HUP0303534A3 - Modified interferon beta with reduced immunogenicity - Google Patents

Modified interferon beta with reduced immunogenicity

Info

Publication number
HUP0303534A3
HUP0303534A3 HU0303534A HUP0303534A HUP0303534A3 HU P0303534 A3 HUP0303534 A3 HU P0303534A3 HU 0303534 A HU0303534 A HU 0303534A HU P0303534 A HUP0303534 A HU P0303534A HU P0303534 A3 HUP0303534 A3 HU P0303534A3
Authority
HU
Hungary
Prior art keywords
interferon beta
reduced immunogenicity
modified interferon
modified
immunogenicity
Prior art date
Application number
HU0303534A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0303534A2 publication Critical patent/HUP0303534A2/hu
Publication of HUP0303534A3 publication Critical patent/HUP0303534A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
HU0303534A 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity HUP0303534A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01106539 2001-03-15
PCT/EP2002/002925 WO2002074783A2 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Publications (2)

Publication Number Publication Date
HUP0303534A2 HUP0303534A2 (hu) 2004-01-28
HUP0303534A3 true HUP0303534A3 (en) 2005-12-28

Family

ID=8176796

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303534A HUP0303534A3 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Country Status (13)

Country Link
US (2) US7381795B2 (hu)
EP (1) EP1368377A2 (hu)
JP (1) JP2004529633A (hu)
KR (1) KR20030084992A (hu)
CN (1) CN1496369A (hu)
BR (1) BR0208041A (hu)
CA (1) CA2441095A1 (hu)
HU (1) HUP0303534A3 (hu)
MX (1) MXPA03008310A (hu)
PL (1) PL362870A1 (hu)
RU (1) RU2003129072A (hu)
WO (1) WO2002074783A2 (hu)
ZA (1) ZA200307992B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0208041A (pt) * 2001-03-15 2004-02-25 Merck Patent Gmbh Interferon beta modificado com imunogenicidade reduzida
AU2003224650A1 (en) * 2002-03-02 2003-09-16 University Of South Florida A method for treating allergic disease and asthma by recombinant adenovirus-and adeno-associated virus-mediated ifn-gamma gene
US7354908B2 (en) * 2002-04-30 2008-04-08 University Of South Florida Materials and methods for prevention and treatment of RNA viral diseases
AU2003217758A1 (en) * 2002-05-01 2003-12-22 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity
US7595303B1 (en) * 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
US7611700B2 (en) 2002-09-09 2009-11-03 Hanall Pharmaceuticals, Co., Ltd. Protease resistant modified interferon alpha polypeptides
CA2516188C (en) * 2003-02-14 2012-04-17 University Of South Florida Chitosan-derivatives for gene delivery and expression
EP1636256A2 (en) * 2003-06-10 2006-03-22 Xencor, Inc. Interferon variants with improved properties
WO2005105136A1 (en) * 2004-04-27 2005-11-10 University Of South Florida Nanogene therapy for cell proliferation disorders
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
WO2008094538A2 (en) 2007-01-30 2008-08-07 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
NZ580686A (en) 2007-05-02 2012-11-30 Ambrx Inc Modified interferon beta polypeptides and their uses
WO2009014835A2 (en) * 2007-06-21 2009-01-29 Angelica Therapeutics, Inc. Modified toxins
WO2009110944A1 (en) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
AU2010238858A1 (en) 2009-04-22 2011-12-08 Merck Patent Gmbh Antibody fusion proteins with modified FcRn binding sites
CN109134642A (zh) 2011-10-01 2019-01-04 株式会社糖锁工学研究所 加成糖链的多肽及含有该多肽的医药组合物
WO2014150600A2 (en) 2013-03-15 2014-09-25 Angelica Therapeutics, Inc. Modified toxins
BR112015024423B1 (pt) 2013-03-29 2023-04-25 Glytech, Inc Polipeptídeo glicosilado tendo atividade de interferon ?, composição farmacêutica e uso de um polipeptídeo glicosilado

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
EP0983303B1 (en) * 1997-05-21 2006-03-08 Biovation Limited Method for the production of non-immunogenic proteins
MXPA01003790A (es) * 1998-10-16 2002-09-18 Biogen Inc Proteinas de fusion beta - interferon y sus usos.
ATE352559T1 (de) * 1998-12-08 2007-02-15 Biovation Ltd Verfahren zur verminderung der immunogenität von proteinen
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
BR0208041A (pt) * 2001-03-15 2004-02-25 Merck Patent Gmbh Interferon beta modificado com imunogenicidade reduzida

Also Published As

Publication number Publication date
CN1496369A (zh) 2004-05-12
US7381795B2 (en) 2008-06-03
RU2003129072A (ru) 2005-04-20
HUP0303534A2 (hu) 2004-01-28
US20090043076A1 (en) 2009-02-12
BR0208041A (pt) 2004-02-25
PL362870A1 (en) 2004-11-02
US20050054052A1 (en) 2005-03-10
WO2002074783A2 (en) 2002-09-26
KR20030084992A (ko) 2003-11-01
CA2441095A1 (en) 2002-09-26
US7615615B2 (en) 2009-11-10
EP1368377A2 (en) 2003-12-10
MXPA03008310A (es) 2003-12-11
WO2002074783A3 (en) 2003-08-28
ZA200307992B (en) 2005-01-14
JP2004529633A (ja) 2004-09-30

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished