ZA200108894B - Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors. - Google Patents

Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors.

Info

Publication number
ZA200108894B
ZA200108894B ZA200108894A ZA200108894A ZA200108894B ZA 200108894 B ZA200108894 B ZA 200108894B ZA 200108894 A ZA200108894 A ZA 200108894A ZA 200108894 A ZA200108894 A ZA 200108894A ZA 200108894 B ZA200108894 B ZA 200108894B
Authority
ZA
South Africa
Prior art keywords
carboxylic acid
acid amides
uptake inhibitors
adenosine uptake
phenylcyclohexane carboxylic
Prior art date
Application number
ZA200108894A
Other languages
English (en)
Inventor
Erwin Bischoff
Stephan Lensky
Stephan-Nicholas Muller
Holger Paulsen
Jorg Keldenich
Thomas Krahn
Joachim Schumacher
Jan Janichen
Wolfgang Thielemann
Henning Steinhagen
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA200108894B publication Critical patent/ZA200108894B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA200108894A 1999-05-29 2001-10-29 Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors. ZA200108894B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19924819A DE19924819A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)

Publications (1)

Publication Number Publication Date
ZA200108894B true ZA200108894B (en) 2003-01-29

Family

ID=7909713

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200108894A ZA200108894B (en) 1999-05-29 2001-10-29 Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors.

Country Status (25)

Country Link
US (1) US6984642B1 (fr)
EP (1) EP1187812B1 (fr)
JP (1) JP2003500474A (fr)
KR (1) KR20020000814A (fr)
CN (1) CN1165526C (fr)
AR (1) AR029639A1 (fr)
AT (1) ATE303995T1 (fr)
AU (1) AU766140B2 (fr)
BR (1) BR0011049A (fr)
CA (1) CA2375188A1 (fr)
CO (1) CO5170503A1 (fr)
DE (2) DE19924819A1 (fr)
DK (1) DK1187812T3 (fr)
ES (1) ES2248071T3 (fr)
GT (1) GT200000085A (fr)
HK (1) HK1047107B (fr)
HN (1) HN2000000078A (fr)
IL (1) IL146231A0 (fr)
MX (1) MXPA01012240A (fr)
PE (1) PE20010132A1 (fr)
PL (1) PL365960A1 (fr)
TR (1) TR200103398T2 (fr)
UY (1) UY26179A1 (fr)
WO (1) WO2000073274A2 (fr)
ZA (1) ZA200108894B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10150310A1 (de) * 2001-10-11 2003-04-24 Bayer Ag Substituierte Piperazincyclohexancarbonsäureamide und ihre Verwendung
KR100762857B1 (ko) * 2005-03-07 2007-10-02 김기완 Ｐｅ시트를 이용한 저수조의 방수 공법
KR100762858B1 (ko) * 2005-03-07 2007-10-02 김기완 Ｐｅ시트를 이용한 저수조의 방수 공법
KR100745024B1 (ko) * 2005-05-09 2007-08-01 김준 거푸집 수평조절장치
JP2011528358A (ja) * 2008-07-16 2011-11-17 ブリストル−マイヤーズ スクイブ カンパニー ケモカイン受容体活性のシクロヘキセニルモジュレーター
EP2380595A1 (fr) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions et procédés pour la fourniture sélective de molécules d'oligonucléotides à des types de neurones spécifiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101311A1 (fr) * 1992-07-31 1994-02-01 Neelakantan Balasubramanian Derives de diphenyloxazoles, de thiazoles et d'imidazoles inhibant la recapture de l'adenosine
DE4304455A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
SK34398A3 (en) * 1995-09-22 1998-11-04 Sumitomo Chemical Co Pyrazin-2-one derivative, method for inhibiting undesirable weeds and use of derivatives
US5723313A (en) * 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle

Also Published As

Publication number Publication date
ATE303995T1 (de) 2005-09-15
DE50011122D1 (de) 2005-10-13
WO2000073274A3 (fr) 2001-04-19
DK1187812T3 (da) 2005-12-12
AU766140B2 (en) 2003-10-09
WO2000073274A2 (fr) 2000-12-07
MXPA01012240A (es) 2002-08-12
BR0011049A (pt) 2002-03-19
ES2248071T3 (es) 2006-03-16
UY26179A1 (es) 2000-12-29
HK1047107A1 (en) 2003-02-07
PL365960A1 (en) 2005-01-24
IL146231A0 (en) 2002-07-25
GT200000085A (es) 2001-11-17
EP1187812B1 (fr) 2005-09-07
AR029639A1 (es) 2003-07-10
HN2000000078A (es) 2001-02-02
CA2375188A1 (fr) 2000-12-07
CO5170503A1 (es) 2002-06-27
AU4405700A (en) 2000-12-18
US6984642B1 (en) 2006-01-10
HK1047107B (zh) 2005-05-20
CN1165526C (zh) 2004-09-08
EP1187812A2 (fr) 2002-03-20
TR200103398T2 (tr) 2002-03-21
CN1353693A (zh) 2002-06-12
DE19924819A1 (de) 2000-11-30
JP2003500474A (ja) 2003-01-07
KR20020000814A (ko) 2002-01-05
PE20010132A1 (es) 2001-04-12

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