YU18697A - Biaryl acetilenes as inhibitors of matrix metalloproteases - Google Patents

Biaryl acetilenes as inhibitors of matrix metalloproteases

Info

Publication number
YU18697A
YU18697A YU18697A YU18697A YU18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A YU 18697 A YU18697 A YU 18697A
Authority
YU
Yugoslavia
Prior art keywords
compounds
disease
conditions
treating
pharmaceutical compositions
Prior art date
Application number
YU18697A
Other languages
English (en)
Serbo-Croatian (sh)
Serbian (sr)
Inventor
R. Brian Dixon
Jinshan Chen
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of YU18697A publication Critical patent/YU18697A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
YU18697A 1996-05-15 1997-05-12 Biaryl acetilenes as inhibitors of matrix metalloproteases YU18697A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64502896A 1996-05-15 1996-05-15

Publications (1)

Publication Number Publication Date
YU18697A true YU18697A (en) 1999-11-22

Family

ID=24587368

Family Applications (1)

Application Number Title Priority Date Filing Date
YU18697A YU18697A (en) 1996-05-15 1997-05-12 Biaryl acetilenes as inhibitors of matrix metalloproteases

Country Status (18)

Country Link
EP (1) EP0912496A1 (ja)
JP (1) JP3090957B2 (ja)
CN (1) CN1139570C (ja)
AR (1) AR007097A1 (ja)
AU (1) AU710759B2 (ja)
BR (1) BR9709077A (ja)
CA (1) CA2253796C (ja)
CO (1) CO5080759A1 (ja)
HN (1) HN1997000088A (ja)
HR (1) HRP970245B1 (ja)
ID (1) ID16910A (ja)
PA (1) PA8429301A1 (ja)
SV (1) SV1997000035A (ja)
TN (1) TNSN97084A1 (ja)
TW (1) TW381079B (ja)
WO (1) WO1997043245A1 (ja)
YU (1) YU18697A (ja)
ZA (1) ZA974031B (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
AR035478A1 (es) * 1999-01-27 2004-06-02 Wyeth Corp Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
US8765814B2 (en) * 2010-07-08 2014-07-01 Kaken Pharmaceutical Co., Ltd. N-hydroxyformamide derivative and medicament containing same
EP3126339A1 (de) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
US20170114049A1 (en) 2014-04-03 2017-04-27 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases
CA2944617A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784701A (en) * 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (de) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
JP3090957B2 (ja) 2000-09-25
CA2253796A1 (en) 1997-11-20
HRP970245B1 (en) 2002-06-30
EP0912496A1 (en) 1999-05-06
HRP970245A2 (en) 1998-04-30
SV1997000035A (es) 1999-01-14
CN1139570C (zh) 2004-02-25
CO5080759A1 (es) 2001-09-25
PA8429301A1 (es) 2000-05-24
CA2253796C (en) 2003-10-28
ID16910A (id) 1997-11-20
BR9709077A (pt) 1999-08-03
TW381079B (en) 2000-02-01
CN1225623A (zh) 1999-08-11
AU710759B2 (en) 1999-09-30
AR007097A1 (es) 1999-10-13
ZA974031B (en) 1998-02-19
TNSN97084A1 (fr) 2005-03-15
AU2938697A (en) 1997-12-05
WO1997043245A1 (en) 1997-11-20
JPH11511179A (ja) 1999-09-28
HN1997000088A (es) 1997-06-18

Similar Documents

Publication Publication Date Title
YU18697A (en) Biaryl acetilenes as inhibitors of matrix metalloproteases
YU18597A (sh) Inhibitori matričnih metaloproteinaza, supstituisane biaril oksibuterne kiseline
CA2201863A1 (en) Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
PT1115695E (pt) (n+1) -alcanois 1-aminossubstituidos (r) -quirais halogenados uteis para inibir a actividade da proteina de transferencia de ester de colesterilo
ATE80633T1 (de) 1-hydroxy-3-(n-methyl-n-propylamino)propan-1,1diphosphons|ure; verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel.
MX202940B (es) Acido araquidonico y metodos para su produccion y uso.
ATE231490T1 (de) Hydroxamsäurederivate zur verwendung in der behandlung von bindegewebserkrankungen
PT1163208E (pt) Inibidores de caspase e as suas utilizacoes
DE69510198D1 (de) Succinyl hydroxamsäure-, n-formyl-n-hydroxy-aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease-inhibitoren
RU94019984A (ru) ПИРИДАЗИНЫ КАК ИНГИБИТОРЫ ИНТЕРЛЕЙКИН-1 β ПРЕОБРАЗУЮЩЕГО ФЕРМЕНТА, ФАРМКОМПОЗИЦИЯ НА ИХ ОСНОВЕ И ИХ ПРИМЕНЕНИЕ
RS50545B (sr) Novi postupak sinteze (7-metoksi-3,4-dihidro-1-naftalenil) acetonitrila i primena u sintezi agomelatina
YU18497A (en) Matrix-metalloproteases inhibiting compounds, supstituted phenethyl compounds
HRP20020530B1 (en) Use of fatty acid salts of alkoxylated oligoamines as lubricity improvers for petroleum products
YU18397A (en) MATRIX METALLOPROTEASES INHIBITING COMPOUND, 2(ω-ARYOYL-ALKYL)-4-BIARYL-4-OXOBUTYRIC ACID
AR007096A1 (es) Compuesto inhibidor de la metaloproteasa de matriz metodo para inhibir su actividad, una composicion que lo contiene y uso de dichos compuestos para preparar composiciones farmaceuticas
FR2439785A1 (fr) Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
FR2546774B1 (fr) Racleur-injecteur de produit de traitement pour conduites
FR2459826B1 (fr) Procede d'amelioration du rendement en produits solubles du charbon dans un procede d'elimination des cendres du charbon
ECSP972113A (es) Inhibicion de las metaloproteasas de matriz por acidos biariloxobutiricos sustituidos
US6043379A (en) Processes and intermediates for preparing 2-fluorothiophene derivatives
MEP33008A (en) Bicyclic imino acid derivatives used as inhibitors of matrixmetalloproteinases
FR2738169B1 (fr) Procede pour la valorisation et la reutilisation des cendres volantes des centrales thermiques fonctionnant au charbon
FR2454765B1 (fr) Procede pour le traitement de produits qui contiennent une huile de graines de plantes oleagineuses
TH12333B (th) การยับยั้งแมทริกซ์เมธัลลอโปรตีเนสโดยสารประกอบซับสทิทิวเทดเฟเนธิล
PL204721A1 (pl) Sposob oczyszczania fenchonu uzyskanego z produktow odpadowych syntezy borneoli z alfa-apinenu