ZA200303250B - Treatment of sexual dysfunction. - Google Patents

Info

Publication number

ZA200303250B

ZA200303250B ZA200303250A ZA200303250A ZA200303250B ZA 200303250 B ZA200303250 B ZA 200303250B ZA 200303250 A ZA200303250 A ZA 200303250A ZA 200303250 A ZA200303250 A ZA 200303250A ZA 200303250 B ZA200303250 B ZA 200303250B

Authority

ZA

South Africa

Prior art keywords

methyl

indol

cyclohexylmethyl

pyridin

propionamide

Prior art date

2000-11-17

Links

• Espacenet
• Global Dossier
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• 238000011282 treatment Methods 0.000 title claims description 45
• 201000001880 Sexual dysfunction Diseases 0.000 title claims description 29
• 231100000872 sexual dysfunction Toxicity 0.000 title claims description 28
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• JJECUALDBPDICU-LJAQVGFWSA-N (2s)-2-[(4-ethyl-1,3-oxazol-2-yl)amino]-3-(1h-indol-3-yl)-n-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methylpropanamide Chemical compound CCC1=COC(N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC(OC)=CC=2)=N1 JJECUALDBPDICU-LJAQVGFWSA-N 0.000 claims description 2
• ZKSUNBJMXUHDLS-DHUJRADRSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-(2-phenylanilino)-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C1=CC=CC=C1C1=CC=CC=C1 ZKSUNBJMXUHDLS-DHUJRADRSA-N 0.000 claims description 2
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• ZQQXUGRFDFKXQQ-DHUJRADRSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(2-phenylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 ZQQXUGRFDFKXQQ-DHUJRADRSA-N 0.000 claims description 2
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• YBAMTVXATSFKGW-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-(quinolin-8-ylsulfonylamino)propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(=O)(=O)C=1C2=NC=CC=C2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 YBAMTVXATSFKGW-YTTGMZPUSA-N 0.000 claims description 2
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• KGJZUYYVSHGMRP-DHUJRADRSA-N naphthalen-1-ylmethyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)OCC=1C2=CC=CC=C2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 KGJZUYYVSHGMRP-DHUJRADRSA-N 0.000 claims description 2
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• HNTQVBKTJKFVKN-PMERELPUSA-N (2s)-2-(benzylsulfonylamino)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)CC1=CC=CC=C1 HNTQVBKTJKFVKN-PMERELPUSA-N 0.000 claims 1
• SEJMDNMPDWLKSQ-NDEPHWFRSA-N (2s)-2-[(1,2-dimethylimidazol-4-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CN1C(C)=NC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 SEJMDNMPDWLKSQ-NDEPHWFRSA-N 0.000 claims 1
• YEESWKBQGRKYCN-TZYYSAMKSA-N (2s)-2-[(2,2-dimethyl-1-phenylpropyl)carbamoylamino]-n-[2,6-di(propan-2-yl)phenyl]-3-(1h-indol-3-yl)propanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)[C@@H](NC(=O)NC(C=1C=CC=CC=1)C(C)(C)C)CC1=CNC2=CC=CC=C12 YEESWKBQGRKYCN-TZYYSAMKSA-N 0.000 claims 1
• GVWLVXZVGSUFQO-PMERELPUSA-N (2s)-2-[(2,4-dichloro-5-methylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=C(Cl)C(C)=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1Cl GVWLVXZVGSUFQO-PMERELPUSA-N 0.000 claims 1
• WFJAPKFXYPJCLD-LJAQVGFWSA-N (2s)-2-[(2,4-dinitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O WFJAPKFXYPJCLD-LJAQVGFWSA-N 0.000 claims 1
• HEJDHTOFZSTYPL-LJAQVGFWSA-N (2s)-2-[(2-chloro-5-nitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC([N+]([O-])=O)=CC=C1Cl HEJDHTOFZSTYPL-LJAQVGFWSA-N 0.000 claims 1
• QIGIAXMBHNLENC-PMERELPUSA-N (2s)-2-[(2-cyanophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1C#N QIGIAXMBHNLENC-PMERELPUSA-N 0.000 claims 1
• IIHXHLWRYKXXNQ-LJAQVGFWSA-N (2s)-2-[(2-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1F IIHXHLWRYKXXNQ-LJAQVGFWSA-N 0.000 claims 1
• NDXQYLACDOAGNF-LJAQVGFWSA-N (2s)-2-[(3-chloro-4-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(F)C(Cl)=C1 NDXQYLACDOAGNF-LJAQVGFWSA-N 0.000 claims 1
• KOWWHVDQINBPMU-PMERELPUSA-N (2s)-2-[(3-chloro-4-methylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=C(Cl)C(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 KOWWHVDQINBPMU-PMERELPUSA-N 0.000 claims 1
• ABMITNHZFHQDKH-LJAQVGFWSA-N (2s)-2-[(3-chlorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(Cl)=C1 ABMITNHZFHQDKH-LJAQVGFWSA-N 0.000 claims 1
• IHJYQLULOPEBHV-LJAQVGFWSA-N (2s)-2-[(3-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(F)=C1 IHJYQLULOPEBHV-LJAQVGFWSA-N 0.000 claims 1
• UTSFHTSLPLJGAY-XIFFEERXSA-N (2s)-2-[(4-butylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(CCCC)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 UTSFHTSLPLJGAY-XIFFEERXSA-N 0.000 claims 1
• YTWXEIDXKCXBRA-LJAQVGFWSA-N (2s)-2-[(4-chloro-2-nitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)C=C1[N+]([O-])=O YTWXEIDXKCXBRA-LJAQVGFWSA-N 0.000 claims 1
• WNUUHBAKGFYPBR-LJAQVGFWSA-N (2s)-2-[(4-chlorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)C=C1 WNUUHBAKGFYPBR-LJAQVGFWSA-N 0.000 claims 1
• JVOPRULHQJVNDE-PMERELPUSA-N (2s)-2-[(4-cyanophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(C#N)C=C1 JVOPRULHQJVNDE-PMERELPUSA-N 0.000 claims 1
• QYMRNEISCYLXGX-LJAQVGFWSA-N (2s)-2-[(4-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(F)C=C1 QYMRNEISCYLXGX-LJAQVGFWSA-N 0.000 claims 1
• QVEJIOMCTNHULQ-XIFFEERXSA-N (2s)-2-[(4-tert-butylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 QVEJIOMCTNHULQ-XIFFEERXSA-N 0.000 claims 1
• RSFYOPASAIKCCL-NDEPHWFRSA-N (2s)-2-[(5-bromo-6-chloropyridin-3-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CN=C(Cl)C(Br)=C1 RSFYOPASAIKCCL-NDEPHWFRSA-N 0.000 claims 1
• VTEXMTCKJHHKMH-MHZLTWQESA-N (2s)-2-[(5-chlorothiophen-2-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)S1 VTEXMTCKJHHKMH-MHZLTWQESA-N 0.000 claims 1
• LBMBSTWOMQGWJA-HKBQPEDESA-N (2s)-2-[[2-(4-hydroxyphenyl)acetyl]amino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC1=CC=C(O)C=C1 LBMBSTWOMQGWJA-HKBQPEDESA-N 0.000 claims 1
• HPMBYMGSARKOLS-XIFFEERXSA-N (2s)-2-[[2-[4-(dimethylamino)phenyl]acetyl]amino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(N(C)C)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HPMBYMGSARKOLS-XIFFEERXSA-N 0.000 claims 1
• SGXZWKBMZURBHA-LJAQVGFWSA-N (2s)-2-[[2-chloro-5-(trifluoromethyl)phenyl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC(C(F)(F)F)=CC=C1Cl SGXZWKBMZURBHA-LJAQVGFWSA-N 0.000 claims 1
• NFWMEEYBTJPYJF-UMSFTDKQSA-N (2s)-2-[[4-(4-cyanophenyl)-1,3-oxazol-2-yl]amino]-3-(1h-indol-3-yl)-n-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methylpropanamide Chemical compound N1=CC(OC)=CC=C1C1(CNC(=O)[C@](C)(CC=2C3=CC=CC=C3NC=2)NC=2OC=C(N=2)C=2C=CC(=CC=2)C#N)CCCCC1 NFWMEEYBTJPYJF-UMSFTDKQSA-N 0.000 claims 1
• NIDBPOHKMKWWBE-XIFFEERXSA-N (2s)-2-[[5-(benzenesulfonyl)thiophen-2-yl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1S(=O)(=O)C1=CC=CC=C1 NIDBPOHKMKWWBE-XIFFEERXSA-N 0.000 claims 1
• FMWIJCCYIUQMAG-DHUJRADRSA-N (2s)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](C)(CC=1C2=CC=CC=C2NC=1)NS(=O)(=O)C1=C2C=CC=C(C2=CC=C1)N(C)C)NCC1(C=2N=CC=CC=2)CCCCC1 FMWIJCCYIUQMAG-DHUJRADRSA-N 0.000 claims 1
• QHISPZNEAIDPFS-DEOSSOPVSA-N (2s)-3-(1h-indol-3-yl)-2-(methanesulfonamido)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(C)(=O)=O)C)NCC1(C=2N=CC=CC=2)CCCCC1 QHISPZNEAIDPFS-DEOSSOPVSA-N 0.000 claims 1
• GGSQCPIHXUHSEN-HKBQPEDESA-N (2s)-3-(1h-indol-3-yl)-2-[(2-methoxy-4-methylphenyl)sulfonylamino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound COC1=CC(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 GGSQCPIHXUHSEN-HKBQPEDESA-N 0.000 claims 1
• JVKUXDMUGHWFFX-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-[(3-methoxyphenyl)sulfonylamino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound COC1=CC=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 JVKUXDMUGHWFFX-PMERELPUSA-N 0.000 claims 1
• HQOCHTKXBPXROI-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-[[2-(4-methoxyphenyl)acetyl]amino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(OC)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HQOCHTKXBPXROI-YTTGMZPUSA-N 0.000 claims 1
• RRWRMIFQCKIUIB-NDEPHWFRSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-(pyridin-4-ylamino)-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C1=CC=NC=C1 RRWRMIFQCKIUIB-NDEPHWFRSA-N 0.000 claims 1
• AZVWOKWQLMUJGR-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(2-nitrophenyl)methylsulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)CC1=CC=CC=C1[N+]([O-])=O AZVWOKWQLMUJGR-PMERELPUSA-N 0.000 claims 1
• VPEQIDDNHDUQFU-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(3-methylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 VPEQIDDNHDUQFU-PMERELPUSA-N 0.000 claims 1
• UCVOTOAGAYUZAN-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(3-nitrophenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC([N+]([O-])=O)=C1 UCVOTOAGAYUZAN-LJAQVGFWSA-N 0.000 claims 1
• NSYLMFIGJCAIJP-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(4-methylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 NSYLMFIGJCAIJP-PMERELPUSA-N 0.000 claims 1
• QZFBSWBKTSAWOF-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(4-methylsulfonylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 QZFBSWBKTSAWOF-PMERELPUSA-N 0.000 claims 1
• UJBNNEPZPPCTGU-XIFFEERXSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(8-nitronaphthalen-1-yl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(=O)(=O)C=1C2=C([N+]([O-])=O)C=CC=C2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 UJBNNEPZPPCTGU-XIFFEERXSA-N 0.000 claims 1
• HNXNQPWVDONFTR-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(2-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HNXNQPWVDONFTR-YTTGMZPUSA-N 0.000 claims 1
• WPNMLCFQBFKZOZ-HKBQPEDESA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(2-nitrophenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC1=CC=CC=C1[N+]([O-])=O WPNMLCFQBFKZOZ-HKBQPEDESA-N 0.000 claims 1
• RWCXRYHJLNGTGO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(3-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC(CC(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 RWCXRYHJLNGTGO-YTTGMZPUSA-N 0.000 claims 1
• OZFAHUYOUXFTJO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(4-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 OZFAHUYOUXFTJO-YTTGMZPUSA-N 0.000 claims 1
• IFBOAVJTYAADPU-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O IFBOAVJTYAADPU-LJAQVGFWSA-N 0.000 claims 1
• DVVKNDOIZRDMJJ-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]-n-phenacylpropanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC(=O)C=1C=CC=CC=1)C(OC=1)=NC=1C1=CC=C([N+]([O-])=O)C=C1 DVVKNDOIZRDMJJ-LJAQVGFWSA-N 0.000 claims 1
• WMYMZKAUWMBOGB-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[5-(1,2-oxazol-3-yl)thiophen-2-yl]sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1C=1C=CON=1 WMYMZKAUWMBOGB-PMERELPUSA-N 0.000 claims 1
• NHRFZRKZJUDCRH-DEOSSOPVSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-(2,2,2-trifluoroethylsulfonylamino)propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(=O)(=O)CC(F)(F)F)C)NCC1(C=2N=CC=CC=2)CCCCC1 NHRFZRKZJUDCRH-DEOSSOPVSA-N 0.000 claims 1
• NVMJVPBCNIHVFH-MHZLTWQESA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-(thiophen-2-ylsulfonylamino)propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CS1 NVMJVPBCNIHVFH-MHZLTWQESA-N 0.000 claims 1
• BROHTICPXHGLTP-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[(2-thiophen-3-ylacetyl)amino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC=1C=CSC=1 BROHTICPXHGLTP-LJAQVGFWSA-N 0.000 claims 1
• SHEBFFBWIUGJAO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1C1=CC=CC=N1 SHEBFFBWIUGJAO-YTTGMZPUSA-N 0.000 claims 1
• SLYFXFFLQHJHCD-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[2-(trifluoromethyl)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1C(F)(F)F SLYFXFFLQHJHCD-LJAQVGFWSA-N 0.000 claims 1
• QKACRBARNNDMNH-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 QKACRBARNNDMNH-LJAQVGFWSA-N 0.000 claims 1
• XENVSVVIUBONMV-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[4-(trifluoromethoxy)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 XENVSVVIUBONMV-LJAQVGFWSA-N 0.000 claims 1
• WRCONAZZEKRJJR-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-n-[[1-(methoxymethyl)cyclohexyl]methyl]-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]propanamide Chemical compound O=C([C@](C)(CC=1C2=CC=CC=C2NC=1)NC=1OC=C(N=1)C=1C=CC(=CC=1)[N+]([O-])=O)NCC1(COC)CCCCC1 WRCONAZZEKRJJR-LJAQVGFWSA-N 0.000 claims 1
• GXVSIUQNFGMAAU-HKBQPEDESA-N (2s)-n-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]-3-phenylpropanamide Chemical compound N1=CC(OC)=CC=C1C1(CNC(=O)[C@](C)(CC=2C=CC=CC=2)NC=2OC=C(N=2)C=2C=CC(=CC=2)[N+]([O-])=O)CCCCC1 GXVSIUQNFGMAAU-HKBQPEDESA-N 0.000 claims 1
• QXUOUBPHUIGWFR-YTTGMZPUSA-N (3-cyanophenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=CC(C#N)=C1 QXUOUBPHUIGWFR-YTTGMZPUSA-N 0.000 claims 1
• INBWANLQJHTHQY-YTTGMZPUSA-N (3-methylphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound CC1=CC=CC(COC(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 INBWANLQJHTHQY-YTTGMZPUSA-N 0.000 claims 1
• CACPIXWTJQQXBY-QNGWXLTQSA-N (3-phenoxyphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC(C=1)=CC=CC=1OC1=CC=CC=C1 CACPIXWTJQQXBY-QNGWXLTQSA-N 0.000 claims 1
• PFMOBPGKDKADKX-HKBQPEDESA-N (4-chlorophenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=C(Cl)C=C1 PFMOBPGKDKADKX-HKBQPEDESA-N 0.000 claims 1
• YMSGEOIBQFOADL-YTTGMZPUSA-N (4-methoxyphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1COC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 YMSGEOIBQFOADL-YTTGMZPUSA-N 0.000 claims 1
• YRLHKVFSAGRKAQ-YTTGMZPUSA-N (4-methylphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1COC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 YRLHKVFSAGRKAQ-YTTGMZPUSA-N 0.000 claims 1
• UOOJTLMZWAEIBZ-XIFFEERXSA-N 2,3-dihydro-1h-inden-2-yl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)OC1CC2=CC=CC=C2C1)C)NCC1(C=2N=CC=CC=2)CCCCC1 UOOJTLMZWAEIBZ-XIFFEERXSA-N 0.000 claims 1
• MUSGYEMSJUFFHT-UWABRSFTSA-N 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[[(2S,3S)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-methylcarbamoyl]-25-(3-amino-3-oxopropyl)-7-(3-carbamimidamidopropyl)-10-(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-13,17-dimethyl-28-[(1-methylindol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33-decaoxo-31-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC(=O)CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(N)=O MUSGYEMSJUFFHT-UWABRSFTSA-N 0.000 claims 1
• BDVDNJKKDRLXTK-PMERELPUSA-N 2-chloro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1Cl BDVDNJKKDRLXTK-PMERELPUSA-N 0.000 claims 1
• UBIFZQFQYQQRNJ-PMERELPUSA-N 2-fluoro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1F UBIFZQFQYQQRNJ-PMERELPUSA-N 0.000 claims 1
• GJBNQQQENHQGEX-UHFFFAOYSA-N 2-methyl-3-(1-pyridin-2-ylcyclohexyl)propanamide Chemical compound C=1C=CC=NC=1C1(CC(C)C(N)=O)CCCCC1 GJBNQQQENHQGEX-UHFFFAOYSA-N 0.000 claims 1
• SQISOBNEDVJTMH-UHFFFAOYSA-N 3-(1h-indol-3-yl)-2-methyl-2-[1-(4-nitrophenyl)ethylcarbamoylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(C)NC(=O)NC(C)(CC=1C2=CC=CC=C2NC=1)C(=O)NCC1(C=2N=CC=CC=2)CCCCC1 SQISOBNEDVJTMH-UHFFFAOYSA-N 0.000 claims 1
• KYFJEEPRKVHYBU-HKBQPEDESA-N 3-cyano-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC(C#N)=C1 KYFJEEPRKVHYBU-HKBQPEDESA-N 0.000 claims 1
• WWLQMWLRNGJKFO-PMERELPUSA-N 4-chloro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C(Cl)C=C1 WWLQMWLRNGJKFO-PMERELPUSA-N 0.000 claims 1
• 206010011953 Decreased activity Diseases 0.000 claims 1
• 102000004279 Oxytocin receptors Human genes 0.000 claims 1
• HGEYOTSQNMEWIP-HKBQPEDESA-N [4-(trifluoromethyl)phenyl]methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=C(C(F)(F)F)C=C1 HGEYOTSQNMEWIP-HKBQPEDESA-N 0.000 claims 1
• TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
• 229940125782 compound 2 Drugs 0.000 claims 1
• KAJMFZBELRFCHM-HKBQPEDESA-N methyl 2-[[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]sulfamoyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 KAJMFZBELRFCHM-HKBQPEDESA-N 0.000 claims 1
• BBSJDZURDHBQSH-LJAQVGFWSA-N methyl 3-[[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]sulfamoyl]thiophene-2-carboxylate Chemical compound S1C=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1C(=O)OC BBSJDZURDHBQSH-LJAQVGFWSA-N 0.000 claims 1
• AEZPANISLZXSDR-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-1-yl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1h-indol-3-yl)-2-methylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C)(C(=O)NC1C2=CC=CC=C2CC1)CC1=CNC2=CC=CC=C12 AEZPANISLZXSDR-UHFFFAOYSA-N 0.000 claims 1
• BUKVFXISAYYMOI-UHFFFAOYSA-N n-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-2-methyl-3-pyridin-2-ylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C)(C(=O)NCC1CCCCC1)CC1=CC=CC=N1 BUKVFXISAYYMOI-UHFFFAOYSA-N 0.000 claims 1
• KWCBBPPGJDRADF-UHFFFAOYSA-N n-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1h-indol-3-yl)-n-methylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C(=O)N(C)CC1CCCCC1)CC1=CNC2=CC=CC=C12 KWCBBPPGJDRADF-UHFFFAOYSA-N 0.000 claims 1
• DXIAAZQPKAIDRD-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1,3-benzothiazole-6-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=C2SC=NC2=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 DXIAAZQPKAIDRD-HKBQPEDESA-N 0.000 claims 1
• YPKOCNNFKMCMPR-YTTGMZPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1h-indole-4-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=2C=CNC=2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 YPKOCNNFKMCMPR-YTTGMZPUSA-N 0.000 claims 1
• JUTWZLGNRSDDLI-YTTGMZPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1h-indole-5-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=C2C=CNC2=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 JUTWZLGNRSDDLI-YTTGMZPUSA-N 0.000 claims 1
• JWLLGKSXLCBXSB-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 JWLLGKSXLCBXSB-HKBQPEDESA-N 0.000 claims 1
• ASCHENDLMZYTLZ-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-methylbenzamide Chemical compound CC1=CC=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 ASCHENDLMZYTLZ-HKBQPEDESA-N 0.000 claims 1
• OUSYGMMKJPPFND-PMERELPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-nitrobenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1[N+]([O-])=O OUSYGMMKJPPFND-PMERELPUSA-N 0.000 claims 1
• AJYARFKVTZRMGL-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-3-methylbenzamide Chemical compound CC1=CC=CC(C(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 AJYARFKVTZRMGL-HKBQPEDESA-N 0.000 claims 1
• VBEYVRVGTNLUKS-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-3-methylsulfonylbenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC(S(C)(=O)=O)=C1 VBEYVRVGTNLUKS-HKBQPEDESA-N 0.000 claims 1
• TZSXYOWKZPUTJF-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methoxybenzamide Chemical compound C1=CC(OC)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 TZSXYOWKZPUTJF-HKBQPEDESA-N 0.000 claims 1
• WULGKNJOPUNCKW-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 WULGKNJOPUNCKW-HKBQPEDESA-N 0.000 claims 1
• QJPDMZJLRRKFFZ-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methylsulfonylbenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C(S(C)(=O)=O)C=C1 QJPDMZJLRRKFFZ-HKBQPEDESA-N 0.000 claims 1
• MXUYTPAMPGUNDN-PMERELPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-nitrobenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C([N+]([O-])=O)C=C1 MXUYTPAMPGUNDN-PMERELPUSA-N 0.000 claims 1
• UMEHIDFGHORJSG-LJAQVGFWSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-5-methylthiophene-2-carboxamide Chemical compound S1C(C)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 UMEHIDFGHORJSG-LJAQVGFWSA-N 0.000 claims 1
• NSNTYGVOFVPUKQ-NDEPHWFRSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]furan-2-carboxamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CO1 NSNTYGVOFVPUKQ-NDEPHWFRSA-N 0.000 claims 1
• IUDTYPYXJBAKQQ-NDEPHWFRSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]furan-3-carboxamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C=1C=COC=1 IUDTYPYXJBAKQQ-NDEPHWFRSA-N 0.000 claims 1
• VJUHHDLMYYQCKC-XIFFEERXSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]isoquinoline-3-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1N=CC2=CC=CC=C2C=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 VJUHHDLMYYQCKC-XIFFEERXSA-N 0.000 claims 1
• GGEPYZSEMMXOGW-LJAQVGFWSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]pyridine-2-carboxamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=N1 GGEPYZSEMMXOGW-LJAQVGFWSA-N 0.000 claims 1
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