ZA200307992B - Modified interferon beta with reduced immunogenicity. - Google Patents
Modified interferon beta with reduced immunogenicity. Download PDFInfo
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- ZA200307992B ZA200307992B ZA200307992A ZA200307992A ZA200307992B ZA 200307992 B ZA200307992 B ZA 200307992B ZA 200307992 A ZA200307992 A ZA 200307992A ZA 200307992 A ZA200307992 A ZA 200307992A ZA 200307992 B ZA200307992 B ZA 200307992B
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 238000002922 simulated annealing Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000003614 tolerogenic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01106539 | 2001-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200307992B true ZA200307992B (en) | 2005-01-14 |
Family
ID=8176796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200307992A ZA200307992B (en) | 2001-03-15 | 2003-10-14 | Modified interferon beta with reduced immunogenicity. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7381795B2 (fr) |
| EP (1) | EP1368377A2 (fr) |
| JP (1) | JP2004529633A (fr) |
| KR (1) | KR20030084992A (fr) |
| CN (1) | CN1496369A (fr) |
| BR (1) | BR0208041A (fr) |
| CA (1) | CA2441095A1 (fr) |
| HU (1) | HUP0303534A3 (fr) |
| MX (1) | MXPA03008310A (fr) |
| PL (1) | PL362870A1 (fr) |
| RU (1) | RU2003129072A (fr) |
| WO (1) | WO2002074783A2 (fr) |
| ZA (1) | ZA200307992B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1368377A2 (fr) * | 2001-03-15 | 2003-12-10 | MERCK PATENT GmbH | Interferon beta modifie a immunogenicite reduite |
| WO2003074561A1 (fr) * | 2002-03-02 | 2003-09-12 | University Of South Florida | Methode de traitement d'une maladie allergique et de l'asthme par transfert du gene ifn-$g(g) medie par un adenovirus et un virus adeno-associe recombinants |
| CA2484251C (fr) | 2002-04-30 | 2015-06-23 | University Of South Florida | Matieres et procedes visant a prevenir et a traiter des maladies provoquees par des virus a arn |
| DE60332556D1 (de) * | 2002-05-01 | 2010-06-24 | Danisco Us Inc | Cytokine und cytokinrezeptoren mit reduzierter immunogenität |
| US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
| DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| EP1594547A2 (fr) * | 2003-02-14 | 2005-11-16 | University Of South Florida Research Foundation, Inc. | Derives de chitosane utiles pour le transfert et l'expression de genes |
| EP1636256A2 (fr) * | 2003-06-10 | 2006-03-22 | Xencor, Inc. | Variantes de l'interferon a proprietes ameliorees |
| WO2005105136A1 (fr) * | 2004-04-27 | 2005-11-10 | University Of South Florida | Therapie nanogenique pour troubles causes par la proliferation cellulaire |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| US20080003202A1 (en) * | 2006-03-28 | 2008-01-03 | Thierry Guyon | Modified interferon-beta (IFN-beta) polypeptides |
| EP2423222B2 (fr) | 2007-01-30 | 2020-07-29 | Epivax, Inc. | Épitopes de lymphocytes t régulateurs, compositions et utilisations de ceux-ci |
| EP2076533B1 (fr) | 2007-05-02 | 2014-10-08 | Ambrx, Inc. | Polypeptides d'interferon beta modifies et leurs utilisations |
| WO2008157776A2 (fr) * | 2007-06-21 | 2008-12-24 | Angelica Therapeutics, Inc. | Toxines de diphtérie modifiées |
| EP2268297A4 (fr) * | 2008-02-29 | 2011-11-16 | Angelica Therapeutics Inc | Toxines modifiées |
| KR20120030383A (ko) | 2009-04-22 | 2012-03-28 | 메르크 파텐트 게엠베하 | 변형된 ＦｃＲｎ 결합 자리를 갖는 항체 융합 단백질 |
| MY168902A (en) | 2011-10-01 | 2018-12-04 | Glytech Inc | Glycosylated polypeptide and pharmaceutical composition containing same |
| JP2016519651A (ja) | 2013-03-15 | 2016-07-07 | アンジェリカ セラピューティックス，インク． | 改質された毒素 |
| DK2982686T3 (en) | 2013-03-29 | 2018-10-08 | Glytech Inc | POLYPEPTIDE WITH SIALYLED SUGAR CHAIN CONNECTED |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| GB8317880D0 (en) * | 1983-07-01 | 1983-08-03 | Searle & Co | Structure and synthesis of interferons |
| CA2290485C (fr) * | 1997-05-21 | 2008-08-05 | Biovation Limited | Procede de production de proteines non immunogenes |
| CN100480266C (zh) * | 1998-10-16 | 2009-04-22 | 拜奥根Idec马萨诸塞公司 | 干扰素-β融合蛋白及用途 |
| ES2278463T3 (es) * | 1998-12-08 | 2007-08-01 | Biovation Limited | Metodo para reducir la inmunogenicidad de proteinas. |
| US6514729B1 (en) * | 1999-05-12 | 2003-02-04 | Xencor, Inc. | Recombinant interferon-beta muteins |
| US6531122B1 (en) * | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| EP1368377A2 (fr) * | 2001-03-15 | 2003-12-10 | MERCK PATENT GmbH | Interferon beta modifie a immunogenicite reduite |
-
2002
- 2002-03-15 EP EP02726180A patent/EP1368377A2/fr not_active Withdrawn
- 2002-03-15 RU RU2003129072/13A patent/RU2003129072A/ru not_active Application Discontinuation
- 2002-03-15 CA CA002441095A patent/CA2441095A1/fr not_active Abandoned
- 2002-03-15 PL PL02362870A patent/PL362870A1/xx unknown
- 2002-03-15 HU HU0303534A patent/HUP0303534A3/hu unknown
- 2002-03-15 CN CNA028065972A patent/CN1496369A/zh active Pending
- 2002-03-15 JP JP2002573792A patent/JP2004529633A/ja active Pending
- 2002-03-15 US US10/471,894 patent/US7381795B2/en not_active Expired - Fee Related
- 2002-03-15 KR KR10-2003-7011997A patent/KR20030084992A/ko not_active Application Discontinuation
- 2002-03-15 WO PCT/EP2002/002925 patent/WO2002074783A2/fr active Application Filing
- 2002-03-15 MX MXPA03008310A patent/MXPA03008310A/es unknown
- 2002-03-15 BR BR0208041-9A patent/BR0208041A/pt not_active IP Right Cessation
-
2003
- 2003-10-14 ZA ZA200307992A patent/ZA200307992B/en unknown
-
2008
- 2008-03-17 US US12/077,120 patent/US7615615B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002074783A2 (fr) | 2002-09-26 |
| US20090043076A1 (en) | 2009-02-12 |
| BR0208041A (pt) | 2004-02-25 |
| EP1368377A2 (fr) | 2003-12-10 |
| RU2003129072A (ru) | 2005-04-20 |
| CA2441095A1 (fr) | 2002-09-26 |
| US7615615B2 (en) | 2009-11-10 |
| WO2002074783A3 (fr) | 2003-08-28 |
| MXPA03008310A (es) | 2003-12-11 |
| HUP0303534A3 (en) | 2005-12-28 |
| JP2004529633A (ja) | 2004-09-30 |
| US7381795B2 (en) | 2008-06-03 |
| PL362870A1 (en) | 2004-11-02 |
| US20050054052A1 (en) | 2005-03-10 |
| CN1496369A (zh) | 2004-05-12 |
| HUP0303534A2 (hu) | 2004-01-28 |
| KR20030084992A (ko) | 2003-11-01 |
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