ZA200206038B - Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. - Google Patents
Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. Download PDFInfo
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- ZA200206038B ZA200206038B ZA200206038A ZA200206038A ZA200206038B ZA 200206038 B ZA200206038 B ZA 200206038B ZA 200206038 A ZA200206038 A ZA 200206038A ZA 200206038 A ZA200206038 A ZA 200206038A ZA 200206038 B ZA200206038 B ZA 200206038B
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- South Africa
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- group
- substituted
- alkyl
- phenyl
- haloalkyl
- Prior art date
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- 230000003449 preventive effect Effects 0.000 title claims description 14
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- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 description 1
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- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 235000010981 methylcellulose Nutrition 0.000 description 1
- OPJBAKXTAPAALK-UHFFFAOYSA-N n-[2-(ethylsulfonylamino)-5-(trifluoromethyl)pyridin-3-yl]-3-fluorobenzamide Chemical compound CCS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=CC(F)=C1 OPJBAKXTAPAALK-UHFFFAOYSA-N 0.000 description 1
- GNSRPLZFSMVDMI-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-2,3-dihydro-1h-indene-5-carboxamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=C(CCC2)C2=C1 GNSRPLZFSMVDMI-UHFFFAOYSA-N 0.000 description 1
- MUOWIDVDOSRPCZ-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-3-(trifluoromethyl)benzamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C1=CC=CC(C(F)(F)F)=C1 MUOWIDVDOSRPCZ-UHFFFAOYSA-N 0.000 description 1
- HLZKWYRERKPMTI-UHFFFAOYSA-N n-[2-(methanesulfonamido)-5-(trifluoromethyl)pyridin-3-yl]-3-thiophen-2-ylprop-2-enamide Chemical compound CS(=O)(=O)NC1=NC=C(C(F)(F)F)C=C1NC(=O)C=CC1=CC=CS1 HLZKWYRERKPMTI-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001196 nonadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000005485 noradamantyl group Chemical group 0.000 description 1
- 125000005593 norbornanyl group Chemical group 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
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- 125000005968 oxazolinyl group Chemical group 0.000 description 1
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- 235000020232 peanut Nutrition 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000005981 pentynyl group Chemical group 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000001422 pyrrolinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
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- 230000009528 severe injury Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
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- 210000002460 smooth muscle Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 201000004415 tendinitis Diseases 0.000 description 1
- 125000005886 tetrahydrobenzothienyl group Chemical group 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetraline Natural products C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000002769 thiazolinyl group Chemical group 0.000 description 1
- 125000004587 thienothienyl group Chemical group S1C(=CC2=C1C=CS2)* 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229950008558 ulinastatin Drugs 0.000 description 1
- 108010088854 urinastatin Proteins 0.000 description 1
- ODVKSTFPQDVPJZ-UHFFFAOYSA-N urinastatin Chemical compound C1C=CCCC11COC(C=2OC=CC=2)OC1 ODVKSTFPQDVPJZ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000024349 | 2000-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206038B true ZA200206038B (en) | 2003-08-18 |
Family
ID=18550353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206038A ZA200206038B (en) | 2000-02-01 | 2002-07-29 | Remedies or preventives for pulmonary insufficiency containing diaminotrifluoromethylpyridine derivatives. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6635665B2 (fr) |
| EP (1) | EP1252889B1 (fr) |
| JP (1) | JP4848092B2 (fr) |
| KR (1) | KR100706725B1 (fr) |
| CN (1) | CN1230170C (fr) |
| AU (1) | AU774479B2 (fr) |
| CA (1) | CA2398992C (fr) |
| DE (1) | DE60122111T8 (fr) |
| ES (1) | ES2269343T3 (fr) |
| IL (2) | IL151009A0 (fr) |
| NZ (1) | NZ520376A (fr) |
| RU (1) | RU2253450C2 (fr) |
| TW (1) | TWI293029B (fr) |
| WO (1) | WO2001056570A1 (fr) |
| ZA (1) | ZA200206038B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003277537A1 (en) * | 2002-10-30 | 2004-05-25 | Ishihara Sangyo Kaisha, Ltd. | REGULATION OF INTERACTION BETWEEN RAPL AND Rap1 |
| ZA200800251B (en) * | 2005-06-24 | 2009-04-29 | Drugrecure Aps | Airway administration of tissue factor pathway inhibitor in inflammatory conditions affecting the respiratory track |
| WO2008136378A1 (fr) * | 2007-04-27 | 2008-11-13 | Toyama Chemical Co., Ltd. | Nouveau dérivé de sulfonamide et son sel |
| JP5584518B2 (ja) * | 2009-05-28 | 2014-09-03 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤 |
| EP3705122A4 (fr) * | 2017-11-02 | 2021-12-22 | Ishihara Sangyo Kaisha, Ltd. | Composition pharmaceutique à libération prolongée |
| CN111787919B (zh) * | 2018-03-01 | 2024-03-08 | 石原产业株式会社 | 保存稳定性优异的医药组合物 |
| EP3970797A4 (fr) | 2019-05-15 | 2022-12-28 | Ishihara Sangyo Kaisha, Ltd. | Cristal anhydre de n-(2-éthylsulfonylamino-5-trifluorométhyl-3-pyridyl) cyclohexane carboxamide monosodique |
| PE20240109A1 (es) | 2020-09-29 | 2024-01-22 | Ishihara Sangyo Kaisha | Composicion farmaceutica en estado liquido que exhibe excelente eficacia conservante |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0465913T3 (da) * | 1990-07-10 | 1997-10-20 | Ishihara Sangyo Kaisha | Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme |
| US5229403A (en) | 1990-07-10 | 1993-07-20 | Ishihara Sangyo Kaisha Ltd. | Diaminotrifluoromethylpyridine derivatives and phospholipase A2 inhibitor containing them |
| TW415843B (en) * | 1997-02-28 | 2000-12-21 | Ishihara Sangyo Kaisha | Anti-cancer pharmaceutical compositions comprising a diaminotrifluoromethylpyridine derivatives or the pharmaceutically acceptable salts thereof |
-
2001
- 2001-01-29 JP JP2001020057A patent/JP4848092B2/ja not_active Expired - Lifetime
- 2001-01-30 EP EP01902668A patent/EP1252889B1/fr not_active Expired - Lifetime
- 2001-01-30 NZ NZ520376A patent/NZ520376A/en not_active IP Right Cessation
- 2001-01-30 AU AU30528/01A patent/AU774479B2/en not_active Ceased
- 2001-01-30 CA CA002398992A patent/CA2398992C/fr not_active Expired - Lifetime
- 2001-01-30 IL IL15100901A patent/IL151009A0/xx active IP Right Grant
- 2001-01-30 ES ES01902668T patent/ES2269343T3/es not_active Expired - Lifetime
- 2001-01-30 DE DE60122111T patent/DE60122111T8/de active Active
- 2001-01-30 WO PCT/JP2001/000616 patent/WO2001056570A1/fr active IP Right Grant
- 2001-01-30 US US10/181,431 patent/US6635665B2/en not_active Expired - Lifetime
- 2001-01-30 RU RU2002123372/15A patent/RU2253450C2/ru not_active IP Right Cessation
- 2001-01-30 CN CNB018042538A patent/CN1230170C/zh not_active Expired - Fee Related
- 2001-01-30 KR KR1020027009852A patent/KR100706725B1/ko not_active IP Right Cessation
- 2001-02-01 TW TW090102077A patent/TWI293029B/zh not_active IP Right Cessation
-
2002
- 2002-07-29 ZA ZA200206038A patent/ZA200206038B/en unknown
- 2002-07-31 IL IL151009A patent/IL151009A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2398992A1 (fr) | 2001-08-09 |
| DE60122111D1 (de) | 2006-09-21 |
| JP4848092B2 (ja) | 2011-12-28 |
| AU3052801A (en) | 2001-08-14 |
| TWI293029B (en) | 2008-02-01 |
| EP1252889B1 (fr) | 2006-08-09 |
| RU2253450C2 (ru) | 2005-06-10 |
| IL151009A (en) | 2008-04-13 |
| AU774479B2 (en) | 2004-07-01 |
| DE60122111T2 (de) | 2006-12-07 |
| US6635665B2 (en) | 2003-10-21 |
| EP1252889A1 (fr) | 2002-10-30 |
| CN1396827A (zh) | 2003-02-12 |
| DE60122111T8 (de) | 2007-04-05 |
| IL151009A0 (en) | 2003-02-12 |
| ES2269343T3 (es) | 2007-04-01 |
| NZ520376A (en) | 2005-02-25 |
| CA2398992C (fr) | 2009-11-17 |
| KR100706725B1 (ko) | 2007-04-12 |
| KR20020072576A (ko) | 2002-09-16 |
| CN1230170C (zh) | 2005-12-07 |
| EP1252889A4 (fr) | 2004-12-15 |
| US20030109551A1 (en) | 2003-06-12 |
| WO2001056570A1 (fr) | 2001-08-09 |
| JP2001288088A (ja) | 2001-10-16 |
| RU2002123372A (ru) | 2004-03-10 |
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