ECSP003580A - NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 - Google Patents
NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8Info
- Publication number
- ECSP003580A ECSP003580A ECSP003580A ECSP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A
- Authority
- EC
- Ecuador
- Prior art keywords
- gdf
- methods
- analogs
- vaccination
- homologous
- Prior art date
Links
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se revelan métodos nuevos para aumentar la masa muscular mediante la inmunización contra el factor de diferenciación de crecimiento 8 (GDF-8, miostatina). La inmunización se efectua preferentemente mediante la administración de análogos de GDF-8 capaces de inducir la producción de anticuerpos contra GDF-8 homólogos. Se prefiere especialmente como un inmunógeno el GDF-8 homólogo modificado por la introducción de un solo o varios, epitopes de célula T extraños inmunodominantes y promiscuos a la vez que se conserva sustancialmente la estructura terciaria del GDF-8 homólogo. También se presenta la vacunación de ácido nucleico contra GDF-8 y la vacunación usando vacunas vivas, como asi también métodos y medios útiles para la vacunación. Dichos métodos y medios incluyen métodos para la identificación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos y formulaciones farmacéuticas como asi también fragmentos de ácido nucleico, vectores, células transformadas polipéptidos y formulaciones farmacéuticas.Novel methods of increasing muscle mass are revealed by immunization against growth differentiation factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of GDF-8 analogs capable of inducing the production of antibodies against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 modified by the introduction of one or more, immunodominant and promiscuous foreign T-cell epitopes while substantially conserving the tertiary structure of the homologous GDF-8. Nucleic acid vaccination against GDF-8 and vaccination using live vaccines are also presented, as well as useful methods and means for vaccination. Such methods and means include methods for the identification of immunogenic GDF-8 analogs, methods for the preparation of immunogenic GDF-8 analogs, methods for the preparation of analogues and pharmaceutical formulations as well as nucleic acid fragments, vectors, transformed cells. polypeptides and pharmaceutical formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003580A true ECSP003580A (en) | 2000-10-24 |
Family
ID=42041192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003580A (en) |
-
2000
- 2000-07-20 EC ECSP003580 patent/ECSP003580A/en unknown
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