ZA200408571B - Composition for stimulating de novo bone induction - Google Patents
Composition for stimulating de novo bone induction Download PDFInfo
- Publication number
- ZA200408571B ZA200408571B ZA2004/08571A ZA200408571A ZA200408571B ZA 200408571 B ZA200408571 B ZA 200408571B ZA 2004/08571 A ZA2004/08571 A ZA 2004/08571A ZA 200408571 A ZA200408571 A ZA 200408571A ZA 200408571 B ZA200408571 B ZA 200408571B
- Authority
- ZA
- South Africa
- Prior art keywords
- bone
- composition
- novo
- trauma
- stimulating
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 89
- 230000006698 induction Effects 0.000 title claims description 37
- 239000000203 mixture Substances 0.000 title claims description 36
- 230000004936 stimulating effect Effects 0.000 title claims description 22
- 210000002469 basement membrane Anatomy 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 28
- 241000124008 Mammalia Species 0.000 claims description 26
- 241001465754 Metazoa Species 0.000 claims description 25
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 24
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 24
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 23
- 208000014674 injury Diseases 0.000 claims description 23
- 230000008733 trauma Effects 0.000 claims description 23
- 230000002188 osteogenic effect Effects 0.000 claims description 22
- 230000003412 degenerative effect Effects 0.000 claims description 21
- 208000020084 Bone disease Diseases 0.000 claims description 19
- 108010082117 matrigel Proteins 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 239000011159 matrix material Substances 0.000 claims description 15
- 239000003102 growth factor Substances 0.000 claims description 13
- 206010065687 Bone loss Diseases 0.000 claims description 10
- 230000009466 transformation Effects 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 208000001132 Osteoporosis Diseases 0.000 claims description 7
- 241000288906 Primates Species 0.000 claims description 6
- 230000007547 defect Effects 0.000 claims description 6
- 230000004069 differentiation Effects 0.000 claims description 6
- 230000009885 systemic effect Effects 0.000 claims description 6
- 231100001055 skeletal defect Toxicity 0.000 claims description 5
- 108010042086 Collagen Type IV Proteins 0.000 claims description 4
- 102000004266 Collagen Type IV Human genes 0.000 claims description 4
- 229920002971 Heparan sulfate Polymers 0.000 claims description 4
- 108010085895 Laminin Proteins 0.000 claims description 4
- 108010067787 Proteoglycans Proteins 0.000 claims description 4
- 230000014616 translation Effects 0.000 claims description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 3
- 108020004511 Recombinant DNA Proteins 0.000 claims description 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 3
- 230000036760 body temperature Effects 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 210000002744 extracellular matrix Anatomy 0.000 claims description 3
- 230000003239 periodontal effect Effects 0.000 claims description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 3
- 101710167839 Morphogenetic protein Proteins 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 2
- 235000004252 protein component Nutrition 0.000 claims 1
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 230000011164 ossification Effects 0.000 description 9
- 241001504519 Papio ursinus Species 0.000 description 8
- 241000283984 Rodentia Species 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000004166 bioassay Methods 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001641 gel filtration chromatography Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000011670 long-evans rat Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 206010058112 Chondrolysis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 210000003049 pelvic bone Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009790 vascular invasion Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200202307 | 2002-03-22 | ||
| PCT/IB2003/001021 WO2003079964A2 (en) | 2002-03-22 | 2003-03-20 | Composition for stimulating de novo bone induction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200408571B true ZA200408571B (en) | 2005-08-31 |
Family
ID=28455332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2004/08571A ZA200408571B (en) | 2002-03-22 | 2004-10-22 | Composition for stimulating de novo bone induction |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1494702A4 (de) |
| AU (1) | AU2003212562A1 (de) |
| WO (1) | WO2003079964A2 (de) |
| ZA (1) | ZA200408571B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279973C (zh) * | 2004-07-22 | 2006-10-18 | 徐放 | 注射的凝胶型骨修复生物活性材料及其制备方法 |
| WO2007045955A2 (en) | 2005-10-17 | 2007-04-26 | University Of The Witwatersrand, Johannesburg | Osteogenic device for inducing bone formation in clinical contexts |
| WO2011154882A1 (en) * | 2010-06-06 | 2011-12-15 | University Of The Witwatersrand, Johannesburg | Induction of bone formation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508188A (en) * | 1994-01-21 | 1996-04-16 | The Regents Of The University Of California | Method of growing cells in a mammal |
| EP0907721A1 (de) * | 1996-05-28 | 1999-04-14 | Brown University Research Foundation | Biologisch abbaubarer träger auf basis von hyaluronan für die gewebewiederherstellung |
| US6391297B1 (en) * | 1997-12-02 | 2002-05-21 | Artecel Sciences, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| WO2000004183A1 (en) * | 1998-07-15 | 2000-01-27 | Human Genome Sciences, Inc. | Bone morphogenic protein |
-
2003
- 2003-03-20 WO PCT/IB2003/001021 patent/WO2003079964A2/en not_active Application Discontinuation
- 2003-03-20 EP EP03708384A patent/EP1494702A4/de not_active Withdrawn
- 2003-03-20 AU AU2003212562A patent/AU2003212562A1/en not_active Abandoned
-
2004
- 2004-10-22 ZA ZA2004/08571A patent/ZA200408571B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1494702A4 (de) | 2009-10-21 |
| AU2003212562A8 (en) | 2003-10-08 |
| AU2003212562A1 (en) | 2003-10-08 |
| WO2003079964A3 (en) | 2004-07-29 |
| EP1494702A2 (de) | 2005-01-12 |
| WO2003079964A2 (en) | 2003-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Boden et al. | Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage | |
| Den Boer et al. | Effect of recombinant human osteogenic protein-1 on the healing of a freshly closed diaphyseal fracture | |
| Pannier | Congenital pseudarthrosis of the tibia | |
| JP3191937B2 (ja) | 骨誘導医薬製剤 | |
| Kanakaris et al. | Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience | |
| ES2443581T3 (es) | Composiciones y métodos para el tratamiento de hueso | |
| WO2007090180A1 (en) | Cohesive osteogenic putty and materials therefor | |
| US20140106447A1 (en) | Compositions and methods for recruiting stem cells | |
| CN110612129B (zh) | 自体骨移植物替代物 | |
| McCarthy | Genetic diseases of bones and joints | |
| KR20110100269A (ko) | 감소된 프로테아제 활성을 갖는 골 이식편 및 선택 방법 및 용도 | |
| Zhang et al. | Bone regeneration after radiotherapy in an animal model | |
| Jiang et al. | The effects of hypoxia-inducible factor (HIF)-1α protein on bone regeneration during distraction osteogenesis: an animal study | |
| Yonezawa et al. | Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: a preliminary study in rabbit mandibles | |
| US20060052304A1 (en) | Method for remodeling bone and related sutures | |
| WO1998031788A1 (en) | Injectable formulations for treatment of osteoporotic bone | |
| ZA200408571B (en) | Composition for stimulating de novo bone induction | |
| Lin et al. | Post-traumatic fronto-ethmoid osteomyelitis treated with free muscle transfer | |
| Newsom et al. | Design and evaluation of 3D-printed Sr-HT-Gahnite bioceramic for FDA regulatory submission: A Good Laboratory Practice sheep study | |
| US20050153883A1 (en) | Composition for stimulating de novo bone induction | |
| Wahl et al. | Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice | |
| Ripamonti et al. | Local delivery of bone morphogenetic proteins in primates using a reconstituted basement membrane gel: tissue engineering with Matrigel: research in action | |
| Love et al. | Mesenchymal stem cells enhance targeted bone growth from injectable hydrogels with BMP‐2 peptides | |
| EP3145514B1 (de) | Formulierung zur regeneration von knochen und knorpel | |
| US20220193203A1 (en) | Methods of improving spinal fusion with abaloparatide |