WO2024113315A1 - Préparation liquide de nicotine permettant de produire un aérosol inhalable et son utilisation - Google Patents

Préparation liquide de nicotine permettant de produire un aérosol inhalable et son utilisation Download PDF

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WO2024113315A1
WO2024113315A1 PCT/CN2022/135957 CN2022135957W WO2024113315A1 WO 2024113315 A1 WO2024113315 A1 WO 2024113315A1 CN 2022135957 W CN2022135957 W CN 2022135957W WO 2024113315 A1 WO2024113315 A1 WO 2024113315A1
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nicotine
acid
liquid preparation
value
nicotine liquid
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PCT/CN2022/135957
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English (en)
Chinese (zh)
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杜振兴
周勇
宁静
廖晓祥
汤建国
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思摩尔国际控股有限公司
深圳麦克韦尔科技有限公司
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Priority to PCT/CN2022/135957 priority Critical patent/WO2024113315A1/fr
Publication of WO2024113315A1 publication Critical patent/WO2024113315A1/fr

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  • the present application belongs to the technical field of nicotine liquid preparations, and specifically relates to a nicotine liquid preparation for generating an inhalable aerosol, and further discloses a method for generating an inhalable aerosol, as well as an atomizer and an electronic atomization device.
  • Electronic cigarettes are an electronic transmission system used to generate aerosols for people to inhale. They can produce the same smoke, taste and feeling after smoking as traditional cigarettes. As an emerging product, electronic cigarettes have received great attention and extensive research from major tobacco companies at home and abroad. The main reason is that electronic cigarettes can not only provide similar consumption habits and satisfaction as traditional cigarettes, but also the harm index of electronic cigarettes is much lower than that of traditional cigarettes. Compared with traditional cigarettes, people inhale the atomized liquid of electronic cigarette oil into the human body, rather than the cracking products produced by the combustion of traditional cigarettes; in addition, electronic cigarettes do not burn, nor do they produce harmful substances such as tar, carbon monoxide, carbon dioxide and acrolein, and almost do not cause the harm of secondhand smoke. Therefore, electronic cigarettes are regarded as harmless smoking cessation products or tobacco substitutes.
  • Nicotine is a key ingredient in tobacco and tobacco products. The reason why traditional cigarettes can make people feel relaxed, happy, and high is that nicotine can stimulate the brain to produce dopamine after crossing the blood-brain barrier. Most early e-cigarette oils directly added free nicotine. In order to achieve the same degree of inhalation satisfaction as traditional cigarettes, many products blindly increased the amount of nicotine. However, excessive free nicotine is very irritating to the mouth, throat and entire respiratory tract, but instead caused severe choking and coughing. Nicotine was not even inhaled into the lungs to cross the blood-brain barrier to reach the brain, and could not produce the expected satisfaction, which seriously affected the experience of using e-cigarettes. In 2015, PAX Laboratory under JUUL developed a nicotine salt formula with an acid-base ratio of 1:1.
  • the e-cigarette policies of various countries indicate that the amount of nicotine in e-cigarette liquid will tend to be low-dose.
  • the draft for comments on China's national standard for e-cigarettes clearly stipulates that "the nicotine concentration in the atomizer should not be higher than 20 mg/g, and the nicotine release should not be higher than 0.2 mg/puff".
  • These regulations all reflect the expectation to protect consumers from the addictive harm of high-concentration nicotine by reducing the nicotine content of the e-liquid.
  • the 20 mg/g nicotine addition has greatly hit the user's demand for the satisfaction of smoking when experiencing e-cigarettes, reducing the pleasure brought by smoking, and failing to meet the user's satisfaction needs, bringing new challenges to the development of e-cigarettes.
  • the currently more popular e-cigarette liquids with multiple flavors developed by adding different flavor substances have seriously affected the user's experience of use due to the influence of flavor perception and the limitation of nicotine dosage.
  • the technical problem to be solved by the present application is to provide a nicotine liquid preparation for generating an inhalable aerosol, wherein the nicotine liquid preparation is obtained by optimizing the ratio of nicotine and organic acid to obtain a liquid preparation with a suitable pH value, which can effectively improve the absorption experience of nicotine;
  • the third technical problem to be solved by the present application is to provide an electronic atomization device for generating an inhalable aerosol
  • the fourth technical problem to be solved by the present application is to provide a method for generating an inhalable aerosol, wherein the method effectively improves the inhalation satisfaction obtained by the user by providing the nicotine liquid preparation to the user and atomizing it.
  • the nicotine liquid preparation for producing an inhalable aerosol described in the present application comprises the following components by mass, based on the total amount of the nicotine liquid preparation:
  • the mass ratio of the nicotine to the organic acid is 10:1-10:6;
  • the pH value of the nicotine liquid preparation is: 7.0 ⁇ pH ⁇ 8.0.
  • the organic acid includes one or a mixture of benzoic acid, lactic acid, levulinic acid, malic acid, citric acid, succinic acid, salicylic acid, oxalic acid, carotene acid, fumaric acid, maleic acid, tartaric acid, sorbic acid, aconitic acid, lauric acid, chlorogenic acid, and pyruvic acid;
  • the liquid carrier includes one or a mixture of water, ethanol, 1,2-propylene glycol, and glycerol.
  • the content of nicotine is 2.0wt%, and the content of tobacco flavor is 5.0%;
  • the mass ratio of the nicotine to the organic acid is 10:1-10:6.
  • the tobacco flavor is a mint flavor
  • the mass ratio of nicotine to organic acid is 10:2-10:5;
  • the pH value of the nicotine liquid preparation is 7.03-7.98.
  • the tobacco flavor is a mint flavor
  • the organic acid includes benzoic acid, levulinic acid, or a mixture of levulinic acid and malic acid;
  • the mass ratio of levulinic acid to malic acid is 2:3-3:2, and more optionally 1:1.
  • the tobacco flavor is a mint flavor:
  • the organic acid is benzoic acid, and the pH value of the nicotine liquid preparation is 7.03-7.98;
  • the mass ratio of the nicotine to the benzoic acid is 10:3.5, and the pH value of the nicotine liquid preparation is 7.55; or,
  • the organic acid is levulinic acid, and the pH value of the nicotine liquid preparation is 7.38-7.92;
  • the mass ratio of the nicotine to the levulinic acid is 10:4, and the pH value of the nicotine liquid preparation is 7.66; or,
  • the organic acid is a mixture of levulinic acid and malic acid, and the pH value of the nicotine liquid preparation is 7.34-7.88;
  • the mass ratio of the nicotine to the mixture of levulinic acid and malic acid is 10:4, and the pH value of the nicotine liquid preparation is 7.59.
  • the tobacco flavor is a fruit flavor
  • the mass ratio of nicotine to organic acid is 10:1-10:3;
  • the pH value of the nicotine liquid preparation is 7.11-7.88.
  • the tobacco flavor is a fruit flavor
  • the organic acid includes benzoic acid, levulinic acid, or a mixture of malic acid and citric acid;
  • the mass ratio of malic acid to citric acid is 2:3-3:2, and more optionally 1:1.
  • the tobacco flavor is a fruit flavor:
  • the organic acid is benzoic acid, and the pH value of the nicotine liquid preparation is 7.23-7.88;
  • the mass ratio of the nicotine to the benzoic acid is 10:2, and the pH value of the nicotine liquid preparation is 7.53; or,
  • the organic acid is levulinic acid, and the pH value of the nicotine liquid preparation is 7.32-7.78;
  • the mass ratio of the nicotine to the levulinic acid is 10:2.5, and the pH value of the nicotine liquid preparation is 7.49; or,
  • the organic acid is a mixture of malic acid and citric acid, and the pH value of the nicotine liquid preparation is 7.11-7.71;
  • the mass ratio of the nicotine to the mixture of malic acid and citric acid is 10:2, and the pH value of the nicotine liquid preparation is 7.48.
  • the tobacco flavor is a tobacco flavor
  • the mass ratio of nicotine to organic acid is 10:2.5-10:4;
  • the pH value of the nicotine liquid preparation is 7.13-7.89.
  • the nicotine liquid preparation further includes tobacco extract
  • the tobacco extract is added in an amount of ⁇ 2.0wt%;
  • the tobacco extract includes one or a mixture of tobacco essential oil, tobacco pure oil, tobacco extract, and tobacco lysate.
  • the tobacco flavor is a tobacco flavor
  • the organic acid includes benzoic acid, lactic acid, or a mixture of levulinic acid and malic acid
  • the mass ratio of levulinic acid to malic acid is 2:3-3:2, and more optionally 1:1.
  • the tobacco flavor is a tobacco flavor:
  • the organic acid is benzoic acid, and the pH value of the nicotine liquid preparation is 7.13-7.87;
  • the mass ratio of the nicotine to the benzoic acid is 10:3, and the pH value of the nicotine liquid preparation is 7.66; or
  • the organic acid is lactic acid, and the pH value of the nicotine liquid preparation is 7.22-7.89;
  • the mass ratio of the nicotine to the lactic acid is 10:3, and the pH value of the nicotine liquid preparation is 7.68; or,
  • the organic acid is a mixture of levulinic acid and malic acid, and the pH value of the nicotine liquid preparation is 7.26-7.89;
  • the mass ratio of the nicotine to the mixture of levulinic acid and malic acid is 10:3, and the pH value of the nicotine liquid preparation is 7.44.
  • the content of nicotine is 2.0wt%, and the content of tobacco flavor is 0%;
  • the mass ratio of the nicotine to the organic acid is 10:3.5-10:6;
  • the pH value of the nicotine liquid preparation is 7.2-8.
  • the organic acid includes benzoic acid, levulinic acid or lactic acid.
  • the nicotine liquid preparation Specifically, the nicotine liquid preparation:
  • the organic acid is benzoic acid, the mass ratio of nicotine to benzoic acid is 10:4-10:6, and the pH value of the nicotine liquid preparation is 7.2-8; or,
  • the organic acid is levulinic acid, the mass ratio of nicotine to levulinic acid is 10:4-10:6, and the pH value of the nicotine liquid preparation is 7.3-8; or,
  • the organic acid is lactic acid
  • the mass ratio of nicotine to lactic acid is 10:3.5-10:5
  • the pH value of the nicotine liquid preparation is 7.3-8.
  • the present application also discloses a nebulizer for generating an inhalable aerosol, comprising a nebulizer assembly and a liquid storage member in fluid communication with the nebulizer assembly;
  • the liquid storage component is used to contain and provide the nicotine liquid preparation as described above to the atomization component, and the atomization component atomizes the nicotine liquid preparation to form an aerosol by heating.
  • the present application also discloses an electronic atomization device for generating inhalable aerosol, comprising a power source and the atomizer.
  • the present application also discloses a method for producing an inhalable aerosol, comprising the steps of atomizing the nicotine liquid preparation to form an aerosol; or,
  • the method comprises the steps of using the atomizer or the electronic atomization device to atomize the nicotine liquid preparation to form an aerosol.
  • the nicotine liquid preparation described in this application the applicant has found through research that the physiological satisfaction of users smoking electronic cigarettes can be determined by the speed at which nicotine enters the blood, and improving the efficiency of nicotine absorption into the blood is the key to improving satisfaction.
  • the transmission rate of nicotine entering the blood through the respiratory system such as the mouth, trachea and lungs will vary greatly.
  • This application explores the ratio of nicotine to organic acid in different nicotine salts, and then regulates to obtain a nicotine liquid preparation (electronic cigarette oil) with a pH value of 7.0-8.0.
  • the nicotine liquid preparation has a faster absorption rate of nicotine into the blood, which can significantly improve the satisfaction experience of smoking electronic cigarettes, so that the satisfaction experience of 2wt% low-nicotine content e-liquid can reach the feeling of 3wt% added level e-liquid, effectively improving the user experience of low-nicotine content e-liquid.
  • the nicotine in the nicotine liquid preparation described in the present application includes a proton state and a free state, wherein the proton state refers to the formation of nicotine salts with organic acids, and the free state refers to the formation of nicotine salts, which exists in the form of nicotine base, which is the reason for the high pH value of the nicotine liquid preparation.
  • the nicotine liquid preparation (electronic cigarette oil) described in the present application optimizes the ratio of nicotine to organic acid and then matches it with flavors of different flavors to form a liquid preparation with a suitable pH value.
  • the e-liquid has a faster absorption rate of nicotine into the blood, which significantly improves the satisfaction experience of smoking electronic cigarettes.
  • the mint-flavored nicotine liquid preparation (electronic cigarette oil) described in the present application can effectively improve the absorption experience of low-nicotine content e-liquid products by regulating the mass ratio of nicotine to organic acid to between 10:2 and 10:5, and by screening suitable organic acids for combination, and effectively improve the nicotine absorption amount of mint-flavored e-liquid, thereby enhancing the user's satisfaction experience.
  • the fruit-flavored nicotine liquid preparation (electronic cigarette oil) described in the present application can effectively improve the absorption experience of low-nicotine content e-liquid products by regulating the mass ratio of nicotine to organic acid to between 10:1 and 10:3, and by screening suitable organic acids for combination, and effectively improve the nicotine absorption of fruit-flavored e-liquid, thereby enhancing the user's satisfaction experience.
  • the tobacco-flavored nicotine liquid preparation (electronic cigarette oil) described in the present application can effectively improve the absorption feeling of low-nicotine content e-liquid products by regulating the mass ratio of nicotine to organic acid to between 10:2.5 and 10:4, and by screening suitable organic acids for combination, and effectively improve the nicotine absorption amount of tobacco-flavored e-liquid, thereby enhancing the user's satisfaction experience.
  • the nicotine liquid preparation (electronic cigarette oil) described in the present application does not require heating during preparation and has the advantage of a simple preparation process. It can not only meet the requirements of industrial production, but also the reduction in the amount of organic acid used greatly reduces the cost of the product.
  • the organic acids used are all additives allowed by the national standards for electronic cigarettes, meeting the safety requirements.
  • FIG1 is a heart rate curve (a) and a nicotine weighted absorption curve (b) of standard e-liquid at different ratios in Example 1;
  • FIG2 is a heart rate curve (a) and a nicotine weighted absorption curve (b) of different nicotine benzoate salts forming e-liquids at 2% nicotine content in Example 2;
  • FIG3 is a heart rate curve (a) and a nicotine weighted absorption curve (b) of different nicotine levulinic acid salts forming e-liquids at 2% nicotine content in Example 3;
  • FIG4 is a heart rate curve (a) and a nicotine weighted absorption curve (b) of different nicotine lactate salts forming e-liquids at 2% nicotine content in Example 4;
  • FIG5 is a graph showing the absorption heart rate of the e-liquids of the experimental samples 1-11 and the control samples 1-10 in Example 5;
  • FIG6 is a graph showing the absorption heart rate of the e-liquids of the experimental samples 1-9 and the control samples 1-11 in Example 6;
  • FIG. 7 is a graph showing the absorption heart rate of the e-liquid of the experimental samples 1-9 and the control samples 1-11 in Example 7.
  • Electronic cigarettes also known as electronic nicotine delivery systems (ENDS) are electronic products that imitate cigarettes, with the same smoke, taste and feeling after smoking as cigarettes.
  • the main components of electronic cigarette liquid are solvents (propylene glycol and glycerol, the total content is generally more than 90%), flavor substances (different flavor components are added according to different flavors, such as tobacco, mint, fruit, etc.) and nicotine (generally 0-5%).
  • the satisfaction generated by smoking cigarettes or e-cigarettes is mainly determined by the speed at which nicotine enters the blood circulation system.
  • nicotine salt formulas mostly use nicotine and organic acids (PAX patent) with the same molar ratio or mass ratio, so that the pH of the liquid is at 5-6, or even lower. Under such conditions, nicotine is completely converted into a proton state or salt form, which is conducive to completely eliminating the irritation caused by free nicotine and making nicotine easier to enter the blood.
  • the nicotine liquid preparation is mainly used to produce electronic cigarette products, that is, an electronic atomization device that can produce an inhalable aerosol.
  • the electronic cigarette described in the present application can be any type of electronic cigarette known to technicians.
  • the term “electronic cigarette”, “electronic cigarette”, “low temperature vaporization device” or “electronic atomization device” refers to an electronic inhaler that vaporizes a liquid solution into an aerosol mist and simulates the act of smoking.
  • an electronic cigarette contains four main components: a mouthpiece, a liquid reservoir, an atomizer that vaporizes the liquid, and a battery. The reservoir stores a nicotine liquid preparation.
  • the reservoir may be replaceable or non-replaceable.
  • the electronic cigarette includes a nicotine liquid preparation, and the nicotine liquid preparation is used to form a reservoir of an electronic cigarette.
  • Other components of the electronic cigarette may include a combined atomizer and a reservoir that may or may not be disposable, a mouthpiece that may be integrated or not integrated with the combined atomizer and the reservoir, and a battery.
  • the atomizer of the electronic cigarette is not further limited, and different technologies can be implemented.
  • An exemplary embodiment of the atomizer is an induction heating device, a light heating device, or an electric heating device.
  • the induction heating device includes a generator for generating an alternating electromagnetic field and one or more susceptors, which, when powered by the generated alternating electromagnetic field, generate heat for vaporizing the nicotine liquid formulation.
  • the light heating device uses a light source such as a laser or a high-power LED to direct light to an absorbing element, which is heated by light absorbed from the light source to vaporize the nicotine liquid formulation.
  • the heat transfer element absorbs heat from the electric heater and transfers the heat to the wick for vaporizing the e-liquid.
  • the liquid carrier used in the nicotine liquid preparation is selected from liquid solvents commonly used in electronic cigarette products in the field, such as water, ethanol, 1,2-propylene glycol, glycerol and other solvents, which can ensure the quality and inhalation effect of electronic cigarette products.
  • the liquid carrier is mostly a mixture of propylene glycol and glycerol.
  • the tester takes 2.0g of the above-mentioned e-cigarette liquid with different nicotine contents and add it to the e-cigarette cartridge.
  • the tester is inhaled through the e-cigarette atomizer, and the heart rate changes of the tester during the inhalation process are measured.
  • the number of testers selected is 3, and they are required to have more than 3 years of experience in traditional cigarettes or e-cigarettes. They need to quit nicotine for more than 10 hours before the test.
  • the inhalation method adopts the overall circulation method, that is, the smoke stays for about 3 seconds after being inhaled into the mouth, and then the smoke is swallowed through the throat, and then slowly exhaled from the nasal cavity.
  • the heart rate measurement lasts for 10 minutes, including 1 minute before inhalation, 5 minutes during inhalation, and 4 minutes after inhalation.
  • the heart rate is recorded every 10 seconds.
  • the tester needs to inhale 10 times during the inhalation period, once every 30 seconds (inhalation for 3 seconds, interval of 27 seconds).
  • the basal heart rate was defined as the average heart rate 1 minute before puffing
  • the normalized heart rate was defined as the ratio between a single heart rate point and the basal heart rate
  • the nicotine absorption efficiency was defined as the sum of the normalized heart rates during and after puffing. All calculated results were the averages of the three testers.
  • This example is based on the formation of nicotine benzoate salt by benzoic acid and nicotine, and further explores its effect on nicotine absorption perception.
  • the pH values of the above-mentioned liquids were tested to be 4.91, 6.95, 7.23, 7.48, 7.76 and 8.06, respectively.
  • the inhalation method adopts the overall circulation method, that is, the smoke stays for about 3 seconds after being inhaled into the mouth, and then the smoke is swallowed through the throat, and then slowly exhaled from the nasal cavity.
  • the heart rate measurement lasts for 10 minutes, including 1 minute before inhalation, 5 minutes during inhalation, and 4 minutes after inhalation, and the heart rate is recorded every 10 seconds.
  • the tester needs to inhale 10 times during the inhalation period, once every 30 seconds (inhalation for 3 seconds, interval of 27 seconds).
  • the basal heart rate was defined as the average heart rate 1 minute before puffing
  • the normalized heart rate was defined as the ratio between a single heart rate point and the basal heart rate
  • the nicotine absorption efficiency was defined as the sum of the normalized heart rates during and after puffing. All calculated results were the averages of the three testers.
  • the heart rate curves and nicotine weighted absorption curves of nicotine benzoate salt at different ratios are shown in (a) and (b) of Figure 2, respectively.
  • This example is based on the formation of nicotine levulinic acid salt by levulinic acid and nicotine, and further explores its effect on nicotine absorption perception.
  • the pH values of the liquids were tested to be 5.50, 6.95, 7.33, 7.68, 7.92 and 8.15, respectively.
  • This example is based on the formation of nicotine lactate salt by lactic acid and nicotine, and further explores its effect on nicotine absorption perception.
  • the pH values of the liquids were tested to be 5.80, 6.95, 7.38, 7.58, 7.78, 7.98 and 8.10, respectively.
  • Example 1 the heart rate curves and nicotine weighted absorption curves of nicotine lactate salt at different ratios are shown in (a) and (b) of Figure 4, respectively.
  • Example 5 Mint flavored electronic cigarette oil
  • This embodiment is used to prepare mint-flavored electronic cigarette oil (nicotine liquid preparation), that is, mint flavor essence is added to the electronic cigarette oil.
  • the weighted nicotine absorption test was conducted on the above experimental samples 1-11 and control samples 1-10 respectively: 2.0g of the above smoke liquid was added to the smoke cartridge respectively, and the test subjects were inhaled through the atomizer, and the heart rate changes of the test subjects during the inhalation process were measured.
  • the number of test subjects selected was 3, and they were required to have more than 3 years of experience in smoking traditional cigarettes or electronic cigarettes, and they needed to quit nicotine for more than 10 hours before the test.
  • the inhalation method adopts the overall circulation method, that is, the smoke stays for about 3 seconds after being inhaled into the mouth, and then the smoke is swallowed through the throat, and then slowly exhaled from the nasal cavity.
  • the heart rate measurement lasts for 10 minutes, including 1 minute before inhalation, 5 minutes during inhalation, and 4 minutes after inhalation, and the heart rate is recorded every 10 seconds.
  • the tester needs to inhale 10 times during the inhalation period, once every 30 seconds (inhalation for 3 seconds, interval of 27 seconds).
  • the basal heart rate was defined as the average heart rate 1 minute before puffing
  • the normalized heart rate was defined as the ratio between a single heart rate point and the basal heart rate
  • the weighted nicotine absorption was defined as the sum of the normalized heart rates during and after puffing. All calculated results were the average of the three testers.
  • test results of the weighted nicotine absorption of the above experimental samples 1-11 and the control samples 1-10 are shown in Table 1 below, and the test results of the heart rate curves are shown in Figures 5 (a)-(k) respectively.
  • the weighted absorption of nicotine in the prepared electronic cigarette oil in the experimental samples 1-11 reached 79.90-94.88, while the weighted absorption of nicotine in the control samples 1-9 at the same low nicotine content level (2%) was only 74.16-75.80.
  • the e-liquid product described in this application can effectively improve the absorption efficiency of nicotine by reasonably adjusting the ratio of nicotine to organic acid and selecting appropriate organic acid for proportioning. Even with the e-liquid at a low nicotine content of 2%, a better sense of satisfaction can still be obtained, which effectively improves the acceptance and use experience of low-content nicotine e-liquid.
  • the mint-flavored electronic cigarette liquid described in this embodiment can effectively improve the absorption experience of low-nicotine content cigarette liquid products by adjusting the mass ratio of nicotine to organic acid to between 10:2 and 10:5, and by screening suitable organic acids for coordination, and effectively improve the nicotine absorption of mint-flavored cigarette liquid, thereby enhancing the user's satisfaction experience.
  • Example 6 Fruit flavored electronic cigarette oil
  • This embodiment is used to prepare fruit-flavored electronic cigarette oil, that is, fruit-flavored essence is added to the electronic cigarette oil.
  • the weighted nicotine absorption test was conducted on the above experimental samples 1-9 and control samples 1-11 respectively: 2.0g of the above smoke liquid was added to the smoke cartridge respectively, and the test subjects were inhaled through the atomizer, and the heart rate changes of the test subjects during the inhalation process were measured.
  • the number of test subjects selected was 3, and they were required to have more than 3 years of experience in smoking traditional cigarettes or electronic cigarettes, and they needed to quit nicotine for more than 10 hours before the test.
  • the inhalation method adopts the overall circulation method, that is, the smoke stays for about 3 seconds after being inhaled into the mouth, and then the smoke is swallowed through the throat, and then slowly exhaled from the nasal cavity.
  • the heart rate measurement lasts for 10 minutes, including 1 minute before inhalation, 5 minutes during inhalation, and 4 minutes after inhalation, and the heart rate is recorded every 10 seconds.
  • the tester needs to inhale 10 times during the inhalation period, once every 30 seconds (inhalation for 3 seconds, interval of 27 seconds).
  • the basal heart rate was defined as the average heart rate 1 minute before puffing
  • the normalized heart rate was defined as the ratio between a single heart rate point and the basal heart rate
  • the weighted nicotine absorption was defined as the sum of the normalized heart rates during and after puffing. All calculated results were the average of the three testers.
  • the weighted absorption of nicotine in the electronic cigarette oil prepared in the experimental samples 1-9 of the present application reached 76.58-89.69, while the weighted absorption of nicotine in the control samples 1-11 at the same low nicotine content level (2%) was only 71.61-73.87. It can be seen that the e-liquid product described in the present application can effectively improve the absorption efficiency of nicotine by rationally adjusting the ratio of nicotine to organic acid and selecting appropriate organic acid for proportioning. Even with the e-liquid at a low nicotine content of 2%, a better sense of satisfaction can still be obtained, which effectively improves the acceptance and use experience of low-content nicotine e-liquid.
  • the fruit-flavored electronic cigarette liquid described in this embodiment can effectively improve the absorption experience of low-nicotine content e-liquid products by adjusting the mass ratio of nicotine to organic acid to between 10:1 and 10:3, and by screening suitable organic acids for combination, and effectively improve the nicotine absorption of fruit-flavored e-liquid, thereby enhancing the user's satisfaction experience.
  • Example 7 Tobacco flavored electronic cigarette oil
  • This embodiment is used to prepare tobacco-flavored electronic cigarette oil, that is, tobacco flavor is added to the electronic cigarette oil.
  • the weighted nicotine absorption test was conducted on the above experimental samples 1-9 and control samples 1-11 respectively: 2.0g of the above smoke liquid was added to the smoke cartridge respectively, and the test subjects were inhaled through the atomizer, and the heart rate changes of the test subjects during the inhalation process were measured.
  • the number of test subjects selected was 3, and they were required to have more than 3 years of experience in smoking traditional cigarettes or electronic cigarettes, and they needed to quit nicotine for more than 10 hours before the test.
  • the inhalation method adopts the overall circulation method, that is, the smoke stays for about 3 seconds after being inhaled into the mouth, and then the smoke is swallowed through the throat, and then slowly exhaled from the nasal cavity.
  • the heart rate measurement lasts for 10 minutes, including 1 minute before inhalation, 5 minutes during inhalation, and 4 minutes after inhalation, and the heart rate is recorded every 10 seconds.
  • the tester needs to inhale 10 times during the inhalation period, once every 30 seconds (inhalation for 3 seconds, interval of 27 seconds).
  • the basal heart rate was defined as the average heart rate 1 minute before puffing
  • the normalized heart rate was defined as the ratio between a single heart rate point and the basal heart rate
  • the weighted nicotine absorption was defined as the sum of the normalized heart rates during and after puffing. All calculated results were the average of the three testers.
  • the weighted absorption of nicotine in the electronic cigarette oil prepared in the experimental samples 1-9 of the present application reached 80.38-86.87, while the weighted absorption of nicotine in the control samples 1-11 at the same low nicotine content level (2%) was only 70.76-75.16. It can be seen that the e-liquid product described in the present application can effectively improve the absorption efficiency of nicotine by rationally adjusting the ratio of nicotine to organic acid and selecting appropriate organic acid for proportioning. Even with the e-liquid at a low nicotine content of 2%, a better sense of satisfaction can still be obtained, which effectively improves the acceptance and use experience of low-content nicotine e-liquid.
  • the tobacco-flavored electronic cigarette liquid described in this embodiment can effectively improve the absorption experience of low-nicotine content e-liquid products by adjusting the mass ratio of nicotine to organic acid to between 10:2.5 and 10:4, and by screening suitable organic acids for combination, and effectively improve the nicotine absorption of tobacco-flavored e-liquid, thereby enhancing the user's satisfaction experience.

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Abstract

L'invention divulgue une préparation liquide de nicotine permettant de produire un aérosol inhalable, et divulgue en outre un procédé de production d'un aérosol inhalable, un atomiseur et un dispositif d'atomisation électronique. Selon la préparation liquide de nicotine, un rapport entre la nicotine et un acide organique est optimisé, puis une régulation est effectuée, de façon à obtenir une préparation liquide de nicotine ayant un pH de 7,0 à 8,0. La préparation liquide de nicotine a un taux d'absorption de nicotine plus rapide dans le sang, de sorte que l'expérience de satisfaction de vapotage d'une cigarette électronique puisse être améliorée de manière significative, et l'expérience de satisfaction apportée par le liquide à vapoter avec une faible teneur en nicotine de 2 % permet d'atteindre la sensation produite par un liquide à vapoter avec un niveau d'ajout de 3 %, ce qui permet d'améliorer efficacement l'expérience de l'utilisateur et les sensations pour un liquide à vapoter à faible teneur en nicotine.
PCT/CN2022/135957 2022-12-01 2022-12-01 Préparation liquide de nicotine permettant de produire un aérosol inhalable et son utilisation WO2024113315A1 (fr)

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