ZA200106298B - Calcilytic compounds. - Google Patents
Calcilytic compounds. Download PDFInfo
- Publication number
- ZA200106298B ZA200106298B ZA200106298A ZA200106298A ZA200106298B ZA 200106298 B ZA200106298 B ZA 200106298B ZA 200106298 A ZA200106298 A ZA 200106298A ZA 200106298 A ZA200106298 A ZA 200106298A ZA 200106298 B ZA200106298 B ZA 200106298B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydroxy
- dimethyl
- cyano
- propyl
- phenoxy
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 90
- 230000001126 calcilytic effect Effects 0.000 title description 12
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 87
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 79
- XWBDWHCCBGMXKG-UHFFFAOYSA-N ethanamine;hydron;chloride Chemical compound Cl.CCN XWBDWHCCBGMXKG-UHFFFAOYSA-N 0.000 claims description 63
- -1 CH(CH3)7 Chemical group 0.000 claims description 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 29
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 210000000988 bone and bone Anatomy 0.000 claims description 14
- 210000002966 serum Anatomy 0.000 claims description 14
- 230000002159 abnormal effect Effects 0.000 claims description 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 11
- 230000000849 parathyroid Effects 0.000 claims description 10
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 claims description 9
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
- 208000010392 Bone Fractures Diseases 0.000 claims description 6
- 206010017076 Fracture Diseases 0.000 claims description 6
- 208000001132 Osteoporosis Diseases 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001475 halogen functional group Chemical group 0.000 claims description 6
- 230000035876 healing Effects 0.000 claims description 6
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 6
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 5
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- 208000010191 Osteitis Deformans Diseases 0.000 claims description 5
- 208000027868 Paget disease Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 230000000148 hypercalcaemia Effects 0.000 claims description 5
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
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- 201000008968 osteosarcoma Diseases 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 230000003042 antagnostic effect Effects 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 3
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- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
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- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 10
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US11824099P | 1999-02-02 | 1999-02-02 |
Publications (1)
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ZA200106298B true ZA200106298B (en) | 2002-10-18 |
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Application Number | Title | Priority Date | Filing Date |
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ZA200106298A ZA200106298B (en) | 1999-02-02 | 2001-07-31 | Calcilytic compounds. |
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US (1) | US6417215B1 (ko) |
EP (1) | EP1148876A4 (ko) |
JP (1) | JP2002536330A (ko) |
KR (1) | KR20010093285A (ko) |
CN (1) | CN1346269A (ko) |
AP (1) | AP2001002220A0 (ko) |
AU (1) | AU3480200A (ko) |
BG (1) | BG105847A (ko) |
BR (1) | BR0007922A (ko) |
CA (1) | CA2361589A1 (ko) |
CO (1) | CO5251439A1 (ko) |
CZ (1) | CZ20012797A3 (ko) |
EA (1) | EA200100854A1 (ko) |
HK (1) | HK1042036A1 (ko) |
HU (1) | HUP0200121A3 (ko) |
ID (1) | ID29533A (ko) |
IL (1) | IL144470A0 (ko) |
MA (1) | MA25379A1 (ko) |
NO (1) | NO20013769L (ko) |
OA (1) | OA11757A (ko) |
PE (1) | PE20001456A1 (ko) |
SK (1) | SK10982001A3 (ko) |
WO (1) | WO2000045816A1 (ko) |
ZA (1) | ZA200106298B (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002014259A1 (fr) * | 2000-08-11 | 2002-02-21 | Japan Tobacco Inc. | Antagonistes du recepteur de calcium |
WO2002034204A2 (en) * | 2000-10-25 | 2002-05-02 | Smithkline Beecham Corporation | Calcilytic compounds |
US6864267B2 (en) * | 2001-07-16 | 2005-03-08 | Smithkline Beecham Corporation | Calcilytic compounds |
UY28089A1 (es) * | 2002-11-26 | 2004-06-30 | Smithkline Beecham Corp | Compuestos calciliticos |
US7105537B2 (en) | 2003-01-28 | 2006-09-12 | Bristol-Myers Squibb Company | 2-substituted cyclic amines as calcium sensing receptor modulators |
US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
AR044075A1 (es) * | 2003-04-23 | 2005-08-24 | Japan Tobacco Inc | Antagonista de un receptor sensible al calcio |
EP1630157A4 (en) | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | ANTAGONIST OF CASR |
US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
EP1964548A1 (en) * | 2007-03-02 | 2008-09-03 | Novartis AG | Pharmaceutical compositions comprising a calcilytic agent |
JP5025795B2 (ja) | 2008-06-05 | 2012-09-12 | 旭化成ファーマ株式会社 | スルホンアミド化合物及びその用途 |
WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
WO2021029517A1 (en) * | 2019-08-13 | 2021-02-18 | Dongguk University Industry-Academic Cooperation Foundation | Pharmaceutical composition for improving or treating post-surgical hypoparathyroidism and treatment method using the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL97219A (en) * | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Elliptical amino compounds converted by biphenyl process for their preparation and pharmaceutical preparations containing them |
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO1997037967A1 (en) * | 1996-04-09 | 1997-10-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
UY24949A1 (es) * | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
-
2000
- 2000-02-01 PE PE2000000070A patent/PE20001456A1/es not_active Application Discontinuation
- 2000-02-02 CZ CZ20012797A patent/CZ20012797A3/cs unknown
- 2000-02-02 KR KR1020017009467A patent/KR20010093285A/ko not_active Application Discontinuation
- 2000-02-02 WO PCT/US2000/002676 patent/WO2000045816A1/en not_active Application Discontinuation
- 2000-02-02 CN CN00805996A patent/CN1346269A/zh active Pending
- 2000-02-02 CO CO00006199A patent/CO5251439A1/es unknown
- 2000-02-02 BR BR0007922-7A patent/BR0007922A/pt not_active IP Right Cessation
- 2000-02-02 OA OA1200100199A patent/OA11757A/en unknown
- 2000-02-02 AP APAP/P/2001/002220A patent/AP2001002220A0/en unknown
- 2000-02-02 EA EA200100854A patent/EA200100854A1/ru unknown
- 2000-02-02 AU AU34802/00A patent/AU3480200A/en not_active Abandoned
- 2000-02-02 ID IDW00200101673A patent/ID29533A/id unknown
- 2000-02-02 JP JP2000596936A patent/JP2002536330A/ja not_active Withdrawn
- 2000-02-02 US US09/890,310 patent/US6417215B1/en not_active Expired - Lifetime
- 2000-02-02 CA CA002361589A patent/CA2361589A1/en not_active Abandoned
- 2000-02-02 EP EP00913335A patent/EP1148876A4/en not_active Withdrawn
- 2000-02-02 HU HU0200121A patent/HUP0200121A3/hu unknown
- 2000-02-02 IL IL14447000A patent/IL144470A0/xx unknown
- 2000-02-02 SK SK1098-2001A patent/SK10982001A3/sk unknown
-
2001
- 2001-07-31 ZA ZA200106298A patent/ZA200106298B/en unknown
- 2001-08-01 MA MA26283A patent/MA25379A1/fr unknown
- 2001-08-01 NO NO20013769A patent/NO20013769L/no not_active Application Discontinuation
- 2001-08-27 BG BG105847A patent/BG105847A/xx unknown
-
2002
- 2002-02-27 HK HK02101521.4A patent/HK1042036A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
PE20001456A1 (es) | 2001-01-28 |
CO5251439A1 (es) | 2003-02-28 |
BR0007922A (pt) | 2001-11-06 |
BG105847A (en) | 2002-04-30 |
WO2000045816A1 (en) | 2000-08-10 |
JP2002536330A (ja) | 2002-10-29 |
HUP0200121A2 (hu) | 2002-05-29 |
ID29533A (id) | 2001-09-06 |
NO20013769L (no) | 2001-09-26 |
OA11757A (en) | 2005-07-19 |
US6417215B1 (en) | 2002-07-09 |
EP1148876A4 (en) | 2003-07-23 |
KR20010093285A (ko) | 2001-10-27 |
EP1148876A1 (en) | 2001-10-31 |
CZ20012797A3 (cs) | 2002-01-16 |
CN1346269A (zh) | 2002-04-24 |
MA25379A1 (fr) | 2002-04-01 |
SK10982001A3 (sk) | 2001-12-03 |
IL144470A0 (en) | 2002-05-23 |
NO20013769D0 (no) | 2001-08-01 |
AU3480200A (en) | 2000-08-25 |
CA2361589A1 (en) | 2000-08-10 |
EA200100854A1 (ru) | 2002-02-28 |
AP2001002220A0 (en) | 2001-09-30 |
HUP0200121A3 (en) | 2002-11-28 |
HK1042036A1 (zh) | 2002-08-02 |
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