CO5170503A1 - Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosina - Google Patents
Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosinaInfo
- Publication number
- CO5170503A1 CO5170503A1 CO00038312A CO00038312A CO5170503A1 CO 5170503 A1 CO5170503 A1 CO 5170503A1 CO 00038312 A CO00038312 A CO 00038312A CO 00038312 A CO00038312 A CO 00038312A CO 5170503 A1 CO5170503 A1 CO 5170503A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- corresponds
- case
- oxygen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Compuestos de fórmula general (I)<EMI FILE="00038312_1" ID="1" IMF=JPEG >en la queA, D, E, y G son iguales o diferentes y corresponden a grupos CH o átomos de nitrógeno,L1 y L2 son iguales o diferentes y corresponden independientemente unos de otros a uno o varios restos seleccionados del grupo de hidrógeno, halógeno, hidroxi, carboxilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo (C1-C6), alcoxi (C1-C6) o alcoxicarbonilo (C1-C6),R1 corresponde a un grupo CH2-OH, o corresponde a un resto de fórmula CO-NR4R5, en el queR4 y R5 son iguales o diferentes y significan hidrógeno o alquilo (C1-C6)R2 corresponde a cicloalquilo (C3-C8), corresponde a alquilo (C1-C8) que en su caso está interrumpido por un átomo de oxígeno o azufre o por un resto NR6,corresponde a un heterociclo saturado de 4 a 8 eslabones unido por un átomo de nitrógeno al anillo de imidazol, que contiene en su caso otro átomo de oxígeno o azufre, ocorresponde a un heterociclo saturado de 4 a 8 eslabones que contiene un resto de fórmula NR7 y en su caso además un átomo de nitrógeno, oxígeno o azufre,estando el cicloalquilo (C3-C8), el alquilo (C1-C8), que en su caso está interrumpido por un átomo de oxígeno o azufre, el heterociclo saturado de 4 a 8 eslabones unido por un átomo de nitrógeno al anillo de imidazol, que contiene en su caso otro átomo de oxígeno o azufre, así como en su caso el alquilo (C1-C8) que está interrumpido por un resto NR6, y en su caso el heterociclo saturado de 4 a 8 eslabones que contiene un resto de fórmula NR7 y en su caso además un átomo de nitrógeno, oxígeno o azufre, sustituidos por uno a tres grupos hidroxilo y/o por un resto de fórmula -NR8R9,en los queR6 y R7 son iguales o diferentes y significan hidrógeno, alquilo (C1-C6), hidroxialquilo (C1-C6) o cicloalquilo (C3-C7),R8 y R9 son iguales o diferentes y significan hidrógeno, - 2 -alquilo (C1-C6) o cicloalquilo (C3-C7),oR8 y R9 junto con el átomo de nitrógeno forman un heterociclo saturado de 4 a 8 eslabones, que en su caso puede contener además un átomo de oxígeno o azufre o un resto de fórmula NR10,en el queR10 significa hidrógeno, alquilo (C1-C6) o cicloalquilo (C3-C7),yR3 corresponde a un anillo fenilo, naftilo, pirimidinilo, piridilo, furilo o tienilo, estando los anillos en su caso sustituidos por uno o más restos seleccionados entre el grupo de halógeno, hidroxi, carboxilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo (C1-C6), alcoxi (C1-C6) o alcoxicarbonilo (C1-C6),y sus enantiómeros y diastereoisómeros así como sus correspondientes sales e hidratos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19924819A DE19924819A1 (de) | 1999-05-29 | 1999-05-29 | Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5170503A1 true CO5170503A1 (es) | 2002-06-27 |
Family
ID=7909713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00038312A CO5170503A1 (es) | 1999-05-29 | 2000-05-24 | Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosina |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6984642B1 (es) |
| EP (1) | EP1187812B1 (es) |
| JP (1) | JP2003500474A (es) |
| KR (1) | KR20020000814A (es) |
| CN (1) | CN1165526C (es) |
| AR (1) | AR029639A1 (es) |
| AT (1) | ATE303995T1 (es) |
| AU (1) | AU766140B2 (es) |
| BR (1) | BR0011049A (es) |
| CA (1) | CA2375188A1 (es) |
| CO (1) | CO5170503A1 (es) |
| DE (2) | DE19924819A1 (es) |
| DK (1) | DK1187812T3 (es) |
| ES (1) | ES2248071T3 (es) |
| GT (1) | GT200000085A (es) |
| HK (1) | HK1047107B (es) |
| HN (1) | HN2000000078A (es) |
| IL (1) | IL146231A0 (es) |
| MX (1) | MXPA01012240A (es) |
| PE (1) | PE20010132A1 (es) |
| PL (1) | PL365960A1 (es) |
| TR (1) | TR200103398T2 (es) |
| UY (1) | UY26179A1 (es) |
| WO (1) | WO2000073274A2 (es) |
| ZA (1) | ZA200108894B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10150310A1 (de) * | 2001-10-11 | 2003-04-24 | Bayer Ag | Substituierte Piperazincyclohexancarbonsäureamide und ihre Verwendung |
| KR100762858B1 (ko) * | 2005-03-07 | 2007-10-02 | 김기완 | Ｐｅ시트를 이용한 저수조의 방수 공법 |
| KR100762857B1 (ko) * | 2005-03-07 | 2007-10-02 | 김기완 | Ｐｅ시트를 이용한 저수조의 방수 공법 |
| KR100745024B1 (ko) * | 2005-05-09 | 2007-08-01 | 김준 | 거푸집 수평조절장치 |
| WO2010009068A2 (en) * | 2008-07-16 | 2010-01-21 | Bristol-Myers Squibb Company | Cyclohexenyl modulators of chemokine receptor activity |
| EP2380595A1 (en) | 2010-04-19 | 2011-10-26 | Nlife Therapeutics S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2101311A1 (en) * | 1992-07-31 | 1994-02-01 | Neelakantan Balasubramanian | Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles |
| DE4304455A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
| DE19503160A1 (de) * | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
| SK34398A3 (en) * | 1995-09-22 | 1998-11-04 | Sumitomo Chemical Co | Pyrazin-2-one derivative, method for inhibiting undesirable weeds and use of derivatives |
| US5723313A (en) * | 1995-09-27 | 1998-03-03 | St. Jude Children's Research Hospital | ARF-p19, a novel regulator of the mammalian cell cycle |
-
1999
- 1999-05-29 DE DE19924819A patent/DE19924819A1/de not_active Withdrawn
-
2000
- 2000-05-16 KR KR1020017015253A patent/KR20020000814A/ko not_active Application Discontinuation
- 2000-05-16 TR TR2001/03398T patent/TR200103398T2/xx unknown
- 2000-05-16 US US09/980,242 patent/US6984642B1/en not_active Expired - Fee Related
- 2000-05-16 CA CA002375188A patent/CA2375188A1/en not_active Abandoned
- 2000-05-16 BR BR0011049-3A patent/BR0011049A/pt not_active IP Right Cessation
- 2000-05-16 EP EP00925290A patent/EP1187812B1/de not_active Expired - Lifetime
- 2000-05-16 JP JP2000621340A patent/JP2003500474A/ja active Pending
- 2000-05-16 IL IL14623100A patent/IL146231A0/xx unknown
- 2000-05-16 DK DK00925290T patent/DK1187812T3/da active
- 2000-05-16 DE DE50011122T patent/DE50011122D1/de not_active Expired - Fee Related
- 2000-05-16 MX MXPA01012240A patent/MXPA01012240A/es active IP Right Grant
- 2000-05-16 AT AT00925290T patent/ATE303995T1/de not_active IP Right Cessation
- 2000-05-16 CN CNB008082170A patent/CN1165526C/zh not_active Expired - Fee Related
- 2000-05-16 ES ES00925290T patent/ES2248071T3/es not_active Expired - Lifetime
- 2000-05-16 WO PCT/EP2000/004431 patent/WO2000073274A2/de not_active Application Discontinuation
- 2000-05-16 PL PL00365960A patent/PL365960A1/xx not_active Application Discontinuation
- 2000-05-16 AU AU44057/00A patent/AU766140B2/en not_active Ceased
- 2000-05-17 HN HN2000000078A patent/HN2000000078A/es unknown
- 2000-05-24 CO CO00038312A patent/CO5170503A1/es not_active Application Discontinuation
- 2000-05-26 PE PE2000000505A patent/PE20010132A1/es not_active Application Discontinuation
- 2000-05-26 GT GT200000085A patent/GT200000085A/es unknown
- 2000-05-29 UY UY26179A patent/UY26179A1/es not_active Application Discontinuation
- 2000-05-29 AR ARP000102649A patent/AR029639A1/es not_active Application Discontinuation
-
2001
- 2001-10-29 ZA ZA200108894A patent/ZA200108894B/xx unknown
-
2002
- 2002-12-04 HK HK02108818.1A patent/HK1047107B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020000814A (ko) | 2002-01-05 |
| AU4405700A (en) | 2000-12-18 |
| HN2000000078A (es) | 2001-02-02 |
| BR0011049A (pt) | 2002-03-19 |
| AU766140B2 (en) | 2003-10-09 |
| CN1165526C (zh) | 2004-09-08 |
| CN1353693A (zh) | 2002-06-12 |
| DK1187812T3 (da) | 2005-12-12 |
| WO2000073274A3 (de) | 2001-04-19 |
| WO2000073274A2 (de) | 2000-12-07 |
| UY26179A1 (es) | 2000-12-29 |
| US6984642B1 (en) | 2006-01-10 |
| IL146231A0 (en) | 2002-07-25 |
| AR029639A1 (es) | 2003-07-10 |
| HK1047107A1 (en) | 2003-02-07 |
| HK1047107B (zh) | 2005-05-20 |
| MXPA01012240A (es) | 2002-08-12 |
| GT200000085A (es) | 2001-11-17 |
| DE50011122D1 (de) | 2005-10-13 |
| ATE303995T1 (de) | 2005-09-15 |
| JP2003500474A (ja) | 2003-01-07 |
| ZA200108894B (en) | 2003-01-29 |
| EP1187812B1 (de) | 2005-09-07 |
| TR200103398T2 (tr) | 2002-03-21 |
| DE19924819A1 (de) | 2000-11-30 |
| PL365960A1 (en) | 2005-01-24 |
| EP1187812A2 (de) | 2002-03-20 |
| PE20010132A1 (es) | 2001-04-12 |
| ES2248071T3 (es) | 2006-03-16 |
| CA2375188A1 (en) | 2000-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |