ZA200408571B - Composition for stimulating de novo bone induction - Google Patents
Composition for stimulating de novo bone induction Download PDFInfo
- Publication number
- ZA200408571B ZA200408571B ZA2004/08571A ZA200408571A ZA200408571B ZA 200408571 B ZA200408571 B ZA 200408571B ZA 2004/08571 A ZA2004/08571 A ZA 2004/08571A ZA 200408571 A ZA200408571 A ZA 200408571A ZA 200408571 B ZA200408571 B ZA 200408571B
- Authority
- ZA
- South Africa
- Prior art keywords
- bone
- composition
- novo
- trauma
- stimulating
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 89
- 230000006698 induction Effects 0.000 title claims description 37
- 239000000203 mixture Substances 0.000 title claims description 36
- 230000004936 stimulating effect Effects 0.000 title claims description 22
- 210000002469 basement membrane Anatomy 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 28
- 241000124008 Mammalia Species 0.000 claims description 26
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- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 24
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- 108010082117 matrigel Proteins 0.000 claims description 18
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- 230000010072 bone remodeling Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 238000011065 in-situ storage Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
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- 210000003049 pelvic bone Anatomy 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200202307 | 2002-03-22 | ||
| PCT/IB2003/001021 WO2003079964A2 (en) | 2002-03-22 | 2003-03-20 | Composition for stimulating de novo bone induction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200408571B true ZA200408571B (en) | 2005-08-31 |
Family
ID=28455332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2004/08571A ZA200408571B (en) | 2002-03-22 | 2004-10-22 | Composition for stimulating de novo bone induction |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1494702A4 (de) |
| AU (1) | AU2003212562A1 (de) |
| WO (1) | WO2003079964A2 (de) |
| ZA (1) | ZA200408571B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279973C (zh) * | 2004-07-22 | 2006-10-18 | 徐放 | 注射的凝胶型骨修复生物活性材料及其制备方法 |
| EP1948218B1 (de) | 2005-10-17 | 2015-04-15 | University of the Witwatersrand, Johannesburg | Osteogene vorrichtung zur induktion der knochenbildung im klinischen kontext |
| WO2011154882A1 (en) * | 2010-06-06 | 2011-12-15 | University Of The Witwatersrand, Johannesburg | Induction of bone formation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508188A (en) * | 1994-01-21 | 1996-04-16 | The Regents Of The University Of California | Method of growing cells in a mammal |
| US5939323A (en) * | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
| US6391297B1 (en) * | 1997-12-02 | 2002-05-21 | Artecel Sciences, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| EP1095159A4 (de) * | 1998-07-15 | 2003-01-02 | Human Genome Sciences Inc | Knochenmorphogenese-protein |
-
2003
- 2003-03-20 WO PCT/IB2003/001021 patent/WO2003079964A2/en not_active Application Discontinuation
- 2003-03-20 AU AU2003212562A patent/AU2003212562A1/en not_active Abandoned
- 2003-03-20 EP EP03708384A patent/EP1494702A4/de not_active Withdrawn
-
2004
- 2004-10-22 ZA ZA2004/08571A patent/ZA200408571B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1494702A4 (de) | 2009-10-21 |
| WO2003079964A2 (en) | 2003-10-02 |
| AU2003212562A1 (en) | 2003-10-08 |
| AU2003212562A8 (en) | 2003-10-08 |
| WO2003079964A3 (en) | 2004-07-29 |
| EP1494702A2 (de) | 2005-01-12 |
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