ZA200509103B - Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof - Google Patents

Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof

Info

Publication number
ZA200509103B
ZA200509103B ZA200509103A ZA200509103A ZA200509103B ZA 200509103 B ZA200509103 B ZA 200509103B ZA 200509103 A ZA200509103 A ZA 200509103A ZA 200509103 A ZA200509103 A ZA 200509103A ZA 200509103 B ZA200509103 B ZA 200509103B
Authority
ZA
South Africa
Prior art keywords
propionamideor
cyclobutylmethyl
intermediates
hydroxy
salts
Prior art date
Application number
ZA200509103A
Other languages
English (en)
Inventor
Minzhang Chen
Fucheng Zhang
Michael D Green
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200509103B publication Critical patent/ZA200509103B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200509103A 2003-06-17 2005-11-10 Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof ZA200509103B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47948703P 2003-06-17 2003-06-17

Publications (1)

Publication Number Publication Date
ZA200509103B true ZA200509103B (en) 2006-09-27

Family

ID=33539180

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200509103A ZA200509103B (en) 2003-06-17 2005-11-10 Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof

Country Status (9)

Country Link
US (3) US6992220B2 (ja)
EP (1) EP1633698A1 (ja)
JP (1) JP4823899B2 (ja)
CN (1) CN100591662C (ja)
CA (1) CA2526634C (ja)
MX (1) MXPA05013751A (ja)
SG (1) SG185140A1 (ja)
WO (1) WO2004113272A1 (ja)
ZA (1) ZA200509103B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004113272A1 (en) * 2003-06-17 2004-12-29 Schering Corporation Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
WO2006130554A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
US20060276404A1 (en) * 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
WO2006130687A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis c virus protease inhibitor
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2006130552A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
JP5160415B2 (ja) * 2005-06-02 2013-03-13 メルク・シャープ・アンド・ドーム・コーポレーション 医薬処方物およびそれを用いる治療方法
WO2006130626A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Method for modulating activity of hcv protease through use of a novel hcv protease inhibitor to reduce duration of treatment period
CA2611145A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Controlled-release formulation useful for treating disorders associated with hepatitis c virus
NZ563361A (en) 2005-06-02 2011-02-25 Schering Corp HCV protease inhibitors in combination with food
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
JP5247466B2 (ja) * 2005-12-22 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション ６，６−ジメチル−３−アザビシクロ−［３．１．０］−ヘキサン化合物およびその鏡像異性体塩を調製するプロセス
SG177906A1 (en) 2006-12-19 2012-02-28 Schering Corp Us Preparation of 3-amino-3-(cyclobutylmethyl)-2-(hydroxy)-propionamide hydrochloride
MX2010005809A (es) * 2007-11-28 2010-06-09 Schering Corp Proceso de dehidrohalogenacion para la preparacion de intermediarios utiles en el suministro de compuestos 6,6-dimetil-3-azabiciclo-[3,1,0]-hexano.
CN102089274B (zh) * 2007-12-21 2014-09-10 默沙东公司 合成3-氨基-3-环丁基甲基-2-羟基丙酰胺或其盐的方法
WO2014083575A2 (en) 2012-11-29 2014-06-05 Mylan Laboratories Ltd Improved process for the preparation of boceprevir intermediate
CN103936627B (zh) * 2013-01-18 2016-08-31 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅶ及其制备方法和应用
CN103936818B (zh) * 2013-01-18 2017-09-29 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅰ及其制备方法和应用
CN103936616B (zh) * 2013-01-18 2016-06-22 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅱ及其制备方法和应用
WO2015004685A2 (en) 2013-07-12 2015-01-15 Mylan Laboratories Ltd An improved process for the purification of boceprevir

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
DK1385870T3 (da) * 2000-07-21 2010-07-05 Schering Corp Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus
WO2003062228A1 (en) * 2002-01-23 2003-07-31 Schering Corporation Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatites c virus infection
WO2004113272A1 (en) * 2003-06-17 2004-12-29 Schering Corporation Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof

Also Published As

Publication number Publication date
CA2526634A1 (en) 2004-12-29
US20060030734A1 (en) 2006-02-09
MXPA05013751A (es) 2006-03-08
WO2004113272A1 (en) 2004-12-29
EP1633698A1 (en) 2006-03-15
SG185140A1 (en) 2012-11-29
CN100591662C (zh) 2010-02-24
US20090312576A1 (en) 2009-12-17
US7595419B2 (en) 2009-09-29
JP4823899B2 (ja) 2011-11-24
US20050020689A1 (en) 2005-01-27
CA2526634C (en) 2012-09-18
US6992220B2 (en) 2006-01-31
JP2006528135A (ja) 2006-12-14
CN1805920A (zh) 2006-07-19

Similar Documents

Publication Publication Date Title
ZA200509103B (en) Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof
PL1651622T3 (pl) Sposób wytwarzania związków 2-(chinoksalin-5-ylosulfonyloamino)benzamidowych
IL173456A0 (en) Process for the preparation of 4-amino-3-quinolinecarbonitriles
HRP20150163T1 (en) Process for the preparation of n-substituted 2-cyanopyrrolidines
IL173736A0 (en) Process for the preparation of renzapride and intermediates thereof
AU2003253188A8 (en) Novel processes and intermediates for preparing triazolo-pyridines
IL175743A0 (en) Process for the preparation of thiazolopyrimidines
PT1753720E (pt) Processo para a preparação de perindopril e sais do mesmo
IL173887A0 (en) A process for the preparation of cilostazol and of the intermediates thereof
HUP0600231A2 (en) Novel process for the preparation of 2h-chromenes
IL182277A0 (en) Method and intermediates for the preparation of derivatives of n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulphonamide
ZA200602603B (en) Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
AU2003265845A8 (en) Methods for the preparation of beta-amino acids
IL182445A0 (en) Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4difluoromethoxy-8-methanesulfona mido-dibenzo[b,d]furan-1-caboxamide
HK1095145A1 (en) Process for the preparation of n-arylmorpholinones n-
SG111997A1 (en) Improved process for the preparation of polyalkylphenoxyaminoalkanes
PL371583A1 (en) Process for the preparation of 7alpha-methylsteroids
SI1622926T1 (sl) Nov postopek in intermediati za pripravo 17-halogen-19-nor-steroidnih spojin
IL164788A0 (en) Process for the preparation of 3-isochromanone
HK1087111A1 (en) Process for the preparation of nicotinaldehydes
AU2003213281A8 (en) Process and intermediates for preparing phenylthiomethyl-thiazoles or oxazoles
PL373972A1 (en) Process for the preparation of morpholine derivatives and intermediates therefore
IL166087A0 (en) Process for preparing nateglinide and intermediates thereof
TWI365874B (en) One-pot process for the preparation of 1,2-benz-isoxazole-3-methanesulfonamide
GB2390088B (en) Combustion process for the preparation of LiCoVO4