YU49082B - A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids - Google Patents

A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids

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Publication number
YU49082B
YU49082B YU174690A YU174690A YU49082B YU 49082 B YU49082 B YU 49082B YU 174690 A YU174690 A YU 174690A YU 174690 A YU174690 A YU 174690A YU 49082 B YU49082 B YU 49082B
Authority
YU
Yugoslavia
Prior art keywords
formula
cyclopropyl
dihydro
fluoro
piperazino
Prior art date
Application number
YU174690A
Other languages
Serbo-Croatian (sh)
Other versions
YU174690A (en
Inventor
Vintro Jose Maria Gelpi
Domingo Antonio Coto
Original Assignee
Union Quimico Farmaceutica S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica S.A. filed Critical Union Quimico Farmaceutica S.A.
Priority to YU174690A priority Critical patent/YU49082B/en
Publication of YU174690A publication Critical patent/YU174690A/en
Publication of YU49082B publication Critical patent/YU49082B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Postupak za pripremanje 1-ciklopropil-6-fluoro-1,4-dihidro-4-okso-7-piperazino-hinolin-3-karboksilnih kiselina, formule I u kojoj R može biti atom vodonika ili, sa pravim ili razgranatim nizom, C1-C4-alkil-grupa, naznače n time, što se sastoji od sledećih stupnjeva: a) reakcija 3-acetil-1-ciklopropil-7-hloro-6-fluoro-1,4-dihidro-4-oksohinolina, formule IV sa viškom derivata piperazina, formule V u kojoj R1 jeste C1-C4-alkil-grupa ili alkoksikarbonil-grupa, opšte formule u kojoj R2 jeste, slično, sa pravim ili razgranatim nizom, C1-C4-alkil-grupa, pri čemu se dobija međuproizvod formule VI u kojoj R1 ima gore navedeno značenje; b) oksidovanje međuproizvoda, formule VI. Prijava sadrži još 22 zavisna zahteva.A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, of formula I wherein R may be a hydrogen atom or, with a straight or branched chain, C1 -C4-alkyl group consisting of the following steps: a) reaction of 3-acetyl-1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline of formula IV with an excess of piperazine derivatives of formula V wherein R 1 is a C 1 -C 4 alkyl group or an alkoxycarbonyl group, of the general formula wherein R 2 is, similarly to a straight or branched chain, a C 1 -C 4 alkyl group to give an intermediate of formula VI wherein R 1 has the above meaning; b) oxidation of the intermediate of formula VI. The application contains 22 more dependent requests.

YU174690A 1990-09-13 1990-09-13 A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids YU49082B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU174690A YU49082B (en) 1990-09-13 1990-09-13 A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU174690A YU49082B (en) 1990-09-13 1990-09-13 A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids

Publications (2)

Publication Number Publication Date
YU174690A YU174690A (en) 1992-09-07
YU49082B true YU49082B (en) 2003-10-31

Family

ID=47291408

Family Applications (1)

Application Number Title Priority Date Filing Date
YU174690A YU49082B (en) 1990-09-13 1990-09-13 A process for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids

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YU (1) YU49082B (en)

Also Published As

Publication number Publication date
YU174690A (en) 1992-09-07

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