ZA200110414B - Synergistic antibacterial combination. - Google Patents
Synergistic antibacterial combination. Download PDFInfo
- Publication number
- ZA200110414B ZA200110414B ZA200110414A ZA200110414A ZA200110414B ZA 200110414 B ZA200110414 B ZA 200110414B ZA 200110414 A ZA200110414 A ZA 200110414A ZA 200110414 A ZA200110414 A ZA 200110414A ZA 200110414 B ZA200110414 B ZA 200110414B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- hydrogenated
- hydrogenated lupulone
- weight
- lupulone
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 26
- 230000002195 synergetic effect Effects 0.000 title description 7
- 239000000203 mixture Substances 0.000 claims description 82
- LSDULPZJLTZEFD-UHFFFAOYSA-N lupulone Chemical class CC(C)CC(=O)C1=C(O)C(CC=C(C)C)=C(O)C(CC=C(C)C)(CC=C(C)C)C1=O LSDULPZJLTZEFD-UHFFFAOYSA-N 0.000 claims description 31
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 22
- 229960003500 triclosan Drugs 0.000 claims description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 17
- -1 halogenated diphenyl ether compound Chemical class 0.000 claims description 16
- 230000002882 anti-plaque Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 241000192125 Firmicutes Species 0.000 claims description 3
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 125000006267 biphenyl group Chemical group 0.000 claims 2
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- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
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- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
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- JTDPJYXDDYUJBS-UHFFFAOYSA-N quinoline-2-carbohydrazide Chemical compound C1=CC=CC2=NC(C(=O)NN)=CC=C21 JTDPJYXDDYUJBS-UHFFFAOYSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/333,543 US6165447A (en) | 1999-06-15 | 1999-06-15 | Synergistic antibacterial combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200110414B true ZA200110414B (en) | 2003-04-24 |
Family
ID=23303247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200110414A ZA200110414B (en) | 1999-06-15 | 2001-12-19 | Synergistic antibacterial combination. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6165447A (ja) |
| EP (1) | EP1185237B1 (ja) |
| JP (1) | JP2003501454A (ja) |
| CN (1) | CN1182831C (ja) |
| AR (1) | AR024370A1 (ja) |
| AT (1) | ATE248579T1 (ja) |
| AU (1) | AU761558B2 (ja) |
| BR (1) | BR0011623A (ja) |
| CA (1) | CA2376851A1 (ja) |
| CO (1) | CO5190676A1 (ja) |
| DE (1) | DE60004998T2 (ja) |
| DK (1) | DK1185237T3 (ja) |
| DO (1) | DOP2000000017A (ja) |
| HK (1) | HK1044889B (ja) |
| MX (1) | MXPA01012968A (ja) |
| MY (1) | MY123532A (ja) |
| TW (1) | TWI229606B (ja) |
| WO (1) | WO2000076470A1 (ja) |
| ZA (1) | ZA200110414B (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129907A (en) * | 1999-08-04 | 2000-10-10 | Colgate Palmolive Company | Stable hydrogenated lupulone antibacterial oral compositions |
| EP1505998B1 (en) * | 2002-05-17 | 2014-07-09 | S.S. Steiner, Inc. | Improved application for hop acids as anti-microbial agents |
| US20030228814A1 (en) * | 2002-06-07 | 2003-12-11 | Barney Michael C. | Antibacterial packaging material including hop acids |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| US20060198795A1 (en) * | 2005-11-07 | 2006-09-07 | Giniger Martin S | Multi-component oral care compositions |
| US7951232B2 (en) * | 2006-02-09 | 2011-05-31 | Elevance Renewable Sciences, Inc. | Surface coating compositions and methods |
| MX2008010359A (es) * | 2006-02-09 | 2009-01-30 | Elevance Renewable Sciences | Composiciones, metodos y sistemas antimicrobianos. |
| JP5041135B2 (ja) * | 2006-12-26 | 2012-10-03 | ライオン株式会社 | 口腔用組成物及び口腔バイオフィルム形成抑制剤 |
| US20090053331A1 (en) * | 2007-08-21 | 2009-02-26 | Cook Colin W | Hands and feet sanitizing system |
| AR076177A1 (es) * | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL |
| CN111603416B (zh) * | 2019-02-22 | 2023-09-01 | 好维股份有限公司 | 包含啤酒花提取物的口腔护理组合物 |
| EP4037780A2 (en) | 2019-09-30 | 2022-08-10 | The Procter & Gamble Company | Oral care compositions with anticaries activity |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| US20220304919A1 (en) * | 2021-03-25 | 2022-09-29 | The Procter & Gamble Company | Edible Oral Compositions Comprising Hops |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932603A (en) * | 1971-05-28 | 1976-01-13 | General Foods Corporation | Oral preparations for reducing the incidence of dental caries |
| US4644084A (en) * | 1984-01-25 | 1987-02-17 | Miller Brewing Company | Preparation of tetrahydroisohumulones |
| US4894220A (en) * | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| US5166449A (en) * | 1988-08-15 | 1992-11-24 | Kalamazoo Holdings, Inc. | Synthesis of hexahydrolupulone, novel forms thereof, and its use as a selective inhibitor of cell growth and multiplication |
| US5082975A (en) * | 1988-08-15 | 1992-01-21 | Kalamazoo Holdings, Inc. | Synthesis of hexahydrolupulone, novel forms thereof, and its use as a selective inhibitor of cell growth and multiplication |
| US4918240A (en) * | 1988-08-15 | 1990-04-17 | Kalamazoo Holdings, Inc. | Purification of beta acids for hydrogenolysis and such purified beta acids |
| US5334375A (en) * | 1988-12-29 | 1994-08-02 | Colgate Palmolive Company | Antibacterial antiplaque oral composition |
| US5370863A (en) * | 1992-12-16 | 1994-12-06 | Miller Brewing Company | Oral care compositions containing hop acids and method |
| US5827895A (en) * | 1996-02-27 | 1998-10-27 | Regents Of The University Of Minnesota | Hexahydrolupulones useful as anticancer agents |
| US5690911A (en) * | 1996-06-07 | 1997-11-25 | Colgate Palmolive Company | Oral composition containing a mixed surfactant system for promoting antibacterial compound uptake on dental tissue |
| US5800803A (en) * | 1997-02-10 | 1998-09-01 | Colgate-Palmolive Company | Oral composition exhibiting enhanced uptake by dental tissue of noncationic antibacterial agents |
| US5976508A (en) * | 1997-10-06 | 1999-11-02 | Colgate-Palmolive Company | Method to enhance the antibacterial efficacy of antibacterial dentifrices |
-
1999
- 1999-06-15 US US09/333,543 patent/US6165447A/en not_active Expired - Fee Related
-
2000
- 2000-06-13 DO DO2000000017A patent/DOP2000000017A/es unknown
- 2000-06-14 DE DE60004998T patent/DE60004998T2/de not_active Expired - Fee Related
- 2000-06-14 CA CA002376851A patent/CA2376851A1/en not_active Abandoned
- 2000-06-14 CN CNB008116717A patent/CN1182831C/zh not_active Expired - Fee Related
- 2000-06-14 AU AU56101/00A patent/AU761558B2/en not_active Ceased
- 2000-06-14 DK DK00941391T patent/DK1185237T3/da active
- 2000-06-14 EP EP00941391A patent/EP1185237B1/en not_active Expired - Lifetime
- 2000-06-14 AT AT00941391T patent/ATE248579T1/de not_active IP Right Cessation
- 2000-06-14 CO CO00044309A patent/CO5190676A1/es not_active Application Discontinuation
- 2000-06-14 JP JP2001502806A patent/JP2003501454A/ja active Pending
- 2000-06-14 BR BR0011623-8A patent/BR0011623A/pt not_active IP Right Cessation
- 2000-06-14 MY MYPI20002685 patent/MY123532A/en unknown
- 2000-06-14 MX MXPA01012968A patent/MXPA01012968A/es active IP Right Grant
- 2000-06-14 WO PCT/US2000/016215 patent/WO2000076470A1/en active IP Right Grant
- 2000-06-15 AR ARP000102969A patent/AR024370A1/es unknown
- 2000-07-10 TW TW089111667A patent/TWI229606B/zh not_active IP Right Cessation
-
2001
- 2001-12-19 ZA ZA200110414A patent/ZA200110414B/en unknown
-
2002
- 2002-08-13 HK HK02105900.6A patent/HK1044889B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60004998T2 (de) | 2004-07-22 |
| BR0011623A (pt) | 2002-03-05 |
| HK1044889B (zh) | 2004-05-28 |
| MY123532A (en) | 2006-05-31 |
| AU5610100A (en) | 2001-01-02 |
| WO2000076470A1 (en) | 2000-12-21 |
| TWI229606B (en) | 2005-03-21 |
| EP1185237B1 (en) | 2003-09-03 |
| EP1185237A1 (en) | 2002-03-13 |
| CN1370064A (zh) | 2002-09-18 |
| AR024370A1 (es) | 2002-10-02 |
| US6165447A (en) | 2000-12-26 |
| DOP2000000017A (es) | 2002-03-30 |
| MXPA01012968A (es) | 2002-07-30 |
| DK1185237T3 (da) | 2003-12-29 |
| AU761558B2 (en) | 2003-06-05 |
| CN1182831C (zh) | 2005-01-05 |
| JP2003501454A (ja) | 2003-01-14 |
| DE60004998D1 (de) | 2003-10-09 |
| HK1044889A1 (en) | 2002-11-08 |
| CA2376851A1 (en) | 2000-12-21 |
| ATE248579T1 (de) | 2003-09-15 |
| CO5190676A1 (es) | 2002-08-29 |
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