ZA200602912B - Combination therapy for HCV infection - Google Patents
Combination therapy for HCV infection Download PDFInfo
- Publication number
- ZA200602912B ZA200602912B ZA200602912A ZA200602912A ZA200602912B ZA 200602912 B ZA200602912 B ZA 200602912B ZA 200602912 A ZA200602912 A ZA 200602912A ZA 200602912 A ZA200602912 A ZA 200602912A ZA 200602912 B ZA200602912 B ZA 200602912B
- Authority
- ZA
- South Africa
- Prior art keywords
- day
- interferon
- therapeutic combination
- ribavirin
- patient
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title claims description 24
- 238000002648 combination therapy Methods 0.000 title claims description 8
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 78
- 229960000329 ribavirin Drugs 0.000 claims description 73
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 64
- 230000001225 therapeutic effect Effects 0.000 claims description 56
- 102000014150 Interferons Human genes 0.000 claims description 34
- 108010050904 Interferons Proteins 0.000 claims description 34
- 108010047761 Interferon-alpha Proteins 0.000 claims description 27
- 102000006992 Interferon-alpha Human genes 0.000 claims description 27
- 229940079322 interferon Drugs 0.000 claims description 27
- 238000011282 treatment Methods 0.000 claims description 20
- 108010092853 peginterferon alfa-2a Proteins 0.000 claims description 16
- 229950000038 interferon alfa Drugs 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 10
- 229940047124 interferons Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 108010078049 Interferon alpha-2 Proteins 0.000 claims description 4
- -1 peginteferon alfa-2b Proteins 0.000 claims description 3
- 238000009097 single-agent therapy Methods 0.000 claims description 3
- 229960003521 interferon alfa-2a Drugs 0.000 claims description 2
- 229960003507 interferon alfa-2b Drugs 0.000 claims description 2
- 229960003930 peginterferon alfa-2a Drugs 0.000 claims description 2
- MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010092851 peginterferon alfa-2b Proteins 0.000 description 16
- 229940106366 pegintron Drugs 0.000 description 16
- 229940002988 pegasys Drugs 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- 238000009472 formulation Methods 0.000 description 11
- 238000002560 therapeutic procedure Methods 0.000 description 9
- 208000005176 Hepatitis C Diseases 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 6
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 208000006154 Chronic hepatitis C Diseases 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000010710 hepatitis C virus infection Diseases 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 108010006088 interferon alfa-n1 Proteins 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000022120 Jeavons syndrome Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007882 cirrhosis Effects 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 229940055354 copegus Drugs 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 208000007475 hemolytic anemia Diseases 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 229940090438 infergen Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 108010055511 interferon alfa-2c Proteins 0.000 description 2
- 108010010648 interferon alfacon-1 Proteins 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 230000006320 pegylation Effects 0.000 description 2
- 229940053146 rebetol Drugs 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 241000710781 Flaviviridae Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010019837 Hepatocellular injury Diseases 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000003996 Interferon-beta Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 102000007397 Species specific proteins Human genes 0.000 description 1
- 108020005719 Species specific proteins Proteins 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229940107810 cellcept Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000005860 defense response to virus Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229960001388 interferon-beta Drugs 0.000 description 1
- 229940065638 intron a Drugs 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51073303P | 2003-10-11 | 2003-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200602912B true ZA200602912B (en) | 2007-06-27 |
Family
ID=34465143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200602912A ZA200602912B (en) | 2003-10-11 | 2004-10-12 | Combination therapy for HCV infection |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20050112093A1 (enExample) |
| EP (1) | EP1670462A1 (enExample) |
| JP (1) | JP2007508326A (enExample) |
| KR (1) | KR20060120037A (enExample) |
| CN (1) | CN1882335A (enExample) |
| AR (1) | AR045870A1 (enExample) |
| AU (1) | AU2004281747A1 (enExample) |
| BR (1) | BRPI0415249A (enExample) |
| CA (1) | CA2541857A1 (enExample) |
| IL (1) | IL174864A0 (enExample) |
| MX (1) | MXPA06004077A (enExample) |
| NO (1) | NO20062104L (enExample) |
| PE (1) | PE20050477A1 (enExample) |
| RU (1) | RU2006115916A (enExample) |
| TW (1) | TW200528104A (enExample) |
| WO (1) | WO2005037274A1 (enExample) |
| ZA (1) | ZA200602912B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ298749B6 (cs) | 1996-10-18 | 2008-01-16 | Vertex Pharmaceuticals Incorporated | Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| US20120201883A1 (en) * | 2004-05-21 | 2012-08-09 | Accu-Break Technologies, Inc | Antiviral compositons |
| MY141025A (en) * | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| CA2617679A1 (en) * | 2005-08-02 | 2007-02-08 | Steve Lyons | Inhibitors of serine proteases |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| WO2008106058A2 (en) * | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| FR2928146B1 (fr) * | 2008-02-28 | 2010-02-19 | Saint Gobain Isover | Produit a base de fibres minerales et son procede d'obtention. |
| EP2337583A1 (en) * | 2008-09-17 | 2011-06-29 | Boehringer Ingelheim International GmbH | Combination of hcv ns3 protease inhibitor with interferon and ribavirin |
| EP2396028A2 (en) * | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| JPWO2011001897A1 (ja) * | 2009-06-30 | 2012-12-13 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 難治性のｃ型慢性肝炎の治療のための薬剤及び方法 |
| US20110027229A1 (en) | 2009-07-31 | 2011-02-03 | Medtronic, Inc. | Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients |
| BR112012010110A2 (pt) | 2009-10-30 | 2019-09-24 | Boehringer Ingelheim Int | regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
| CA2811203C (en) | 2011-10-21 | 2015-05-05 | Abbvie Inc. | Methods for treating hcv |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| WO2017062840A1 (en) * | 2015-10-09 | 2017-04-13 | Trek Therapeutics, Pbc | Combination therapy for the treatment of hepatitis c virus |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| WO2017223178A1 (en) * | 2016-06-21 | 2017-12-28 | Trek Therapeutics, Pbc | Treating viral infections with impdh inhibitors |
| KR101991365B1 (ko) * | 2017-03-14 | 2019-06-21 | 국립암센터 | C형 간염 바이러스 질환 치료를 위한 리고세르팁의 신규 용도 |
| CN109745315B (zh) * | 2019-03-08 | 2021-04-16 | 中国农业科学院兰州兽医研究所 | 一种Merimepodib在制备预防口蹄疫病毒感染的药物中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ298463B6 (cs) * | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
| TWI277424B (en) * | 1998-05-15 | 2007-04-01 | Schering Corp | Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection |
| US6824769B2 (en) * | 2001-08-28 | 2004-11-30 | Vertex Pharmaceuticals Incorporated | Optimal compositions and methods thereof for treating HCV infections |
| WO2003101199A1 (en) * | 2002-05-31 | 2003-12-11 | Schering Corporation | Combination therapy for rna virus infections involving ribavirin and impdh inhibitors |
-
2004
- 2004-10-08 AR ARP040103677A patent/AR045870A1/es not_active Application Discontinuation
- 2004-10-11 PE PE2004000979A patent/PE20050477A1/es not_active Application Discontinuation
- 2004-10-11 TW TW093130756A patent/TW200528104A/zh unknown
- 2004-10-12 ZA ZA200602912A patent/ZA200602912B/en unknown
- 2004-10-12 JP JP2006534467A patent/JP2007508326A/ja active Pending
- 2004-10-12 KR KR1020067006996A patent/KR20060120037A/ko not_active Withdrawn
- 2004-10-12 RU RU2006115916/15A patent/RU2006115916A/ru not_active Application Discontinuation
- 2004-10-12 EP EP04794964A patent/EP1670462A1/en not_active Withdrawn
- 2004-10-12 CN CNA2004800335847A patent/CN1882335A/zh active Pending
- 2004-10-12 BR BRPI0415249-2A patent/BRPI0415249A/pt not_active Application Discontinuation
- 2004-10-12 WO PCT/US2004/033739 patent/WO2005037274A1/en not_active Ceased
- 2004-10-12 MX MXPA06004077A patent/MXPA06004077A/es not_active Application Discontinuation
- 2004-10-12 US US10/964,243 patent/US20050112093A1/en not_active Abandoned
- 2004-10-12 CA CA002541857A patent/CA2541857A1/en not_active Abandoned
- 2004-10-12 AU AU2004281747A patent/AU2004281747A1/en not_active Abandoned
-
2006
- 2006-04-09 IL IL174864A patent/IL174864A0/en unknown
- 2006-05-10 NO NO20062104A patent/NO20062104L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20050112093A1 (en) | 2005-05-26 |
| CA2541857A1 (en) | 2005-04-28 |
| PE20050477A1 (es) | 2005-08-24 |
| NO20062104L (no) | 2006-05-10 |
| AU2004281747A1 (en) | 2005-04-28 |
| MXPA06004077A (es) | 2006-06-27 |
| AR045870A1 (es) | 2005-11-16 |
| RU2006115916A (ru) | 2007-12-10 |
| EP1670462A1 (en) | 2006-06-21 |
| JP2007508326A (ja) | 2007-04-05 |
| WO2005037274A1 (en) | 2005-04-28 |
| KR20060120037A (ko) | 2006-11-24 |
| CN1882335A (zh) | 2006-12-20 |
| BRPI0415249A (pt) | 2006-12-12 |
| TW200528104A (en) | 2005-09-01 |
| IL174864A0 (en) | 2008-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20050112093A1 (en) | Combination therapy for HCV infection | |
| US20020127203A1 (en) | Ribavirin-pegylated interferon alfa HCV combination therapy | |
| US20110270212A1 (en) | Pharmacokinetic control for optimized interferon delivery | |
| US20090226400A1 (en) | Continuous delivery methods for treating hepatitis virus infection | |
| EP1536839B1 (en) | Combination therapy comprising omega-interferon for treating infection with hepatitis c virus or yellow fever virus | |
| US20150258167A1 (en) | New Treatments of Hepatitis C Virus Infection | |
| MXPA00003401A (es) | Tratamiento del carcinoma de celula renal. | |
| US20150273015A1 (en) | Treatments of hepatitis c virus infection | |
| US20150139950A1 (en) | Alisporivir to treat hepatitis c virus infection | |
| Zhang | Pegylated interferons in the treatment of chronic hepatitis C | |
| HK1098359A (en) | Combination therapy for hcv infection | |
| US20160235808A1 (en) | Treatment of Hepatitis C Virus Infection with Alisporivir | |
| CN103732242A (zh) | 用与IFN-α2b组合的IFN-α5在患者群体中治疗慢性丙型肝炎 | |
| WO2013138064A1 (en) | Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population | |
| NZ615539B2 (en) | Treatment of hepatitis c virus infection with alisporivir | |
| US20120100105A1 (en) | Agent and method for treating refractory chronic hepatitis c |