ZA200005758B - Riluzole and levodopa combinations for treating Parkinson's disease. - Google Patents
Riluzole and levodopa combinations for treating Parkinson's disease. Download PDFInfo
- Publication number
- ZA200005758B ZA200005758B ZA200005758A ZA200005758A ZA200005758B ZA 200005758 B ZA200005758 B ZA 200005758B ZA 200005758 A ZA200005758 A ZA 200005758A ZA 200005758 A ZA200005758 A ZA 200005758A ZA 200005758 B ZA200005758 B ZA 200005758B
- Authority
- ZA
- South Africa
- Prior art keywords
- riluzole
- dopa
- levodopa
- weight
- combinations according
- Prior art date
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title claims description 63
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title claims description 63
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 title claims description 37
- 229960004181 riluzole Drugs 0.000 title claims description 36
- 229960004502 levodopa Drugs 0.000 title claims description 10
- 208000018737 Parkinson disease Diseases 0.000 title claims description 8
- 239000003954 decarboxylase inhibitor Substances 0.000 claims description 16
- 229940123736 Decarboxylase inhibitor Drugs 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 208000012661 Dyskinesia Diseases 0.000 claims description 10
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical group OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims description 8
- 229960000911 benserazide Drugs 0.000 claims description 8
- 229960004205 carbidopa Drugs 0.000 claims description 7
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
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- 238000012360 testing method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
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- 241001465754 Metazoa Species 0.000 description 7
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- 229960003638 dopamine Drugs 0.000 description 4
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- VIYKYVYAKVNDPS-HKGPVOKGSA-N (2s)-2-azanyl-3-[3,4-bis(oxidanyl)phenyl]propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 VIYKYVYAKVNDPS-HKGPVOKGSA-N 0.000 description 1
- ISHXLNHNDMZNMC-VTKCIJPMSA-N (3e,8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C\1 ISHXLNHNDMZNMC-VTKCIJPMSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- 206010006100 Bradykinesia Diseases 0.000 description 1
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- 208000006083 Hypokinesia Diseases 0.000 description 1
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- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
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- 101100113998 Mus musculus Cnbd2 gene Proteins 0.000 description 1
- 208000002740 Muscle Rigidity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
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- 241000288906 Primates Species 0.000 description 1
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- 206010042135 Stomatitis necrotising Diseases 0.000 description 1
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- 108010035075 Tyrosine decarboxylase Proteins 0.000 description 1
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- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
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- 239000002775 capsule Substances 0.000 description 1
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- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9805153A FR2777781B1 (fr) | 1998-04-24 | 1998-04-24 | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200005758B true ZA200005758B (en) | 2002-01-17 |
Family
ID=9525640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200005758A ZA200005758B (en) | 1998-04-24 | 2000-10-17 | Riluzole and levodopa combinations for treating Parkinson's disease. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6387936B1 (cs) |
| EP (1) | EP1071422B1 (cs) |
| JP (1) | JP2002512963A (cs) |
| KR (1) | KR100597170B1 (cs) |
| AT (1) | ATE386520T1 (cs) |
| AU (1) | AU768069B2 (cs) |
| CA (1) | CA2329636C (cs) |
| CY (1) | CY1110448T1 (cs) |
| CZ (1) | CZ300825B6 (cs) |
| DE (1) | DE69938179T2 (cs) |
| DK (1) | DK1071422T3 (cs) |
| ES (1) | ES2300141T3 (cs) |
| FR (1) | FR2777781B1 (cs) |
| HU (1) | HU228902B1 (cs) |
| IL (1) | IL139164A (cs) |
| NO (1) | NO329032B1 (cs) |
| PT (1) | PT1071422E (cs) |
| RU (1) | RU2225204C2 (cs) |
| SK (1) | SK285531B6 (cs) |
| UA (1) | UA70319C2 (cs) |
| WO (1) | WO1999055336A1 (cs) |
| ZA (1) | ZA200005758B (cs) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786101B1 (fr) * | 1998-11-24 | 2002-07-05 | Aventis Laboratoire | Utilisation de la nicergoline dans le traitement de la spasticite |
| US6872739B1 (en) * | 1999-06-04 | 2005-03-29 | Vereniging Voor Christelijk Wetenshappelikjk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
| GB0007193D0 (en) * | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
| US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
| WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
| WO2005025561A1 (en) * | 2003-09-04 | 2005-03-24 | Synergia Pharma, Inc. | Compositions and methods for orthostatic intolerance |
| EP1746985A4 (en) * | 2004-05-21 | 2010-08-11 | Univ Duke | METHOD FOR INCREASING THE EFFECT OF SEROTONINE RECOVERY INHIBITORS |
| SE0401842D0 (sv) | 2004-07-12 | 2004-07-12 | Dizlin Medical Design Ab | Infusion and injection solution of levodopa |
| JP5112876B2 (ja) * | 2004-11-07 | 2013-01-09 | エフ． ギルフォード ティモシー | 還元型グルタチオン経口投与のためのリポソーム処方物 |
| GB0504103D0 (en) * | 2005-02-28 | 2005-04-06 | Syngenta Ltd | Novel method |
| AU2006261893A1 (en) * | 2005-06-23 | 2007-01-04 | Combinatorx, Incorporated | Improved dosage forms for movement disorder treatment |
| US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| ES2383768T3 (es) * | 2006-06-28 | 2012-06-26 | Chelsea Therapeutics Inc. | Composiciones farmacéuticas que comprenden droxidopa |
| AU2007338631A1 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| CN101657193A (zh) * | 2007-03-09 | 2010-02-24 | 切尔西治疗公司 | 用于治疗纤维肌痛的屈昔多巴及其药物组合物 |
| EP2514417A3 (en) * | 2007-05-07 | 2013-01-30 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders |
| EP2320892A2 (en) * | 2008-06-30 | 2011-05-18 | Novartis AG | Combination products |
| MX2011004769A (es) * | 2008-11-06 | 2011-11-29 | Biotie Therapies Inc | Tratamiento de sindrome de pierna sin reposo y alteraciones del sueño. |
| EP2228054A1 (en) * | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| EP2629615B1 (en) | 2010-10-22 | 2018-10-10 | Duke University | Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies |
| JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状（姿勢反射異常）の治療剤 |
| WO2014172372A1 (en) | 2013-04-15 | 2014-10-23 | Northwestern University | Treatment for dopaminergic disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700117B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
| RU2057529C1 (ru) * | 1994-05-30 | 1996-04-10 | Алексей Михайлович Коршунов | Способ лечения синдрома паркинсонизма |
-
1998
- 1998-04-24 FR FR9805153A patent/FR2777781B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-22 EP EP99915809A patent/EP1071422B1/fr not_active Expired - Lifetime
- 1999-04-22 DE DE69938179T patent/DE69938179T2/de not_active Expired - Lifetime
- 1999-04-22 CA CA002329636A patent/CA2329636C/fr not_active Expired - Fee Related
- 1999-04-22 PT PT99915809T patent/PT1071422E/pt unknown
- 1999-04-22 SK SK1588-2000A patent/SK285531B6/sk not_active IP Right Cessation
- 1999-04-22 IL IL13916499A patent/IL139164A/xx not_active IP Right Cessation
- 1999-04-22 RU RU2000129121/15A patent/RU2225204C2/ru not_active IP Right Cessation
- 1999-04-22 UA UA2000105983A patent/UA70319C2/uk unknown
- 1999-04-22 AT AT99915809T patent/ATE386520T1/de active
- 1999-04-22 CZ CZ20003908A patent/CZ300825B6/cs not_active IP Right Cessation
- 1999-04-22 DK DK99915809T patent/DK1071422T3/da active
- 1999-04-22 ES ES99915809T patent/ES2300141T3/es not_active Expired - Lifetime
- 1999-04-22 AU AU34255/99A patent/AU768069B2/en not_active Ceased
- 1999-04-22 HU HU0101645A patent/HU228902B1/hu not_active IP Right Cessation
- 1999-04-22 KR KR1020007011786A patent/KR100597170B1/ko not_active Expired - Fee Related
- 1999-04-22 JP JP2000545534A patent/JP2002512963A/ja not_active Withdrawn
- 1999-04-22 WO PCT/FR1999/000953 patent/WO1999055336A1/fr not_active Ceased
-
2000
- 2000-10-17 ZA ZA200005758A patent/ZA200005758B/en unknown
- 2000-10-20 NO NO20005290A patent/NO329032B1/no not_active IP Right Cessation
- 2000-10-24 US US09/694,860 patent/US6387936B1/en not_active Expired - Lifetime
-
2008
- 2008-04-24 CY CY20081100457T patent/CY1110448T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2329636C (fr) | 2009-09-08 |
| FR2777781A1 (fr) | 1999-10-29 |
| AU768069B2 (en) | 2003-12-04 |
| KR100597170B1 (ko) | 2006-07-05 |
| ATE386520T1 (de) | 2008-03-15 |
| WO1999055336A1 (fr) | 1999-11-04 |
| CY1110448T1 (el) | 2015-04-29 |
| HUP0101645A3 (en) | 2002-10-28 |
| EP1071422B1 (fr) | 2008-02-20 |
| NO329032B1 (no) | 2010-08-02 |
| RU2225204C2 (ru) | 2004-03-10 |
| IL139164A0 (en) | 2001-11-25 |
| NO20005290L (no) | 2000-10-20 |
| DK1071422T3 (da) | 2008-06-16 |
| DE69938179T2 (de) | 2009-02-12 |
| JP2002512963A (ja) | 2002-05-08 |
| AU3425599A (en) | 1999-11-16 |
| IL139164A (en) | 2005-12-18 |
| CZ20003908A3 (cs) | 2001-02-14 |
| DE69938179D1 (de) | 2008-04-03 |
| CA2329636A1 (fr) | 1999-11-04 |
| SK15882000A3 (sk) | 2001-04-09 |
| FR2777781B1 (fr) | 2004-04-09 |
| KR20010042960A (ko) | 2001-05-25 |
| UA70319C2 (en) | 2004-10-15 |
| SK285531B6 (sk) | 2007-03-01 |
| HU228902B1 (en) | 2013-06-28 |
| CZ300825B6 (cs) | 2009-08-19 |
| ES2300141T3 (es) | 2008-06-01 |
| EP1071422A1 (fr) | 2001-01-31 |
| US6387936B1 (en) | 2002-05-14 |
| NO20005290D0 (no) | 2000-10-20 |
| PT1071422E (pt) | 2008-05-05 |
| HUP0101645A2 (hu) | 2001-09-28 |
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