ZA200303250B - Treatment of sexual dysfunction. - Google Patents
Treatment of sexual dysfunction. Download PDFInfo
- Publication number
- ZA200303250B ZA200303250B ZA200303250A ZA200303250A ZA200303250B ZA 200303250 B ZA200303250 B ZA 200303250B ZA 200303250 A ZA200303250 A ZA 200303250A ZA 200303250 A ZA200303250 A ZA 200303250A ZA 200303250 B ZA200303250 B ZA 200303250B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- indol
- cyclohexylmethyl
- pyridin
- propionamide
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims description 45
- 201000001880 Sexual dysfunction Diseases 0.000 title claims description 29
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- HNTQVBKTJKFVKN-PMERELPUSA-N (2s)-2-(benzylsulfonylamino)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)CC1=CC=CC=C1 HNTQVBKTJKFVKN-PMERELPUSA-N 0.000 claims 1
- SEJMDNMPDWLKSQ-NDEPHWFRSA-N (2s)-2-[(1,2-dimethylimidazol-4-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CN1C(C)=NC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 SEJMDNMPDWLKSQ-NDEPHWFRSA-N 0.000 claims 1
- YEESWKBQGRKYCN-TZYYSAMKSA-N (2s)-2-[(2,2-dimethyl-1-phenylpropyl)carbamoylamino]-n-[2,6-di(propan-2-yl)phenyl]-3-(1h-indol-3-yl)propanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)[C@@H](NC(=O)NC(C=1C=CC=CC=1)C(C)(C)C)CC1=CNC2=CC=CC=C12 YEESWKBQGRKYCN-TZYYSAMKSA-N 0.000 claims 1
- GVWLVXZVGSUFQO-PMERELPUSA-N (2s)-2-[(2,4-dichloro-5-methylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=C(Cl)C(C)=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1Cl GVWLVXZVGSUFQO-PMERELPUSA-N 0.000 claims 1
- WFJAPKFXYPJCLD-LJAQVGFWSA-N (2s)-2-[(2,4-dinitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O WFJAPKFXYPJCLD-LJAQVGFWSA-N 0.000 claims 1
- HEJDHTOFZSTYPL-LJAQVGFWSA-N (2s)-2-[(2-chloro-5-nitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC([N+]([O-])=O)=CC=C1Cl HEJDHTOFZSTYPL-LJAQVGFWSA-N 0.000 claims 1
- QIGIAXMBHNLENC-PMERELPUSA-N (2s)-2-[(2-cyanophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1C#N QIGIAXMBHNLENC-PMERELPUSA-N 0.000 claims 1
- IIHXHLWRYKXXNQ-LJAQVGFWSA-N (2s)-2-[(2-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1F IIHXHLWRYKXXNQ-LJAQVGFWSA-N 0.000 claims 1
- NDXQYLACDOAGNF-LJAQVGFWSA-N (2s)-2-[(3-chloro-4-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(F)C(Cl)=C1 NDXQYLACDOAGNF-LJAQVGFWSA-N 0.000 claims 1
- KOWWHVDQINBPMU-PMERELPUSA-N (2s)-2-[(3-chloro-4-methylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=C(Cl)C(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 KOWWHVDQINBPMU-PMERELPUSA-N 0.000 claims 1
- ABMITNHZFHQDKH-LJAQVGFWSA-N (2s)-2-[(3-chlorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(Cl)=C1 ABMITNHZFHQDKH-LJAQVGFWSA-N 0.000 claims 1
- IHJYQLULOPEBHV-LJAQVGFWSA-N (2s)-2-[(3-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(F)=C1 IHJYQLULOPEBHV-LJAQVGFWSA-N 0.000 claims 1
- UTSFHTSLPLJGAY-XIFFEERXSA-N (2s)-2-[(4-butylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(CCCC)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 UTSFHTSLPLJGAY-XIFFEERXSA-N 0.000 claims 1
- YTWXEIDXKCXBRA-LJAQVGFWSA-N (2s)-2-[(4-chloro-2-nitrophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)C=C1[N+]([O-])=O YTWXEIDXKCXBRA-LJAQVGFWSA-N 0.000 claims 1
- WNUUHBAKGFYPBR-LJAQVGFWSA-N (2s)-2-[(4-chlorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)C=C1 WNUUHBAKGFYPBR-LJAQVGFWSA-N 0.000 claims 1
- JVOPRULHQJVNDE-PMERELPUSA-N (2s)-2-[(4-cyanophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(C#N)C=C1 JVOPRULHQJVNDE-PMERELPUSA-N 0.000 claims 1
- QYMRNEISCYLXGX-LJAQVGFWSA-N (2s)-2-[(4-fluorophenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(F)C=C1 QYMRNEISCYLXGX-LJAQVGFWSA-N 0.000 claims 1
- QVEJIOMCTNHULQ-XIFFEERXSA-N (2s)-2-[(4-tert-butylphenyl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 QVEJIOMCTNHULQ-XIFFEERXSA-N 0.000 claims 1
- RSFYOPASAIKCCL-NDEPHWFRSA-N (2s)-2-[(5-bromo-6-chloropyridin-3-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CN=C(Cl)C(Br)=C1 RSFYOPASAIKCCL-NDEPHWFRSA-N 0.000 claims 1
- VTEXMTCKJHHKMH-MHZLTWQESA-N (2s)-2-[(5-chlorothiophen-2-yl)sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(Cl)S1 VTEXMTCKJHHKMH-MHZLTWQESA-N 0.000 claims 1
- LBMBSTWOMQGWJA-HKBQPEDESA-N (2s)-2-[[2-(4-hydroxyphenyl)acetyl]amino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC1=CC=C(O)C=C1 LBMBSTWOMQGWJA-HKBQPEDESA-N 0.000 claims 1
- HPMBYMGSARKOLS-XIFFEERXSA-N (2s)-2-[[2-[4-(dimethylamino)phenyl]acetyl]amino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(N(C)C)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HPMBYMGSARKOLS-XIFFEERXSA-N 0.000 claims 1
- SGXZWKBMZURBHA-LJAQVGFWSA-N (2s)-2-[[2-chloro-5-(trifluoromethyl)phenyl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC(C(F)(F)F)=CC=C1Cl SGXZWKBMZURBHA-LJAQVGFWSA-N 0.000 claims 1
- NFWMEEYBTJPYJF-UMSFTDKQSA-N (2s)-2-[[4-(4-cyanophenyl)-1,3-oxazol-2-yl]amino]-3-(1h-indol-3-yl)-n-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methylpropanamide Chemical compound N1=CC(OC)=CC=C1C1(CNC(=O)[C@](C)(CC=2C3=CC=CC=C3NC=2)NC=2OC=C(N=2)C=2C=CC(=CC=2)C#N)CCCCC1 NFWMEEYBTJPYJF-UMSFTDKQSA-N 0.000 claims 1
- NIDBPOHKMKWWBE-XIFFEERXSA-N (2s)-2-[[5-(benzenesulfonyl)thiophen-2-yl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1S(=O)(=O)C1=CC=CC=C1 NIDBPOHKMKWWBE-XIFFEERXSA-N 0.000 claims 1
- FMWIJCCYIUQMAG-DHUJRADRSA-N (2s)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](C)(CC=1C2=CC=CC=C2NC=1)NS(=O)(=O)C1=C2C=CC=C(C2=CC=C1)N(C)C)NCC1(C=2N=CC=CC=2)CCCCC1 FMWIJCCYIUQMAG-DHUJRADRSA-N 0.000 claims 1
- QHISPZNEAIDPFS-DEOSSOPVSA-N (2s)-3-(1h-indol-3-yl)-2-(methanesulfonamido)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(C)(=O)=O)C)NCC1(C=2N=CC=CC=2)CCCCC1 QHISPZNEAIDPFS-DEOSSOPVSA-N 0.000 claims 1
- GGSQCPIHXUHSEN-HKBQPEDESA-N (2s)-3-(1h-indol-3-yl)-2-[(2-methoxy-4-methylphenyl)sulfonylamino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound COC1=CC(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 GGSQCPIHXUHSEN-HKBQPEDESA-N 0.000 claims 1
- JVKUXDMUGHWFFX-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-[(3-methoxyphenyl)sulfonylamino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound COC1=CC=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 JVKUXDMUGHWFFX-PMERELPUSA-N 0.000 claims 1
- HQOCHTKXBPXROI-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-[[2-(4-methoxyphenyl)acetyl]amino]-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(OC)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HQOCHTKXBPXROI-YTTGMZPUSA-N 0.000 claims 1
- RRWRMIFQCKIUIB-NDEPHWFRSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-(pyridin-4-ylamino)-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C1=CC=NC=C1 RRWRMIFQCKIUIB-NDEPHWFRSA-N 0.000 claims 1
- AZVWOKWQLMUJGR-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(2-nitrophenyl)methylsulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)CC1=CC=CC=C1[N+]([O-])=O AZVWOKWQLMUJGR-PMERELPUSA-N 0.000 claims 1
- VPEQIDDNHDUQFU-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(3-methylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 VPEQIDDNHDUQFU-PMERELPUSA-N 0.000 claims 1
- UCVOTOAGAYUZAN-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(3-nitrophenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC([N+]([O-])=O)=C1 UCVOTOAGAYUZAN-LJAQVGFWSA-N 0.000 claims 1
- NSYLMFIGJCAIJP-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(4-methylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 NSYLMFIGJCAIJP-PMERELPUSA-N 0.000 claims 1
- QZFBSWBKTSAWOF-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(4-methylsulfonylphenyl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 QZFBSWBKTSAWOF-PMERELPUSA-N 0.000 claims 1
- UJBNNEPZPPCTGU-XIFFEERXSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[(8-nitronaphthalen-1-yl)sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(=O)(=O)C=1C2=C([N+]([O-])=O)C=CC=C2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 UJBNNEPZPPCTGU-XIFFEERXSA-N 0.000 claims 1
- HNXNQPWVDONFTR-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(2-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 HNXNQPWVDONFTR-YTTGMZPUSA-N 0.000 claims 1
- WPNMLCFQBFKZOZ-HKBQPEDESA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(2-nitrophenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC1=CC=CC=C1[N+]([O-])=O WPNMLCFQBFKZOZ-HKBQPEDESA-N 0.000 claims 1
- RWCXRYHJLNGTGO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(3-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound CC1=CC=CC(CC(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 RWCXRYHJLNGTGO-YTTGMZPUSA-N 0.000 claims 1
- OZFAHUYOUXFTJO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-(4-methylphenyl)acetyl]amino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C1=CC(C)=CC=C1CC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 OZFAHUYOUXFTJO-YTTGMZPUSA-N 0.000 claims 1
- IFBOAVJTYAADPU-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O IFBOAVJTYAADPU-LJAQVGFWSA-N 0.000 claims 1
- DVVKNDOIZRDMJJ-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]-n-phenacylpropanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC(=O)C=1C=CC=CC=1)C(OC=1)=NC=1C1=CC=C([N+]([O-])=O)C=C1 DVVKNDOIZRDMJJ-LJAQVGFWSA-N 0.000 claims 1
- WMYMZKAUWMBOGB-PMERELPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-2-[[5-(1,2-oxazol-3-yl)thiophen-2-yl]sulfonylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1C=1C=CON=1 WMYMZKAUWMBOGB-PMERELPUSA-N 0.000 claims 1
- NHRFZRKZJUDCRH-DEOSSOPVSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-(2,2,2-trifluoroethylsulfonylamino)propanamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NS(=O)(=O)CC(F)(F)F)C)NCC1(C=2N=CC=CC=2)CCCCC1 NHRFZRKZJUDCRH-DEOSSOPVSA-N 0.000 claims 1
- NVMJVPBCNIHVFH-MHZLTWQESA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-(thiophen-2-ylsulfonylamino)propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CS1 NVMJVPBCNIHVFH-MHZLTWQESA-N 0.000 claims 1
- BROHTICPXHGLTP-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[(2-thiophen-3-ylacetyl)amino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)CC=1C=CSC=1 BROHTICPXHGLTP-LJAQVGFWSA-N 0.000 claims 1
- SHEBFFBWIUGJAO-YTTGMZPUSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C(S1)=CC=C1C1=CC=CC=N1 SHEBFFBWIUGJAO-YTTGMZPUSA-N 0.000 claims 1
- SLYFXFFLQHJHCD-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[2-(trifluoromethyl)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC=C1C(F)(F)F SLYFXFFLQHJHCD-LJAQVGFWSA-N 0.000 claims 1
- QKACRBARNNDMNH-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=CC(C(F)(F)F)=C1 QKACRBARNNDMNH-LJAQVGFWSA-N 0.000 claims 1
- XENVSVVIUBONMV-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-2-methyl-n-[(1-pyridin-2-ylcyclohexyl)methyl]-2-[[4-(trifluoromethoxy)phenyl]sulfonylamino]propanamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)S(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 XENVSVVIUBONMV-LJAQVGFWSA-N 0.000 claims 1
- WRCONAZZEKRJJR-LJAQVGFWSA-N (2s)-3-(1h-indol-3-yl)-n-[[1-(methoxymethyl)cyclohexyl]methyl]-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]propanamide Chemical compound O=C([C@](C)(CC=1C2=CC=CC=C2NC=1)NC=1OC=C(N=1)C=1C=CC(=CC=1)[N+]([O-])=O)NCC1(COC)CCCCC1 WRCONAZZEKRJJR-LJAQVGFWSA-N 0.000 claims 1
- GXVSIUQNFGMAAU-HKBQPEDESA-N (2s)-n-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[[4-(4-nitrophenyl)-1,3-oxazol-2-yl]amino]-3-phenylpropanamide Chemical compound N1=CC(OC)=CC=C1C1(CNC(=O)[C@](C)(CC=2C=CC=CC=2)NC=2OC=C(N=2)C=2C=CC(=CC=2)[N+]([O-])=O)CCCCC1 GXVSIUQNFGMAAU-HKBQPEDESA-N 0.000 claims 1
- QXUOUBPHUIGWFR-YTTGMZPUSA-N (3-cyanophenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=CC(C#N)=C1 QXUOUBPHUIGWFR-YTTGMZPUSA-N 0.000 claims 1
- INBWANLQJHTHQY-YTTGMZPUSA-N (3-methylphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound CC1=CC=CC(COC(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 INBWANLQJHTHQY-YTTGMZPUSA-N 0.000 claims 1
- CACPIXWTJQQXBY-QNGWXLTQSA-N (3-phenoxyphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC(C=1)=CC=CC=1OC1=CC=CC=C1 CACPIXWTJQQXBY-QNGWXLTQSA-N 0.000 claims 1
- PFMOBPGKDKADKX-HKBQPEDESA-N (4-chlorophenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=C(Cl)C=C1 PFMOBPGKDKADKX-HKBQPEDESA-N 0.000 claims 1
- YMSGEOIBQFOADL-YTTGMZPUSA-N (4-methoxyphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1COC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 YMSGEOIBQFOADL-YTTGMZPUSA-N 0.000 claims 1
- YRLHKVFSAGRKAQ-YTTGMZPUSA-N (4-methylphenyl)methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1COC(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 YRLHKVFSAGRKAQ-YTTGMZPUSA-N 0.000 claims 1
- UOOJTLMZWAEIBZ-XIFFEERXSA-N 2,3-dihydro-1h-inden-2-yl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)OC1CC2=CC=CC=C2C1)C)NCC1(C=2N=CC=CC=2)CCCCC1 UOOJTLMZWAEIBZ-XIFFEERXSA-N 0.000 claims 1
- MUSGYEMSJUFFHT-UWABRSFTSA-N 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[[(2S,3S)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-methylcarbamoyl]-25-(3-amino-3-oxopropyl)-7-(3-carbamimidamidopropyl)-10-(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-13,17-dimethyl-28-[(1-methylindol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33-decaoxo-31-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC(=O)CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(N)=O MUSGYEMSJUFFHT-UWABRSFTSA-N 0.000 claims 1
- BDVDNJKKDRLXTK-PMERELPUSA-N 2-chloro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1Cl BDVDNJKKDRLXTK-PMERELPUSA-N 0.000 claims 1
- UBIFZQFQYQQRNJ-PMERELPUSA-N 2-fluoro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1F UBIFZQFQYQQRNJ-PMERELPUSA-N 0.000 claims 1
- GJBNQQQENHQGEX-UHFFFAOYSA-N 2-methyl-3-(1-pyridin-2-ylcyclohexyl)propanamide Chemical compound C=1C=CC=NC=1C1(CC(C)C(N)=O)CCCCC1 GJBNQQQENHQGEX-UHFFFAOYSA-N 0.000 claims 1
- SQISOBNEDVJTMH-UHFFFAOYSA-N 3-(1h-indol-3-yl)-2-methyl-2-[1-(4-nitrophenyl)ethylcarbamoylamino]-n-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(C)NC(=O)NC(C)(CC=1C2=CC=CC=C2NC=1)C(=O)NCC1(C=2N=CC=CC=2)CCCCC1 SQISOBNEDVJTMH-UHFFFAOYSA-N 0.000 claims 1
- KYFJEEPRKVHYBU-HKBQPEDESA-N 3-cyano-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC(C#N)=C1 KYFJEEPRKVHYBU-HKBQPEDESA-N 0.000 claims 1
- WWLQMWLRNGJKFO-PMERELPUSA-N 4-chloro-n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]benzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C(Cl)C=C1 WWLQMWLRNGJKFO-PMERELPUSA-N 0.000 claims 1
- 206010011953 Decreased activity Diseases 0.000 claims 1
- 102000004279 Oxytocin receptors Human genes 0.000 claims 1
- HGEYOTSQNMEWIP-HKBQPEDESA-N [4-(trifluoromethyl)phenyl]methyl n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]carbamate Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)OCC1=CC=C(C(F)(F)F)C=C1 HGEYOTSQNMEWIP-HKBQPEDESA-N 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- KAJMFZBELRFCHM-HKBQPEDESA-N methyl 2-[[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]sulfamoyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 KAJMFZBELRFCHM-HKBQPEDESA-N 0.000 claims 1
- BBSJDZURDHBQSH-LJAQVGFWSA-N methyl 3-[[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]sulfamoyl]thiophene-2-carboxylate Chemical compound S1C=CC(S(=O)(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1C(=O)OC BBSJDZURDHBQSH-LJAQVGFWSA-N 0.000 claims 1
- AEZPANISLZXSDR-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-1-yl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1h-indol-3-yl)-2-methylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C)(C(=O)NC1C2=CC=CC=C2CC1)CC1=CNC2=CC=CC=C12 AEZPANISLZXSDR-UHFFFAOYSA-N 0.000 claims 1
- BUKVFXISAYYMOI-UHFFFAOYSA-N n-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-2-methyl-3-pyridin-2-ylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C)(C(=O)NCC1CCCCC1)CC1=CC=CC=N1 BUKVFXISAYYMOI-UHFFFAOYSA-N 0.000 claims 1
- KWCBBPPGJDRADF-UHFFFAOYSA-N n-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1h-indol-3-yl)-n-methylpropanamide Chemical compound CC(C)C1=CC=CC(C(C)C)=C1NC(=O)NC(C(=O)N(C)CC1CCCCC1)CC1=CNC2=CC=CC=C12 KWCBBPPGJDRADF-UHFFFAOYSA-N 0.000 claims 1
- DXIAAZQPKAIDRD-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1,3-benzothiazole-6-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=C2SC=NC2=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 DXIAAZQPKAIDRD-HKBQPEDESA-N 0.000 claims 1
- YPKOCNNFKMCMPR-YTTGMZPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1h-indole-4-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=2C=CNC=2C=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 YPKOCNNFKMCMPR-YTTGMZPUSA-N 0.000 claims 1
- JUTWZLGNRSDDLI-YTTGMZPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-1h-indole-5-carboxamide Chemical compound O=C([C@](CC=1C2=CC=CC=C2NC=1)(NC(=O)C=1C=C2C=CNC2=CC=1)C)NCC1(C=2N=CC=CC=2)CCCCC1 JUTWZLGNRSDDLI-YTTGMZPUSA-N 0.000 claims 1
- JWLLGKSXLCBXSB-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-methoxybenzamide Chemical compound COC1=CC=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 JWLLGKSXLCBXSB-HKBQPEDESA-N 0.000 claims 1
- ASCHENDLMZYTLZ-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-methylbenzamide Chemical compound CC1=CC=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 ASCHENDLMZYTLZ-HKBQPEDESA-N 0.000 claims 1
- OUSYGMMKJPPFND-PMERELPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-2-nitrobenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC=C1[N+]([O-])=O OUSYGMMKJPPFND-PMERELPUSA-N 0.000 claims 1
- AJYARFKVTZRMGL-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-3-methylbenzamide Chemical compound CC1=CC=CC(C(=O)N[C@@](C)(CC=2C3=CC=CC=C3NC=2)C(=O)NCC2(CCCCC2)C=2N=CC=CC=2)=C1 AJYARFKVTZRMGL-HKBQPEDESA-N 0.000 claims 1
- VBEYVRVGTNLUKS-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-3-methylsulfonylbenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CC(S(C)(=O)=O)=C1 VBEYVRVGTNLUKS-HKBQPEDESA-N 0.000 claims 1
- TZSXYOWKZPUTJF-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methoxybenzamide Chemical compound C1=CC(OC)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 TZSXYOWKZPUTJF-HKBQPEDESA-N 0.000 claims 1
- WULGKNJOPUNCKW-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 WULGKNJOPUNCKW-HKBQPEDESA-N 0.000 claims 1
- QJPDMZJLRRKFFZ-HKBQPEDESA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-methylsulfonylbenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C(S(C)(=O)=O)C=C1 QJPDMZJLRRKFFZ-HKBQPEDESA-N 0.000 claims 1
- MXUYTPAMPGUNDN-PMERELPUSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-4-nitrobenzamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=C([N+]([O-])=O)C=C1 MXUYTPAMPGUNDN-PMERELPUSA-N 0.000 claims 1
- UMEHIDFGHORJSG-LJAQVGFWSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-5-methylthiophene-2-carboxamide Chemical compound S1C(C)=CC=C1C(=O)N[C@](C)(C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)CC1=CNC2=CC=CC=C12 UMEHIDFGHORJSG-LJAQVGFWSA-N 0.000 claims 1
- NSNTYGVOFVPUKQ-NDEPHWFRSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]furan-2-carboxamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C1=CC=CO1 NSNTYGVOFVPUKQ-NDEPHWFRSA-N 0.000 claims 1
- IUDTYPYXJBAKQQ-NDEPHWFRSA-N n-[(2s)-3-(1h-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]furan-3-carboxamide Chemical compound N([C@](CC=1C2=CC=CC=C2NC=1)(C)C(=O)NCC1(CCCCC1)C=1N=CC=CC=1)C(=O)C=1C=COC=1 IUDTYPYXJBAKQQ-NDEPHWFRSA-N 0.000 claims 1
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Classifications
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2000/004380 WO2002040022A1 (en) | 2000-11-17 | 2000-11-17 | Treatment of sexual dysfunction using bombesin antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200303250B true ZA200303250B (en) | 2004-04-26 |
Family
ID=9886325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200303250A ZA200303250B (en) | 2000-11-17 | 2003-04-25 | Treatment of sexual dysfunction. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1333829A1 (hu) |
JP (1) | JP2004525864A (hu) |
KR (1) | KR20040062416A (hu) |
CN (1) | CN1479618A (hu) |
AU (1) | AU2001214046A1 (hu) |
BR (1) | BR0017374A (hu) |
CA (1) | CA2426521A1 (hu) |
HU (1) | HUP0303500A2 (hu) |
IL (1) | IL155814A0 (hu) |
MX (1) | MXPA03003481A (hu) |
PL (1) | PL366002A1 (hu) |
WO (1) | WO2002040022A1 (hu) |
ZA (1) | ZA200303250B (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
US7244743B2 (en) | 2002-06-05 | 2007-07-17 | Solvay Pharmaceuticals Gmbh | Non-peptidic BRS-3 agonists |
CN117665174B (zh) * | 2024-02-01 | 2024-04-23 | 巴中市产品质量检验检测中心 | 一种检测pde5和ssri的方法及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
US5650395A (en) * | 1995-03-13 | 1997-07-22 | Hurel; Steven | Treatment of pulmonary hypertension |
WO1998007718A1 (en) * | 1996-08-22 | 1998-02-26 | Warner-Lambert Company | Non-peptide bombesin receptor antagonists |
AU2180600A (en) * | 1998-12-18 | 2000-07-12 | Warner-Lambert Company | Non-peptide nk1 receptors antagonists |
AU4825200A (en) * | 1999-05-07 | 2000-11-21 | Board Of Regents, The University Of Texas System | Oral steroidal hormone compositions and methods of use |
ES2183500T3 (es) * | 1999-06-04 | 2003-03-16 | Jordanian Pharmaceutical Mfg A | Nuevos compuestos y composiciones farmaceuticas que los contienen. |
-
2000
- 2000-11-17 IL IL15581400A patent/IL155814A0/xx unknown
- 2000-11-17 WO PCT/GB2000/004380 patent/WO2002040022A1/en not_active Application Discontinuation
- 2000-11-17 HU HU0303500A patent/HUP0303500A2/hu unknown
- 2000-11-17 AU AU2001214046A patent/AU2001214046A1/en not_active Abandoned
- 2000-11-17 KR KR10-2003-7006676A patent/KR20040062416A/ko active IP Right Grant
- 2000-11-17 JP JP2002542395A patent/JP2004525864A/ja active Pending
- 2000-11-17 EP EP00976165A patent/EP1333829A1/en not_active Withdrawn
- 2000-11-17 MX MXPA03003481A patent/MXPA03003481A/es unknown
- 2000-11-17 CN CNA008201218A patent/CN1479618A/zh active Pending
- 2000-11-17 CA CA002426521A patent/CA2426521A1/en not_active Abandoned
- 2000-11-17 BR BR0017374-6A patent/BR0017374A/pt not_active IP Right Cessation
- 2000-11-17 PL PL00366002A patent/PL366002A1/xx not_active Application Discontinuation
-
2003
- 2003-04-25 ZA ZA200303250A patent/ZA200303250B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1479618A (zh) | 2004-03-03 |
WO2002040022A1 (en) | 2002-05-23 |
CA2426521A1 (en) | 2002-05-23 |
KR20040062416A (ko) | 2004-07-07 |
IL155814A0 (en) | 2003-12-23 |
MXPA03003481A (es) | 2004-09-10 |
HUP0303500A2 (hu) | 2004-01-28 |
JP2004525864A (ja) | 2004-08-26 |
EP1333829A1 (en) | 2003-08-13 |
AU2001214046A1 (en) | 2002-05-27 |
PL366002A1 (en) | 2005-01-24 |
BR0017374A (pt) | 2003-09-30 |
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