ZA200606277B - Polysubstituted 1,1-pyridyloxycyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them - Google Patents

Polysubstituted 1,1-pyridyloxycyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA200606277B
ZA200606277B ZA200606277A ZA200606277A ZA200606277B ZA 200606277 B ZA200606277 B ZA 200606277B ZA 200606277 A ZA200606277 A ZA 200606277A ZA 200606277 A ZA200606277 A ZA 200606277A ZA 200606277 B ZA200606277 B ZA 200606277B
Authority
ZA
South Africa
Prior art keywords
pyridyloxycyclopropanamine
polysubstituted
compounds
preparation
pharmaceutical compositions
Prior art date
Application number
ZA200606277A
Other languages
English (en)
Inventor
Goldstein Solo
Guillonneua Claude
Charton Yves
Lockhart Brian
Lestage Pierre
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200606277B publication Critical patent/ZA200606277B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200606277A 2005-07-28 2006-07-28 Polysubstituted 1,1-pyridyloxycyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them ZA200606277B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0508033A FR2889187B1 (fr) 2005-07-28 2005-07-28 Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA200606277B true ZA200606277B (en) 2007-04-25

Family

ID=35841768

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200606277A ZA200606277B (en) 2005-07-28 2006-07-28 Polysubstituted 1,1-pyridyloxycyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US7348344B2 (de)
EP (1) EP1748043B1 (de)
JP (1) JP2007077135A (de)
KR (1) KR100824830B1 (de)
CN (1) CN100519531C (de)
AR (1) AR054875A1 (de)
AT (1) ATE405550T1 (de)
AU (1) AU2006203241A1 (de)
BR (1) BRPI0603064A (de)
CA (1) CA2552827A1 (de)
DE (1) DE602006002328D1 (de)
DK (1) DK1748043T3 (de)
EA (1) EA011126B1 (de)
ES (1) ES2313589T3 (de)
FR (1) FR2889187B1 (de)
GE (1) GEP20084548B (de)
HR (1) HRP20080536T5 (de)
MA (1) MA28426B1 (de)
MX (1) MXPA06008415A (de)
NO (1) NO20063461L (de)
NZ (1) NZ548747A (de)
PL (1) PL1748043T3 (de)
PT (1) PT1748043E (de)
SG (1) SG129411A1 (de)
SI (1) SI1748043T1 (de)
WO (1) WO2007012762A1 (de)
ZA (1) ZA200606277B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896800B1 (fr) * 2006-01-30 2008-04-11 Servier Lab Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUE033352T2 (en) * 2009-11-18 2017-11-28 Suven Life Sciences Ltd Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2095350C1 (ru) * 1993-10-13 1997-11-10 Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) 3-(n,n-диметилкарбамоилокси)-2-этил-6-метилпиридина сукцинат, обладающий антигипоксической активностью
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
FR2810664B1 (fr) * 2000-06-27 2004-12-24 Adir Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
WO2007012762A1 (fr) 2007-02-01
MXPA06008415A (es) 2007-01-29
DE602006002328D1 (de) 2008-10-02
HRP20080536T3 (en) 2009-02-28
BRPI0603064A (pt) 2007-08-14
ATE405550T1 (de) 2008-09-15
EP1748043B1 (de) 2008-08-20
PT1748043E (pt) 2008-10-07
MA28426B1 (fr) 2007-02-01
SG129411A1 (en) 2007-02-26
US7348344B2 (en) 2008-03-25
DK1748043T3 (da) 2008-12-08
GEP20084548B (en) 2008-11-25
AR054875A1 (es) 2007-07-25
EA011126B1 (ru) 2008-12-30
CA2552827A1 (fr) 2007-01-28
KR100824830B1 (ko) 2008-04-23
FR2889187A1 (fr) 2007-02-02
EP1748043A1 (de) 2007-01-31
PL1748043T3 (pl) 2008-12-31
JP2007077135A (ja) 2007-03-29
CN100519531C (zh) 2009-07-29
HRP20080536T5 (en) 2009-03-31
CN1903843A (zh) 2007-01-31
EA200601248A1 (ru) 2007-04-27
ES2313589T3 (es) 2009-03-01
NO20063461L (no) 2007-01-29
NZ548747A (en) 2007-06-29
KR20070015011A (ko) 2007-02-01
US20070027191A1 (en) 2007-02-01
SI1748043T1 (sl) 2008-12-31
AU2006203241A1 (en) 2007-02-15
FR2889187B1 (fr) 2007-09-07

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