YU87201A - Procedure for down motion regulation of gdf-8 activities - Google Patents
Procedure for down motion regulation of gdf-8 activitiesInfo
- Publication number
- YU87201A YU87201A YU87201A YUP87201A YU87201A YU 87201 A YU87201 A YU 87201A YU 87201 A YU87201 A YU 87201A YU P87201 A YUP87201 A YU P87201A YU 87201 A YU87201 A YU 87201A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- gdf
- methods
- analogs
- homologues
- nucleic acid
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Otkriveni su novi postupci za povećanje mišićne mase pomoću imunizacije na Faktor Diferencijacije Rasta 8 (GDF-8, miostatin). Imunizacija se poželjno izvodi primenom analoga GDF-8 koji su sposobni da indukuju proizvodnju antitela na homologi GDF-8. Posebno poželjan kao imunogen je homologi GDF-8 koji je modifikovan introdukcijom jednog ili nekoliko stranih, imunodominantnih i raznorodnih T-ćelijskih epitopa dok je znatno očuvana tercijarna struktura homologog GDF-8. Takodje su otkrivene vakcinacije sa nukleinskim klselinama protiv GDF-8 i vakcinacije koje koriste žive vakcine kao i postupci i sredstva korisni za vakcinaciju. Takvi postupci i sredstva obuhvataju postupke za identifikaciju korisnih imunogenih GDF-8 analoga, postupke za pripremanje analoga i farmaceutskih formulacija, kao i fragmente nukleinskih kiselina, vektore, transformisane ćelije, polipeptide i farmaceutske formulacije.New procedures for increasing muscle mass using immunization against Growth Differentiation Factor 8 (GDF-8, myostatin) have been discovered. Immunization is preferably performed using GDF-8 analogs capable of inducing the production of antibodies against GDF-8 homologues. Particularly preferred as an immunogen is GDF-8 homologues that have been modified by the introduction of one or several foreign, immunodominant and heterogeneous T-cell epitopes, while the tertiary structure of the GDF-8 homologue is significantly preserved. Also disclosed are nucleic acid vaccinations against GDF-8 and vaccinations using live vaccines as well as methods and means useful for vaccination. Such methods and means include methods for identifying useful immunogenic GDF-8 analogs, methods for preparing analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides, and pharmaceutical formulations.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901014 | 1999-07-20 | ||
| US14527599P | 1999-07-26 | 1999-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU87201A true YU87201A (en) | 2004-09-03 |
Family
ID=44359331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU87201A YU87201A (en) | 1999-07-20 | 2000-07-20 | Procedure for down motion regulation of gdf-8 activities |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR024808A1 (en) |
| MY (1) | MY135691A (en) |
| PE (1) | PE20010479A1 (en) |
| YU (1) | YU87201A (en) |
-
2000
- 2000-07-20 AR ARP000103736A patent/AR024808A1/en not_active Application Discontinuation
- 2000-07-20 PE PE2000000733A patent/PE20010479A1/en not_active Application Discontinuation
- 2000-07-20 MY MYPI20003324A patent/MY135691A/en unknown
- 2000-07-20 YU YU87201A patent/YU87201A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY135691A (en) | 2008-06-30 |
| PE20010479A1 (en) | 2001-04-24 |
| AR024808A1 (en) | 2002-10-23 |
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