ZA200307468B - Modified thrombopoietin with reduced immunogenicity. - Google Patents

Modified thrombopoietin with reduced immunogenicity. Download PDF

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Publication number
ZA200307468B
ZA200307468B ZA200307468A ZA200307468A ZA200307468B ZA 200307468 B ZA200307468 B ZA 200307468B ZA 200307468 A ZA200307468 A ZA 200307468A ZA 200307468 A ZA200307468 A ZA 200307468A ZA 200307468 B ZA200307468 B ZA 200307468B
Authority
ZA
South Africa
Prior art keywords
amino acid
molecule
peptide
binding
modified
Prior art date
Application number
ZA200307468A
Other languages
English (en)
Inventor
Francis J Carr
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200307468B publication Critical patent/ZA200307468B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/524Thrombopoietin, i.e. C-MPL ligand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307468A 2001-02-26 2003-09-25 Modified thrombopoietin with reduced immunogenicity. ZA200307468B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01104702 2001-02-26

Publications (1)

Publication Number Publication Date
ZA200307468B true ZA200307468B (en) 2004-07-02

Family

ID=8176606

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307468A ZA200307468B (en) 2001-02-26 2003-09-25 Modified thrombopoietin with reduced immunogenicity.

Country Status (13)

Country Link
US (1) US20040071688A1 (pl)
EP (1) EP1364011A2 (pl)
JP (1) JP2004533812A (pl)
KR (1) KR20030077632A (pl)
CN (1) CN1494590A (pl)
BR (1) BR0207542A (pl)
CA (1) CA2439168A1 (pl)
HU (1) HUP0401121A3 (pl)
MX (1) MXPA03007625A (pl)
PL (1) PL363520A1 (pl)
RU (1) RU2003127409A (pl)
WO (1) WO2002068469A2 (pl)
ZA (1) ZA200307468B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1636261T3 (pl) * 2003-06-26 2007-12-31 Merck Patent Gmbh Białka trombopoetynowe o ulepszonych właściwościach
US7879318B2 (en) * 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
WO2008157776A2 (en) * 2007-06-21 2008-12-24 Angelica Therapeutics, Inc. Modified diphtheria toxins
EP2268297A4 (en) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc MODIFIED TOXINS
US20110294733A1 (en) * 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
JP2016519651A (ja) 2013-03-15 2016-07-07 アンジェリカ セラピューティックス,インク. 改質された毒素

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG79882A1 (en) * 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
CA2212006A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. Novel c-mpl ligands

Also Published As

Publication number Publication date
WO2002068469A2 (en) 2002-09-06
BR0207542A (pt) 2004-03-09
US20040071688A1 (en) 2004-04-15
RU2003127409A (ru) 2005-04-10
JP2004533812A (ja) 2004-11-11
HUP0401121A3 (en) 2006-01-30
HUP0401121A2 (hu) 2004-09-28
KR20030077632A (ko) 2003-10-01
WO2002068469A3 (en) 2003-08-28
CA2439168A1 (en) 2002-09-06
PL363520A1 (pl) 2004-11-29
MXPA03007625A (es) 2003-12-04
CN1494590A (zh) 2004-05-05
EP1364011A2 (en) 2003-11-26

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