EP1494702A4 - Composition for stimulating de novo bone induction - Google Patents

Composition for stimulating de novo bone induction

Info

Publication number
EP1494702A4
EP1494702A4 EP03708384A EP03708384A EP1494702A4 EP 1494702 A4 EP1494702 A4 EP 1494702A4 EP 03708384 A EP03708384 A EP 03708384A EP 03708384 A EP03708384 A EP 03708384A EP 1494702 A4 EP1494702 A4 EP 1494702A4
Authority
EP
European Patent Office
Prior art keywords
stimulating
composition
bone induction
novo bone
novo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03708384A
Other languages
German (de)
French (fr)
Other versions
EP1494702A2 (en
Inventor
Ugo Ripamonti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of the Witwatersrand, Johannesburg
Medical Research Council of South Africa
Original Assignee
University of the Witwatersrand, Johannesburg
Medical Research Council of South Africa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of the Witwatersrand, Johannesburg, Medical Research Council of South Africa filed Critical University of the Witwatersrand, Johannesburg
Publication of EP1494702A2 publication Critical patent/EP1494702A2/en
Publication of EP1494702A4 publication Critical patent/EP1494702A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
EP03708384A 2002-03-22 2003-03-20 Composition for stimulating de novo bone induction Withdrawn EP1494702A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA200202307 2002-03-22
ZA200202307 2002-03-22
PCT/IB2003/001021 WO2003079964A2 (en) 2002-03-22 2003-03-20 Composition for stimulating de novo bone induction

Publications (2)

Publication Number Publication Date
EP1494702A2 EP1494702A2 (en) 2005-01-12
EP1494702A4 true EP1494702A4 (en) 2009-10-21

Family

ID=28455332

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03708384A Withdrawn EP1494702A4 (en) 2002-03-22 2003-03-20 Composition for stimulating de novo bone induction

Country Status (4)

Country Link
EP (1) EP1494702A4 (en)
AU (1) AU2003212562A1 (en)
WO (1) WO2003079964A2 (en)
ZA (1) ZA200408571B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279973C (en) * 2004-07-22 2006-10-18 徐放 Injected gel type bone repairing biological active material and its preparing method
US20100068239A1 (en) 2005-10-17 2010-03-18 Ugo Ripamonti Osteogenic Device for Inducing Bone Formation in Clinical Contexts
WO2011154882A1 (en) * 2010-06-06 2011-12-15 University Of The Witwatersrand, Johannesburg Induction of bone formation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508188A (en) * 1994-01-21 1996-04-16 The Regents Of The University Of California Method of growing cells in a mammal
WO1997045532A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
CN100529063C (en) * 1997-12-02 2009-08-19 泽恩比奥公司 Differentiation of adipose stromal cells into osteobalsts and uses thereof
CA2334075A1 (en) * 1998-07-15 2000-01-27 Human Genome Sciences, Inc. Bone morphogenic protein

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BASIC NIKOLINA ET AL: "TGF-beta and basement membrane matrigel stimulate the chondrogenic phenotype in osteoblastic cells derived from fetal rat calvaria", JOURNAL OF BONE AND MINERAL RESEARCH, AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 11, no. 3, 1 January 1996 (1996-01-01), pages 384 - 391, XP009122398, ISSN: 0884-0431 *
DESAI B J ET AL: "The influence of Matrigel(R) or growth factor reduced Matrigel(R) on human intervertebral disc cell growth and proliferation", HISTOLOGY AND HISTOPATHOLOGY: CELLULAR AND MOLECULAR BIOLOGY, GUTENBERG, ES, vol. 14, no. 2, 1 April 1999 (1999-04-01), pages 359 - 368, XP009171724, ISSN: 0213-3911 *
HELM GA ET AL: "Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent", JOURNAL OF NEUROSURGERY, AMERICAN ASSOCIATION OF NEUROLOGICAL SURGEONS, US, vol. 92, no. 2, suppl, 1 April 2000 (2000-04-01), pages 191 - 196, XP009171702, ISSN: 0022-3085 *
RIPAMONTI U ET AL: "Local delivery of bone morphogenetic proteins in primates using a reconstituted basement membrane gel: Tissue engineering with Matrigel.", SOUTH AFRICAN JOURNAL OF SCIENCE, vol. 98, no. 9-10, September 2002 (2002-09-01), pages 429 - 433, XP009122335, ISSN: 0038-2353 *
TABATA YASUHIKO: "The importance of drug delivery systems in tissue engineering", PHARMACEUTICAL SCIENCE AND TECHNOLOGY TODAY, vol. 3, no. 3, March 2000 (2000-03-01), pages 80 - 89, XP002544869, ISSN: 1461-5347 *
UGO RIPAMONTI ET AL: "Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus)", EUROPEAN JOURNAL OF ORAL SCIENCES, vol. 109, no. 4, 1 August 2001 (2001-08-01), pages 241 - 248, XP055073958, ISSN: 0909-8836, DOI: 10.1034/j.1600-0722.2001.00041.x *
VUKICEVIC S ET AL: "Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 202, no. 1, 1 September 1992 (1992-09-01), pages 1 - 8, XP024791756, ISSN: 0014-4827, [retrieved on 19920901] *

Also Published As

Publication number Publication date
ZA200408571B (en) 2005-08-31
WO2003079964A2 (en) 2003-10-02
AU2003212562A8 (en) 2003-10-08
AU2003212562A1 (en) 2003-10-08
WO2003079964A3 (en) 2004-07-29
EP1494702A2 (en) 2005-01-12

Similar Documents

Publication Publication Date Title
HUP0500849A2 (en) Implant for fixing bones
GB0512560D0 (en) Bioreactors for well treatment
AU2003218126A8 (en) Universal implant
AU2003243150A8 (en) Resorption-controllable medical implants
ZA200600384B (en) Compositions and methods for increasing bone mineralization
IL190642A0 (en) Dental implant system
AU2003221726A8 (en) Implant for tissue repair
IL156033A0 (en) Dental implant
IL209352A0 (en) 4-tetrazolyl-4phenylpiperidine derivatives for treating pain
EP1418849A4 (en) Implant devices for nerve repair
IL164149A0 (en) Surgical implant
PL358848A1 (en) Bone treatment material
AU2003270736A8 (en) Nell-1 enhanced bone mineralization
EP1476583A4 (en) Calcification-resistant fixation
AU2003212186A8 (en) Bone screw
GB0222945D0 (en) Therapeutic compositions
AU2003282722A8 (en) Therapeutic compositions
AU2003212562A8 (en) Composition for stimulating de novo bone induction
GB0221157D0 (en) Novel treatment
AU2003226470A8 (en) Apical penil implant for enlargement phalloplasty
AU2003240174A8 (en) Compositions for the treatment of edematous-firbrosclerotic panniculopathy
AU2003289773A8 (en) Bone implant
GB2413798B (en) Bioreactors for well treatment
GB2389046B (en) Spinal prosthesis
PL376151A1 (en) Implant for fixing bones

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20041022

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

A4 Supplementary search report drawn up and despatched

Effective date: 20090922

17Q First examination report despatched

Effective date: 20100216

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140103