ZA200206851B - 6-hydroxy-indazole derivatives for treating glaucoma. - Google Patents
6-hydroxy-indazole derivatives for treating glaucoma. Download PDFInfo
- Publication number
- ZA200206851B ZA200206851B ZA200206851A ZA200206851A ZA200206851B ZA 200206851 B ZA200206851 B ZA 200206851B ZA 200206851 A ZA200206851 A ZA 200206851A ZA 200206851 A ZA200206851 A ZA 200206851A ZA 200206851 B ZA200206851 B ZA 200206851B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogen
- alkyl
- halogen
- independently chosen
- trifluoromethyl
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title claims description 16
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US19038000P | 2000-03-17 | 2000-03-17 |
Publications (1)
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|---|---|
| ZA200206851B true ZA200206851B (en) | 2003-10-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206851A ZA200206851B (en) | 2000-03-17 | 2002-08-27 | 6-hydroxy-indazole derivatives for treating glaucoma. |
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| Country | Link |
|---|---|
| EP (1) | EP1268438A1 (zh) |
| JP (1) | JP2003528085A (zh) |
| KR (1) | KR20030065304A (zh) |
| CN (1) | CN1450994A (zh) |
| AR (1) | AR032138A1 (zh) |
| AU (1) | AU2001216072A1 (zh) |
| BR (1) | BR0017157A (zh) |
| CA (1) | CA2402403A1 (zh) |
| GC (1) | GC0000155A (zh) |
| MX (1) | MXPA02008547A (zh) |
| PL (1) | PL358481A1 (zh) |
| TW (1) | TWI221839B (zh) |
| WO (1) | WO2001070702A1 (zh) |
| ZA (1) | ZA200206851B (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| WO2003057213A2 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| CN100384827C (zh) * | 2002-11-08 | 2008-04-30 | 默克公司 | 用于治疗高眼压症的眼用组合物 |
| US7196082B2 (en) | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| WO2004043354A2 (en) | 2002-11-08 | 2004-05-27 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
| CA2506204A1 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| JP2004262812A (ja) * | 2003-02-28 | 2004-09-24 | Rohto Pharmaceut Co Ltd | 眼圧低下剤 |
| JP2007504228A (ja) | 2003-09-02 | 2007-03-01 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼組成物 |
| CN1842335A (zh) | 2003-09-04 | 2006-10-04 | 默克公司 | 用于治疗高眼压的眼用组合物 |
| JP4546961B2 (ja) | 2003-09-04 | 2010-09-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 高眼圧の治療のための眼科用組成物 |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| WO2005058911A2 (en) | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| CA2574078A1 (en) | 2004-07-20 | 2006-02-23 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| WO2006056873A2 (en) | 2004-11-29 | 2006-06-01 | Warner-Lambert Company Llc | Therapeutic pyrazolo[3,4-b] pyridines and indazoles |
| WO2006062839A1 (en) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| CN101704785B (zh) * | 2009-11-16 | 2012-02-29 | 东南大学 | 有机二羧酸和其盐及其制备方法 |
| CN105884687B (zh) * | 2016-04-14 | 2018-06-22 | 梯尔希（南京）药物研发有限公司 | 一种5-苄基苄达明的制备方法 |
Family Cites Families (5)
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|---|---|---|---|---|
| JP2002515408A (ja) * | 1998-05-19 | 2002-05-28 | アルコン ラボラトリーズ， インコーポレーテッド | 眼および中枢神経系疾患治療用セロトニン作動性５ｈｔ７受容体化合物 |
| EP0985414B1 (en) * | 1998-05-26 | 2003-08-27 | Pfizer Products Inc. | Medicament for the treatment of glaucoma and ischemic retinopathy |
| GB9819032D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| CN1269484C (zh) * | 1998-09-18 | 2006-08-16 | 艾尔科实验室公司 | 用于治疗青光眼的5－羟色胺激活性激动剂 |
| GB9820767D0 (en) * | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
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2000
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- 2000-11-14 WO PCT/US2000/031247 patent/WO2001070702A1/en not_active Application Discontinuation
- 2000-11-14 MX MXPA02008547A patent/MXPA02008547A/es unknown
- 2000-11-14 PL PL00358481A patent/PL358481A1/xx not_active Application Discontinuation
- 2000-11-14 AU AU2001216072A patent/AU2001216072A1/en not_active Abandoned
- 2000-11-14 JP JP2001568912A patent/JP2003528085A/ja not_active Withdrawn
- 2000-11-14 CA CA002402403A patent/CA2402403A1/en not_active Abandoned
- 2000-11-14 BR BR0017157-3A patent/BR0017157A/pt not_active IP Right Cessation
- 2000-11-14 KR KR1020027011867A patent/KR20030065304A/ko not_active Application Discontinuation
- 2000-11-14 EP EP00978628A patent/EP1268438A1/en not_active Withdrawn
- 2000-11-27 TW TW089125127A patent/TWI221839B/zh not_active IP Right Cessation
- 2000-12-01 AR ARP000106394A patent/AR032138A1/es not_active Application Discontinuation
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| TWI221839B (en) | 2004-10-11 |
| AR032138A1 (es) | 2003-10-29 |
| PL358481A1 (en) | 2004-08-09 |
| KR20030065304A (ko) | 2003-08-06 |
| WO2001070702A1 (en) | 2001-09-27 |
| AU2001216072A1 (en) | 2001-10-03 |
| JP2003528085A (ja) | 2003-09-24 |
| CA2402403A1 (en) | 2001-09-27 |
| MXPA02008547A (es) | 2003-03-12 |
| EP1268438A1 (en) | 2003-01-02 |
| BR0017157A (pt) | 2002-11-26 |
| CN1450994A (zh) | 2003-10-22 |
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