ZA200501843B - A method of extending the dose range of vitamin D compounds - Google Patents
A method of extending the dose range of vitamin D compounds Download PDFInfo
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- ZA200501843B ZA200501843B ZA200501843A ZA200501843A ZA200501843B ZA 200501843 B ZA200501843 B ZA 200501843B ZA 200501843 A ZA200501843 A ZA 200501843A ZA 200501843 A ZA200501843 A ZA 200501843A ZA 200501843 B ZA200501843 B ZA 200501843B
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- South Africa
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- vitamin
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- 210000000496 pancreas Anatomy 0.000 description 1
- 210000002990 parathyroid gland Anatomy 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 239000000651 prodrug Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 229940089617 risedronate Drugs 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
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- 239000007762 w/o emulsion Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/235,244 US7259143B2 (en) | 2002-09-05 | 2002-09-05 | Method of extending the dose range of vitamin D compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200501843B true ZA200501843B (en) | 2006-05-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200501843A ZA200501843B (en) | 2002-09-05 | 2005-03-03 | A method of extending the dose range of vitamin D compounds |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7259143B2 (fr) |
| EP (1) | EP1545549A1 (fr) |
| JP (1) | JP2006500388A (fr) |
| KR (1) | KR100835456B1 (fr) |
| CN (1) | CN1694711A (fr) |
| AU (2) | AU2003245748A1 (fr) |
| BR (1) | BR0314006A (fr) |
| CA (1) | CA2497828A1 (fr) |
| MX (1) | MXPA05002467A (fr) |
| NZ (1) | NZ539129A (fr) |
| PL (1) | PL375558A1 (fr) |
| WO (1) | WO2004022068A1 (fr) |
| ZA (1) | ZA200501843B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| CA2480814A1 (fr) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Procede d'inhibition de resorption osseuse a l'aide d'une formulation a base d'alendronate et de vitamine d |
| US20080249068A1 (en) * | 2002-09-05 | 2008-10-09 | Deluca Hector F | Method of Extending the Dose Range of Vitamin D Compounds |
| US7566696B2 (en) * | 2002-09-05 | 2009-07-28 | Wisconsin Alumni Research Foundation | Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis |
| EP1656157B1 (fr) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | Composes de la 2-methylene-19-nor-vitamine d2 |
| WO2005027929A1 (fr) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Compositions pharmaceutiques et methodes de traitement consistant en des associations d'un derive de la 2-alkylidene-19-nor-vitamine d et d'un oestrogene |
| KR20060040746A (ko) * | 2003-09-19 | 2006-05-10 | 화이자 프로덕츠 인크. | 2-알킬리덴-19-노르-비타민 ｄ 유도체와 에스트로겐효능제/길항제의 조합물을 포함하는 제약 조성물 및 방법 |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| US20050261250A1 (en) * | 2004-05-19 | 2005-11-24 | Merck & Co., Inc., | Compositions and methods for inhibiting bone resorption |
| WO2006061683A1 (fr) * | 2004-12-09 | 2006-06-15 | Pfizer Products Inc. | Derives 2-alkylidene-19-nor de la vitamine d pour le traitement d'une osteogenese imparfaite |
| WO2006086661A2 (fr) * | 2005-02-10 | 2006-08-17 | Above Sea Level, Llc | Procede et systeme de production de liste de clients potentiels |
| MX2007009725A (es) * | 2005-02-11 | 2007-09-26 | Wisconsin Alumni Res Found | 2-metilen-19-nor-(20s-24epi)-1a, 25-dihidroxivitamina-d2. |
| AU2006213727B2 (en) * | 2005-02-11 | 2011-08-18 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20S-24S) - 1alpha, 25-dihydroxyvitamin-D2 |
| EP1848455A1 (fr) * | 2005-02-14 | 2007-10-31 | Wisconsin Alumni Research Foundation | Utilisation de la calcitonine et de peptides du type calcitonine dans le traitement de la sclerose en plaques |
| CA2619311A1 (fr) * | 2005-08-18 | 2007-02-22 | Bioxell S.P.A. | Synthese de 1.alpha.-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol |
| US20070165866A1 (en) * | 2006-01-13 | 2007-07-19 | Motorola, Inc. | Method and apparatus to facilitate conveying audio content |
| ES2956794T3 (es) * | 2007-04-25 | 2023-12-28 | Eirgen Pharma Ltd | Liberación controlada de 25-hidroxivitamina D |
| US20100331286A1 (en) * | 2008-02-25 | 2010-12-30 | Ray Chow | Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function |
| TR200900880A2 (tr) | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Tek bir dozaj formunda kombine edilen farmasötik bileşimler. |
| TR200900878A2 (tr) | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Tek bir dozaj formunda kombine edilen farmasötik formülasyonlar |
| MX2012003882A (es) * | 2009-10-02 | 2012-06-25 | Wisconsin Alumni Res Found | Analogos de 1-desoxi-2-metileno-19-nor-vitamina d y sus usos. |
| WO2012075326A2 (fr) * | 2010-12-01 | 2012-06-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Traitement de maladies inflammatoires par ciblage de la protéine adaptatrice ciks |
| EP2768804B1 (fr) * | 2011-10-21 | 2018-02-28 | Wisconsin Alumni Research Foundation | Analogues de 2-méthylène-vitamine d et leurs utilisations |
| WO2017023617A1 (fr) * | 2015-08-05 | 2017-02-09 | Wisconsin Alumni Research Foundation | Synthèse et activité biologique d'analogues 2-méthylène du calcitriol et de composés apparentés |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6357527A (ja) | 1986-08-28 | 1988-03-12 | Toyo Jozo Co Ltd | 薬剤の吸着防止方法 |
| US5391567A (en) * | 1986-09-03 | 1995-02-21 | Macrochem Corporation | Method for treating hypercalcemia using salts of TNCA |
| US6489288B1 (en) * | 1990-03-16 | 2002-12-03 | Applied Research Systems Ars Holding | Treatment of polycystic ovarian disease |
| US5780437A (en) * | 1995-12-14 | 1998-07-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6369027B1 (en) * | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| US6613544B1 (en) * | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| US6271349B1 (en) * | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6034075A (en) * | 1997-03-20 | 2000-03-07 | The Trustees Of Columbia University In The City Of New York | Method of treating polycystic ovarian syndrome |
| US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| US6087555A (en) * | 1997-10-15 | 2000-07-11 | Amgen Inc. | Mice lacking expression of osteoprotegerin |
| US6335170B1 (en) * | 1999-02-22 | 2002-01-01 | Torben F. Orntoft | Gene expression in bladder tumors |
| EP1267888A4 (fr) * | 2000-01-04 | 2005-12-28 | Univ California | Utilisation de bisphosphonates a faible dose pour inhiber la calcification cardiaque et arterielle |
| CA2454200A1 (fr) * | 2001-07-17 | 2003-01-30 | Teva Pharmaceutical Industries Ltd. | Formes posologiques pour la liberation gastrique immediate d'un stimulateur de transport du calcium et la liberation gastrique retardee d'un bis-phosphonate |
-
2002
- 2002-09-05 US US10/235,244 patent/US7259143B2/en not_active Expired - Fee Related
-
2003
- 2003-06-26 WO PCT/US2003/020517 patent/WO2004022068A1/fr active Application Filing
- 2003-06-26 BR BR0314006-7A patent/BR0314006A/pt not_active IP Right Cessation
- 2003-06-26 KR KR1020057003765A patent/KR100835456B1/ko not_active IP Right Cessation
- 2003-06-26 AU AU2003245748A patent/AU2003245748A1/en not_active Abandoned
- 2003-06-26 MX MXPA05002467A patent/MXPA05002467A/es active IP Right Grant
- 2003-06-26 CA CA002497828A patent/CA2497828A1/fr not_active Abandoned
- 2003-06-26 JP JP2004534233A patent/JP2006500388A/ja active Pending
- 2003-06-26 CN CNA038248883A patent/CN1694711A/zh active Pending
- 2003-06-26 PL PL03375558A patent/PL375558A1/xx not_active Application Discontinuation
- 2003-06-26 NZ NZ539129A patent/NZ539129A/en not_active IP Right Cessation
- 2003-06-26 EP EP03739354A patent/EP1545549A1/fr not_active Withdrawn
-
2005
- 2005-03-03 ZA ZA200501843A patent/ZA200501843B/en unknown
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2009
- 2009-09-21 AU AU2009217403A patent/AU2009217403A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL375558A1 (en) | 2005-11-28 |
| JP2006500388A (ja) | 2006-01-05 |
| US20040053813A1 (en) | 2004-03-18 |
| AU2009217403A1 (en) | 2009-10-08 |
| CA2497828A1 (fr) | 2004-03-18 |
| KR20050057180A (ko) | 2005-06-16 |
| WO2004022068A1 (fr) | 2004-03-18 |
| BR0314006A (pt) | 2005-08-09 |
| NZ539129A (en) | 2008-05-30 |
| MXPA05002467A (es) | 2005-05-27 |
| AU2003245748A1 (en) | 2004-03-29 |
| EP1545549A1 (fr) | 2005-06-29 |
| US7259143B2 (en) | 2007-08-21 |
| KR100835456B1 (ko) | 2008-06-09 |
| CN1694711A (zh) | 2005-11-09 |
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