YU42991A - PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE - Google Patents

PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE

Info

Publication number
YU42991A
YU42991A YU42991A YU42991A YU42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A
Authority
YU
Yugoslavia
Prior art keywords
general formula
imidazole
hydroxyalkyl
nitro
preparation
Prior art date
Application number
YU42991A
Other languages
Serbo-Croatian (sh)
Inventor
M. Lavigne
Cazin B. Mandard
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU42991A publication Critical patent/YU42991A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Postupak za dobivanje hidroksialkil-1-nitro-5 im-idazola opšte formule (I) dejstvom alkilen oksida na kompleks sumpornog anhidrida sa derivatom imidazola opšte formule (II), što je dalje praćeno kiselom hidrolizom ili alkoholizom dobivenog proizvoda. U opštim formulama (I) i (II), R predstavlja vodonik, alkil, fenilalkil ili fenil ventualno supstituisan. U opštoj formuli (I), ne je 2 ili 3 i jedan ili više atoma ugljenika alkilenskog lanca može biti supstituisano sa jednim ili više metil radikala U opštoj formuli (II), X predstavlja grupu eliminisivu kiselom hidrolizom ili alkoholizom.A process for the preparation of hydroxyalkyl-1-nitro-5-imidazole of general formula (I) by the action of an alkylene oxide on a complex of sulfuric anhydride with an imidazole derivative of general formula (II), followed by acid hydrolysis or alcoholysis of the product obtained. In general formulas (I) and (II), R represents hydrogen, alkyl, phenylalkyl or phenyl vantally substituted. In general formula (I), there are not 2 or 3 and one or more carbon atoms of the alkylene chain may be substituted by one or more methyl radicals In general formula (II), X represents a group eliminable by acid hydrolysis or alcoholism.

YU42991A 1990-03-12 1991-03-11 PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE YU42991A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9003087A FR2659326A1 (en) 1990-03-12 1990-03-12 PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 NITRO-5 IMIDAZOLES.

Publications (1)

Publication Number Publication Date
YU42991A true YU42991A (en) 1994-01-20

Family

ID=9394608

Family Applications (1)

Application Number Title Priority Date Filing Date
YU42991A YU42991A (en) 1990-03-12 1991-03-11 PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE

Country Status (15)

Country Link
EP (1) EP0519984A1 (en)
JP (1) JPH05505187A (en)
CN (1) CN1055536A (en)
AU (1) AU7471791A (en)
CA (1) CA2081372A1 (en)
FI (1) FI923866A (en)
FR (1) FR2659326A1 (en)
HU (1) HU208676B (en)
IE (1) IE910801A1 (en)
IL (1) IL97512A0 (en)
NZ (1) NZ237380A (en)
PT (1) PT97014A (en)
WO (1) WO1991013877A1 (en)
YU (1) YU42991A (en)
ZA (1) ZA911768B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100376559C (en) * 2006-05-22 2008-03-26 浙江苏泊尔制药有限公司 Method for preparing secnidazole
CN102321028B (en) * 2011-06-30 2013-12-25 湖北省宏源药业有限公司 Method for synthesizing 2-methyl-5-nitroimidazole-1-ethanol
CN104072424A (en) * 2013-03-29 2014-10-01 黄冈师范学院 Environmental novel co-production technology of metronidazole and composite fertilizer
CN104177297B (en) * 2013-05-20 2016-09-28 东港市宏达制药有限公司 A kind of metronidazole API synthesis clean production method
CN103539745B (en) * 2013-10-11 2015-09-02 黄冈赛康药业有限公司 A kind of preparation method of secnidazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1379915A (en) * 1963-12-17 1964-11-27 Rhone Poulenc Sa Process for the preparation of imidazole derivatives
FR1035872A (en) * 1965-04-16 1953-09-01 William Prym Process for the production of slide closures
DE2359625A1 (en) * 1973-11-30 1975-06-05 Basf Ag PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-5-NITROIMIDAZOLE
FR2625998B1 (en) * 1988-01-15 1990-06-08 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 METHYL-2 NITRO-5 IMIDAZOLES
EP0325512B1 (en) * 1988-01-15 1993-01-20 Rhone-Poulenc Sante Process for the preparation of 1-alkyl-5-nitro-imidazoles

Also Published As

Publication number Publication date
HUT61530A (en) 1993-01-28
HU208676B (en) 1993-12-28
FR2659326A1 (en) 1991-09-13
HU9202920D0 (en) 1992-11-30
IL97512A0 (en) 1992-06-21
CN1055536A (en) 1991-10-23
FI923866A0 (en) 1992-08-28
CA2081372A1 (en) 1991-09-13
WO1991013877A1 (en) 1991-09-19
AU7471791A (en) 1991-10-10
FI923866A (en) 1992-08-28
JPH05505187A (en) 1993-08-05
NZ237380A (en) 1992-02-25
ZA911768B (en) 1991-12-24
IE910801A1 (en) 1991-09-25
EP0519984A1 (en) 1992-12-30
PT97014A (en) 1991-10-31

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