TNSN92117A1 - STABLE ACID SALTS (+) (-1S, 2R) -2 [N-2-HYDROXYLAMINO-2- OXOETHYL] -N-METHYL-AMINO] CARBONYL] CYCLOHEXANE -1- CARBOXYLIC, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING - Google Patents
STABLE ACID SALTS (+) (-1S, 2R) -2 [N-2-HYDROXYLAMINO-2- OXOETHYL] -N-METHYL-AMINO] CARBONYL] CYCLOHEXANE -1- CARBOXYLIC, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAININGInfo
- Publication number
- TNSN92117A1 TNSN92117A1 TNTNSN92117A TNSN92117A TNSN92117A1 TN SN92117 A1 TNSN92117 A1 TN SN92117A1 TN TNSN92117 A TNTNSN92117 A TN TNSN92117A TN SN92117 A TNSN92117 A TN SN92117A TN SN92117 A1 TNSN92117 A1 TN SN92117A1
- Authority
- TN
- Tunisia
- Prior art keywords
- hydroxylamino
- oxoethyl
- cyclohexane
- carbonyl
- carboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
LES NOUVEAUX SELS DE L'ACIDE (+) -(1S,2R)-2-[[N-(2- HYDROXYLAMINO-2-OXOETHYL) N-METHYLAMINO] CARBONYL] CYCLOHEXANE-1- CARBOXYLIQUE AVEC DES METAUX ET BASES ORGANIQUES REPRESENTE PAR LA FORMULE GENERALE (I) OU R ET R', S'ILS SONT PRIS ENSEMBLE, REPRESENTENT UN CATION BIVALENT CHOISI PARMI LE CALCIUM, L'ETHYLENE DIAMINO ET AUTRES CATIONS PHARMACEUTIQUEMENT ACCEPTABLES OU BASES ORGANIQUES, OU BIEN SI R' = H+, R REPRESENTE LE SODIUM, LE POTASSIUM, UN GROUPE IMIDAZOLE, LA LYSINE, LA CHOLINE, LA DIETHANOLAMINE, L'ARGININE OU L'HISTIDINE, POSSEDENT UNE ACTIVITE D'INHIBITION DE ACE ET SONT PAR CONSEQUENT UTILES COMME INGREDIENTS ACTIFS DE MEDICAMENTS CONTRE L'HYPERTENSION. LE PROCEDE POUR LEUR PREPARATION COMPORTE DE PREFERENCE LA REACTION DE L'ACIDE DE DEPART, PROTEGE PAR UN GROUPE BENZYLE, AVEC L'HYDRATE, CARBONATE OU BASE ORGANIQUE APPROPRIE EN CONDITIONS D'HYDROGENATION EN PRESENCE D'UN CATALYSEUR D'HYDROGENATIONTHE NEW SALTS OF ACID (+) - (1S, 2R) -2 - [[N- (2- HYDROXYLAMINO-2-OXOETHYL) N-METHYLAMINO] CARBONYL] CYCLOHEXANE-1- CARBOXYLIC WITH ORGANIC METALS AND BASES BY THE GENERAL FORMULA (I) OR R AND R ', IF TAKEN TOGETHER, REPRESENT A BIVALENT CATION CHOSEN AMONG CALCIUM, ETHYLENE DIAMINO AND OTHER PHARMACEUTICALLY ACCEPTABLE OR ORGANIC BASE CATIONS, OR IF R' = H +, R REPRESENTS SODIUM, POTASSIUM, AN IMIDAZOLE GROUP, LYSINE, CHOLINE, DIETHANOLAMINE, ARGININE OR HISTIDINE, HAVE ACE INHIBITION ACTIVITY AND ARE THEREFORE USEFUL AS ACTIVE INGREDIENTS IN DRUGS HYPERTENSION. THE PROCESS FOR THEIR PREPARATION PREFERABLY INCORPORATES THE REACTION OF THE STARTING ACID, PROTECTED BY A BENZYL GROUP, WITH HYDRATE, CARBONATE OR ORGANIC BASE APPROPRIATE IN HYDROGENATION CONDITIONS IN THE PRESENCE OF A HYDROGENATION CATALYST
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913448A IT1252708B (en) | 1991-12-23 | 1991-12-23 | STABLE SALTS OF (+) - (1R, 2S) -2 ((N- (2-HYDROXYLAMINE-2-OSSOETHL) -N-METHYLAMINE) CARBONYL) CYCLOHEXAN-1-CARBOXYL, ACE INHIBITIVE ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN92117A1 true TNSN92117A1 (en) | 1993-06-08 |
Family
ID=11361409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN92117A TNSN92117A1 (en) | 1991-12-23 | 1992-12-23 | STABLE ACID SALTS (+) (-1S, 2R) -2 [N-2-HYDROXYLAMINO-2- OXOETHYL] -N-METHYL-AMINO] CARBONYL] CYCLOHEXANE -1- CARBOXYLIC, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0575572A1 (en) |
| JP (1) | JPH06506002A (en) |
| CN (1) | CN1079474A (en) |
| AU (1) | AU657591B2 (en) |
| BG (1) | BG98050A (en) |
| BR (1) | BR9205652A (en) |
| CA (1) | CA2104372A1 (en) |
| CZ (1) | CZ379692A3 (en) |
| EE (1) | EE9400006A (en) |
| FI (1) | FI933685A (en) |
| HR (1) | HRP921454A2 (en) |
| HU (1) | HUT69287A (en) |
| IT (1) | IT1252708B (en) |
| LV (1) | LV10426B (en) |
| MA (1) | MA22749A1 (en) |
| MX (1) | MX9207543A (en) |
| NZ (1) | NZ245547A (en) |
| PL (1) | PL169086B1 (en) |
| PT (1) | PT101156A (en) |
| RU (1) | RU2079489C1 (en) |
| SI (1) | SI9200409A (en) |
| SK (1) | SK379692A3 (en) |
| TN (1) | TNSN92117A1 (en) |
| WO (1) | WO1993013056A1 (en) |
| YU (1) | YU110892A (en) |
| ZA (1) | ZA9210004B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264860B1 (en) * | 1993-06-21 | 1996-10-17 | Guidotti & C Spa Labor | DERIVATIVES OF CIS- AND TRANS-2(((2-(HYDROXYAMINO)-2-OXOETHYL)- ALKYLAMINO)CARBONYL)CYCLOHEXINECARBOXYLIC ACIDS |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| FR2817241B1 (en) | 2000-11-30 | 2003-03-07 | Cebal | ALUMINUM TUBE WITH SPLITABLE END |
| EP2079304A4 (en) * | 2006-09-28 | 2010-01-06 | Merck & Co Inc | Amine base salts of saha and polymorphs thereof |
| US20210332635A1 (en) * | 2020-04-27 | 2021-10-28 | Carter-Hoffmann LLC | Door movement system for cabinet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1224627B (en) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | ACID STARCHES CYCLOMETHYLEN_1,2_DICARBOSSILS THERAPEUTIC ADAPTIVITY, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1991
- 1991-12-23 IT ITMI913448A patent/IT1252708B/en active IP Right Grant
-
1992
- 1992-12-12 WO PCT/EP1992/002903 patent/WO1993013056A1/en not_active Application Discontinuation
- 1992-12-12 AU AU30871/92A patent/AU657591B2/en not_active Ceased
- 1992-12-12 JP JP5511398A patent/JPH06506002A/en active Pending
- 1992-12-12 HU HU9302389A patent/HUT69287A/en unknown
- 1992-12-12 RU RU9293052414A patent/RU2079489C1/en active
- 1992-12-12 BR BR9205652A patent/BR9205652A/en not_active Application Discontinuation
- 1992-12-12 CA CA002104372A patent/CA2104372A1/en not_active Abandoned
- 1992-12-12 EP EP92924726A patent/EP0575572A1/en not_active Withdrawn
- 1992-12-21 CZ CS923796A patent/CZ379692A3/en unknown
- 1992-12-21 SK SK3796-92A patent/SK379692A3/en unknown
- 1992-12-21 NZ NZ245547A patent/NZ245547A/en unknown
- 1992-12-22 HR HR921454A patent/HRP921454A2/en not_active Application Discontinuation
- 1992-12-22 MA MA23040A patent/MA22749A1/en unknown
- 1992-12-22 SI SI9200409A patent/SI9200409A/en unknown
- 1992-12-23 LV LVP-92-358A patent/LV10426B/en unknown
- 1992-12-23 TN TNTNSN92117A patent/TNSN92117A1/en unknown
- 1992-12-23 CN CN92113839A patent/CN1079474A/en active Pending
- 1992-12-23 YU YU110892A patent/YU110892A/en unknown
- 1992-12-23 PL PL92297118A patent/PL169086B1/en unknown
- 1992-12-23 ZA ZA9210004A patent/ZA9210004B/en unknown
- 1992-12-23 MX MX9207543A patent/MX9207543A/en unknown
- 1992-12-23 PT PT101156A patent/PT101156A/en not_active Application Discontinuation
-
1993
- 1993-08-18 BG BG98050A patent/BG98050A/en unknown
- 1993-08-20 FI FI933685A patent/FI933685A/en not_active Application Discontinuation
-
1994
- 1994-05-23 EE EE9400006A patent/EE9400006A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9302389D0 (en) | 1993-11-29 |
| ITMI913448A0 (en) | 1991-12-23 |
| LV10426A (en) | 1995-02-20 |
| PL297118A1 (en) | 1993-09-06 |
| NZ245547A (en) | 1995-12-21 |
| LV10426B (en) | 1995-08-20 |
| JPH06506002A (en) | 1994-07-07 |
| EE9400006A (en) | 1995-12-15 |
| WO1993013056A1 (en) | 1993-07-08 |
| BG98050A (en) | 1994-04-29 |
| FI933685A0 (en) | 1993-08-20 |
| SK379692A3 (en) | 1995-04-12 |
| FI933685A (en) | 1993-08-20 |
| HUT69287A (en) | 1995-09-28 |
| BR9205652A (en) | 1994-05-03 |
| ZA9210004B (en) | 1993-12-13 |
| CN1079474A (en) | 1993-12-15 |
| EP0575572A1 (en) | 1993-12-29 |
| AU3087192A (en) | 1993-07-28 |
| SI9200409A (en) | 1993-09-30 |
| ITMI913448A1 (en) | 1993-06-23 |
| HRP921454A2 (en) | 1995-02-28 |
| MX9207543A (en) | 1993-08-01 |
| RU2079489C1 (en) | 1997-05-20 |
| MA22749A1 (en) | 1993-07-01 |
| PT101156A (en) | 1994-06-30 |
| CA2104372A1 (en) | 1993-06-24 |
| CZ379692A3 (en) | 1993-09-15 |
| IT1252708B (en) | 1995-06-26 |
| YU110892A (en) | 1996-01-08 |
| PL169086B1 (en) | 1996-05-31 |
| AU657591B2 (en) | 1995-03-16 |
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