ZA200105994B - Chimeric gene encoding the antigenic determinants of four proteins of L. infantum. - Google Patents
Chimeric gene encoding the antigenic determinants of four proteins of L. infantum. Download PDFInfo
- Publication number
- ZA200105994B ZA200105994B ZA200105994A ZA200105994A ZA200105994B ZA 200105994 B ZA200105994 B ZA 200105994B ZA 200105994 A ZA200105994 A ZA 200105994A ZA 200105994 A ZA200105994 A ZA 200105994A ZA 200105994 B ZA200105994 B ZA 200105994B
- Authority
- ZA
- South Africa
- Prior art keywords
- ala
- gly
- ser
- protein
- val
- Prior art date
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- 108090000623 proteins and genes Proteins 0.000 title claims description 272
- 102000004169 proteins and genes Human genes 0.000 title claims description 217
- 230000000890 antigenic effect Effects 0.000 title description 52
- 241000222697 Leishmania infantum Species 0.000 title description 35
- 206010047505 Visceral leishmaniasis Diseases 0.000 title description 33
- 241001465754 Metazoa Species 0.000 claims description 91
- RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 claims description 59
- 244000045947 parasite Species 0.000 claims description 46
- 241000282414 Homo sapiens Species 0.000 claims description 44
- 241000222722 Leishmania <genus> Species 0.000 claims description 32
- 208000004554 Leishmaniasis Diseases 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 30
- 230000028993 immune response Effects 0.000 claims description 28
- 239000002671 adjuvant Substances 0.000 claims description 27
- 150000001413 amino acids Chemical class 0.000 claims description 27
- 230000002265 prevention Effects 0.000 claims description 27
- 241000282465 Canis Species 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 239000013598 vector Substances 0.000 claims description 25
- 108020004414 DNA Proteins 0.000 claims description 23
- 239000012634 fragment Substances 0.000 claims description 21
- 229960005486 vaccine Drugs 0.000 claims description 21
- 102000037865 fusion proteins Human genes 0.000 claims description 19
- 108020001507 fusion proteins Proteins 0.000 claims description 19
- 241000282412 Homo Species 0.000 claims description 17
- 238000007918 intramuscular administration Methods 0.000 claims description 17
- 238000007912 intraperitoneal administration Methods 0.000 claims description 17
- 238000007920 subcutaneous administration Methods 0.000 claims description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 16
- 230000001681 protective effect Effects 0.000 claims description 15
- 239000002773 nucleotide Substances 0.000 claims description 14
- 125000003729 nucleotide group Chemical group 0.000 claims description 14
- 238000006467 substitution reaction Methods 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 230000004048 modification Effects 0.000 claims description 13
- 238000012986 modification Methods 0.000 claims description 13
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- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 11
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2256124A CA2256124C (en) | 1998-12-23 | 1998-12-23 | Chimeric gene formed of the dna sequences that encode the antigenic determinants of four proteins of l. infantum, and protein encoded by said gene, and pharmaceutical composition useful for preventing and/or treating leishmaniosis in animals or humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105994B true ZA200105994B (en) | 2002-07-22 |
Family
ID=27671952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105994A ZA200105994B (en) | 1998-12-23 | 2001-07-20 | Chimeric gene encoding the antigenic determinants of four proteins of L. infantum. |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4883839B2 (enExample) |
| BR (1) | BRPI9917863B8 (enExample) |
| CA (1) | CA2256124C (enExample) |
| RS (1) | RS50013B (enExample) |
| ZA (1) | ZA200105994B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187751B2 (en) * | 2010-11-10 | 2015-11-17 | Laboratorios Leti, S.L. | Adjuvant |
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1998
- 1998-12-23 CA CA2256124A patent/CA2256124C/en not_active Expired - Lifetime
-
1999
- 1999-12-23 RS YUP-516/01A patent/RS50013B/sr unknown
- 1999-12-23 JP JP2000591189A patent/JP4883839B2/ja not_active Expired - Lifetime
- 1999-12-23 BR BRPI9917863A patent/BRPI9917863B8/pt not_active IP Right Cessation
-
2001
- 2001-07-20 ZA ZA200105994A patent/ZA200105994B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2256124A1 (en) | 2000-06-23 |
| BRPI9917863B1 (pt) | 2016-08-02 |
| BRPI9917863B8 (pt) | 2022-08-30 |
| YU51601A (sh) | 2005-07-19 |
| CA2256124C (en) | 2015-06-16 |
| BRPI9917863C1 (pt) | 2021-05-25 |
| RS50013B (sr) | 2008-09-29 |
| JP4883839B2 (ja) | 2012-02-22 |
| JP2002533474A (ja) | 2002-10-08 |
| BRPI9917863A2 (enExample) | 2010-12-21 |
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