auspex Pharmaceuticals Inc | PHARMACOKINETIC FORMULATIONS OF DEUTERATED BENZOCHINOL INHIBITORS OF THE VESICLE MONOAMINE TRANSPORTER 2 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| JP2016506957A (ja) * | 2013-01-31 | 2016-03-07 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｖｍａｔ２のベンゾキノロン阻害剤 |
| EA032920B1 (ru) | 2013-12-03 | 2019-08-30 | Оспекс Фармасьютикалз, Инк. | Способы получения соединений бензохинолина |
| US20160346270A1 (en) | 2014-01-27 | 2016-12-01 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| KR20160117596A (ko) | 2014-02-07 | 2016-10-10 | 오스펙스 파마슈티칼스, 인코포레이티드 | 신규 제약 제제 |
| CN106061506A (zh) * | 2014-02-07 | 2016-10-26 | 纽罗克里生物科学有限公司 | 包含抗精神病药物和vmat2抑制剂的药物组合物及其用途 |
| SG11201706959TA (en) * | 2015-03-06 | 2017-09-28 | Auspex Pharmaceuticals Inc | Methods for the treatment of abnormal involuntary movement disorders |
| KR20180015260A (ko) * | 2015-06-23 | 2018-02-12 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 신경계 질환 또는 장애를 치료하기 위한 vmat2 억제제 |
| US10065952B2 (en) | 2015-10-30 | 2018-09-04 | Neurocrine Biosciences, Inc. | Valbenazine salts and polymorphs thereof |
| HRP20220621T1 (hr) | 2015-12-23 | 2022-06-24 | Neurocrine Biosciences, Inc. | Postupak sinteze za proizvodnju (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1-a]izokinolin-2-il 2-amino-3-metilbutanoat di(4-metilbenzensulfonata) |
| TW201827051A (zh) | 2016-12-02 | 2018-08-01 | 美商神經性分泌生物科學公司 | 戊苯那嗪（valbenazine）於治療精神分裂症或情感性精神分裂症之用途 |
| KR20230170135A (ko) * | 2017-01-27 | 2023-12-18 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| WO2018164996A1 (en) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Dosing regimen for valbenazine |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| CN110678181A (zh) * | 2017-04-01 | 2020-01-10 | 阿德普蒂奥制药有限公司 | (+)-α-二氢丁苯那嗪在治疗运动障碍中的用途 |
| CN110691596A (zh) * | 2017-04-01 | 2020-01-14 | 阿德普蒂奥制药有限公司 | 药物组合物 |
| WO2018200605A1 (en) | 2017-04-26 | 2018-11-01 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
| CN107089980B (zh) * | 2017-05-11 | 2019-08-30 | 合肥工业大学 | 一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法 |
| IL309802A (en) | 2017-09-21 | 2024-02-01 | Neurocrine Biosciences Inc | High dose valbenazine formulation and related preparations, methods and kits |
| US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| CN116492340A (zh) | 2017-10-10 | 2023-07-28 | 纽罗克里生物科学有限公司 | 施用某些vmat2抑制剂的方法 |
| JOP20200298A1 (ar) | 2018-06-14 | 2020-11-22 | Neurocrine Biosciences Inc | مركبات مثبطة لـ vmat2 وتركيبات وطرق تتعلق بها |
| CA3104693A1 (en) | 2018-08-15 | 2020-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| WO2022203984A1 (en) | 2021-03-22 | 2022-09-29 | Neurocrine Biosciences, Inc. | Vmat2 inhibitors and methods of use |
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|---|---|---|---|---|
| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US2954382A (en) * | 1960-09-27 | Xpreparation of hexahydrobenzoquinol- | ||
| US3132147A (en) * | 1964-05-05 | |||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US3159638A (en) * | 1964-12-01 | Xcha-chj | ||
| US3123609A (en) * | 1964-03-03 | Benzo | ||
| US3053845A (en) * | 1962-09-11 | Benzofykedocolines | ||
| US3095419A (en) * | 1963-06-25 | Process for preparing z-oxo-j- | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3079395A (en) * | 1963-02-26 | Novel z-oxq-benzoquinoliaine | ||
| US3314966A (en) * | 1967-04-18 | Substituted benzo[a]quinolizines | ||
| US3009918A (en) * | 1961-11-21 | Chz ch | ||
| US3045021A (en) * | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| GB999092A (en) * | 1959-11-24 | 1965-07-21 | Wellcome Found | Method for making benzo(a)-quinolizine derivatives |
| US3375254A (en) * | 1961-09-29 | 1968-03-26 | Burroughs Wellcome Co | Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines |
| US3105079A (en) * | 1961-12-29 | 1963-09-24 | Pfizer & Co C | 10-aminobenzopyridocolines |
| US3390152A (en) * | 1965-10-21 | 1968-06-25 | Abbott Lab | 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines |
| US3635986A (en) * | 1969-12-22 | 1972-01-18 | Miles Lab | 2-substituted amino-hexahydrobenzo(a)quinolizines |
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| YU264675A (en) * | 1974-10-23 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | Process for obtaining benzo (a)-quinolizidine derivatives |
| GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
| US4133812A (en) * | 1975-11-21 | 1979-01-09 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for producing benzo (a) quinolizine derivatives |
| US4304913A (en) * | 1978-11-20 | 1981-12-08 | Miles Laboratories, Inc. | Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
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| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
-
2004
- 2004-02-11 GB GB0403037A patent/GB2410947B/en not_active Expired - Fee Related
-
2005
- 2005-02-11 DK DK05708289T patent/DK1716145T3/da active
- 2005-02-11 CA CA002555815A patent/CA2555815A1/en not_active Abandoned
- 2005-02-11 RS RSP-2008/0550A patent/RS50660B/sr unknown
- 2005-02-11 CN CN200580012044A patent/CN100591680C/zh not_active Expired - Fee Related
- 2005-02-11 SI SI200530470T patent/SI1716145T1/sl unknown
- 2005-02-11 NZ NZ549105A patent/NZ549105A/en not_active IP Right Cessation
- 2005-02-11 ZA ZA200607425A patent/ZA200607425B/xx unknown
- 2005-02-11 MX MXPA06009164A patent/MXPA06009164A/es active IP Right Grant
- 2005-02-11 PL PL05708289T patent/PL1716145T3/pl unknown
- 2005-02-11 DE DE602005009327T patent/DE602005009327D1/de active Active
- 2005-02-11 AT AT05708289T patent/ATE406370T1/de active
- 2005-02-11 ES ES05708289T patent/ES2313292T3/es active Active
- 2005-02-11 JP JP2006552683A patent/JP2007522193A/ja active Pending
- 2005-02-11 EP EP05708289A patent/EP1716145B1/en active Active
- 2005-02-11 US US10/597,803 patent/US20080108645A1/en not_active Abandoned
- 2005-02-11 AU AU2005213525A patent/AU2005213525B2/en not_active Ceased
- 2005-02-11 WO PCT/GB2005/000464 patent/WO2005077946A1/en active Application Filing
- 2005-02-11 RU RU2006132329/04A patent/RU2365590C2/ru not_active IP Right Cessation
- 2005-02-11 PT PT05708289T patent/PT1716145E/pt unknown
-
2007
- 2007-04-25 HK HK07104428.7A patent/HK1098138A1/xx not_active IP Right Cessation
-
2008
- 2008-11-06 HR HR20080564T patent/HRP20080564T3/xx unknown
- 2008-11-26 CY CY20081101360T patent/CY1108592T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1716145A1 (en) | 2006-11-02 |
| HK1098138A1 (en) | 2007-07-13 |
| EP1716145B1 (en) | 2008-08-27 |
| NZ549105A (en) | 2009-04-30 |
| CA2555815A1 (en) | 2005-08-25 |
| PL1716145T3 (pl) | 2009-04-30 |
| GB2410947B (en) | 2008-09-17 |
| CN1980924A (zh) | 2007-06-13 |
| AU2005213525B2 (en) | 2011-01-06 |
| MXPA06009164A (es) | 2007-01-26 |
| CN100591680C (zh) | 2010-02-24 |
| RS50660B (sr) | 2010-06-30 |
| GB2410947A (en) | 2005-08-17 |
| DK1716145T3 (da) | 2008-11-10 |
| CY1108592T1 (el) | 2014-04-09 |
| DE602005009327D1 (de) | 2008-10-09 |
| AU2005213525A1 (en) | 2005-08-25 |
| ES2313292T3 (es) | 2009-03-01 |
| SI1716145T1 (sl) | 2009-02-28 |
| US20080108645A1 (en) | 2008-05-08 |
| PT1716145E (pt) | 2008-11-14 |
| WO2005077946A1 (en) | 2005-08-25 |
| HRP20080564T3 (en) | 2009-02-28 |
| RU2006132329A (ru) | 2008-03-20 |
| JP2007522193A (ja) | 2007-08-09 |
| ATE406370T1 (de) | 2008-09-15 |
| GB0403037D0 (en) | 2004-03-17 |
| RU2365590C2 (ru) | 2009-08-27 |
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