ZA200101787B - Activation and protection of T-cells (CD4+ and CD8+) using ant H 2 receptor agonist and other T-cell activating agents. - Google Patents

Activation and protection of T-cells (CD4+ and CD8+) using ant H 2 receptor agonist and other T-cell activating agents. Download PDF

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Publication number
ZA200101787B
ZA200101787B ZA200101787A ZA200101787A ZA200101787B ZA 200101787 B ZA200101787 B ZA 200101787B ZA 200101787 A ZA200101787 A ZA 200101787A ZA 200101787 A ZA200101787 A ZA 200101787A ZA 200101787 B ZA200101787 B ZA 200101787B
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ZA
South Africa
Prior art keywords
cells
histamine
cell
compounds
vaccines
Prior art date
Application number
ZA200101787A
Other languages
English (en)
Inventor
Kristoffer Hellstrand
Svante Hermodsson
Kurt R Gehlsen
Original Assignee
Maxim Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxim Pharm Inc filed Critical Maxim Pharm Inc
Publication of ZA200101787B publication Critical patent/ZA200101787B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200101787A 1998-08-24 2001-03-02 Activation and protection of T-cells (CD4+ and CD8+) using ant H 2 receptor agonist and other T-cell activating agents. ZA200101787B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13928198A 1998-08-24 1998-08-24

Publications (1)

Publication Number Publication Date
ZA200101787B true ZA200101787B (en) 2001-09-27

Family

ID=22485908

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200101787A ZA200101787B (en) 1998-08-24 2001-03-02 Activation and protection of T-cells (CD4+ and CD8+) using ant H 2 receptor agonist and other T-cell activating agents.

Country Status (11)

Country Link
US (1) US20030039628A1 (fr)
EP (1) EP1107784A2 (fr)
JP (1) JP2002523378A (fr)
KR (1) KR20010072957A (fr)
CN (1) CN1217698C (fr)
AU (1) AU765625C (fr)
CA (1) CA2341742A1 (fr)
IL (1) IL141627A0 (fr)
TW (1) TW576745B (fr)
WO (1) WO2000010600A2 (fr)
ZA (1) ZA200101787B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
AU2001282717A1 (en) 2000-07-28 2002-02-13 Cancer Research Technology Limited Cancer treatment by combination therapy
US20020094323A1 (en) 2000-10-12 2002-07-18 Kristoffer Hellstrand Methods and compositions for promoting the maturation of monocytes
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
CN1608204A (zh) * 2001-12-21 2005-04-20 东弗吉尼亚医学院 分析药物效果的方法
GB2386836B (en) 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
EP1603567A4 (fr) * 2003-02-28 2006-10-18 Inotek Pharmaceuticals Corp Derives de benzamide tetracyclique et leurs procedes d'utilisation
WO2005023293A1 (fr) * 2003-09-09 2005-03-17 Pohang University Of Science And Technology Composition de vaccin comprenant un adjuvant d'il-12 encapsule dans une microsphere a liberation controlee
CA2557547A1 (fr) * 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Derives d'isoquinoline et methodes d'utilisation
EP1722796A4 (fr) * 2004-02-26 2008-01-23 Inotek Pharmaceuticals Corp Derives de lactame tetracyclique et utilisations
CA2571001A1 (fr) * 2004-06-16 2006-01-26 Inotek Pharmaceuticals Corporation Methodes de traitement ou de prevention de la dysfonction erectile ou de l'incontinence urinaire
US20060079510A1 (en) * 2004-09-30 2006-04-13 Kristoffer Hellstrand Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis
EP1850848A4 (fr) * 2005-02-25 2008-02-20 Inotek Pharmaceuticals Corp Composes tetracycliques de sulfonamide et methodes d'utilisation desdits composes
JP2008531562A (ja) * 2005-02-25 2008-08-14 イノテック ファーマシューティカルズ コーポレイション 四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法
MX2007010335A (es) * 2005-02-25 2007-11-06 Inotek Pharmaceuticals Corp Compuestos de isoquinolina y metodos de uso de los mismos.
KR100735081B1 (ko) * 2005-04-21 2007-07-06 고려대학교 산학협력단 Cd4 t 세포 활성화 방법
KR100735083B1 (ko) * 2005-04-21 2007-07-06 고려대학교 산학협력단 Cd8 t 세포 활성화 방법
EP1937268A4 (fr) * 2005-08-24 2009-07-22 Inotek Pharmaceuticals Corp Analogues d'indenoisoquinolinone et leurs procedes d'utilisation
FR2903311B1 (fr) * 2006-07-10 2012-06-15 Centre Nat Rech Scient Utilisation de ligands du recepteur h4 de l'histamine pour proteger les progeniteurs hematopoietiques contre la toxicite hematologique des agents chimiotherapeutiques
JP2010520220A (ja) * 2007-02-28 2010-06-10 イノテック ファーマシューティカルズ コーポレイション インデノイソキノリノン類似体およびその使用方法
RU2499043C1 (ru) * 2012-09-26 2013-11-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Стимулятор пролиферации регуляторных т-лимфоцитов и способ их стимуляции
CL2013001774A1 (es) * 2013-06-18 2014-08-01 Univ Santiago Chile Formulacion con actividad inmunoestimulante/adyuvante que comprende alpinona , dimetil sulfóxido y suero fisiológico; uso de dicha formulación para preparar vacunas para vertebrados.
US20160256388A1 (en) * 2015-03-05 2016-09-08 Uri Galili Compositions and methods for treatment of respiratory tract infections
CN115894595B (zh) * 2021-09-30 2024-04-30 山东新时代药业有限公司 一种10,19-开环环阿屯烷三萜i及其制备方法和应用
CN115894601A (zh) * 2021-09-30 2023-04-04 山东新时代药业有限公司 一种10,19-开环环阿屯烷三萜ii及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025240A2 (fr) * 1992-06-09 1993-12-23 Neorx Corporation Procedes et composes de preciblage
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
CA2066728C (fr) * 1989-09-19 2001-12-25 Jan K. Hellstrand Preparation anti-tumorale composee d'interleukine-2 et d'histamine, leurs analogues ou agonistes des recepteurs h2
SE513429C2 (sv) * 1992-06-03 2000-09-11 Syntello Inc Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer
JPH10504304A (ja) * 1994-08-08 1998-04-28 マキシム ファーマシューティカルズ,インコーポレイテッド ナチュラルキラー細胞活性化物質と過酸化水素スカベンジャーまたは過酸化水素阻害物質とを用いるナチュラルキラー細胞の活性増強
GB9416657D0 (en) * 1994-08-17 1994-10-12 Biocine Spa T cell activation
WO1997030174A1 (fr) * 1996-02-20 1997-08-21 Sloan-Kettering Institute For Cancer Research Combinaison d'inhibiteurs de la proteine kinase c et agents therapeutiques pour traiter des cancers
ATE437366T1 (de) * 1998-05-11 2009-08-15 Miltenyi Biotec Gmbh Verfahren zur direkten auswahl von antigen- spezifischen t-zellen

Also Published As

Publication number Publication date
WO2000010600A3 (fr) 2000-06-15
IL141627A0 (en) 2002-03-10
CA2341742A1 (fr) 2000-03-02
WO2000010600A2 (fr) 2000-03-02
KR20010072957A (ko) 2001-07-31
EP1107784A2 (fr) 2001-06-20
WO2000010600A9 (fr) 2001-11-22
TW576745B (en) 2004-02-21
CN1217698C (zh) 2005-09-07
AU5687099A (en) 2000-03-14
CN1324245A (zh) 2001-11-28
JP2002523378A (ja) 2002-07-30
US20030039628A1 (en) 2003-02-27
AU765625C (en) 2004-11-18
AU765625B2 (en) 2003-09-25

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