YU69604A - Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja - Google Patents

Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja

Info

Publication number
YU69604A
YU69604A YU69604A YUP69604A YU69604A YU 69604 A YU69604 A YU 69604A YU 69604 A YU69604 A YU 69604A YU P69604 A YUP69604 A YU P69604A YU 69604 A YU69604 A YU 69604A
Authority
YU
Yugoslavia
Prior art keywords
antithrombic
polymorphs
compounds
clopidogrel hydrochloride
hydrochloride
Prior art date
Application number
YU69604A
Other languages
English (en)
Inventor
Nagy Peter Kotay
Jozsef Barkoczy
Gyula Simig
Kirallyi Zsuzsa Szent
Tamas Gregor
Bela Farkas
Donath Gyorgyi Vereczkeyne
Kalman Nagy
Gyulane Kortvelyessy
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of YU69604A publication Critical patent/YU69604A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pronalazak se odnosi na kristalne oblike I i II metil-(S)-(+)-(2-hlorofenil)-2-(6,7-dihidro-4H-tieno[3,2-c]piridin-5-il)-acetat hlorovodonika formule (I) i njegove hidrate, postupak za njihovo pripremanje i farmaceutske rpeparate koji sadrže isti. Novi polimorfi, u skladu sa pronalaskom, pokazuju inhibitorni efekat agregacije trombocita i antitrombni efekt.[The invention relates to crystalline forms I and II methyl-(S)- (+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2.c]pyridine-5-yl)- acetate hydrochloride of the Formula (I) and hydrates thereof, a process for the preparation thereof and pharmaceutical compositions containing the same. The new polymorphs according to the invention exhibit blood platelet aggregation inhibiting and antithrombotic effect.
YU69604A 2002-02-06 2002-12-20 Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja YU69604A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0200438A HUP0200438A3 (en) 2002-02-06 2002-02-06 Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
YU69604A true YU69604A (sh) 2006-08-17

Family

ID=89980128

Family Applications (1)

Application Number Title Priority Date Filing Date
YU69604A YU69604A (sh) 2002-02-06 2002-12-20 Polimorfi klopidogrel hlorovodonika i njihova upotreba kao antitrombnih jedinjenja

Country Status (15)

Country Link
US (1) US20050113406A1 (sh)
EP (1) EP1474427A1 (sh)
JP (1) JP2005522441A (sh)
KR (1) KR20040079987A (sh)
AU (1) AU2002353251A1 (sh)
BG (1) BG108868A (sh)
CZ (1) CZ2004901A3 (sh)
EA (1) EA007119B1 (sh)
HR (1) HRP20040741A2 (sh)
HU (1) HUP0200438A3 (sh)
IS (1) IS7385A (sh)
PL (1) PL370038A1 (sh)
SK (1) SK3362004A3 (sh)
WO (1) WO2003066637A1 (sh)
YU (1) YU69604A (sh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2005068471A1 (en) * 2004-01-13 2005-07-28 Zentiva, A.S. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
EP1732932B1 (en) * 2004-04-09 2012-03-21 Hanmi Holdings Co., Ltd. Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
ZA200608035B (en) * 2004-04-20 2008-07-30 Sanofi Aventis Clopidogrel salt and polymorphic forms thereof
ZA200608569B (en) * 2004-04-20 2007-12-27 Sanofi Aventis Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
EP1750701A1 (en) * 2004-06-01 2007-02-14 IVAX Pharmaceuticals s.r.o. Amorphous clopidogrel hydrochloride and its antithrombotic use
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
WO2007029080A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Preparation of form i of clopidogrel hydrochloride
WO2007029096A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Novel polymorphic forms of clopidogrel hydrochloride
KR20070066518A (ko) * 2005-12-22 2007-06-27 에스케이케미칼주식회사 고체상 반응을 이용한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR101235117B1 (ko) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR100742134B1 (ko) * 2006-02-07 2007-07-24 경동제약 주식회사 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
KR20150041173A (ko) 2007-04-27 2015-04-15 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
US7985859B2 (en) * 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
KR101743591B1 (ko) 2009-05-13 2017-06-20 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102367257B (zh) * 2011-11-21 2014-05-07 天津红日药业股份有限公司 氯吡格雷盐酸盐的单晶晶型，它们的制备及应用
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

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FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Also Published As

Publication number Publication date
WO2003066637A1 (en) 2003-08-14
US20050113406A1 (en) 2005-05-26
EP1474427A1 (en) 2004-11-10
HU0200438D0 (en) 2002-04-29
EA007119B1 (ru) 2006-06-30
JP2005522441A (ja) 2005-07-28
KR20040079987A (ko) 2004-09-16
HUP0200438A3 (en) 2003-10-28
EA200401025A1 (ru) 2004-12-30
IS7385A (is) 2004-08-05
BG108868A (en) 2005-09-30
HRP20040741A2 (en) 2004-12-31
CZ2004901A3 (cs) 2005-02-16
AU2002353251A1 (en) 2003-09-02
SK3362004A3 (sk) 2005-03-04
PL370038A1 (en) 2005-05-16
HUP0200438A2 (hu) 2003-09-29

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