Classifications

• • G—PHYSICS
  • G02—OPTICS
  • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
  • G02C7/00—Optical parts
  • G02C7/10—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses
  • G02C7/104—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses having spectral characteristics for purposes other than sun-protection
• • G—PHYSICS
  • G02—OPTICS
  • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
  • G02B5/00—Optical elements other than lenses
  • G02B5/20—Filters
• • G—PHYSICS
  • G02—OPTICS
  • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
  • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
  • G02C2202/10—Optical elements and systems for visual disorders other than refractive errors, low vision

Definitions

• the present invention relates to eyeglass lenses and eyeglasses.
• Non-Patent Document 1 discloses the results of research into symptoms and diseases caused by abnormalities in the lens epithelium, such as secondary cataracts. Secondary cataracts are as follows:
• Cataract surgery is one treatment for patients who have developed cataracts.
• the cloudy lens is removed from the incision in the lens capsule (phacoemulsification) and an intraocular lens is inserted into the capsule instead.
• the intraocular lens is covered by the incision in the lens capsule.
• Complications may occur after surgery.
• One of these is when lens epithelial cells remaining in the lens capsule proliferate, particularly in the gap between the posterior surface of the intraocular lens (the surface on the inside of the eye, facing away from the object in front of the eye) and the lens capsule, clouding the lens capsule (posterior capsule opacification), which can progress further and reduce light transmission into the eye, resulting in a decrease in visual function; this is called secondary cataract.
• the typical treatment is to remove the opacification using a YAG laser.
• cataract surgery to treat secondary cataracts will account for approximately 30% of all cataract surgeries (lens reconstruction surgeries), and this is considered to be a problem.
• cataract surgeries lacs reconstruction surgeries
• abnormalities in the lens epithelial cells are thought to be related to other symptoms and diseases related to the lens.
• Non-Patent Document 1 it would be extremely useful to know what characteristics of light entering the subject's eye will cause changes in the lens epithelial cells in the living environment of each individual (hereinafter also referred to as the subject), and how such changes will occur.
• Non-Patent Document 1 discloses the results of a study on the effects of light wavelength and irradiance on lens epithelial cells.
• the study results show that depending on the wavelength and irradiance of light, morphological changes and irregular morphology can occur in lens epithelial cells, and the migration of lens epithelial cells can be reduced.
• Figure 1 which shows the results of the investigation in Non-Patent Document 1, is a plot that collectively shows the morphological changes and migratory changes in lens epithelial cells in relation to the irradiance (vertical axis: units of W/ m2 ) and wavelength (horizontal axis: units of nm) of each light source (half-width 10 nm) used in the experiment. Sunlight is also included in the plot for reference.
• Non-Patent Document 1 in Figure 1, the dashed line indicates the boundary between small and middle effects, the dotted line indicates the boundary between middle and large effects, and the solid line indicates the boundary between the presence or absence of cell morphological abnormalities. It is stated that Figure 1 reveals that light with lower irradiance than sunlight tends to reduce motility in the range of 400 to 520 nm. It is also stated that the reduction in migration is more pronounced under conditions of short wavelengths and high irradiance, and therefore a filter design that assumes exponential dependence is appropriate.
• Figure 2 is a plot showing the blocking characteristics of an optical filter that blocks the large effect and middle effect, derived from the boundary line in Figure 1, as a relationship between transmittance (vertical axis: unit: %) and wavelength (horizontal axis: unit: nm).
• the range of irradiance is set solely based on the approximate irradiance of sunlight (AM1.5) on the front surface of the crystalline lens.
• the approximate irradiance is calculated based on the spectral irradiance of sunlight (AM1.5) on the front surface of the crystalline lens, with the half-width of each bandpass filter as the wavelength width.
• AM air mass, and is the ratio of the path of sunlight to the standard (AM1) where sunlight is perpendicular to the earth's surface; at Japan's latitudes, AM1.5 is usually used.
• the radiation intensity of light varies greatly from region to region on Earth.
• simply solar irradiance varies greatly around the world, as shown on the following site (https://documents1.worldbank.org/curated/en/529431592893043403/pdf/Global-Solar-Atlas-2-0-Technical-Report.pdf).
• the amount of short-wavelength light reflected by snow is about two to three times greater than the amount of short-wavelength light reflected by soil (https://pdfs.semanticscholar.org/5fa8/86d72e792fdd0c5e8818e3025b3354db4372.pdf).
• Non-Patent Document 1 also describes the following: - It has been reported that when porcine retinal pigment epithelial cells are exposed to light of 415 to 455 nm with an irradiance equivalent to that of sunlight, the cell survival rate decreases. - The region coincides with the range of large effects of the action spectrum obtained in this study. - Based on this, it is believed that the wavelength-irradiance band with a large effect has a deleterious effect on retinal pigment epithelial cells and is therefore an area that should be blocked.
• ocular cells cells related to the eye other than lens epithelial cells. Specific examples of ocular cells are described below).
• the inventor has set the following as the first stage of the objective of one embodiment of the present invention. That is, the inventor has set the first stage of the objective of providing eyeglass lenses that have been designed to prevent phototoxicity to ocular cells.
• the inventors further investigated the above first stage problem. As a result, they discovered the following second stage problem.
• lowering transmittance is the quickest way to reduce phototoxicity to ocular cells.
• simply lowering transmittance may not provide the wearer with a clear field of vision.
• One embodiment of the present invention aims to provide technology related to eyeglass lenses that can ensure clear vision while suppressing phototoxicity to eye cells.
• the first aspect of the present invention is a method for producing a cellular membrane comprising the steps of: When ⁇ is any number between 360 and 450, In the spectral transmittance curve, the vertical axis is the spectral transmittance and the horizontal axis is the wavelength, When the wavelength of light is ⁇ nm, the transmittance is 10% or less. In a range where the wavelength of light is equal to or greater than ( ⁇ +20) nm and less than ( ⁇ +30) nm, the spectral transmittance curve has a first maximum value, The spectacle lens has a spectral transmittance curve having a first minimum value in the light wavelength range of ( ⁇ +30) nm or more and ( ⁇ +40) nm or less.
• a second aspect of the present invention is a method for producing a composition comprising the steps of:
• the a is an arbitrary numerical value between 420 and 430.
• a third aspect of the present invention is a method for producing a composition comprising the steps of: The eyeglass lens according to the first or second aspect, wherein the first maximum transmittance value is 40% or more.
• a fourth aspect of the present invention is a method for producing a composition
• a fifth aspect of the present invention is a method for producing a composition
• the ⁇ is any one numerical value between 420 and 430, the first maximum transmittance value is 40% or more;
• the spectacle lens according to the first aspect wherein in a light wavelength range of 490 nm or more and 530 nm or less, the spectral transmittance curve has a second maximum value, and the transmittance value at the second maximum value is 85% or more.
• a sixth aspect of the present invention is a method for producing a composition
• a seventh aspect of the present invention is a method for producing a composition comprising the steps of: A pair of glasses comprising the eyeglass lens according to any one of the first to sixth aspects and a frame.
• One embodiment of the present invention provides technology for eyeglass lenses that can ensure clear vision while suppressing phototoxicity to eye cells.
• FIG. 1 is a plot showing the morphological and migratory changes in lens epithelial cells in relation to the irradiance (vertical axis: units of W/ m2 ) and wavelength (horizontal axis: units of nm) at the position of the subject to be irradiated for each light source (half-width 10 nm) used in the experiment. Solar light is also included in the plot for reference.
• FIG. 2 is a plot showing the blocking characteristics of an optical filter that blocks the large effect and middle effect, derived from the boundary line in FIG. 1, and is a plot of transmittance (vertical axis: unit: %) versus wavelength (horizontal axis: unit: nm).
• FIG. 1 is a plot showing the morphological and migratory changes in lens epithelial cells in relation to the irradiance (vertical axis: units of W/ m2 ) and wavelength (horizontal axis: units of nm) at the position of the subject to
• FIG. 3A is a plot of transmittance (vertical axis: in %) versus wavelength (horizontal axis: in nm) for FT11( ⁇ ) (left), FT21( ⁇ ) (middle), and FT31( ⁇ ) (right).
• FIG. 3B is a plot of FT11( ⁇ ), FT21( ⁇ ), FT31( ⁇ ), FT32( ⁇ ), FT22′( ⁇ ), and FT21( ⁇ ) as a function of transmittance (vertical axis: in %) versus wavelength (horizontal axis: in nm).
• Figure 4 is a plot for Case 1, with the horizontal axis representing wavelength (unit: nm) and the vertical axis representing the "relative value of individual user data with respect to a reference value.”
• the relative illuminance in the user's environment with respect to the reference solar illuminance is represented by a two-dot chain line
• the relative transmittance of an intraocular lens-implanted eye with respect to the spectral transmittance of a standard eye for wearer J is represented by a one-dot chain line.
• FIG. 5 is a plot in Case 1 with the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis, where the dotted line indicates the upper limit of the spectral transmittance suitable for wearer J under reference conditions (AM1.5), the dashed line indicates the upper limit of the spectral transmittance suitable for wearer J in the area where the spectacle lenses are used, and the solid line indicates the spectral transmittance of the spectacle lenses.
• FIG. 1 the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis
• Figure 7 is a plot for Case 2, with the horizontal axis representing wavelength (unit: nm) and the vertical axis representing the "relative value of individual user data with respect to a reference value.”
• the relative illuminance in the user's environment with respect to the reference solar illuminance is represented by a two-dot chain line
• the relative transmittance of an intraocular lens-implanted eye with respect to the spectral transmittance of a standard eye for wearer K is represented by a one-dot chain line.
• FIG. 8 is a plot in Case 2 with the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis, where the dotted line indicates the upper limit of the spectral transmittance suitable for wearer K under reference conditions (AM1.5), the dashed line indicates the upper limit of the spectral transmittance suitable for wearer K in the area where the spectacle lenses are used, and the solid line indicates the spectral transmittance of the spectacle lenses.
• FIG. 1 the spectral transmittance
• ⁇ refers to a value equal to or greater than a given value and equal to or less than a given value. Any content not described below may be used in its entirety in Non-Patent Document 1. If the discussion concerns the situation when light is received (when there is an object on which light is shining), the term irradiance is used, otherwise the term radiant intensity is used.
• the "object-side surface” of a spectacle lens is the surface that is located on the object side when a wearer wears spectacles equipped with the spectacle lens
• the "eyeball-side surface” is the opposite, that is, the surface that is located on the eyeball side when a wearer wears spectacles equipped with the spectacle lens.
• This relationship also applies to the lens substrate that forms the basis of spectacle lenses.
• the lens substrate also has an object-side surface and an eyeball-side surface.
• spectral transmittance refers to the spectral transmittance at or near the center of the eyeglass lens when light is incident perpendicularly from the object-side surface to the surface.
• the spectral transmittance at the peripheral portion can be controlled as described later in one embodiment of the present invention in the same manner as in the case of the lens center, thereby further reducing the risk of phototoxicity.
• transmittance varies depending on the position of the glasses and the angle of incidence onto the glasses, it is safe to manage the value when the light is perpendicularly incident onto the eyepoint, which is when transmittance is likely to be highest.
• the "eye point” is the position through which the line of sight passes when the eyeglass lens is worn and the eye faces a specific position (for example, directly ahead).
• the eye point for far use determined for each lens may be used, and in the case of intermediate-near lenses described below, the eye point may be the position through which the eye passes when the eye faces an object at an intermediate distance (1 m to 40 cm).
• the transmittance at that point may be managed.
• the spectacle lens according to one aspect of the present invention may be either a single-focus lens or a progressive-power lens.
• the lens may be an intermediate-near lens corresponding to an object distance of an intermediate distance (1 m to 40 cm) to a near distance (40 cm to 10 cm), a near-near lens corresponding within the near distance, or a far-near lens corresponding to a far distance (e.g., 2 m to infinity) and the near distance.
• a spectacle lens supply system has the following configuration.
• a spectacle lens supply system including a spectral transmittance setting unit that sets the spectral transmittance of the spectacle lens from the solar radiation intensity in the region in which the spectacle lens is used and the spectral transmittance of the eye of the spectacle lens wearer, based on at least one of the following relationships: (1) The relationship between the wavelength of light and the irradiance that determines whether or not a morphological change in ocular cells is caused, according to the degree of morphological change required for the ocular cell of the wearer of the eyeglass lenses.
• the relationship 1 between the wavelength of light and the irradiance that determines whether or not a morphological change occurs in the ocular cells (hereinafter, exemplified as lens epithelial cells) of a wearer of eyeglass lenses may be a plot 1 (solid lines in Figures 1 and 2) that determines whether or not a morphological change occurs in the ocular cells in the relationship between the wavelength of light and the irradiance.
• the relationship 2 between the wavelength of light and the irradiance that determines whether or not the migration of ocular cells of a wearer of a spectacle lens is changed may be a plot 2 that determines whether or not the migration of ocular cells is changed (e.g., decreased) in the relationship between the wavelength of light and the irradiance.
• plot 2 One of the plots in plot 2 (labeled "Plot 2") is the dotted line in Figures 1 and 2, which separates the rate of decrease in migration speed from over 75% (left side of the line) to under 75% (right side of the line).
• the other of the plots in plot 2 (labeled “Plot 3") is the dashed-dotted line in Figures 1 and 2, which separates the rate of decrease in migration speed from over 35% (left side of the line) to under 35% (right side of the line).
• the relationship 3 between the wavelength of light and the irradiance, which determines whether or not the invasiveness of the ocular cells of a wearer of a spectacle lens is changed may be a plot 3 that determines whether or not the invasiveness of the ocular cells is changed (e.g., increased) in the relationship between the wavelength of light and the irradiance.
• the change in invasiveness is specified as relationship 3, similar to relationships 1 and 2 above.
• Relationships 1, 2, and 3 are not limited to being embodied in the form of a plot, and may be obtained as data.
• the "solar irradiance in the region where the eyeglass lenses are used” may be the annual average horizontal solar irradiance in the region where the eyeglass lenses are used.
• the global solar radiation monthly average, annual average, etc.
• Solar irradiance is the amount of radiant energy (irradiance) that a unit area receives from the sun per unit time, and the units often used are kilowatts per square meter (kW/ m2 ) or watts per square meter (W/ m2 ).
• solar radiation from all directions in the sky is called global solar radiation
• the global solar radiation energy per unit area received on a horizontal surface is called global solar radiation.
• Solar radiation is radiation in the 0.29-3 ⁇ m wavelength range, which accounts for about 97% of the total energy of solar radiation originating from the sun, which has a high surface temperature of about 6000 K.
• spectral transmittance of the eye of a spectacle lens wearer refers to the spectral transmittance of the entire eye including the intraocular lens when the wearer is using an intraocular lens.
• spectral transmittance refers to a spectrum (or plot) with transmittance (unit: %) on the vertical axis and wavelength (unit: nm) on the horizontal axis.
• Spectral transmittance is also called the spectral transmittance.
• the wearer does not use an intraocular lens, it means the spectral transmittance of the eye.
• the spectral transmittance of the eye may be obtained by measuring each wearer, or typical spectral transmittances according to age, race, etc. may be prepared in advance and selected according to the attributes of the wearer.
• an estimated value based on the catalog value of the intraocular lens may be used.
• spectral transmittance of a spectacle lens based on the solar radiation intensity in the area in which the spectacle lens is used and the spectral transmittance of the eye of the spectacle lens wearer, based on at least one of the above relationships 1, 2, and 3.
• the following example assumes secondary cataracts as a factor that is detrimental to health, and assumes that the ocular cells are lens epithelial cells.
• Non-Patent Document 1 A database relating to the following relationships disclosed in Non-Patent Document 1 is used. ⁇ Relationship between the threshold irradiance and wavelength that causes morphological changes in lens epithelial cells 1 (ACTI1( ⁇ )) - Relationship between the threshold irradiance and wavelength that changes the migration of lens epithelial cells 2 (ACTI2( ⁇ ), ACTI3( ⁇ )). ACTI2 means a slight reduction in migration (a reduction rate of 30% or more and less than 70%), and ACTI3 means a significant reduction in migration (a reduction rate of 70% or more). It should be noted that a database relating to the relationship 3 between the irradiance threshold value and the wavelength that changes the invasiveness of lens epithelial cells may be used, but the description thereof will be omitted hereinafter.
• FTx The spectral transmittance FTx required for an eyeglass lens not to exceed each threshold value is expressed as follows when the spectral irradiance ATOM of the sun or the like is used: In the following formula, x corresponds to the numbers 1 to 3 in ACTI1 to 3. FTx( ⁇ ) ⁇ ATOM( ⁇ ) ⁇ P( ⁇ ) ⁇ ACTIx( ⁇ )...(Formula 1)
• P( ⁇ ) is a coefficient that indicates the degree to which the radiant intensity (irradiance) of light incident on the eye is attenuated due to physiological characteristics.
• P( ⁇ ) may be a coefficient that corresponds to the pupil diameter area (unit: mm2 ).
• the wavelength ⁇ is used as a variable because the pupil also changes depending on the wavelength of the incident light.
• P( ⁇ ) may be based on other publicly known data.
• a certain characteristic standard is determined, and the coefficient under that condition, the standard P( ⁇ ), is determined from measurement data of the human body.
• each individual's characteristics may be measured as a relative value from the standard, and the relative value may be multiplied by the standard P( ⁇ ) to determine the individual's P( ⁇ ).
• P( ⁇ ) may be a function related to the pupil diameter and the spectral transmittance of the iris. This function may be referred to as the "pupil diameter function" in this specification. P( ⁇ ) may be a number between 0 and 1.
• the pupil diameter generally changes due to factors described on the following website (https://acuvuevision.jp/eyelife/vol18), but also changes due to the spectral shape.
• ATOM( ⁇ ) is the spectral irradiance (converted value) characteristic of the environment, and is the irradiance (converted value) at each wavelength.
• ACTI( ⁇ ) is the transmission spectrum when the characteristics of cells change due to phototoxicity, and corresponds to the solid line, dotted line, and dashed dotted line in Figures 1 and 2.
• FTx( ⁇ ) When the equality sign is satisfied in the above formula 1, FTx( ⁇ ) will be at its maximum value. Maximum spectral transmittance is preferable because it makes the outside world appear brighter to the wearer of the eyeglass lenses. On the other hand, inequality in the above formula 1 should also be tolerated. It is meaningful to ensure a margin based on factors that affect the phototoxicity of the wearer's eyes, such as the spectral irradiance of light and exposure time, as well as other requirements required of a filter.
• B( ⁇ ) is used when adjustment is necessary due to the above factors and/or requirements.
• the specific value may be determined between 0 and 1 depending on the degree of the above factors and/or requirements.
• B may be a value for each wavelength, or a simple constant. For example, people who tend to have ptosis have less risk because light is cut off more than the narrowness of their pupil diameter, and they also tend to have difficulty seeing, so it is multiplied by 0.7 according to the degree of ptosis.
• the reference irradiance ATOM'( ⁇ ) and the reference pupil diameter P'( ⁇ ) may be used instead of ATOM( ⁇ ).
• the reference irradiance ATOM'( ⁇ ) means the magnification in the area where the spectacle lens is used, for example, with respect to the standard solar irradiance in an area with AM1.5 (e.g., Tokyo).
• the reference pupil diameter P'( ⁇ ) means the magnification in the area where the spectacle lens is used, for example, with respect to the standard pupil diameter P0( ⁇ ) in an area with AM1.5 (e.g., Tokyo).
• the following formula may be used.
• FTx( ⁇ ) ⁇ FTx( ⁇ )' ⁇ ATOM( ⁇ )' ⁇ P( ⁇ )' ⁇ ATOM( ⁇ ) ⁇ P( ⁇ ) ⁇ ...(Formula 3) Equation 3 can be transformed as follows: FTx( ⁇ ) ⁇ [FTx( ⁇ )' ⁇ ATOM( ⁇ )/ATOM( ⁇ )' ⁇ ] ⁇ P( ⁇ )/P( ⁇ )' ⁇ ...(Formula 4)
• the first brace on the right side of equation 4 corresponds to ACTIx ⁇ ATOM.
• Non-Patent Document 1 Disclosed in Non-Patent Document 1, -ACTI1, in which relatively severe phototoxicity occurs after 24-30 hours of continuous light exposure ("phototoxicity” here refers to a situation in which abnormal changes in cell morphology occur in 20% or more of all cells). ⁇ Changes in cell migration (clear decrease in migration speed) were observed, but the degree of decrease was about 30-70% ACTI2 -ATCT I3, which has strong phototoxicity against migration and reduces the rate to 30% or less Prepare a database on.
• ACTI1 plot 1 above
• ACTI2 plot 2 above
• ACTI3 plot 3 above
• FT11 FT21( ⁇ )
• FT31 FT31
• ACTx( ⁇ ) is the value when light with a half-width of approximately 10 nm is used for each central wavelength.
• the adjustment coefficient B1( ⁇ ) is obtained.
• FT31( ⁇ ) represents the filter characteristic with the lowest transmittance. Light transmitted through a spectacle lens with a filter characteristic of FT31( ⁇ ) does not change the migration of lens epithelial cells and is the safest for eye cells.
• FT31( ⁇ ) may be set as the lower limit of the transmittance.
• FT21( ⁇ ) has filter properties that aim to prevent the loss of migration of lens epithelial cells and the occurrence of abnormalities.
• the decrease in migration speed which is an indicator of changes in migration, is kept to less than 30%. Even under light with a lower intensity than sunlight, the decrease is kept to a similar rate or less. In reality, most people do not spend much time under direct sunlight, so the effect of migration is thought to be even less, and when considering the cells of the lens, this is a characteristic that is actually useful for many people from the perspective of identification and color discrimination.
• FT11( ⁇ ) is a filter characteristic that is intended to prevent morphological abnormalities in lens epithelial cells.
• FT11( ⁇ ) has the highest transmittance. Therefore, the use of FT11( ⁇ ) facilitates the basic functions of the eye, namely object identification and color discrimination.
• exposure to high-intensity ambient light can have a negative effect on eye cells.
• the filter characteristic of FT11( ⁇ ) may only have a limited effect on migration.
• FT11( ⁇ ) may be set as the upper limit of the transmittance.
• Figure 3A shows plots of transmittance (vertical axis: units in %) versus wavelength (horizontal axis: units in nm) for FT11( ⁇ ) (left, legend: circle), FT21( ⁇ ) (middle, legend: triangle), and FT31( ⁇ ) (right, legend: diamond).
• the practical range of filter transmittance is considered to be between FT31( ⁇ ) and FT11( ⁇ ), with the FT21( ⁇ ) value set as the boundary.
• the boundary on the low transmittance side is set to FT32( ⁇ ) by doubling the transmittance of FT31( ⁇ ) overall.
• the amount of irradiation decreases when exposed to sunlight due to pupil contraction, so the impact on migration is taken into consideration, assuming that the irradiance is halved on average.
• the boundary on the high transmittance side is determined by comparing FT11( ⁇ ) with FT22( ⁇ ), which has twice the transmittance of FT21( ⁇ ), at each wavelength, and taking the one with the lower transmittance as FT22'( ⁇ ).
• FIG. 3B is a plot of FT11( ⁇ ), FT21( ⁇ ), FT31( ⁇ ), FT32( ⁇ ), FT22′( ⁇ ), and FT21( ⁇ ) as a function of transmittance (vertical axis: in %) versus wavelength (horizontal axis: in nm). Taking into account the effect to be obtained (suppression of the onset of phototoxicity) and the manufacturing costs of the filter, it is realistic and preferable to provide a spectacle lens having filter characteristics with a transmittance between FT22′( ⁇ ) and FT32( ⁇ ) in FIG. 3B.
• the conditions for the filter characteristics to ensure good visibility for the spectacle lens wearer while minimizing the effect on cells include, first of all, satisfying the above-mentioned practically effective filter transmittance range.
• the following conditions can be mentioned. That is, the range of the spectral irradiance IRRA( ⁇ ) on the crystalline lens surface is minimized between the wavelength integrals of visible light of IRRA1( ⁇ ) and -IRRA2( ⁇ ), and the wavelength integral of the spectral irradiance IRRA( ⁇ ) and the standard spectral luminous efficiency V( ⁇ ) (photopic vision) is maximized.
• IRRA1( ⁇ ) ATOM1 ⁇ FT( ⁇ )22'...(Formula 5)
• IRRA2( ⁇ ) ATOM1 ⁇ FT( ⁇ )32...(Formula 6)
• the range of IRRA( ⁇ ) in which the integral value of IRRA( ⁇ ) ⁇ V( ⁇ ) in the visible light region (390 nm to 720 nm) is maximum and the integral value of IRRA( ⁇ ) is minimum may be adopted for the eyeglass lenses.
• a colorant may be mixed into the lens substrate, which is the main body of the lens, to achieve filter properties. Multiple types of colorants may also be mixed into the lens substrate.
• the composition of the lens substrate may be resin or glass.
• the resin may be a thermosetting resin, a photocurable resin, or other resin.
• the spectral transmittance of the eyeglass lens may also be achieved by a functional film provided on each of the main surfaces of the lens substrate on the object side and the eyeball side.
• This functional film may include a primer film provided directly on the lens substrate, and a hard coat film, an anti-reflection film, an anti-fouling film, etc., provided on the primer film.
• a photochromic material may be used in at least one of the lens substrate and the functional film.
• the function of the photochromic material is to keep the amount of sunlight entering the eye of the eyeglass lens wearer approximately constant, regardless of fluctuations in the intensity of solar radiation (sunlight).
• the role of achieving the spectral transmittance of the eyeglass lens may be shared between the lens substrate and the functional film.
• Figure 4 is a plot for Case 1, with the horizontal axis representing wavelength (unit: nm) and the vertical axis representing the "relative value of individual user data with respect to a reference value.”
• the relative illuminance in the user's environment with respect to the reference solar illuminance is represented by a two-dot chain line
• the relative transmittance of an eye implanted with an intraocular lens with respect to the spectral transmittance of a standard eye is represented by a one-dot chain line.
• FIG. 5 is a plot in Case 1 with the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis, where the dotted line indicates the upper limit of the spectral transmittance suitable for wearer J under reference conditions (AM1.5), the dashed line indicates the upper limit of the spectral transmittance suitable for wearer J in the area where the spectacle lenses are used, and the solid line indicates the spectral transmittance of the spectacle lenses.
• FIG. 1 the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis
• Figure 7 is a plot for Case 2, with the horizontal axis representing wavelength (unit: nm) and the vertical axis representing the "relative value of individual user data with respect to a reference value.”
• the relative illuminance in the user's environment with respect to the reference solar illuminance is represented by a two-dot chain line
• the relative transmittance of an intraocular lens-implanted eye with respect to the spectral transmittance of a standard eye for wearer K is represented by a one-dot chain line.
• FIG. 8 is a plot in Case 2 with the spectral transmittance (unit: %) on the vertical axis and the wavelength (unit: nm) on the horizontal axis, where the dotted line indicates the upper limit of the spectral transmittance suitable for wearer K under reference conditions (AM1.5), the dashed line indicates the upper limit of the spectral transmittance suitable for wearer K in the area where the spectacle lenses are used, and the solid line indicates the spectral transmittance of the spectacle lenses.
• FIG. 1 the spectral transmittance
• the lens substrate contains a colorant, and the functional film is also dyed.
• the eyeglass lens has the following characteristics. "When ⁇ is any number between 360 and 450, In the spectral transmittance curve, the vertical axis is the spectral transmittance and the horizontal axis is the wavelength, When the wavelength of light is ⁇ nm, the transmittance is 10% or less.
• the spectral transmittance curve In a range where the wavelength of light is equal to or greater than ( ⁇ +20) nm and less than ( ⁇ +30) nm, the spectral transmittance curve has a first maximum value, A spectacle lens, the spectral transmittance curve of which has a first minimum value in the range of light wavelengths equal to or greater than ( ⁇ +30) nm and equal to or less than ( ⁇ +40) nm.
• the reason for having the above features is to ensure a clear field of vision for the wearer.
• the aim is to pinpoint and increase the transmittance only at 445 nm, where the spectral radiation intensity of blue LEDs used as white light sources peaks. This makes it possible to transmit a lot of the blue light from the LED (440-450 nm), but not much of the blue light from sunlight (400-480 nm). This not only means that the field of vision is clearer for the wearer, but also that a fairly wide range of wavelengths of sunlight can be blocked. In other words, it means that a clear field of vision can be ensured while suppressing the phototoxicity caused by sunlight.
• the transmittance of different wavelengths may be selectively increased depending on the environment and purpose.
• the transmittance of 460 nm may be increased, considering that the blue color of organic EL is a longer wavelength.
• light of 470 to 490 nm, centered around 480 nm may be transmitted for circadian rhythms (daily rhythms, also referred to as biological clocks in this specification).
• circadian rhythms also referred to as biological clocks in this specification.
• the transmittance may be set according to individual differences. If a wavelength that is beneficial rather than harmful to lens epithelial cells is discovered, light of that wavelength may be transmitted.
• the spectacle lens of this example may further include at least one (preferably all) of the following configurations.
• the following configurations take into account the above cases 1 and 2.
• the ⁇ is any one number between 420 and 430.”
• the first maximum transmittance value is 40% or more.”
• the spectral transmittance curve has a second maximum value, and the transmittance value at the second maximum value is 85% or more.”
• the ocular cells may be lens epithelial cells, retinal pigment epithelial cells, corneal endothelial cells, corneal epithelial stem cells, or subconjunctival fibroblasts.
• lens epithelial cells have a high sensitivity to phototoxicity, and as a result, the effects of the present invention are particularly pronounced.
• the spectral transmittance of the dyeing material or functional film may be at a minimum value or the shape of the spectral transmittance curve may be downwardly convex.
• the blocking effect of the dyeing material or functional film is strong, the blocking effect of the wavelength is strengthened and the maximum value is eliminated.
• the shielding effect increases in the upper and lower parts of the lens where the lens thickness increases, as the light path length increases, and this is particularly noticeable at the above wavelengths.
• the present invention can be applied to contact lenses and goggles, in addition to spectacle lenses and spectacles. As mentioned above, this specification also considers the case where an intraocular lens is not being worn when referring to the "spectral transmittance of the eye of a spectacle lens wearer.” The present invention can also be applied to cases where an intraocular lens is needed by someone who does not wear an intraocular lens. In other words, the present invention can also be applied to intraocular lenses.

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• 2024
  • 2024-03-26 CN CN202480021746.2A patent/CN120883120A/zh active Pending
  • 2024-03-26 EP EP24780271.3A patent/EP4692907A1/en active Pending
  • 2024-03-26 WO PCT/JP2024/011884 patent/WO2024204158A1/ja not_active Ceased
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