WO2003079964A3 - Composition for stimulating de novo bone induction - Google Patents

Composition for stimulating de novo bone induction Download PDF

Info

Publication number
WO2003079964A3
WO2003079964A3 PCT/IB2003/001021 IB0301021W WO03079964A3 WO 2003079964 A3 WO2003079964 A3 WO 2003079964A3 IB 0301021 W IB0301021 W IB 0301021W WO 03079964 A3 WO03079964 A3 WO 03079964A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
stimulating
mammal
bone induction
novo bone
Prior art date
Application number
PCT/IB2003/001021
Other languages
French (fr)
Other versions
WO2003079964A2 (en
Inventor
Ugo Ripamonti
Original Assignee
Univ Witwatersrand
Medical Res Council Of South A
Ugo Ripamonti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Witwatersrand, Medical Res Council Of South A, Ugo Ripamonti filed Critical Univ Witwatersrand
Priority to EP03708384A priority Critical patent/EP1494702A4/en
Priority to AU2003212562A priority patent/AU2003212562A1/en
Publication of WO2003079964A2 publication Critical patent/WO2003079964A2/en
Publication of WO2003079964A3 publication Critical patent/WO2003079964A3/en
Priority to US10/947,394 priority patent/US20050153883A1/en
Priority to ZA2004/08571A priority patent/ZA200408571B/en
Priority to US12/138,301 priority patent/US20080248116A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to a composition for stimulating de novo bone induction in a mammal, to the use of this composition in stimulating de novo bone induction in a mammal and to a method of treating a mammal to stimulate de novo bone induction. The use and method involve introducing the composition, preferably by local injection, into the mammal at a site where de novo bone induction is desired. The composition consists of a combination of a bone morphogenetic protein and a reconstituted basement membrane which, in a preferred embodiment of the invention is Matrigel®. The Matrigel® serves, at least partly, to retain the bone morphogenetic protein at the site of introduction for a period sufficient to trigger a bone differentiation cascade.
PCT/IB2003/001021 2002-03-20 2003-03-20 Composition for stimulating de novo bone induction WO2003079964A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03708384A EP1494702A4 (en) 2002-03-22 2003-03-20 Composition for stimulating de novo bone induction
AU2003212562A AU2003212562A1 (en) 2002-03-22 2003-03-20 Composition for stimulating de novo bone induction
US10/947,394 US20050153883A1 (en) 2002-03-20 2004-09-22 Composition for stimulating de novo bone induction
ZA2004/08571A ZA200408571B (en) 2002-03-22 2004-10-22 Composition for stimulating de novo bone induction
US12/138,301 US20080248116A1 (en) 2002-03-20 2008-06-12 Composition for stimulating de novo bone induction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA2002/2307 2002-03-20
ZA200202307 2002-03-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/947,394 Continuation US20050153883A1 (en) 2002-03-20 2004-09-22 Composition for stimulating de novo bone induction

Publications (2)

Publication Number Publication Date
WO2003079964A2 WO2003079964A2 (en) 2003-10-02
WO2003079964A3 true WO2003079964A3 (en) 2004-07-29

Family

ID=28455332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/001021 WO2003079964A2 (en) 2002-03-20 2003-03-20 Composition for stimulating de novo bone induction

Country Status (4)

Country Link
EP (1) EP1494702A4 (en)
AU (1) AU2003212562A1 (en)
WO (1) WO2003079964A2 (en)
ZA (1) ZA200408571B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279973C (en) * 2004-07-22 2006-10-18 徐放 Injected gel type bone repairing biological active material and its preparing method
US20100068239A1 (en) 2005-10-17 2010-03-18 Ugo Ripamonti Osteogenic Device for Inducing Bone Formation in Clinical Contexts
WO2011154882A1 (en) * 2010-06-06 2011-12-15 University Of The Witwatersrand, Johannesburg Induction of bone formation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643787A (en) * 1994-01-21 1997-07-01 The Regents Of The University Of California Adenocarcinoma cell basement membrane composition
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US6391297B1 (en) * 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US20030032098A1 (en) * 1998-07-15 2003-02-13 Human Genome Sciences, Inc. Bone morphogenic protein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643787A (en) * 1994-01-21 1997-07-01 The Regents Of The University Of California Adenocarcinoma cell basement membrane composition
US5939323A (en) * 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US6391297B1 (en) * 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US20030032098A1 (en) * 1998-07-15 2003-02-13 Human Genome Sciences, Inc. Bone morphogenic protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1494702A4 *

Also Published As

Publication number Publication date
WO2003079964A2 (en) 2003-10-02
EP1494702A4 (en) 2009-10-21
AU2003212562A8 (en) 2003-10-08
AU2003212562A1 (en) 2003-10-08
EP1494702A2 (en) 2005-01-12
ZA200408571B (en) 2005-08-31

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