YU42991A - PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE - Google Patents
PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLEInfo
- Publication number
- YU42991A YU42991A YU42991A YU42991A YU42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A YU 42991 A YU42991 A YU 42991A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- general formula
- imidazole
- hydroxyalkyl
- nitro
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Postupak za dobivanje hidroksialkil-1-nitro-5 im-idazola opšte formule (I) dejstvom alkilen oksida na kompleks sumpornog anhidrida sa derivatom imidazola opšte formule (II), što je dalje praćeno kiselom hidrolizom ili alkoholizom dobivenog proizvoda. U opštim formulama (I) i (II), R predstavlja vodonik, alkil, fenilalkil ili fenil ventualno supstituisan. U opštoj formuli (I), ne je 2 ili 3 i jedan ili više atoma ugljenika alkilenskog lanca može biti supstituisano sa jednim ili više metil radikala U opštoj formuli (II), X predstavlja grupu eliminisivu kiselom hidrolizom ili alkoholizom.A process for the preparation of hydroxyalkyl-1-nitro-5-imidazole of general formula (I) by the action of an alkylene oxide on a complex of sulfuric anhydride with an imidazole derivative of general formula (II), followed by acid hydrolysis or alcoholysis of the product obtained. In general formulas (I) and (II), R represents hydrogen, alkyl, phenylalkyl or phenyl vantally substituted. In general formula (I), there are not 2 or 3 and one or more carbon atoms of the alkylene chain may be substituted by one or more methyl radicals In general formula (II), X represents a group eliminable by acid hydrolysis or alcoholism.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9003087A FR2659326A1 (en) | 1990-03-12 | 1990-03-12 | PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 NITRO-5 IMIDAZOLES. |
Publications (1)
Publication Number | Publication Date |
---|---|
YU42991A true YU42991A (en) | 1994-01-20 |
Family
ID=9394608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU42991A YU42991A (en) | 1990-03-12 | 1991-03-11 | PROCESS FOR PREPARATION OF HYDROXYALKYL -1-NITRO-5-IMIDAZOLE |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0519984A1 (en) |
JP (1) | JPH05505187A (en) |
CN (1) | CN1055536A (en) |
AU (1) | AU7471791A (en) |
CA (1) | CA2081372A1 (en) |
FI (1) | FI923866A (en) |
FR (1) | FR2659326A1 (en) |
HU (1) | HU208676B (en) |
IE (1) | IE910801A1 (en) |
IL (1) | IL97512A0 (en) |
NZ (1) | NZ237380A (en) |
PT (1) | PT97014A (en) |
WO (1) | WO1991013877A1 (en) |
YU (1) | YU42991A (en) |
ZA (1) | ZA911768B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100376559C (en) * | 2006-05-22 | 2008-03-26 | 浙江苏泊尔制药有限公司 | Method for preparing secnidazole |
CN102321028B (en) * | 2011-06-30 | 2013-12-25 | 湖北省宏源药业有限公司 | Method for synthesizing 2-methyl-5-nitroimidazole-1-ethanol |
CN104072424A (en) * | 2013-03-29 | 2014-10-01 | 黄冈师范学院 | Environmental novel co-production technology of metronidazole and composite fertilizer |
CN104177297B (en) * | 2013-05-20 | 2016-09-28 | 东港市宏达制药有限公司 | A kind of metronidazole API synthesis clean production method |
CN103539745B (en) * | 2013-10-11 | 2015-09-02 | 黄冈赛康药业有限公司 | A kind of preparation method of secnidazole |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1379915A (en) * | 1963-12-17 | 1964-11-27 | Rhone Poulenc Sa | Process for the preparation of imidazole derivatives |
FR1035872A (en) * | 1965-04-16 | 1953-09-01 | William Prym | Process for the production of slide closures |
DE2359625A1 (en) * | 1973-11-30 | 1975-06-05 | Basf Ag | PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-5-NITROIMIDAZOLE |
FR2625998B1 (en) * | 1988-01-15 | 1990-06-08 | Rhone Poulenc Sante | PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 METHYL-2 NITRO-5 IMIDAZOLES |
EP0325512B1 (en) * | 1988-01-15 | 1993-01-20 | Rhone-Poulenc Sante | Process for the preparation of 1-alkyl-5-nitro-imidazoles |
-
1990
- 1990-03-12 FR FR9003087A patent/FR2659326A1/en active Pending
-
1991
- 1991-03-11 JP JP3505797A patent/JPH05505187A/en active Pending
- 1991-03-11 EP EP91906063A patent/EP0519984A1/en not_active Withdrawn
- 1991-03-11 CA CA002081372A patent/CA2081372A1/en not_active Abandoned
- 1991-03-11 ZA ZA911768A patent/ZA911768B/en unknown
- 1991-03-11 HU HU292092A patent/HU208676B/en not_active IP Right Cessation
- 1991-03-11 NZ NZ237380A patent/NZ237380A/en unknown
- 1991-03-11 YU YU42991A patent/YU42991A/en unknown
- 1991-03-11 CN CN91102093A patent/CN1055536A/en active Pending
- 1991-03-11 AU AU74717/91A patent/AU7471791A/en not_active Abandoned
- 1991-03-11 IL IL97512A patent/IL97512A0/en unknown
- 1991-03-11 WO PCT/FR1991/000196 patent/WO1991013877A1/en not_active Application Discontinuation
- 1991-03-11 IE IE080191A patent/IE910801A1/en unknown
- 1991-03-12 PT PT97014A patent/PT97014A/en not_active Application Discontinuation
-
1992
- 1992-08-28 FI FI923866A patent/FI923866A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUT61530A (en) | 1993-01-28 |
HU208676B (en) | 1993-12-28 |
FR2659326A1 (en) | 1991-09-13 |
HU9202920D0 (en) | 1992-11-30 |
IL97512A0 (en) | 1992-06-21 |
CN1055536A (en) | 1991-10-23 |
FI923866A0 (en) | 1992-08-28 |
CA2081372A1 (en) | 1991-09-13 |
WO1991013877A1 (en) | 1991-09-19 |
AU7471791A (en) | 1991-10-10 |
FI923866A (en) | 1992-08-28 |
JPH05505187A (en) | 1993-08-05 |
NZ237380A (en) | 1992-02-25 |
ZA911768B (en) | 1991-12-24 |
IE910801A1 (en) | 1991-09-25 |
EP0519984A1 (en) | 1992-12-30 |
PT97014A (en) | 1991-10-31 |
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