ZA200307992B - Modified interferon beta with reduced immunogenicity. - Google Patents

Modified interferon beta with reduced immunogenicity. Download PDF

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Publication number
ZA200307992B
ZA200307992B ZA200307992A ZA200307992A ZA200307992B ZA 200307992 B ZA200307992 B ZA 200307992B ZA 200307992 A ZA200307992 A ZA 200307992A ZA 200307992 A ZA200307992 A ZA 200307992A ZA 200307992 B ZA200307992 B ZA 200307992B
Authority
ZA
South Africa
Prior art keywords
molecule
amino acid
peptide
sequence
modified
Prior art date
Application number
ZA200307992A
Other languages
English (en)
Inventor
Francis J Carr
Tim Jones
Matthew Baker
Graham Carter
John Watkins
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200307992B publication Critical patent/ZA200307992B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/565IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307992A 2001-03-15 2003-10-14 Modified interferon beta with reduced immunogenicity. ZA200307992B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01106539 2001-03-15

Publications (1)

Publication Number Publication Date
ZA200307992B true ZA200307992B (en) 2005-01-14

Family

ID=8176796

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307992A ZA200307992B (en) 2001-03-15 2003-10-14 Modified interferon beta with reduced immunogenicity.

Country Status (13)

Country Link
US (2) US7381795B2 (hu)
EP (1) EP1368377A2 (hu)
JP (1) JP2004529633A (hu)
KR (1) KR20030084992A (hu)
CN (1) CN1496369A (hu)
BR (1) BR0208041A (hu)
CA (1) CA2441095A1 (hu)
HU (1) HUP0303534A3 (hu)
MX (1) MXPA03008310A (hu)
PL (1) PL362870A1 (hu)
RU (1) RU2003129072A (hu)
WO (1) WO2002074783A2 (hu)
ZA (1) ZA200307992B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL362870A1 (en) * 2001-03-15 2004-11-02 Merck Patent Gmbh Modified interferon beta with reduced immunogenicity
US20030198624A1 (en) * 2002-03-02 2003-10-23 Mohapatra Shyam S. Method of treating allergic disease and asthma by recombinant adenovirus- and adeno-associated virus- mediated IFN-gamma gene transfer
AU2003225281A1 (en) * 2002-04-30 2003-11-17 University Of South Florida Materials and methods for prevention and treatment of rna viral diseases
AU2003217758A1 (en) * 2002-05-01 2003-12-22 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity
US7595303B1 (en) 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
WO2004022593A2 (en) 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
CA2516188C (en) * 2003-02-14 2012-04-17 University Of South Florida Chitosan-derivatives for gene delivery and expression
WO2005003157A2 (en) * 2003-06-10 2005-01-13 Xencor, Inc. Interferon variants with improved properties
US20050266093A1 (en) * 2004-04-27 2005-12-01 Mohapatra Shyam S Nanogene therapy for cell proliferation disorders
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
CA2963138C (en) 2007-01-30 2019-05-14 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
AU2008247815B2 (en) 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
AU2008279550B2 (en) * 2007-06-21 2012-08-09 Angelica Therapeutics, Inc. Modified toxins
EP2268297A4 (en) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc MODIFIED TOXINS
EA201171259A1 (ru) 2009-04-22 2012-05-30 Мерк Патент Гмбх Антительные гибридные белки с модифицированными сайтами связывания fcrn
CA2850469C (en) 2011-10-01 2020-07-07 Glytech, Inc. Glycosylated polypeptide and pharmaceutical composition containing same
JP2016519651A (ja) 2013-03-15 2016-07-07 アンジェリカ セラピューティックス,インク. 改質された毒素
BR112015024423B1 (pt) 2013-03-29 2023-04-25 Glytech, Inc Polipeptídeo glicosilado tendo atividade de interferon ?, composição farmacêutica e uso de um polipeptídeo glicosilado

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
JP2002512624A (ja) * 1997-05-21 2002-04-23 バイオベーション リミテッド 非免疫原性タンパク質の製造方法
IL142350A0 (en) * 1998-10-16 2002-03-10 Biogen Inc Interferon-beta fusion proteins and pharmaceutical compositions containing the same
EP1051432B1 (en) * 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
PL362870A1 (en) * 2001-03-15 2004-11-02 Merck Patent Gmbh Modified interferon beta with reduced immunogenicity

Also Published As

Publication number Publication date
US7381795B2 (en) 2008-06-03
US20050054052A1 (en) 2005-03-10
US20090043076A1 (en) 2009-02-12
RU2003129072A (ru) 2005-04-20
CN1496369A (zh) 2004-05-12
CA2441095A1 (en) 2002-09-26
JP2004529633A (ja) 2004-09-30
KR20030084992A (ko) 2003-11-01
WO2002074783A3 (en) 2003-08-28
HUP0303534A3 (en) 2005-12-28
PL362870A1 (en) 2004-11-02
BR0208041A (pt) 2004-02-25
US7615615B2 (en) 2009-11-10
HUP0303534A2 (hu) 2004-01-28
MXPA03008310A (es) 2003-12-11
EP1368377A2 (en) 2003-12-10
WO2002074783A2 (en) 2002-09-26

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