ZA200201426B - Fatty acid synthase inhibitors. - Google Patents
Fatty acid synthase inhibitors. Download PDFInfo
- Publication number
- ZA200201426B ZA200201426B ZA200201426A ZA200201426A ZA200201426B ZA 200201426 B ZA200201426 B ZA 200201426B ZA 200201426 A ZA200201426 A ZA 200201426A ZA 200201426 A ZA200201426 A ZA 200201426A ZA 200201426 B ZA200201426 B ZA 200201426B
- Authority
- ZA
- South Africa
- Prior art keywords
- dichlorobenzyloxy
- benzyl
- mmol
- compound
- group
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title description 10
- 108010039731 Fatty Acid Synthases Proteins 0.000 title description 7
- 102000015303 Fatty Acid Synthases Human genes 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 51
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 7
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
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- 208000035143 Bacterial infection Diseases 0.000 claims description 4
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- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
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- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15027799P | 1999-08-23 | 1999-08-23 |
Publications (1)
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|---|---|
| ZA200201426B true ZA200201426B (en) | 2003-11-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200201426A ZA200201426B (en) | 1999-08-23 | 2002-02-20 | Fatty acid synthase inhibitors. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6559179B1 (no) |
| EP (1) | EP1206465A4 (no) |
| JP (1) | JP2003507469A (no) |
| KR (1) | KR20020033767A (no) |
| CN (1) | CN1370158A (no) |
| AR (1) | AR029001A1 (no) |
| AU (1) | AU6935900A (no) |
| BR (1) | BR0013515A (no) |
| CA (1) | CA2384197A1 (no) |
| CZ (1) | CZ2002638A3 (no) |
| HK (1) | HK1047927A1 (no) |
| HU (1) | HUP0202457A3 (no) |
| IL (1) | IL148324A0 (no) |
| MX (1) | MXPA02001821A (no) |
| NO (1) | NO20020609D0 (no) |
| NZ (1) | NZ517322A (no) |
| PL (1) | PL364920A1 (no) |
| TR (1) | TR200200494T2 (no) |
| WO (1) | WO2001014364A1 (no) |
| ZA (1) | ZA200201426B (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101117328B (zh) * | 2006-08-01 | 2012-11-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 脂肪酸合成酶抑制剂及其用于治疗细菌感染的用途 |
| CN101190904A (zh) * | 2006-11-23 | 2008-06-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 脂肪酸合成酶抑制剂及其制药用途 |
| CN101450912B (zh) * | 2007-11-24 | 2012-05-30 | 山东轩竹医药科技有限公司 | 四氢化萘取代的苯甲酸衍生物 |
| CN101450911B (zh) * | 2007-11-30 | 2012-02-29 | 山东轩竹医药科技有限公司 | 被金刚烷取代的苯甲酸衍生物 |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| CN102675211A (zh) * | 2011-03-17 | 2012-09-19 | 南京大学 | 塞克硝唑肉桂酸酯衍生物的合成及其在抗菌药物方面的应用 |
| RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
| WO2017184844A1 (en) * | 2016-04-21 | 2017-10-26 | Duke University | Fatty acid synthase inhibitors |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| EP3873214A4 (en) | 2018-10-29 | 2022-07-13 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1H-BENZO[D]IMIDAZOL-5-YL)BENZOYL)PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
Family Cites Families (2)
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|---|---|---|---|---|
| FR2676052B1 (fr) * | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
| US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
-
2000
- 2000-08-18 AR ARP000104301A patent/AR029001A1/es not_active Application Discontinuation
- 2000-08-23 KR KR1020027002280A patent/KR20020033767A/ko not_active Application Discontinuation
- 2000-08-23 PL PL00364920A patent/PL364920A1/xx not_active Application Discontinuation
- 2000-08-23 CA CA002384197A patent/CA2384197A1/en not_active Abandoned
- 2000-08-23 IL IL14832400A patent/IL148324A0/xx unknown
- 2000-08-23 BR BR0013515-1A patent/BR0013515A/pt not_active Application Discontinuation
- 2000-08-23 JP JP2001518451A patent/JP2003507469A/ja not_active Withdrawn
- 2000-08-23 AU AU69359/00A patent/AU6935900A/en not_active Abandoned
- 2000-08-23 WO PCT/US2000/023324 patent/WO2001014364A1/en active IP Right Grant
- 2000-08-23 TR TR2002/00494T patent/TR200200494T2/xx unknown
- 2000-08-23 CZ CZ2002638A patent/CZ2002638A3/cs unknown
- 2000-08-23 HU HU0202457A patent/HUP0202457A3/hu unknown
- 2000-08-23 MX MXPA02001821A patent/MXPA02001821A/es not_active Application Discontinuation
- 2000-08-23 NZ NZ517322A patent/NZ517322A/en not_active IP Right Cessation
- 2000-08-23 US US10/049,353 patent/US6559179B1/en not_active Expired - Lifetime
- 2000-08-23 CN CN00811896A patent/CN1370158A/zh active Pending
- 2000-08-23 EP EP00957791A patent/EP1206465A4/en not_active Withdrawn
-
2002
- 2002-02-07 NO NO20020609A patent/NO20020609D0/no not_active Application Discontinuation
- 2002-02-20 ZA ZA200201426A patent/ZA200201426B/en unknown
- 2002-10-24 HK HK02107739.9A patent/HK1047927A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20020609L (no) | 2002-02-07 |
| NO20020609D0 (no) | 2002-02-07 |
| CA2384197A1 (en) | 2001-03-01 |
| TR200200494T2 (tr) | 2003-02-21 |
| WO2001014364A1 (en) | 2001-03-01 |
| CN1370158A (zh) | 2002-09-18 |
| EP1206465A4 (en) | 2003-01-02 |
| JP2003507469A (ja) | 2003-02-25 |
| MXPA02001821A (es) | 2002-08-06 |
| HUP0202457A3 (en) | 2003-03-28 |
| BR0013515A (pt) | 2002-05-07 |
| AU6935900A (en) | 2001-03-19 |
| HK1047927A1 (zh) | 2003-03-14 |
| IL148324A0 (en) | 2002-09-12 |
| HUP0202457A2 (en) | 2002-10-28 |
| KR20020033767A (ko) | 2002-05-07 |
| AR029001A1 (es) | 2003-06-04 |
| NZ517322A (en) | 2003-11-28 |
| US6559179B1 (en) | 2003-05-06 |
| CZ2002638A3 (cs) | 2002-05-15 |
| PL364920A1 (en) | 2004-12-27 |
| EP1206465A1 (en) | 2002-05-22 |
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