ZA200302292B - Arylalkane-sulfonamides having endothelin-antagonist activity. - Google Patents
Arylalkane-sulfonamides having endothelin-antagonist activity. Download PDFInfo
- Publication number
- ZA200302292B ZA200302292B ZA200302292A ZA200302292A ZA200302292B ZA 200302292 B ZA200302292 B ZA 200302292B ZA 200302292 A ZA200302292 A ZA 200302292A ZA 200302292 A ZA200302292 A ZA 200302292A ZA 200302292 B ZA200302292 B ZA 200302292B
- Authority
- ZA
- South Africa
- Prior art keywords
- lower alkyl
- amino
- compounds
- general formula
- formula
- Prior art date
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- 230000000694 effects Effects 0.000 title claims 2
- 239000002308 endothelin receptor antagonist Substances 0.000 title description 5
- 229940124530 sulfonamide Drugs 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 91
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- -1 tri-substituted phenyl Chemical group 0.000 claims description 43
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0009327 | 2000-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200302292B true ZA200302292B (en) | 2004-06-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200302292A ZA200302292B (en) | 2000-09-25 | 2003-03-24 | Arylalkane-sulfonamides having endothelin-antagonist activity. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7091201B2 (zh) |
| JP (1) | JP2004509874A (zh) |
| KR (1) | KR100835770B1 (zh) |
| CN (1) | CN1326841C (zh) |
| AR (1) | AR032896A1 (zh) |
| AT (1) | ATE446289T1 (zh) |
| AU (2) | AU1217102A (zh) |
| BR (1) | BR0114082A (zh) |
| CA (1) | CA2423351C (zh) |
| DE (1) | DE60140263D1 (zh) |
| ES (1) | ES2333409T3 (zh) |
| HU (1) | HUP0303364A3 (zh) |
| IL (1) | IL154364A0 (zh) |
| MX (1) | MXPA03001991A (zh) |
| NO (1) | NO20031332L (zh) |
| NZ (1) | NZ524172A (zh) |
| WO (1) | WO2002024665A1 (zh) |
| ZA (1) | ZA200302292B (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| DE60318219T2 (de) | 2002-08-24 | 2009-01-15 | Astrazeneca Ab | PYRIMIDINDERIVATE ALS MODULATOREN DER AKTIVITuT VON CHEMOKINREZEPTOREN |
| SE0301653D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0301654D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| DK1725540T5 (da) | 2004-03-05 | 2012-10-22 | Hoffmann La Roche | Diaminopyrimidiner som p2x3- og p2x2/3-antagonister |
| JP4795352B2 (ja) | 2004-08-28 | 2011-10-19 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体モジュレーターとしてのピリミジンスルホンアミド誘導体 |
| CA2619919C (en) | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| CN101253159B (zh) | 2005-09-01 | 2011-12-07 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物 |
| EP1924566B1 (en) | 2005-09-01 | 2016-01-13 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2012151440A1 (en) * | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| CN103864701B (zh) * | 2014-03-10 | 2016-08-24 | 常熟市金申医化制品有限责任公司 | 4-磺胺-5-甲氧基-6-氯嘧啶的制备方法 |
| EP3870574B1 (en) | 2018-10-23 | 2023-01-04 | Step Pharma S.A.S. | Aminopyrimidine/pyrazine derivatives as ctps1 inhibitors |
| US20230086703A1 (en) * | 2019-06-04 | 2023-03-23 | Step Pharma S.A.S. | N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases |
| WO2020245664A1 (en) * | 2019-06-04 | 2020-12-10 | Step Pharma S.A.S. | N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1549494A (zh) | 1967-10-31 | 1968-12-13 | ||
| TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| JP2790065B2 (ja) * | 1993-12-17 | 1998-08-27 | 田辺製薬株式会社 | ベンゼンスルホンアミド誘導体及びその製法 |
| US5837708A (en) * | 1994-11-25 | 1998-11-17 | Hoffmann-La Roche Inc. | Sulphonamides |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| JP3013752B2 (ja) * | 1995-05-16 | 2000-02-28 | 田辺製薬株式会社 | スルホンアミド誘導体 |
| JP3067131B2 (ja) * | 1995-06-16 | 2000-07-17 | 田辺製薬株式会社 | 医薬組成物 |
| ATE201202T1 (de) * | 1995-12-20 | 2001-06-15 | Yamanouchi Pharma Co Ltd | Arylethensulfonamid-derivate und diese enthaltende medikamente |
| JP3116347B2 (ja) * | 1996-11-13 | 2000-12-11 | 田辺製薬株式会社 | 医薬組成物 |
| WO1998057938A1 (fr) * | 1997-06-19 | 1998-12-23 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'alcanesulfonamide inferieur substitue et composition pharmaceutique les contenant |
| JPH11343239A (ja) * | 1998-03-31 | 1999-12-14 | Tanabe Seiyaku Co Ltd | 排尿障害の予防・治療剤 |
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2001
- 2001-08-28 IL IL15436401A patent/IL154364A0/xx unknown
- 2001-08-28 JP JP2002529075A patent/JP2004509874A/ja not_active Ceased
- 2001-08-28 NZ NZ524172A patent/NZ524172A/en unknown
- 2001-08-28 US US10/381,568 patent/US7091201B2/en not_active Expired - Fee Related
- 2001-08-28 AU AU1217102A patent/AU1217102A/xx active Pending
- 2001-08-28 KR KR1020037003599A patent/KR100835770B1/ko not_active IP Right Cessation
- 2001-08-28 HU HU0303364A patent/HUP0303364A3/hu unknown
- 2001-08-28 BR BR0114082-5A patent/BR0114082A/pt not_active Application Discontinuation
- 2001-08-28 ES ES01980288T patent/ES2333409T3/es not_active Expired - Lifetime
- 2001-08-28 WO PCT/EP2001/009894 patent/WO2002024665A1/en active IP Right Grant
- 2001-08-28 DE DE60140263T patent/DE60140263D1/de not_active Expired - Lifetime
- 2001-08-28 CN CNB01815896XA patent/CN1326841C/zh not_active Expired - Fee Related
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- 2001-08-28 CA CA2423351A patent/CA2423351C/en not_active Expired - Fee Related
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- 2001-08-28 MX MXPA03001991A patent/MXPA03001991A/es active IP Right Grant
- 2001-09-24 AR ARP010104490A patent/AR032896A1/es not_active Application Discontinuation
-
2003
- 2003-03-24 NO NO20031332A patent/NO20031332L/no not_active Application Discontinuation
- 2003-03-24 ZA ZA200302292A patent/ZA200302292B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2423351A1 (en) | 2002-03-28 |
| NO20031332D0 (no) | 2003-03-24 |
| CN1633418A (zh) | 2005-06-29 |
| IL154364A0 (en) | 2003-09-17 |
| JP2004509874A (ja) | 2004-04-02 |
| AR032896A1 (es) | 2003-12-03 |
| BR0114082A (pt) | 2003-07-22 |
| HUP0303364A2 (hu) | 2004-03-01 |
| AU2002212171B2 (en) | 2006-12-14 |
| MXPA03001991A (es) | 2003-06-24 |
| WO2002024665A8 (en) | 2002-06-06 |
| HUP0303364A3 (en) | 2004-04-28 |
| US7091201B2 (en) | 2006-08-15 |
| ES2333409T3 (es) | 2010-02-22 |
| KR100835770B1 (ko) | 2008-06-09 |
| ATE446289T1 (de) | 2009-11-15 |
| NO20031332L (no) | 2003-03-24 |
| US20040102464A1 (en) | 2004-05-27 |
| CA2423351C (en) | 2010-12-21 |
| AU1217102A (en) | 2002-04-02 |
| CN1326841C (zh) | 2007-07-18 |
| DE60140263D1 (de) | 2009-12-03 |
| NZ524172A (en) | 2004-09-24 |
| KR20030029979A (ko) | 2003-04-16 |
| WO2002024665A1 (en) | 2002-03-28 |
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