YU110892A - STABLE SALTS (+) - (1S, 2R) -2 - {[N- (2-HYDROXYAMINO-2-OXOETHYL) -N-METHYLAMINO] CARBONYL} -CYCLOHEXANE-1-CARBOHYLIC ACIDS, PROCEDURE FOR THEIR PRODUCTION AND PREPARATION CONTAIN - Google Patents
STABLE SALTS (+) - (1S, 2R) -2 - {[N- (2-HYDROXYAMINO-2-OXOETHYL) -N-METHYLAMINO] CARBONYL} -CYCLOHEXANE-1-CARBOHYLIC ACIDS, PROCEDURE FOR THEIR PRODUCTION AND PREPARATION CONTAINInfo
- Publication number
- YU110892A YU110892A YU110892A YU110892A YU110892A YU 110892 A YU110892 A YU 110892A YU 110892 A YU110892 A YU 110892A YU 110892 A YU110892 A YU 110892A YU 110892 A YU110892 A YU 110892A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydroxyamino
- oxoethyl
- methylamino
- cyclohexane
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Pronalazak se odnosi na nove soli (+H1S, 2R>2-((N-(2-hidroksiamino-2-oksoetil)-N-metilamino)karbonil)cikloheksan-l-karbonske kiseline sa metalima i organskim bazama, predstavljene opštom formulom: gde R i R', uzeti za jedno, predstavljaju dvovalentni katjon odabran od kalcijuma, etilen diamine i drugih farmaceutski prihvatljivih katjona ili organskih baza, ili, kada R' predstavlja H+, R predstavlja natrijum, kalijum, imidazol grupu, lizin, holin, dietanolamin, arginin ili histidin. Soli iz pronalaska ispoljavaju ACE-inhibitorno dejstvo i prema tome su korisne kao aktivni sastojci u antihipertenzivnirn lekovima. Postupak za dobijanje opisanih soli poželjno obuhvata reakciju polazne kiseline, zaštićene benzil grapom, sa pogodnim hidratom, karbonatom ili organskom bazom, pod uslovima hidrogenacije i u prisustvu katalizatoraza hidrogenaciju.The invention relates to novel salts (+ H1S, 2R> 2 - ((N- (2-hydroxyamino-2-oxoethyl) -N-methylamino) carbonyl) cyclohexane-1-carboxylic acids with metals and organic bases, represented by the general formula: wherein R and R ', taken as one, represent a divalent cation selected from calcium, ethylene diamine and other pharmaceutically acceptable cations or organic bases, or, when R' represents H +, R represents sodium, potassium, imidazole group, lysine, choline, diethanolamine The salts of the invention exhibit an ACE-inhibitory effect and are therefore useful as active ingredients in antihypertensive drugs. hydrogenation conditions and in the presence of a hydrogenation catalyst.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913448A IT1252708B (en) | 1991-12-23 | 1991-12-23 | STABLE SALTS OF (+) - (1R, 2S) -2 ((N- (2-HYDROXYLAMINE-2-OSSOETHL) -N-METHYLAMINE) CARBONYL) CYCLOHEXAN-1-CARBOXYL, ACE INHIBITIVE ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU110892A true YU110892A (en) | 1996-01-08 |
Family
ID=11361409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU110892A YU110892A (en) | 1991-12-23 | 1992-12-23 | STABLE SALTS (+) - (1S, 2R) -2 - {[N- (2-HYDROXYAMINO-2-OXOETHYL) -N-METHYLAMINO] CARBONYL} -CYCLOHEXANE-1-CARBOHYLIC ACIDS, PROCEDURE FOR THEIR PRODUCTION AND PREPARATION CONTAIN |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0575572A1 (en) |
| JP (1) | JPH06506002A (en) |
| CN (1) | CN1079474A (en) |
| AU (1) | AU657591B2 (en) |
| BG (1) | BG98050A (en) |
| BR (1) | BR9205652A (en) |
| CA (1) | CA2104372A1 (en) |
| CZ (1) | CZ379692A3 (en) |
| EE (1) | EE9400006A (en) |
| FI (1) | FI933685A0 (en) |
| HR (1) | HRP921454A2 (en) |
| HU (1) | HUT69287A (en) |
| IT (1) | IT1252708B (en) |
| LV (1) | LV10426B (en) |
| MA (1) | MA22749A1 (en) |
| MX (1) | MX9207543A (en) |
| NZ (1) | NZ245547A (en) |
| PL (1) | PL169086B1 (en) |
| PT (1) | PT101156A (en) |
| RU (1) | RU2079489C1 (en) |
| SI (1) | SI9200409A (en) |
| SK (1) | SK379692A3 (en) |
| TN (1) | TNSN92117A1 (en) |
| WO (1) | WO1993013056A1 (en) |
| YU (1) | YU110892A (en) |
| ZA (1) | ZA9210004B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264860B1 (en) * | 1993-06-21 | 1996-10-17 | Guidotti & C Spa Labor | DERIVATIVES OF CIS- AND TRANS-2(((2-(HYDROXYAMINO)-2-OXOETHYL)- ALKYLAMINO)CARBONYL)CYCLOHEXINECARBOXYLIC ACIDS |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| FR2817241B1 (en) | 2000-11-30 | 2003-03-07 | Cebal | ALUMINUM TUBE WITH SPLITABLE END |
| AU2007302670A1 (en) * | 2006-09-28 | 2008-04-10 | Merck & Co., Inc. | Amine base salts of SAHA and polymorphs thereof |
| WO2021221984A1 (en) * | 2020-04-27 | 2021-11-04 | Carter-Hoffmann, Llc | Door movement system for cabinet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1224627B (en) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | ACID STARCHES CYCLOMETHYLEN_1,2_DICARBOSSILS THERAPEUTIC ADAPTIVITY, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1991
- 1991-12-23 IT ITMI913448A patent/IT1252708B/en active IP Right Grant
-
1992
- 1992-12-12 JP JP5511398A patent/JPH06506002A/en active Pending
- 1992-12-12 RU RU9293052414A patent/RU2079489C1/en active
- 1992-12-12 HU HU9302389A patent/HUT69287A/en unknown
- 1992-12-12 WO PCT/EP1992/002903 patent/WO1993013056A1/en not_active Application Discontinuation
- 1992-12-12 EP EP92924726A patent/EP0575572A1/en not_active Withdrawn
- 1992-12-12 BR BR9205652A patent/BR9205652A/en not_active Application Discontinuation
- 1992-12-12 AU AU30871/92A patent/AU657591B2/en not_active Ceased
- 1992-12-12 CA CA002104372A patent/CA2104372A1/en not_active Abandoned
- 1992-12-21 CZ CS923796A patent/CZ379692A3/en unknown
- 1992-12-21 NZ NZ245547A patent/NZ245547A/en unknown
- 1992-12-21 SK SK3796-92A patent/SK379692A3/en unknown
- 1992-12-22 HR HR921454A patent/HRP921454A2/en not_active Application Discontinuation
- 1992-12-22 SI SI9200409A patent/SI9200409A/en unknown
- 1992-12-22 MA MA23040A patent/MA22749A1/en unknown
- 1992-12-23 MX MX9207543A patent/MX9207543A/en unknown
- 1992-12-23 PL PL92297118A patent/PL169086B1/en unknown
- 1992-12-23 LV LVP-92-358A patent/LV10426B/en unknown
- 1992-12-23 YU YU110892A patent/YU110892A/en unknown
- 1992-12-23 ZA ZA9210004A patent/ZA9210004B/en unknown
- 1992-12-23 PT PT101156A patent/PT101156A/en not_active Application Discontinuation
- 1992-12-23 TN TNTNSN92117A patent/TNSN92117A1/en unknown
- 1992-12-23 CN CN92113839A patent/CN1079474A/en active Pending
-
1993
- 1993-08-18 BG BG98050A patent/BG98050A/en unknown
- 1993-08-20 FI FI933685A patent/FI933685A0/en not_active Application Discontinuation
-
1994
- 1994-05-23 EE EE9400006A patent/EE9400006A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ379692A3 (en) | 1993-09-15 |
| CA2104372A1 (en) | 1993-06-24 |
| PT101156A (en) | 1994-06-30 |
| IT1252708B (en) | 1995-06-26 |
| SK379692A3 (en) | 1995-04-12 |
| HRP921454A2 (en) | 1995-02-28 |
| LV10426B (en) | 1995-08-20 |
| BR9205652A (en) | 1994-05-03 |
| HUT69287A (en) | 1995-09-28 |
| SI9200409A (en) | 1993-09-30 |
| AU3087192A (en) | 1993-07-28 |
| EP0575572A1 (en) | 1993-12-29 |
| HU9302389D0 (en) | 1993-11-29 |
| PL297118A1 (en) | 1993-09-06 |
| JPH06506002A (en) | 1994-07-07 |
| CN1079474A (en) | 1993-12-15 |
| RU2079489C1 (en) | 1997-05-20 |
| ZA9210004B (en) | 1993-12-13 |
| ITMI913448A0 (en) | 1991-12-23 |
| EE9400006A (en) | 1995-12-15 |
| MA22749A1 (en) | 1993-07-01 |
| AU657591B2 (en) | 1995-03-16 |
| WO1993013056A1 (en) | 1993-07-08 |
| ITMI913448A1 (en) | 1993-06-23 |
| FI933685A (en) | 1993-08-20 |
| FI933685A0 (en) | 1993-08-20 |
| MX9207543A (en) | 1993-08-01 |
| LV10426A (en) | 1995-02-20 |
| TNSN92117A1 (en) | 1993-06-08 |
| NZ245547A (en) | 1995-12-21 |
| PL169086B1 (en) | 1996-05-31 |
| BG98050A (en) | 1994-04-29 |
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