ZA200305383B - Naphthostyril derivatives and their use as inhibitors of cyclin-dependent kinases. - Google Patents
Naphthostyril derivatives and their use as inhibitors of cyclin-dependent kinases. Download PDFInfo
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- ZA200305383B ZA200305383B ZA200305383A ZA200305383A ZA200305383B ZA 200305383 B ZA200305383 B ZA 200305383B ZA 200305383 A ZA200305383 A ZA 200305383A ZA 200305383 A ZA200305383 A ZA 200305383A ZA 200305383 B ZA200305383 B ZA 200305383B
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- ZA
- South Africa
- Prior art keywords
- fluoro
- pyrrol
- indol
- benzo
- compound
- Prior art date
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- 108091007914 CDKs Proteins 0.000 title description 16
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title description 11
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title description 11
- 239000003112 inhibitor Substances 0.000 title description 2
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- 229910052736 halogen Inorganic materials 0.000 claims description 15
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
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- 125000004429 atom Chemical group 0.000 claims description 10
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- 125000005842 heteroatom Chemical group 0.000 claims description 9
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- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 description 1
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- GWGVDNZFTPIGDY-UHFFFAOYSA-M magnesium;ethyne;chloride Chemical compound [Mg+2].[Cl-].[C-]#C GWGVDNZFTPIGDY-UHFFFAOYSA-M 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- LULAYUGMBFYYEX-UHFFFAOYSA-N metachloroperbenzoic acid Natural products OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 1
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- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 description 1
- RSMUVYRMZCOLBH-UHFFFAOYSA-N metsulfuron methyl Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)NC1=NC(C)=NC(OC)=N1 RSMUVYRMZCOLBH-UHFFFAOYSA-N 0.000 description 1
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- 102000020233 phosphotransferase Human genes 0.000 description 1
- BIWOSRSKDCZIFM-UHFFFAOYSA-N piperidin-3-ol Chemical compound OC1CCCNC1 BIWOSRSKDCZIFM-UHFFFAOYSA-N 0.000 description 1
- VUNPWIPIOOMCPT-UHFFFAOYSA-N piperidin-3-ylmethanol Chemical compound OCC1CCCNC1 VUNPWIPIOOMCPT-UHFFFAOYSA-N 0.000 description 1
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical compound OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- ZSKGQVFRTSEPJT-UHFFFAOYSA-N pyrrole-2-carboxaldehyde Chemical compound O=CC1=CC=CN1 ZSKGQVFRTSEPJT-UHFFFAOYSA-N 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 238000003419 tautomerization reaction Methods 0.000 description 1
- AIVOYFQVTNBARM-UHFFFAOYSA-N tert-butyl 2-formyl-3,4-dimethylpyrrole-1-carboxylate Chemical compound CC1=CN(C(=O)OC(C)(C)C)C(C=O)=C1C AIVOYFQVTNBARM-UHFFFAOYSA-N 0.000 description 1
- GPTXCAZYUMDUMN-UHFFFAOYSA-N tert-butyl n-(2-hydroxyethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCCO GPTXCAZYUMDUMN-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
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- 229940124597 therapeutic agent Drugs 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26365801P | 2001-01-23 | 2001-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200305383B true ZA200305383B (en) | 2004-10-11 |
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|---|---|---|---|
| ZA200305383A ZA200305383B (en) | 2001-01-23 | 2003-07-11 | Naphthostyril derivatives and their use as inhibitors of cyclin-dependent kinases. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6504034B2 (zh) |
| EP (1) | EP1358180B1 (zh) |
| JP (1) | JP4091434B2 (zh) |
| KR (1) | KR100563429B1 (zh) |
| CN (1) | CN1231479C (zh) |
| AR (1) | AR035738A1 (zh) |
| AT (1) | ATE283852T1 (zh) |
| AU (1) | AU2002240905B2 (zh) |
| BR (1) | BR0206621A (zh) |
| CA (1) | CA2434381C (zh) |
| DE (1) | DE60202131T2 (zh) |
| ES (1) | ES2232736T3 (zh) |
| MX (1) | MXPA03006423A (zh) |
| PE (1) | PE20020916A1 (zh) |
| UY (1) | UY27132A1 (zh) |
| WO (1) | WO2002059109A2 (zh) |
| ZA (1) | ZA200305383B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2315751A1 (en) * | 2008-06-26 | 2011-05-04 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| CN109665987B (zh) * | 2018-12-28 | 2022-02-18 | 河南大学 | 萘内酰亚胺-多胺缀合物及其制备方法和用途 |
| BR112021019669A2 (pt) | 2019-04-12 | 2021-12-07 | C4 Therapeutics Inc | Composto, composição farmacêutica, método para tratar um transtorno, composto para uso na produção de um medicamento, e, uso de um composto no tratamento de um transtorno |
| EP4228639A1 (en) * | 2020-10-14 | 2023-08-23 | C4 Therapeutics, Inc. | Tricyclic ligands for degradation of ikzf2 or ikzf4 |
| US12097261B2 (en) | 2021-05-07 | 2024-09-24 | Kymera Therapeutics, Inc. | CDK2 degraders and uses thereof |
| MX2024009897A (es) * | 2022-02-09 | 2024-08-20 | C4 Therapeutics Inc | Formas morficas de cft7455 y sus metodos de fabricacion. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081131A (en) * | 1986-01-13 | 1992-01-14 | American Cyanamid Company | Omega-((hetero)alkyl)benz(cd)-indol-2-amines |
| US5206261A (en) | 1989-07-25 | 1993-04-27 | Taiho Pharmaceutical Company, Limited | Oxindole derivative |
| WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
| FR2694004B1 (fr) | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
| GB9313638D0 (en) | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9423997D0 (en) | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9501567D0 (en) | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| DE29513441U1 (de) | 1995-08-22 | 1995-10-19 | Engelhardt, Rolf, 45883 Gelsenkirchen | Aschenbecher zum Mitführen |
| AU4155697A (en) | 1996-08-23 | 1998-03-06 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5750556A (en) * | 1996-10-30 | 1998-05-12 | American Home Products Corporation | 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives |
| EP0984930B1 (en) | 1997-05-07 | 2005-04-06 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DK1157019T3 (da) | 1998-12-17 | 2003-07-14 | Hoffmann La Roche | 4-alkenyl- (og alkynyl-)oxindoler som inhibitorer af cyklinafhængige kinaser, især CDK2 |
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2002
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- 2002-01-16 AT AT02706711T patent/ATE283852T1/de not_active IP Right Cessation
- 2002-01-16 BR BR0206621-1A patent/BR0206621A/pt not_active IP Right Cessation
- 2002-01-16 ES ES02706711T patent/ES2232736T3/es not_active Expired - Lifetime
- 2002-01-16 WO PCT/EP2002/000366 patent/WO2002059109A2/en active IP Right Grant
- 2002-01-16 EP EP02706711A patent/EP1358180B1/en not_active Expired - Lifetime
- 2002-01-16 AU AU2002240905A patent/AU2002240905B2/en not_active Ceased
- 2002-01-16 JP JP2002559411A patent/JP4091434B2/ja not_active Expired - Fee Related
- 2002-01-16 KR KR1020037009680A patent/KR100563429B1/ko not_active IP Right Cessation
- 2002-01-16 CN CNB028040406A patent/CN1231479C/zh not_active Expired - Fee Related
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2003
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Also Published As
| Publication number | Publication date |
|---|---|
| JP4091434B2 (ja) | 2008-05-28 |
| US6531598B1 (en) | 2003-03-11 |
| DE60202131D1 (de) | 2005-01-05 |
| ATE283852T1 (de) | 2004-12-15 |
| UY27132A1 (es) | 2002-07-31 |
| CA2434381C (en) | 2009-11-24 |
| CA2434381A1 (en) | 2002-08-01 |
| AR035738A1 (es) | 2004-07-07 |
| JP2004517150A (ja) | 2004-06-10 |
| WO2002059109A2 (en) | 2002-08-01 |
| DE60202131T2 (de) | 2005-12-01 |
| KR20030069223A (ko) | 2003-08-25 |
| EP1358180A2 (en) | 2003-11-05 |
| US6504034B2 (en) | 2003-01-07 |
| WO2002059109A3 (en) | 2002-09-19 |
| AU2002240905B2 (en) | 2007-03-01 |
| MXPA03006423A (es) | 2003-10-15 |
| EP1358180B1 (en) | 2004-12-01 |
| ES2232736T3 (es) | 2005-06-01 |
| BR0206621A (pt) | 2004-02-25 |
| PE20020916A1 (es) | 2002-10-21 |
| CN1487931A (zh) | 2004-04-07 |
| KR100563429B1 (ko) | 2006-03-22 |
| CN1231479C (zh) | 2005-12-14 |
| US20020147343A1 (en) | 2002-10-10 |
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