WO2024108597A1 - Appareil et procédé de test chimique à sec - Google Patents

Appareil et procédé de test chimique à sec Download PDF

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Publication number
WO2024108597A1
WO2024108597A1 PCT/CN2022/134492 CN2022134492W WO2024108597A1 WO 2024108597 A1 WO2024108597 A1 WO 2024108597A1 CN 2022134492 W CN2022134492 W CN 2022134492W WO 2024108597 A1 WO2024108597 A1 WO 2024108597A1
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WIPO (PCT)
Prior art keywords
test paper
color block
dry chemical
image
chemical test
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PCT/CN2022/134492
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English (en)
Chinese (zh)
Inventor
翁少葵
张普
李学荣
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
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Priority to PCT/CN2022/134492 priority Critical patent/WO2024108597A1/fr
Publication of WO2024108597A1 publication Critical patent/WO2024108597A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/90—Determination of colour characteristics

Definitions

  • the present invention relates to the technical field of dry chemical detection, and in particular to a dry chemical detection device and a dry chemical detection method.
  • Dry chemical testing is a routine screening test currently used by clinical laboratories in hospitals. Take the dry chemical test of urine as an example. Through the use of dry chemical urine analyzer and dry chemical multi-urinalysis test strips, common chemical and physical components in urine can be quickly detected. Due to the advantages of fast speed, low cost and easy operation, dry chemical testing has become an important screening technology for routine tests such as urine and is widely used in clinical testing.
  • the present invention provides a dry chemical detection device and a dry chemical detection method, which are described in detail below.
  • an embodiment provides a dry chemical detection device, including: a plurality of test paper areas, a carrying component, a sample adding component, a driving component, an imaging component, and a processor;
  • the plurality of test paper areas include a sample addition area
  • the bearing component is used to place the dry chemical test paper located in the test paper area, the dry chemical test paper includes a first dry chemical test paper, the first dry chemical test paper has one or more color blocks, each color block corresponds to a test item;
  • the driving component is used to drive the carrying component so that the dry chemical test paper placed on the carrying component is transported along a preset direction in the plurality of test paper areas;
  • the sample adding component is used to add the biological sample to be tested to the target color block in the first dry chemical test paper conveyed to the sample adding area;
  • the imaging component comprises a global camera, the shooting field of the global camera can cover at least two test paper areas among the multiple test paper areas, and the global camera is used to shoot the first dry chemical test paper to obtain at least two images of the first dry chemical test paper at different shooting times; and
  • the processor is configured to:
  • the detection results of the test items corresponding to the target color block are calculated.
  • an embodiment provides a dry chemical detection device, including: a carrying component, a sample adding component, an imaging component and a processor;
  • the bearing component is used to place dry chemical test paper, the dry chemical test paper includes a first dry chemical test paper, the first dry chemical test paper has one or more color blocks, each color block corresponds to a test item;
  • the sample adding component is used to add the biological sample to be tested to the color block of the first dry chemical test paper
  • the imaging component is used to photograph the first dry chemical test paper after the sample adding component adds the biological sample to the target color block of the first dry chemical test paper, so as to obtain a plurality of images; wherein the plurality of images at least include a first image and a second image, and the first image and the second image are photographed at different times;
  • the processor is used to:
  • the color block information of the target color block of the first dry chemical test paper at different times is determined at least according to the first image and the second image, and the detection result of the test item corresponding to the target color block is calculated based on the color block information of the target color block at different times.
  • the processor determines the color block information of the target color block of the first dry chemical test paper at different times based on at least the first image and the second image, including:
  • the preset first area corresponds to the target color block of the first dry chemical test paper
  • Image information in a preset second area of the second image is used as second color block information of the target color block, and the preset second area corresponds to the target color block of the first dry chemical test paper.
  • the processor determines the color block information of the target color block of the first dry chemical test paper at different times at least according to the first image and the second image, it further includes:
  • the preset first area and the preset second area are acquired according to the test paper type of the first dry chemical test paper.
  • the imaging component is further used to photograph the first dry chemical test paper to obtain a third image before the sample adding component adds the biological sample to be tested to the target color block of the first dry chemical test paper;
  • the processor is also used to perform abnormality judgment on the first dry chemical test paper based on the third image, and the abnormality includes at least one of a first type of abnormality and a second type of abnormality; the first type of abnormality is used to indicate that the first dry chemical test paper is unusable, and the second type of abnormality is used to indicate that there is a deviation in the position of at least one color block in the first dry chemical test paper.
  • the processor determines the color block information of the target color block of the first dry chemical test paper at different times according to at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block based on the color block information of the target color block at different times, including:
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component comprises a global camera, the shooting field of the global camera can cover at least two test paper areas among the multiple test paper areas, and the global camera is used to shoot the dry chemical test paper located in the at least two test paper areas.
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that when the first dry chemical test paper is conveyed in the at least two test paper areas covered by the shooting field of view of the global camera, it can be photographed by the global camera to obtain the first image and the second image;
  • the processor determines the first image, including:
  • For an image at any shooting moment determine the position of the first dry chemical test paper in the image at any shooting moment according to the second preset period, the any shooting moment, and the test paper area where the target color block of the first dry chemical test paper is located when the biological sample to be tested is added, and obtain color block information of the target color block in the first dry chemical test paper from the image at any shooting moment according to the position of the first dry chemical test paper in the image at any shooting moment and the position of the target color block on the first dry chemical test paper, so as to calculate the color feature difference between the color block information of the target color block in the first dry chemical test paper in images at different shooting moments, so as to determine the first image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the global camera is used to photograph the dry chemical test paper located in the at least two test paper areas, including:
  • the global camera periodically photographs the dry chemical test paper located in the at least two test paper areas at a first preset period; wherein the second preset period is an integer multiple of the first preset period.
  • the dry chemical test paper placed on the carrying component is relatively stationary with respect to the imaging component, so that when the first dry chemical test paper is in any one of the at least two test paper areas covered by the shooting field of view of the global camera, it can be photographed to obtain the first image and the second image;
  • the processor determines the first image, including:
  • For an image at any shooting moment determine the position of the first dry chemical test paper in the image at any shooting moment according to the test paper area where the first dry chemical test paper is located, and obtain color block information of the target color block in the first dry chemical test paper from the image at any shooting moment according to the position of the first dry chemical test paper in the image at any shooting moment and the position of the target color block on the first dry chemical test paper, thereby calculating the color feature difference between the color block information of the target color block in the first dry chemical test paper in images at different shooting moments, so as to determine the first image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the first dry chemical test paper has a test paper mark
  • the processor determines the first image, including:
  • the color block information of the target color block in the first dry chemical test paper is obtained from the image at any shooting time, so as to calculate the color feature difference between the color block information of the target color block in the first dry chemical test paper in the images at different shooting times, so as to determine the first image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component includes at least two local cameras, the shooting field of view of each local camera is one test paper area among the multiple test paper areas, and the test paper areas corresponding to the shooting fields of different local cameras are different; each local camera is used to shoot the dry chemical test paper on the test paper area corresponding to its own shooting field of view.
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that when the first dry chemical test paper is conveyed between the test paper areas corresponding to the shooting fields of the local cameras, it can be photographed by the corresponding local cameras to obtain the first image and the second image;
  • the processor determines the first image, including:
  • the any shooting moment and the test paper area where the target color block of the first dry chemical test paper is located when the biological sample to be tested is added determining the test paper area where the first dry chemical test paper is located at the any shooting moment;
  • a corresponding local camera is determined from the at least two local cameras included in the imaging component, and an image captured by the local camera at any of the shooting moments is acquired, and color block information of a target color block in the first dry chemical test paper is determined from the image according to the position of the target color block on the first dry chemical test paper, thereby calculating a color feature difference between the color block information of the target color block in the first dry chemical test paper in images at different shooting moments, so as to determine the first image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • each local camera is used to photograph the dry chemical test paper on the test paper area corresponding to the respective shooting field of view, including:
  • Each local camera synchronously and periodically photographs the dry chemical test paper on the test paper area corresponding to its own photographing field of view in a first preset period; wherein the second preset period is an integer multiple of the first preset period.
  • the dry chemical test paper placed on the carrying component is relatively stationary with respect to the imaging component, so that when the first dry chemical test paper is in the test paper area corresponding to the shooting field of view of any local camera, it can be photographed by the corresponding local camera to obtain the first image and the second image;
  • the processor determines the first image, including:
  • the color block information of the target color block is determined from the image of the target local camera at the any shooting time, so as to calculate the color feature difference between the color block information of the target color block in the first dry chemical test paper in images at different shooting times, so as to determine the first image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the processor determines the color block information of the target color block of the first dry chemical test paper at different times according to at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block based on the color block information of the target color block at different times, including:
  • the first image is an image captured by the imaging component after the target color block of the first dry chemical test paper is added with the biological sample to be tested and after a set reaction time;
  • the imaging component is used to photograph the first dry chemical test paper after the sample adding component adds the biological sample to the target color block of the first dry chemical test paper to obtain a plurality of images, including:
  • the set reaction time is the time corresponding to M first preset cycles after the target color block of the first dry chemical test paper is added with the biological sample to be tested; accordingly, the first image is an image obtained by taking the target color block of the first dry chemical test paper after the biological sample to be tested is added and after M first preset cycles, wherein M is a preset positive integer.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component comprises a global camera, the shooting field of the global camera can cover at least two test paper areas among the multiple test paper areas, and the global camera is used to shoot the dry chemical test paper located in the at least two test paper areas.
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that when the first dry chemical test paper is conveyed in the at least two test paper areas covered by the shooting field of view of the global camera, it can be photographed by the global camera to obtain the first image and the second image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the global camera is used to photograph the dry chemical test paper located in the at least two test paper areas, including:
  • the global camera periodically photographs the dry chemical test paper located in the at least two test paper areas with a first preset period; wherein the second preset period is an integer multiple of the first preset period.
  • the dry chemical test paper placed on the carrying component is relatively stationary with respect to the imaging component, so that when the first dry chemical test paper is in any one of the at least two test paper areas covered by the shooting field of view of the global camera, it can be photographed to obtain the first image and the second image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the first dry chemical test paper has a test paper mark
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • the second color block information is determined from the second image according to the position of the first dry chemical test paper in the second image and the position of the target color block on the first dry chemical test paper.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component includes at least two local cameras, the shooting field of view of each local camera is one test paper area among the multiple test paper areas, and the test paper areas corresponding to the shooting fields of different local cameras are different; each local camera is used to shoot the dry chemical test paper on the test paper area corresponding to its own shooting field of view.
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that when the first dry chemical test paper is conveyed between the test paper areas corresponding to the shooting fields of the local cameras, it can be photographed by the corresponding local cameras to obtain the first image and the second image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • each local camera is used to photograph the dry chemical test paper on the test paper area corresponding to the respective shooting field of view, including:
  • Each local camera synchronously and periodically photographs the dry chemical test paper on the test paper area corresponding to its own photographing field of view in a first preset period; wherein the second preset period is an integer multiple of the first preset period.
  • the dry chemical test paper placed on the carrying component is relatively stationary with respect to the imaging component, so that when the first dry chemical test paper is in the test paper area corresponding to the shooting field of view of any local camera, it can be photographed by the corresponding local camera to obtain the first image and the second image;
  • the processor determines first color block information of the target color block from the first image, including:
  • the processor determines second color block information of the target color block from the second image, including:
  • second color block information of the target color block is determined from the second image.
  • the processor calculates the detection result of the test item corresponding to the target color block based on at least the first color block information and the second color block information, including:
  • the dry chemical detection device determines the detection result of the test item corresponding to the target color block according to the comparison result, comprising:
  • the processor determines the standard detection result corresponding to the standard color curve having the highest similarity with the actual color curve among the plurality of standard color curves as the detection result of the test item corresponding to the target color block.
  • the processor determines the color block information of the target color block of the first dry chemical test paper at different times according to at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block based on the color block information of the target color block at different times, including:
  • the matching fails: continuing to generate the actual color change of the target color block of the first dry chemical test paper and performing the matching;
  • the match is successful: the standard test result corresponding to the standard color curve among the multiple standard color curves whose similarity with the actual color curve is greater than the target threshold is determined as the test result of the test item corresponding to the target color block, and the generation of the actual color change of the target color block of the first dry chemical test paper and the matching are stopped.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component comprises a global camera, the shooting field of the global camera can cover at least two of the multiple test paper areas, and the global camera is used to shoot the dry chemical test paper in the at least two test paper areas;
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that the first dry chemical test paper can be photographed by the global camera when being conveyed in the at least two test paper areas covered by the shooting field of view of the global camera;
  • the processor starts from the image captured at the Kth capturing moment of the first dry chemical test paper, and generates an actual color change of the target color block of the first dry chemical test paper according to the image captured at the capturing moment and part or all of the images captured of the first dry chemical test paper before the capturing moment, including:
  • the color block information of the target color block is determined from the image at the i-th shooting moment.
  • the global camera is used to photograph the dry chemical test paper in the at least two test paper areas, including:
  • the global camera periodically photographs the dry chemical test paper located in the at least two test paper areas at a first preset period; wherein the second preset period is an integer multiple of the first preset period.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component includes at least two local cameras, the shooting field of each local camera is one of the multiple test paper areas, and the test paper areas corresponding to the shooting fields of different local cameras are different; each local camera is used to shoot the dry chemical test paper on the test paper area corresponding to its shooting field;
  • the carrying component includes a conveying component and a power mechanism, and the conveying component is driven by the power mechanism to periodically convey the dry chemical test paper thereon along a preset direction at a second preset period, so as to drive the dry chemical test paper to be conveyed in the plurality of test paper areas along the preset direction, so that when the first dry chemical test paper is conveyed between the test paper areas corresponding to the shooting fields of the local cameras, it can be photographed by the corresponding local cameras;
  • the processor starts from the image captured at the Kth capturing time of the first dry chemical test paper, and generates an actual color change of the target color block of the first dry chemical test paper according to the image captured at the capturing time and part or all of the images captured of the first dry chemical test paper before the capturing time, including:
  • the corresponding local camera is determined from the at least two local cameras included in the imaging component, and the image taken by the local camera at the i-th shooting moment is obtained, and according to the position of the target color block on the first dry chemical test paper, the color block information of the target color block is determined from the image at the i-th shooting moment.
  • the processor calculates the detection result of the test item corresponding to the target color block based on the color block information of the target color block at different times, including:
  • the color block information of the target color block at different times is input into a pre-established machine learning model to obtain the detection result of the test item corresponding to the target color block through the machine learning model.
  • the dry chemical detection device further includes a plurality of test paper areas for placing dry chemical test papers; and,
  • the imaging component includes a global camera, the shooting field of the global camera can cover at least two test paper areas among the multiple test paper areas, and the global camera is used to shoot the dry chemical test paper located in the at least two test paper areas.
  • the dry chemical test paper further comprises a second dry chemical test paper, wherein the second dry chemical test paper has one or more color blocks, each color block corresponding to a test item;
  • the global camera is used to shoot to obtain the first image and the fourth image, the first image and the fourth image are shot at different times; the first image and the fourth image both contain the second dry chemical test paper; the processor further determines the color block information of a color block of the second dry chemical test paper at different times based on at least the first image and the fourth image, and calculates the detection result of the test item corresponding to the color block based on the color block information of the color block at different times;
  • the global camera is used to shoot to obtain the second image and the fourth image, and the shooting time of the second image and the fourth image is different; the processor also determines the color block information of a color block of the second dry chemical test paper at different times based on at least the second image and the fourth image, and calculates the detection result of the test item corresponding to the color block based on the color block information of the color block at different times.
  • the biological sample to be tested includes a urine sample, a body fluid sample and/or a vaginal secretion.
  • an embodiment provides a dry chemical detection method, comprising:
  • the driving component drives the bearing component so that the dry chemical test paper placed on the bearing component is transferred in a plurality of test paper areas along a preset direction; wherein the plurality of test paper areas include a sample addition area, the dry chemical test paper includes a first dry chemical test paper, the first dry chemical test paper has one or more color blocks, and each color block corresponds to a test item;
  • the sample adding component adds the biological sample to the target color block of the first dry chemical test paper
  • the first dry chemical test paper is photographed by a global camera to obtain at least two images of the first dry chemical test paper at different photographing times;
  • the detection results of the test items corresponding to the target color block are calculated.
  • an embodiment provides a dry chemical detection method, comprising:
  • the dry chemical test paper comprises a first dry chemical test paper, the first dry chemical test paper has one or more color blocks, each color block corresponds to a test item;
  • the sample adding component adds the biological sample to the target color block of the first dry chemical test paper
  • the first dry chemical test paper is photographed by an imaging component to obtain a plurality of images; wherein the plurality of images include at least a first image and a second image, wherein the first image and the second image are photographed at different times;
  • the color block information of the target color block of the first dry chemical test paper at different times is determined at least according to the first image and the second image, and the detection result of the test item corresponding to the target color block is calculated based on the color block information of the target color block at different times.
  • the actual color of the target color block at different times is obtained based on at least two images of the first dry chemical test paper taken at different times, and the detection result of the test item corresponding to the target color block is calculated based on the actual color of the target color block at different times, so that the detection result is more accurate.
  • FIG1 is a schematic diagram of a dry chemical test paper according to an embodiment
  • FIG. 2( a ) is a schematic diagram of the structure of a dry chemical detection device according to an embodiment
  • FIG. 2( b ) is a schematic diagram of the structure of a dry chemical detection device according to an embodiment
  • FIG3 is a schematic structural diagram of a dry chemical detection device according to an embodiment
  • FIG4 is a schematic structural diagram of a dry chemical detection device according to an embodiment
  • FIG. 5( a ) is a schematic diagram of the structure of a dry chemical detection device according to an embodiment
  • FIG. 5( b ) is a schematic diagram of the structure of a dry chemical detection device according to an embodiment
  • FIG6 is a schematic diagram of a flow chart of a dry chemical detection method according to an embodiment
  • FIG. 7 is a flowchart of an embodiment of determining color block information of a target color block of a first dry chemical test paper at different times based on at least a first image and a second image, and calculating a test result of a test item corresponding to the target color block based on the color block information of the target color block at different times;
  • FIG8 is a schematic flow chart of a dry chemical detection method according to an embodiment
  • FIG. 9( a ) is a schematic diagram of a process of determining a first image according to an embodiment
  • FIG. 9( b ) is a schematic diagram of a process of determining a first image according to an embodiment
  • FIG10 is a schematic diagram of a flow chart of a dry chemical detection method according to an embodiment
  • FIG. 11( a ) is a schematic diagram of a process of determining a first image according to an embodiment
  • FIG. 11( b ) is a schematic diagram of a process of determining a first image according to an embodiment
  • FIG. 12 is a flowchart of an embodiment of determining color block information of a target color block of a first dry chemical test paper at different times based on at least a first image and a second image, and calculating a test result of a test item corresponding to the target color block based on the color block information of the target color block at different times;
  • FIG13(a) is a flow chart of determining first color block information of a target color block from a first image according to an embodiment
  • FIG13(b) is a flow chart of determining first color block information of a target color block from a first image according to an embodiment
  • FIG13(c) is a flow chart of determining first color block information of a target color block from a first image according to an embodiment
  • FIG13(d) is a flow chart of determining first color block information of a target color block from a first image according to an embodiment
  • FIG14 is a schematic diagram of a flow chart of calculating a test result of a test item corresponding to a target color block based on at least the first color block information and the second color block information according to an embodiment
  • FIG15 is a flowchart of an embodiment of determining color block information of a target color block of a first dry chemical test paper at different times based on at least a first image and a second image, and calculating a test result of a test item corresponding to the target color block based on the color block information of the target color block at different times;
  • FIG. 16 is a schematic flow chart of a dry chemical detection method according to an embodiment.
  • connection and “coupling” mentioned in this application include direct and indirect connections (couplings) unless otherwise specified.
  • Dry chemical testing is relative to wet chemical testing. Dry chemical testing refers to adding a sample to be tested (e.g., a sample in a flowing or liquid state) to a reagent strip specifically produced for different test items. A plurality of color blocks are generally arranged on the reagent strip, and each color block corresponds to a test item. When the sample to be tested is added to the color block, a specific chemical reaction will occur with the reagent on the color block, thereby causing the color of the color block to change.
  • the reagent strip can generally be referred to as a dry chemical test paper.
  • FIG1 is a schematic diagram of a dry chemical test paper.
  • the dry chemical test paper 90 includes a plurality of color blocks 99 (seven color blocks 99 in the figure), for example, a plurality of color blocks 99 are sequentially distributed along the length direction (or axial direction) of the dry chemical test paper 90; each color block 99 includes a pre-set reagent, so that each color block 99 can indicate the test result of a test item after reacting with the sample to be tested.
  • the types of test items include but are not limited to test items such as red blood cell count and white blood cell count.
  • the position of each color block 99 in the dry chemical test paper is determined.
  • dry chemical test strips generally have multiple color blocks, each color block corresponds to a test item; in actual situations, the optimal reaction time of each color block may be inconsistent; for example, taking the dry chemical test strips that can include more than ten test items such as white blood cells, urobilinogen, protein, glucose, etc.
  • the optimal reaction time of each item on the strips of some manufacturers is inconsistent - for example, the optimal reaction time of the color blocks of the same test item of dry chemical test strips from different manufacturers is inconsistent, for another example, the optimal reaction time of the color blocks of different test items of dry chemical test strips from different manufacturers is inconsistent, and for another example, a specific dry chemical test strip from the same manufacturer has color blocks with different optimal reaction times; a specific example is: in some dry chemical test strips, the optimal time for the white blood cell item is 120s, while the optimal reaction time for other items is 60s.
  • the dry chemical detection device adds samples to the dry chemical test paper in the same sample addition area
  • the dry chemical test paper will continue to be transported in a certain direction, and then all test items on the dry chemical test paper will be tested simultaneously at a fixed detection time (or detection area). This causes the test items corresponding to some color blocks on the dry chemical test paper to not be tested within their optimal reaction time, which often leads to inaccurate test results.
  • the specific color block when it comes to a specific color block on a dry chemical test paper, the specific color block will be photographed at a detection time (or a detection area), and the color block information (such as color information) will be extracted based on the image captured at this moment, and the detection result of the corresponding test item will be calculated; or, further, the specific color block will be photographed multiple times at different time points, and then an image will be selected from it, and the color block information will be provided from the selected image, and the detection result of the corresponding test item will be calculated; however, when all conditions are normal, inaccurate detection results of the color blocks will still occur.
  • the color block information such as color information
  • images of the color block at at least two different times are obtained to extract the color block information of the color block at at least two different times, and the detection result of the test item corresponding to the color block is calculated based on the color block information of the color block at at least two different times.
  • calculating the test result of the test item corresponding to the color block through the color block information at least two different times of the color block means that the color block information at least two different times actually and directly participates in the calculation of the test result.
  • the color block information at least two different times is used to jointly characterize the reaction process of the color block. They are intrinsically related to each other.
  • the dry chemical detection device is first described below.
  • the dry chemical detection device in some embodiments includes a carrying component 10, a sample adding component 30, an imaging component 50 and a processor 70; please refer to Figure 2(b), the dry chemical detection device in some embodiments also includes a test paper area 20, which is described in detail below.
  • the supporting component 10 is used to place the dry chemical test paper 90.
  • the concept of the test paper area 20 can be introduced, and the supporting component 10 is used to place the dry chemical test paper 90 located in the test paper area 20.
  • One test paper area 20 can hold one dry chemical test paper 90.
  • the dry chemical detection device can include one or more test paper areas 20.
  • the figure shows a schematic diagram of a dry chemical detection device including 10 test paper areas 20.
  • the supporting component 10 includes a conveying component 11 and a power mechanism 13.
  • the conveying component 11 is driven by the power mechanism 13 to convey the dry chemical test paper 90 thereon along a preset direction, so as to drive the dry chemical test paper 90 to be conveyed along the preset direction in multiple test paper areas 20 included in the dry chemical detection device, for example, from one test paper area 20 to the next test paper area 20 in the preset direction; more specifically, the dry chemical test paper 90 can be transported in this way: the dry chemical test paper 90 is transported to a test paper area 20, stays for a period of time, and then is transported from the current test paper area 20 to the next test paper area 20 along the preset direction.
  • the conveying component 11 is driven by the power mechanism 13 to periodically convey the dry chemical test paper 90 thereon along a preset direction with a second preset period, so as to drive the dry chemical test paper 90 to be conveyed along the preset direction in the multiple test paper areas 20 included in the dry chemical detection device; more specifically, the dry chemical test paper 90 can be transported in this way: the dry chemical test paper 90 is conveyed to a test paper area 20 and stays for a period of time, and then is conveyed from the current test paper area 20 to the next test paper area 20 along the preset direction, wherein the time interval from the dry chemical test paper 90 entering one test paper area 20 to entering the next test paper area 20 is the above-mentioned second preset period, or the time interval from the dry chemical test paper 90 leaving one test paper area 20 to leaving the next test paper area 20 is the above-mentioned second preset period.
  • the dry chemical test paper 90 placed on the carrier 10 is relatively stationary with the imaging component 50.
  • the imaging component 50 does not move, so if the dry chemical test paper 90 placed on the carrier 10 is relatively stationary with the imaging component 50, the dry chemical test paper 90 placed on the carrier 10 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20.
  • the situation where the supporting component 10 includes the transmission component 11 and the power mechanism 13 is referred to as a dynamic scene
  • the situation where the dry chemical test paper 90 placed on the supporting component 10 and the imaging component 50 are relatively still is referred to as a static scene.
  • the dry chemical detection device also includes a driving component 10a, and the driving component 10a is used to drive the carrying component 10 so that the dry chemical test paper 90 placed on the carrying component 10 is transported in a preset direction in multiple test paper areas 20; it can be understood that the driving component 10a and the carrying component 10 are two components divided according to the functions they implement, which implement the dynamic scene referred to in this article, so the driving component 10a and the carrying component 10 can also be divided into the same component.
  • the carrying component 10 includes the above-mentioned conveying component 11 and the power mechanism 13, so the conveying component 11 is driven by the power mechanism 13 to convey the dry chemical test paper 90 thereon in a preset direction to drive the dry chemical test paper 90 to be transported in the preset direction in the multiple test paper areas 20 included in the dry chemical detection device.
  • the driving component 10a drives the carrying component 10 so that the dry chemical test paper 90 carried by the carrying component 10 is transported in multiple test paper areas 20.
  • the sample adding component 30 is used to add the biological sample to be tested to the color block 99 on the dry chemical test paper 90.
  • the sample adding component 30 is used to add the biological sample to be tested to the color block 99 on the dry chemical test paper 90 located on the carrier component 10; in other words, the sample adding component 30 is used to add the biological sample to be tested to the color block 99 on the dry chemical test paper 90 located in the test paper area 20 - the corresponding test paper area 20 can be called the sample adding area 21.
  • the sample adding component 30 can complete the sample adding action - that is, the action of adding the biological sample to be tested to the color block 99 of the dry chemical test paper 90 - under the control of the processor 70.
  • the biological sample to be tested includes a urine sample, a body fluid sample and/or a vaginal secretion.
  • the imaging component 50 is used to capture images, for example, to capture images of part or all of the dry chemical test paper 90 located on the supporting component 10, or to capture images of the dry chemical test paper 90 located in all or part of the test paper area 20.
  • the imaging component 50 periodically photographs the dry chemical test paper 90 at a first preset period, for example, once every T seconds.
  • the second preset period is an integer multiple of the first preset period, and the integer multiple may be 1 or more times; for example, the second preset period is 10s, and the first preset period is also 10s, and for another example, the second preset period is 20 or 30s, and the first preset period is 10s.
  • the imaging component 50 includes a global camera 51
  • the shooting field of the global camera 51 can cover at least two test paper areas 20 of the multiple test paper areas 20 included in the dry chemical detection device
  • the global camera 51 is used to shoot the dry chemical test paper 90 located in the at least two test paper areas.
  • the shooting field of the global camera 51 can cover all test paper areas 20 included in the dry chemical detection device.
  • the global camera 51 periodically photographs the dry chemical test paper 90 located in the at least two test paper areas 20 at a first preset period, for example, once every T seconds; in some embodiments, the second preset period is an integer multiple of the first preset period, and the integer multiple can be 1 or more times; for example, the second preset period is 10s, and the first preset period is also 10s, and for another example, the second preset period is 20 or 30s, and the first preset period is 10s.
  • the imaging component 50 includes a plurality of local cameras 53, for example, at least two local cameras 53; the shooting field of each local camera 53 is one of the multiple test paper areas 20 included in the dry chemical detection device, and the test paper areas 20 corresponding to the shooting fields of different local cameras 53 are different; each local camera 53 is used to shoot the dry chemical test paper 90 in the test paper area 20 corresponding to the shooting field of each local camera 53.
  • the number of local cameras 53 is the same as the number of test paper areas 20 included in the dry chemical detection device, that is, each test paper area 20 corresponds to a local camera 53.
  • each local camera 53 synchronously and periodically photographs the dry chemical test paper 90 in the test paper area 20 corresponding to its respective shooting field of view with a first preset period, for example, each local camera synchronously (or simultaneously) photographs once every T seconds;
  • the second preset period is an integer multiple of the first preset period, and the integer multiple can be 1 or more times; for example, the second preset period is 10s, and the first preset period is also 10s, and for another example, the second preset period is 20 or 30s, and the first preset period is 10s.
  • the processor 70 can obtain the image captured by the imaging component 50, and determine the color block information of the color block on the dry chemical test paper 90 from the image, thereby obtaining the test result of the test item corresponding to the color block 99.
  • the color block information herein refers to color-related information, such as RGB values.
  • the dry chemical test paper 90 includes a first dry chemical test paper 91, or at least one dry chemical test paper 90 is the first dry chemical test paper 91, and the first dry chemical test paper 91 has one or more color blocks 99, each color block 99 corresponding to a test item.
  • the sample adding component 30 is used to add the biological sample to be tested to the color block 99 of the first dry chemical test paper 91.
  • one of the color blocks 99 may be referred to as the target color block 99.
  • the imaging component 50 is used to shoot the first dry chemical test paper 91 after the sample adding component 30 adds the biological sample to be tested to the target color block 99 of the first dry chemical test paper 91, so as to obtain multiple images; wherein, the multiple images include at least a first image and a second image, and the shooting time of the first image and the second image is different.
  • the processor 70 obtains the first image and the second image, and determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times at least according to the first image and the second image, and calculates the detection result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times.
  • the “calculation” involved in “calculating the test results of the test items corresponding to the target color block 99 based on the color block information of the target color block 99 at different times”, or “calculating the test results of the test items corresponding to the target color block 99 based on the color block information of the target color block 99 at different times” essentially means that the color block information of the target color block 99 at at least two different times actually and directly participates in the calculation of the test results, and the color block information of the target color block 99 at at least two different times is used to jointly characterize the reaction process of the target color block 99, which are intrinsically related to each other, and they are combined to characterize the reaction process of the target color block 99 at any time.
  • the color information of the target color block 99 that changes with time during the reaction process, it is possible to obtain the color information of the standard concentration of the biological sample to be tested that is similar or identical to the color information of the target color block 99 during the reaction process after the biological sample is added to the target color block 99, thereby obtaining the test result of the test item corresponding to the target color block 99; calculating the test result of the test item corresponding to the target color block 99 through the color information of the target color block 99 at at least two different moments does not mean selecting the color information of one moment from the color information of at least two moments, and finally calculating the test result of the test item corresponding to the target color block 99 through the color information of this moment; this will be further explained below.
  • One solution may be to preset two test paper areas 20 for the first dry chemical test paper 91, especially in a dynamic scene, when the first dry chemical test paper 91 reaches the two test paper areas 20 in turn, the imaging component 50 shoots the first dry chemical test paper 91, and the two test paper areas 20 essentially correspond to two shooting moments; therefore, two shooting moments may be preset for the first dry chemical test paper 91 in advance, so that the first dry chemical test paper is preset to correspond to two test paper areas 20, so that the position of the first dry chemical test paper 91 in the image taken at the two shooting moments may be predetermined, and since the position of the target color block 99 on the first dry chemical test paper 91 is determined, the position of the target color block 99 in the image taken at the two shooting moments may be predetermined.
  • one of the above-mentioned two preset shooting moments may generally be selected as the reaction end moment or the basic reaction end moment of the target color block 99, and the other shooting moment is taken before the reaction end moment or the basic reaction end moment of the target color block 99 and after the addition of the biological sample to be tested. Therefore, the two test paper areas 20 corresponding to the first dry chemical test paper 91 or more precisely the target color block 99 are actually mostly determined by the type of the target color block 99, and generally, the type of the target color block 99 can be obtained by the test paper type of the first dry chemical test paper 91. Further expanded, for any dry chemical test paper 90, two corresponding areas can be preset for any color block 99 thereon, and the color block information can be extracted from the two images based on the two areas.
  • the processor 70 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, including: using the image information located in the preset first area in the first image as the first color block information of the target color block 99, and the preset first area corresponds to the target color block 99 of the first dry chemical test paper 91; using the image information located in the preset second area in the second image as the second color block information of the target color block 99, and the preset second area corresponds to the target color block 99 of the first dry chemical test paper 91.
  • the processor 70 can obtain the preset area corresponding to each color block 99 on the dry chemical test paper 90 by the test paper type of the dry chemical test paper 90.
  • the test paper type may refer to the number of color blocks and/or the type of color blocks (i.e., the test items corresponding to the color blocks) of the dry chemical test paper 90. It can be understood that the processor 70 can obtain the test paper type of the dry chemical test paper 90 by scanning the dry chemical test paper 90 through a scanner, etc., or can obtain the test paper type of the dry chemical test paper 90 by the test paper type of the dry chemical test paper 90 input by the operator through an input tool.
  • the processor 70 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, it also includes: obtaining the test paper type of the first dry chemical test paper 91; according to the test paper type of the first dry chemical test paper 91, obtaining the above-mentioned preset first area and the above-mentioned preset second area.
  • the dry chemical detection device can also photograph the dry chemical test paper 90 before adding the biological sample to be tested to the dry chemical test paper 90 to determine whether there is any abnormality in the dry chemical test paper 90. Therefore, in some embodiments, the imaging component 50 is also used to photograph the first dry chemical test paper 91 before the sample adding component 30 adds the biological sample to be tested to the target color block 99 of the first dry chemical test paper 91 to obtain a third image; the processor 70 is also used to judge the abnormality of the first dry chemical test paper 91 according to the third image, and the abnormality includes at least one of the first type of abnormality and the second type of abnormality; the first type of abnormality is used to indicate that the first dry chemical test paper 91 is unusable, and the second type of abnormality is used to indicate that there is a deviation in the position of at least one color block 99 in the first dry chemical test paper 91.
  • the first type of abnormality may specifically be that at least one color block in the first dry chemical test paper 91 is unusable, including but not limited to the color block being bent, falling off, or being affected by moisture, causing the original color of the color block to change, all of which will cause abnormalities in subsequent test results.
  • the second type of abnormality may specifically be that the position of the first dry chemical test paper 91 in its width direction is not as expected, the first dry chemical test paper 91 is placed incorrectly, and/or there is a deviation in the position of at least one color block in the first dry chemical test paper 91 in its length direction.
  • the position of the first dry chemical test paper 91 in its width direction is not as expected, which means that the first dry chemical test paper 91 is offset in the position of the bearing component 10 or the test paper area 20 in the width direction, etc., which will cause the biological sample to be tested to not drip on the color block 99 or drip on the edge of the color block 99 when adding the biological sample to be tested to the first dry chemical test paper 91.
  • the incorrect placement of the first dry chemical test paper 91 includes but is not limited to inverted head and tail, etc.; the placement of the dry chemical test paper in the length direction is divided into "head and tail", and if the operator accidentally inverts the head and tail when placing the dry chemical test paper, the subsequent test results will naturally be abnormal. There is a deviation in the position of at least one color block in the first dry chemical test paper 91 in the length direction of the first dry chemical test paper 91.
  • the cause of this abnormality may be a defect in the manufacture of the test paper, such as too large a distance between adjacent color blocks. It may also be caused by the first dry chemical test paper 91 being displaced along its own length direction on the supporting component 10 or in the test paper area 20.
  • one is how to determine the first image and the second image, which is essentially how to select at least two representative images from multiple images of the target color block 99 at different times; the other is how to determine the color block information of the target color block 99 from the selected images.
  • the first image is determined by the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times, so that the color feature difference between the color block information of the target color block in the first image and the color block information of the target color block in at least one image shot before the first image is less than a set threshold value; wherein the color feature difference between the color block information of the target color block 99 at two different times is calculated, for example, it can be the difference in grayscale value represented by the color block information.
  • the first image selected in this way is generally an image of the target color block 99 shot at the time of reaction completion or basic reaction completion.
  • the processor 70 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including: calculating the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times to determine the first image, so that the color feature difference between the color block information of the target color block 99 in the first image and the color block information of the target color block 99 in at least one image shot before it is less than a set threshold; determining the second image, the shooting time of the second image is before the shooting time of the first image; determining the first color block information of the target color block 99 from the first image, and determining the second color block information of the target color block 99 from the second image, and calculating the detection result of the test item corresponding to the target color block 99 based on at least the
  • the following further describes how to determine the first image by using the color feature differences between the color block information of the target color block 99 in the first dry chemical test paper 91 in images at different shooting times, and how to determine the color block information of the target color block 99 in the image in conjunction with specific scenarios.
  • the imaging component 50 includes a global camera 51
  • the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed in multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, and when the first dry chemical test paper 91 is conveyed in the at least two test paper areas 20 covered by the shooting field of view of the global camera 51, it can be photographed by the global camera 51 to obtain a first image and a second image, for example, one of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a first image, and another test paper area 20 of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a second image.
  • the processor 70 determines the first image including: for an image at any shooting moment i, determining the position of the first dry chemical test paper 91 in the image at any shooting moment i according to the second preset period, the any shooting moment i, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, and obtaining the color block information of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting moment i according to the position of the first dry chemical test paper 91 in the image at any shooting moment i and the position of the target color block 99 on the first dry chemical test paper 91.
  • the color block information of the target color block 99 in the images at each shooting moment can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting moments can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the second preset period, the shooting time of the first image, and the test paper area 20 where the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the second preset period, the shooting time of the second image, and the test paper area 20 where the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second color block information of the target color block 99 from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes a global camera 51
  • the dry chemical test paper 90 placed on the carrying component 10 is relatively stationary with respect to the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in any of the at least two test paper areas covered by the shooting field of view of the global camera 51, it can be photographed to obtain the first image and the second image, for example, the first image is obtained at one time, and the second image is obtained at another time. It can be understood that since the first dry chemical test paper 91 is stationary and non-moving on the carrying component 10, the position of the first dry chemical test paper 91 in the first image and the second image is also the same and unchanged.
  • the processor 70 determines the first image including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; for an image at any shooting time i, determining the position of the first dry chemical test paper 91 in the image at any shooting time i according to the test paper area 20 where the first dry chemical test paper 91 is located, and obtaining the color block information of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i according to the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91.
  • the color block information of the target color block 99 in the images at each shooting time can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the test paper area 20 where the first dry chemical test paper 91 is located and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the test paper area 20 where the first dry chemical test paper 91 is located and the position of the target color block 99 on the first dry chemical test paper 91.
  • the position of the first dry chemical test paper 91 in the image can also be determined by the test paper mark, thereby determining the color block information of the target color block 99.
  • the first dry chemical test paper 91 has a test paper mark, which can be determined by image recognition to distinguish different dry chemical test papers; the processor 70 determines the first image including: for an image at any shooting time i, according to the test paper mark of the first dry chemical test paper 91, determining the position of the first dry chemical test paper 91 in the image at any shooting time i; obtaining the position of the target color block 99 on the first dry chemical test paper 91; according to the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91, obtaining the color block information of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i, in this way, the color block information of the target color block 99 in the image at each shooting time can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times can be calculated to determine the first image.
  • test paper marking scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the test paper mark of the first dry chemical test paper 91; determining the first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the first color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the test paper mark of the first dry chemical test paper 91; determining the second color block information of the target color block 99 from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes at least two local cameras 53, and the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed in multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, so that when the first dry chemical test paper 91 is conveyed between the test paper areas 20 corresponding to the shooting field of view of each local camera 53, it can be photographed by the corresponding local camera 53 to obtain a first image and a second image.
  • the processor 70 determines the first image including: for any shooting time i, determining the test paper area where the first dry chemical test paper 91 is located at the any shooting time i according to the second preset period, the any shooting time i and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the corresponding local camera 53 from the at least two local cameras included in the imaging component 50 according to the test paper area 20 where the first dry chemical test paper 91 is located at the any shooting time i, and obtaining the image captured by the local camera 53 at the any shooting time i, and determining the color block information of the target color block 99 in the first dry chemical test paper 91 from the image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the color block information of the target color block 99 in the images at each shooting time can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes at least two local cameras 53, and the dry chemical test paper 90 placed on the supporting component 10 is relatively stationary with respect to the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in the test paper area 20 corresponding to the shooting field of view of any local camera 53, it can be photographed by the corresponding local camera 53 to obtain the first image and the second image, for example, the first image is obtained by the same local camera 53 at one time, and the second image is obtained at another time.
  • the processor 70 determines the first image including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the target local camera 53 from the at least two local cameras included in the imaging component 50 according to the test paper area 20 where the first dry chemical test paper 91 is located; for the image at any shooting time i, according to the position of the target color block 99 on the first dry chemical test paper 91, determining the color block information of the target color block 99 from the target local camera 53 in the image at any shooting time i, in this way, the color block information of the target color block 99 in the image at each shooting time can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the above is some explanation on how to determine the first image by the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times, and how to determine the color block information of the target color block 99 in the image in combination with specific scenarios.
  • the target color block 99 corresponds to a set reaction time Ts. After the target color block 99 is added with the biological sample to be tested and after the set reaction time Ts has passed, the first dry chemical test paper 91 is photographed to obtain a first image.
  • the processor 70 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including: determining the first image, the first image is an image captured by the imaging component 50 after the target color block 99 of the first dry chemical test paper 91 is added with the biological sample to be tested and after a set reaction time Ts; determining the second image, the shooting time of the second image is before the shooting time of the first image; determining the first color block information of the target color block 99 from the first image, and determining the second color block information of the target color block 99 from the second image, and calculating the detection result of the test item corresponding to the target color block 99 based on at least the first color block information and the second color block information.
  • the set reaction time Ts can be timed by the shooting cycle of the imaging component 50.
  • the imaging component 50 periodically shoots the first dry chemical test paper 91 in a first preset cycle; the set reaction time Ts is the time corresponding to the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added, and accordingly, the first image is the image of the first dry chemical test paper 91 obtained by shooting the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added and after M first preset cycles, where M is a preset positive integer.
  • the following further describes how to determine the color block information of the target color block 99 from the first image taken by the imaging component 50 after the target color block 99 of the first dry chemical test paper 91 is added with the biological sample to be tested and after the set reaction time Ts, in conjunction with a specific scenario.
  • the imaging component 50 includes a global camera 51
  • the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed in multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, and when the first dry chemical test paper 91 is conveyed in the at least two test paper areas 20 covered by the shooting field of view of the global camera 51, it can be photographed by the global camera 51 to obtain a first image and a second image, for example, one of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a first image, and another test paper area 20 of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a second image.
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image based on the second preset cycle, the set reaction time Ts, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the first color block information of the target color block 99 from the first image based on the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image based on the second preset period, the shooting time of the second image, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second color block information of the target color block 99 from the second image based on the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes a global camera 51
  • the dry chemical test paper 90 placed on the carrying component 10 is relatively stationary with respect to the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in any of the at least two test paper areas covered by the shooting field of view of the global camera 51, it can be photographed to obtain the first image and the second image, for example, the first image is obtained at one time, and the second image is obtained at another time. It can be understood that since the first dry chemical test paper 91 is stationary and non-moving on the carrying component 10, the position of the first dry chemical test paper 91 in the first image and the second image is also the same and unchanged.
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the position of the first dry chemical test paper 91 in the first image based on the test paper area 20 where the first dry chemical test paper 91 is located; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the first color block information of the target color block 99 from the first image based on the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the position of the first dry chemical test paper 91 in the second image based on the test paper area 20 where the first dry chemical test paper 91 is located; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the second color block information of the target color block 99 from the second image based on the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the position of the first dry chemical test paper 91 in the image can also be determined by the test paper identification, thereby determining the color block information of the target color block 99. Therefore, in some embodiments, the first dry chemical test paper 91 has a test paper identification, which can be determined by image recognition to distinguish different dry chemical test papers.
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the test paper identification of the first dry chemical test paper 91; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the first color block information from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image based on the test paper identification of the first dry chemical test paper 91; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the second color block information from the second image based on the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes at least two local cameras 53, and the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed in multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, so that when the first dry chemical test paper 91 is conveyed between the test paper areas 20 corresponding to the shooting field of view of each local camera 53, it can be photographed by the corresponding local camera 53 to obtain a first image and a second image.
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: determining the first test paper area 20 of the first dry chemical test paper 91 in the test paper area when the biological sample to be tested is added and the set reaction time Ts is passed according to the second preset cycle, the set reaction time Ts and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, wherein the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added and the set reaction time Ts is passed; determining the first local camera 53 from the at least two local cameras 53 included in the imaging component 50 according to the first test paper area 20; obtaining the image taken by the first local camera 53 on the target color block 99 of the first dry chemical test paper 91 when the biological sample to be tested is added and the set reaction time Ts is passed as the first image; and determining the first color block information of the target color block 99 from the first image according to the position of the
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: determining the second test paper area 20 of the first dry chemical test paper 91 in the test paper area at the time of shooting the second image according to the second preset period, the shooting time of the second image and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second local camera 53 from the at least two local cameras 53 included in the imaging component 50 according to the second test paper area 20; acquiring the image shot by the second local camera 53 at the shooting time of the second image as the second image; and determining the second color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes at least two local cameras 53, and the dry chemical test paper 90 placed on the supporting component 10 is relatively stationary with respect to the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in the test paper area 20 corresponding to the shooting field of view of any local camera 53, it can be photographed by the corresponding local camera 53 to obtain the first image and the second image, for example, the first image is obtained by the same local camera 53 at one time, and the second image is obtained at another time.
  • the processor 70 determines the first color block information of the target color block 99 from the first image, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the target local camera 53 from the at least two local cameras 53 included in the imaging component 50 according to the test paper area 20 where the first dry chemical test paper 91 is located; obtaining the image taken by the target local camera 53 at the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added and the set reaction time Ts is passed as the first image; and determining the first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 determines the second color block information of the target color block 99 from the second image, including: obtaining the image taken by the target local camera 53 at the time of taking the second image as the second image; and determining the second color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the processor 70 calculates the detection result of the test item corresponding to the target color block 99 based on at least the first color block information and the second color block information.
  • the processor 70 obtains the actual color curve of the target color block 99 changing with time based on at least the first color block information and the second color block information; compares the actual color curve with a plurality of standard color curves, wherein the plurality of standard color curves are pre-established corresponding to the standard detection results of the test item corresponding to the target color block 99; determines the detection result of the test item corresponding to the target color block 99 according to the comparison result, for example, determines the standard detection result corresponding to the standard color curve with the highest similarity to the actual color curve among the plurality of standard color curves as the detection result of the test item corresponding to the target color block 99.
  • the actual color curve of the target color block 99 changing with time can also be referred to as the reaction curve of the target color block 99, whose horizontal coordinate can be time, and the vertical coordinate can be data representing the color, such as RGB value, and another example is grayscale value.
  • the multiple standard color curves correspond to the standard test results of the test items corresponding to the target color block 99, that is, each standard color curve corresponds to a standard test result of the test items corresponding to the target color block 99, and the standard color curve is a reaction curve after the biological sample with the corresponding standard test result is added to the target color block 99.
  • the existing method of comparing the similarity of two curves can be used, such as calculating the degree of fit of a nonlinear regression equation; further, in particular, a method of calculating the similarity of time series can be used, such as a DTW algorithm and a PLR algorithm.
  • each time the first dry chemical test paper 91 is photographed an actual color curve of the target color block 99 that changes with time is generated and updated in real time, and the real-time actual color curve is matched with multiple standard color curves.
  • the process stops and the standard test result corresponding to the successfully matched standard color curve is determined as the test result of the test item corresponding to the target color block 99; if the match fails, the process continues to generate and update the actual color curve of the target color block 99 that changes with time.
  • the processor 70 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times according to at least the first image and the second image, and calculates the detection result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including:
  • an actual color curve of the target color block of the first dry chemical test paper 91 changing with time is generated according to the image captured at the shooting moment and part or all of the images captured of the first dry chemical test paper 91 before the shooting moment, and the actual color curve is matched with a plurality of standard color curves, wherein the plurality of standard color curves are pre-established corresponding to the standard test results of the test items corresponding to the target color block;
  • the matching fails: continuing to generate the actual color change of the target color block 99 of the first dry chemical test paper 91 and performing the matching;
  • the match is successful: the standard test result corresponding to the standard color curve among the multiple standard color curves whose similarity with the actual color curve is greater than the target threshold is determined as the test result of the test item corresponding to the target color block 99, and the generation of the actual color change of the target color block 99 of the first dry chemical test paper 91 and the matching are stopped.
  • K is 1, 2, 3, 4, 5 or 6, etc.
  • the imaging component 50 includes a global camera 51
  • the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed in multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, and the first dry chemical test paper 91 can be photographed by the global camera 51 when it is conveyed in the at least two test paper areas 20 covered by the shooting field of view of the global camera 51.
  • the processor 70 starts from the image taken at the Kth shooting moment of the first dry chemical test paper 91, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: for the image at any i-th shooting moment, according to the second preset period, the i-th shooting moment and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, determine the position of the first dry chemical test paper in the image at the i-th shooting moment; obtain the position of the target color block 99 on the first dry chemical test paper 91; determine the color block information of the target color block 99 from the image at the i-th shooting moment according to the position of the first dry chemical test paper 91 in the image at the i-th shooting moment and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes a global camera 51
  • the dry chemical test paper 90 placed on the carrying component 10 is relatively stationary with the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in any of the at least two test paper areas covered by the shooting field of view of the global camera 51, it can be photographed. It can be understood that since the first dry chemical test paper 91 is stationary and non-moving on the carrying component 10, the position of the first dry chemical test paper 91 in the first image and the second image is also the same and unchanged.
  • the processor 70 starts from the image taken of the first dry chemical test paper 91 at the Kth shooting moment, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; for the image at any i-th shooting moment, determining the position of the first dry chemical test paper 91 in the image at the i-th shooting moment according to the test paper area 20 where the first dry chemical test paper 91 is located, and determining the color block information of the target color block 99 from the image at the i-th shooting moment according to the position of the first dry chemical test paper 91 in the image at the i-th shooting moment and the position of the target color block 99 on the first dry chemical test paper 91.
  • the imaging component 50 includes at least two local cameras 53, and the supporting component 10 includes a conveying assembly 11 and a power mechanism 13; in such an embodiment, the first dry chemical test paper 91 will be conveyed among multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction, so that when the first dry chemical test paper 91 is conveyed between the test paper areas 20 corresponding to the shooting field of view of each local camera 53, it can be photographed by the corresponding local camera 53.
  • the processor 70 starts from the image taken at the Kth shooting moment of the first dry chemical test paper 91, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: for any i-th shooting moment, according to the second preset period, the i-th shooting moment and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, determine the test paper area 20 where the first dry chemical test paper 91 is located at the i-th shooting moment; according to the test paper area 20 where the first dry chemical test paper 91 is located at the i-th shooting moment, determine the corresponding local camera 53 from the at least two local cameras 53 included in the imaging component 50, and obtain the image taken by the local camera 53 at the i-th shooting moment, and determine the color block information of the target color block 99 from the image at the i-
  • the imaging component 50 includes at least two local cameras 53, and the dry chemical test paper 90 placed on the supporting component 10 is relatively stationary with respect to the imaging component 50; therefore, in some embodiments, the first dry chemical test paper 91 is also stationary and non-moving, that is, when the dry chemical test paper 90 is located in a certain test paper area 20, the dry chemical test paper 90 will always be located in this test paper area 20. Therefore, when the first dry chemical test paper 91 is in the test paper area 20 corresponding to the shooting field of view of any local camera 53, it can be photographed by the corresponding local camera 53.
  • the processor 70 starts from the image taken of the first dry chemical test paper 91 at the Kth shooting moment, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the target local camera 53 from the at least two local cameras included in the imaging component 50 according to the test paper area 20 where the first dry chemical test paper 91 is located; for any i-th shooting moment, determining the color block information of the target color block 99 from the image taken by the target local camera 53 at the i-th shooting moment according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the dry chemical test paper 90 includes not only the first dry chemical test paper 91 but also the second dry chemical test paper 92.
  • the second dry chemical test paper 92 has one or more color blocks 99, and each color block 99 corresponds to a test item.
  • the global camera 51 also captures the fourth image.
  • the first image, the second image, and the fourth image are captured at different times. It can be seen from the description in this article that the detection result of the test item corresponding to the target color block 99 of the first dry chemical test paper 91 can be calculated based on at least the first image and the second image; in addition to the first dry chemical test paper 91, the first image and the second image may also have other dry chemical test papers 90.
  • the processor 70 can determine the color block information of a color block 99 of the second dry chemical test paper 92 at different times based on at least the first image and the fourth image, and calculate the test result of the test item corresponding to the color block 99 based on the color block information of the color block 99 at different times.
  • the processor 70 can determine the color block information of a color block 99 of the second dry chemical test paper 92 at different times based on at least the second image and the fourth image, and calculate the test result of the test item corresponding to the color block 99 based on the color block information of the color block 99 at different times. It can be understood that at this time, the detection result of the test item corresponding to the color block 99 is calculated based on the color block information of the color block 99 of the second dry chemical test paper 92 at at least two moments.
  • the color block information may be relevant information that characterizes the color. Therefore, the processor 70 obtains the actual color of the target color block 99 at different times based on at least two images of the first dry chemical test paper 91 taken at different times, and calculates the detection result of the test item corresponding to the target color block 99 based on the actual color of the target color block at different times.
  • the processor 70 determines the position of the first dry chemical test paper 91 in the image at any shooting time i based on the second preset cycle, the any shooting time i, and the position of the sample application area 21, and obtains the actual color of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i based on the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91; then For example, in the case where the first dry chemical test paper 91 has a test paper mark, for an image at any shooting time i among at least two images at different shooting times, the position of the first dry chemical test paper 91 in the image at any shooting time i is determined based on the test paper mark of the first dry chemical test paper 91, and the position of the target color block 99 on
  • the processor 70 can calculate the test results of the test items corresponding to the target color block 99 according to the actual colors of the target color block 99 at different times and multiple sets of standard colors, wherein each set of standard colors is pre-established corresponding to the standard test results of the test items corresponding to the target color block 99, and includes at least two standard colors at different reaction times. That is, for each of the multiple standard test results of the test items corresponding to the target color block 99, the biological sample with the corresponding standard test result is added to the target color block 99 and reacted, thereby forming a standard color at different reaction times during the reaction process, and the standard colors at different reaction times during the reaction process corresponding to the same standard test result form a set of standard colors.
  • each set of standard colors includes standard colors at multiple different reaction times during the reaction process corresponding to a corresponding standard test result.
  • a set of standard colors can be a standard color group; when presented in a continuous state, a set of standard colors can be a standard color curve, which is further described below.
  • the processor 70 calculates an actual color curve of the target color block 99 that changes with time based on the actual color of the target color block 99 at different moments, and compares the actual color curve with a plurality of standard color curves, wherein the plurality of standard color curves are pre-established corresponding to standard test results of the test items corresponding to the target color block 99; determines the test results of the test items corresponding to the target color block 99 based on the comparison results, for example, determining the standard test result corresponding to the standard color curve among the plurality of standard color curves that has the highest similarity to the actual color curve as the test result of the test item corresponding to the target color block 99.
  • the processor 70 compares the actual color of the target color block 99 at different times with a plurality of standard color groups, each standard color group includes a standard color corresponding to the reaction time at the different time; each standard color group is pre-established corresponding to the standard test result of the test item corresponding to the target color block 99; and the test result of the test item corresponding to the target color block 99 is determined according to the comparison result.
  • each standard color group is also a group of time series data groups, which reflects a group of data groups that change with time during the reaction process after the biological sample with the corresponding standard test result is added to the target color block 99, and can be equivalently considered as a discretization of a continuous reaction curve.
  • the color block in the dry chemical test paper 90 is calculated based on the color block information or actual color of the color block at at least two moments to obtain the test result of the test item corresponding to the color block.
  • the specific calculation method can be, for example, the above-mentioned method of calculating the test result by calculating the similarity between the actual color curve and the standard color curve; in some embodiments, it can also be calculated by artificial intelligence AI.
  • the processor 70 calculates the detection results of the test items corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including: inputting the color block information of the target color block 99 at different times into a pre-established machine learning model to obtain the detection results of the test items corresponding to the target color block 99 through the machine learning model.
  • training can be performed using training sets, and test sets can be used to fine-tune parameters; the data sets of both training and test sets can be color block information at different times (i.e., a time series data set consisting of color block information at at least two times), and the labels of the data sets can be the corresponding test results.
  • different machine learning models can be introduced for different types of color blocks (mainly distinguished by test items and reagents of the color blocks).
  • a dry chemical detection method is also disclosed.
  • the dry chemical detection method of the present application can be applied to the dry chemical detection device disclosed in the present application.
  • the dry chemical detection method of some embodiments includes the following steps:
  • Step 1000 Add the biological sample to be tested to the color block 99 of the dry chemical test paper 90 located in the test paper area 20 through the sample adding component 30, wherein the dry chemical test paper 90 includes a first dry chemical test paper 91, or at least one dry chemical test paper 90 is the first dry chemical test paper 91, and the first dry chemical test paper 91 has one or more color blocks 99, and each color block 99 corresponds to a test item.
  • the color blocks 99 may be referred to as a target color block 99.
  • the biological sample to be tested includes a urine sample, a body fluid sample and/or a vaginal secretion.
  • Step 1100 After the sample adding component 30 adds the biological sample to the target color block 99 of the first dry chemical test paper 91, the first dry chemical test paper 91 is photographed by the imaging component 50 to obtain multiple images; the multiple images include at least a first image and a second image, and the first image and the second image are photographed at different times.
  • Step 1200 Determine the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, and calculate the detection result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times.
  • step 1200 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, including: using the image information of the first image located in the preset first area as the first color block information of the target color block 99, the preset first area corresponds to the target color block 99 of the first dry chemical test paper 91; using the image information of the second image located in the preset second area as the second color block information of the target color block 99, the preset second area corresponds to the target color block 99 of the first dry chemical test paper 91.
  • step 1200 before determining the color block information of the target color block 99 of the first dry chemical test paper 91 at different times based on at least the first image and the second image, step 1200 further includes: obtaining the test paper type of the first dry chemical test paper 91, and obtaining the above-mentioned preset first area and preset second area according to the test paper type of the first dry chemical test paper 91.
  • the dry chemical detection method can also photograph the dry chemical test paper 90 before adding the biological sample to be tested to the dry chemical test paper 90 to determine whether there is any abnormality in the dry chemical test paper 90. Therefore, in some embodiments, the dry chemical detection method further includes step 1: photographing the first dry chemical test paper 91 by the imaging component 50 before the sample adding component 30 adds the biological sample to be tested to the target color block 99 of the first dry chemical test paper 91 to obtain a third image, and judging the abnormality of the first dry chemical test paper 91 according to the third image, the abnormality includes at least one of the first type of abnormality and the second type of abnormality; the first type of abnormality is used to indicate that the first dry chemical test paper 91 is unusable, and the second type of abnormality is used to indicate that there is a deviation in the position of at least one color block in the first dry chemical test paper 91.
  • the first image is determined by the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times, so that the color feature difference between the color block information of the target color block in the first image and the color block information of the target color block in at least one image shot before the first image is less than a set threshold value; wherein the color feature difference between the color block information of the target color block 99 at two different times is calculated, for example, it can be the difference in grayscale value represented by the color block information.
  • the first image selected in this way is generally an image of the target color block 99 shot at the time of reaction completion or basic reaction completion.
  • step 1200 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times according to at least the first image and the second image, and calculates the test result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including:
  • Step 1210 Calculate the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times to determine the first image, so that the color feature difference between the color block information of the target color block 99 in the first image and the color block information of the target color block 99 in at least one image taken before it is less than a set threshold.
  • Step 1230 Determine a second image, where the shooting time of the second image is before the shooting time of the first image.
  • Step 1240 Determine the first color block information of the target color block 99 from the first image, and determine the second color block information of the target color block 99 from the second image, and calculate the detection result of the test item corresponding to the target color block 99 based at least on the first color block information and the second color block information.
  • the dry chemical detection method also includes step 1010: driving the supporting component 10 by the driving component 10a so that the dry chemical test paper 90 placed on the supporting component 10 is periodically transmitted in multiple test paper areas 20 along a preset direction with a second preset period, so that when the first dry chemical test paper 91 is transmitted in the at least two test paper areas 20 covered by the shooting field of view of the global camera 51, it can be photographed by the global camera 51 to obtain the first image and the second image.
  • the first dry chemical test paper 91 will be transported among multiple test paper areas 20, for example, from one test paper area 20 to the next test paper area 20 along a preset direction.
  • the first dry chemical test paper 91 is transported among the at least two test paper areas 20 covered by the shooting field of view of the global camera 51, it can be photographed by the global camera 51 to obtain a first image and a second image.
  • one of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a first image
  • another of the at least two test paper areas 20 is photographed by the global camera 51 to obtain a second image.
  • step 1210 may determine the first image as follows:
  • Step 1211 For an image at any shooting time i, determine the position of the first dry chemical test paper 91 in the image at any shooting time i according to the second preset period, the any shooting time i, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added.
  • Step 1212 According to the position of the first dry chemical test paper 91 in the image at any shooting moment i and the position of the target color block 99 on the first dry chemical test paper 91, the color block information of the target color block 99 in the first dry chemical test paper 91 is obtained from the image at any shooting moment i. In this way, the color block information of the target color block 99 in the image at each shooting moment can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting moments can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • step 1240 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the second preset period, the shooting time of the first image, and the test paper area 20 where the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1240 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the second preset period, the shooting time of the second image, and the test paper area 20 where the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second color block information of the target color block 99 from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1210 may determine the first image as follows:
  • Step 1213 Acquire the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1214 for an image at any shooting time i, determine the position of the first dry chemical test paper 91 in the image at any shooting time i according to the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1215 According to the position of the first dry chemical test paper 91 in the image at any shooting moment i and the position of the target color block 99 on the first dry chemical test paper 91, the color block information of the target color block 99 in the first dry chemical test paper 91 is obtained from the image at any shooting moment i. In this way, the color block information of the target color block 99 in the image at each shooting moment can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting moments can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • step 1240 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the test paper area 20 where the first dry chemical test paper 91 is located and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1240 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the test paper area 20 where the first dry chemical test paper 91 is located and the position of the target color block 99 on the first dry chemical test paper 91.
  • the position of the first dry chemical test paper 91 in the image can also be determined by the test paper mark, thereby determining the color block information of the target color block 99. Therefore, in some embodiments, the first dry chemical test paper 91 has a test paper mark, which can be determined by image recognition to distinguish different dry chemical test papers; step 1210 can determine the first image in this way: for an image at any shooting time i, according to the test paper mark of the first dry chemical test paper 91, determine the position of the first dry chemical test paper 91 in the image at any shooting time i; obtain the position of the target color block 99 on the first dry chemical test paper 91; according to the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91, obtain the color block information of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i.
  • the color block information of the target color block 99 in the images at each shooting time can be obtained, so that the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times can be calculated to determine the first image.
  • the above-mentioned test paper identification scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • step 1240 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the test paper identification of the first dry chemical test paper 91; determining the first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1240 determines the first color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the test paper identification of the first dry chemical test paper 91; determining the second color block information of the target color block 99 from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the dry chemical detection method also includes step 1011: driving the supporting component 10 by the driving component 10a so that the dry chemical test paper 90 placed on the supporting component 10 is periodically transmitted in multiple test paper areas 20 along a preset direction with a second preset period, so that when the first dry chemical test paper 91 is transmitted between the test paper areas 20 corresponding to the shooting field of view of each local camera 53, it can be photographed by the corresponding local camera 53 to obtain the first image and the second image.
  • step 1210 may determine the first image as follows:
  • Step 1216 For any shooting moment i, determine the test paper area where the first dry chemical test paper 91 is located at the any shooting moment i according to the second preset period, the any shooting moment i and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added.
  • Step 1217 According to the test paper area 20 where the first dry chemical test paper 91 is located at any shooting time i, determine the corresponding local camera 53 from the at least two local cameras included in the imaging component 50, and obtain the image taken by the local camera 53 at any shooting time i.
  • Step 1218 Determine the color block information of the target color block 99 in the first dry chemical test paper 91 in the image captured at any one of the shooting moments i from the local camera 53 determined in step 1217 according to the position of the target color block 99 on the first dry chemical test paper 91. In this way, the color block information of the target color block 99 in the image at each shooting moment can be obtained, so that the color feature differences between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting moments can be calculated to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting moment i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • step 1240 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1240 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1210 may determine the first image as follows:
  • Step 1219 Acquire the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1220 According to the test paper area 20 where the first dry chemical test paper 91 is located, determine the target local camera 53 from the at least two local cameras included in the imaging component 50 .
  • Step 1221 For the image at any shooting moment i, according to the position of the target color block 99 on the first dry chemical test paper 91, determine the color block information of the target color block 99 in the image at any shooting moment i from the target local camera 53. In this way, the color block information of the target color block 99 in the image at each shooting moment can be obtained, so as to calculate the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting moments, so as to determine the first image.
  • the above scheme provides a method for determining the color block information of the target color block 99 from an image at any shooting time i, and is therefore also applicable to determining the color block information of the target color block 99 from the first image (referred to as the first color block information), and determining the color block information of the target color block 99 from the second image (referred to as the second color block information).
  • step 1230 determines the first color block information of the target color block 99 from the first image, including: determining the first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1230 determines the second color block information of the target color block 99 from the second image, including: determining the first color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the above is some explanation on how to determine the first image by the color feature difference between the color block information of the target color block 99 in the first dry chemical test paper 91 in the images at different shooting times, and how to determine the color block information of the target color block 99 in the image in combination with specific scenarios.
  • the target color block 99 corresponds to a set reaction time Ts. After the target color block 99 is added with the biological sample to be tested and after the set reaction time Ts has passed, the first dry chemical test paper 91 is photographed to obtain a first image.
  • step 1200 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times according to at least the first image and the second image, and calculates the test result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including:
  • Step 1250 determine a first image, which is an image captured by the imaging component 50 after the target color block 99 of the first dry chemical test paper 91 is added with the biological sample to be tested and after a set reaction time Ts.
  • the set reaction time Ts can be timed by the shooting cycle of the imaging component 50.
  • the imaging component 50 periodically shoots the first dry chemical test paper 91 in a first preset cycle; the set reaction time Ts is the time corresponding to the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added, and accordingly, the first image is the image of the first dry chemical test paper 91 obtained by shooting the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added and after M first preset cycles, wherein M is a preset positive integer.
  • Step 1260 Determine a second image, where the shooting time of the second image is before the shooting time of the first image.
  • Step 1270 Determine the first color block information of the target color block 99 from the first image, and determine the second color block information of the target color block 99 from the second image, and calculate the detection result of the test item corresponding to the target color block 99 based at least on the first color block information and the second color block information.
  • step 1270 may determine the first color block information of the target color block 99 from the first image as follows:
  • Step 1271 Determine the position of the first dry chemical test paper 91 in the first image according to the second preset cycle, the set reaction time Ts, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added.
  • Step 1272 Obtain the position of the target color block 99 on the first dry chemical test paper 91 .
  • Step 1273 Determine first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91 .
  • step 1270 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the second preset period, the shooting time of the second image, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second color block information of the target color block 99 from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1270 may determine the first color block information of the target color block 99 from the first image as follows:
  • Step 1274 Obtain the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1275 Determine the position of the first dry chemical test paper 91 in the first image according to the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1276 Obtain the position of the target color block 99 on the first dry chemical test paper 91 .
  • Step 1277 Determine first color block information of the target color block 99 from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91 .
  • step 1270 determines the second color block information of the target color block 99 from the second image, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; determining the position of the first dry chemical test paper 91 in the second image based on the test paper area 20 where the first dry chemical test paper 91 is located; obtaining the position of the target color block 99 on the first dry chemical test paper 91; and determining the second color block information of the target color block 99 from the second image based on the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • the position of the first dry chemical test paper 91 in the image can also be determined by the test paper identification, thereby determining the color block information of the target color block 99. Therefore, in some embodiments, the first dry chemical test paper 91 has a test paper identification, which can be determined by image recognition to distinguish different dry chemical test papers.
  • step 1270 determines the first color block information of the target color block 99 from the first image, including: determining the position of the first dry chemical test paper 91 in the first image according to the test paper identification of the first dry chemical test paper 91; obtaining the position of the target color block 99 on the first dry chemical test paper 91; determining the first color block information from the first image according to the position of the first dry chemical test paper 91 in the first image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1270 determines the second color block information of the target color block 99 from the second image, including: determining the position of the first dry chemical test paper 91 in the second image according to the test paper identification of the first dry chemical test paper 91; obtaining the position of the target color block 99 on the first dry chemical test paper 91; and determining the second color block information from the second image according to the position of the first dry chemical test paper 91 in the second image and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1270 may determine the first color block information of the target color block 99 from the first image as follows:
  • Step 1278 According to the second preset cycle, the set reaction time Ts, and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, determine that the first dry chemical test paper 91 is in the first test paper area 20 in the test paper area when the target color block 99 of the first dry chemical test paper 91 is added with the biological sample to be tested and the set reaction time Ts has passed.
  • Step 1279 Determine a first local camera 53 from the at least two local cameras 53 included in the imaging component 50 according to the first test paper area 20 .
  • Step 1280 Obtain an image captured by the first local camera 53 at the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added and the set reaction time Ts has elapsed as the first image.
  • Step 1281 Determine first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91 .
  • step 1270 determines the second color block information of the target color block 99 from the second image, including: determining the second test paper area 20 of the first dry chemical test paper 91 in the test paper area at the time of shooting the second image according to the second preset period, the shooting time of the second image and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added; determining the second local camera 53 from the at least two local cameras 53 included in the imaging component 50 according to the second test paper area 20; acquiring the image shot by the second local camera 53 at the shooting time of the second image as the second image; and determining the second color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1270 may determine the first color block information of the target color block 99 from the first image as follows:
  • Step 1282 Obtain the test paper area 20 where the first dry chemical test paper 91 is located.
  • Step 1283 According to the test paper area 20 where the first dry chemical test paper 91 is located, determine the target local camera 53 from the at least two local cameras 53 included in the imaging component 50 .
  • Step 1284 Obtain an image captured by the target local camera 53 at the target color block 99 of the first dry chemical test paper 91 after the biological sample to be tested is added and the set reaction time Ts has elapsed as the first image.
  • Step 1285 Determine first color block information of the target color block 99 from the first image according to the position of the target color block 99 on the first dry chemical test paper 91 .
  • step 1270 determines the second color block information of the target color block 99 from the second image, including: obtaining the image taken by the target local camera 53 at the shooting time of the second image as the second image; and determining the second color block information of the target color block 99 from the second image according to the position of the target color block 99 on the first dry chemical test paper 91.
  • the detection results of the test items corresponding to the calculated target color block 99 in step 1240 and step 1270, please refer to FIG. 14, can be done as follows:
  • Step 1241 Based at least on the first color block information and the second color block information, obtain an actual color curve of the target color block 99 changing over time.
  • Step 1242 Compare the actual color curve with a plurality of standard color curves, wherein the plurality of standard color curves are pre-established corresponding to standard detection results of the test items corresponding to the target color block 99 .
  • Step 1243 Determine the detection result of the test item corresponding to the target color block 99 based on the comparison result, for example, determine the standard detection result corresponding to the standard color curve with the highest similarity to the actual color curve among the multiple standard color curves as the detection result of the test item corresponding to the target color block 99.
  • each time the first dry chemical test paper 91 is photographed an actual color curve of the target color block 99 that changes with time is generated and updated in real time, and the real-time actual color curve is matched with multiple standard color curves.
  • the process stops and the standard test result corresponding to the successfully matched standard color curve is determined as the test result of the test item corresponding to the target color block 99; if the match fails, the process continues to generate and update the actual color curve of the target color block 99 that changes with time.
  • step 1200 determines the color block information of the target color block 99 of the first dry chemical test paper 91 at different times according to at least the first image and the second image, and calculates the test result of the test item corresponding to the target color block 99 based on the color block information of the target color block 99 at different times, including:
  • Step 1290 Starting from the image taken at the Kth shooting moment of the first dry chemical test paper 91, generate an actual color curve of the target color block of the first dry chemical test paper 91 changing over time based on the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, and match the actual color curve with multiple standard color curves, which are pre-established corresponding to the standard test results of the test items corresponding to the target color blocks.
  • K is 1, 2, 3, 4, 5 or 6, etc.
  • Step 1291 when there is no standard color curve in the plurality of standard color curves whose similarity to the actual color curve is greater than the target threshold, the matching fails: continuing to generate the actual color change of the target color block 99 of the first dry chemical test paper 91 and performing the matching;
  • Step 1292 When there is a standard color curve among the multiple standard color curves whose similarity with the actual color curve is greater than the target threshold, the match is successful: the standard test result corresponding to the standard color curve among the multiple standard color curves whose similarity with the actual color curve is greater than the target threshold is determined as the test result of the test item corresponding to the target color block 99, and the generation of the actual color change of the target color block 99 of the first dry chemical test paper 91 and the matching are stopped.
  • step 1290 starts from the image taken at the Kth shooting moment of the first dry chemical test paper 91, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: for the image at any i-th shooting moment, according to the second preset period, the i-th shooting moment and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, determine the position of the first dry chemical test paper in the image at the i-th shooting moment; obtain the position of the target color block 99 on the first dry chemical test paper 91; determine the color block information of the target color block 99 from the image at the i-th shooting moment according to the position of the first dry chemical test paper 91 in the image at the i-th shooting moment and the position of the target color block 99 on the first dry chemical
  • step 1290 starts from the image taken of the first dry chemical test paper 91 at the Kth shooting moment, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; for the image at any i-th shooting moment, determining the position of the first dry chemical test paper 91 in the image at the i-th shooting moment according to the test paper area 20 where the first dry chemical test paper 91 is located, and determining the color block information of the target color block 99 from the image at the i-th shooting moment according to the position of the first dry chemical test paper 91 in the image at the i-th shooting moment and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1290 starts from the image taken at the Kth shooting moment of the first dry chemical test paper 91, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: for any i-th shooting moment, according to the second preset period, the i-th shooting moment and the test paper area 20 where the target color block 99 of the first dry chemical test paper 91 is located when the biological sample to be tested is added, determine the test paper area 20 where the first dry chemical test paper 91 is located at the i-th shooting moment; according to the test paper area 20 where the first dry chemical test paper 91 is located at the i-th shooting moment, determine the corresponding local camera 53 from the at least two local cameras 53 included in the imaging component 50, and obtain the image taken by the local camera 53 at the i-th shooting moment, and determine the color block information of the target color
  • step 1290 starts from the image taken of the first dry chemical test paper 91 at the Kth shooting moment, and generates the actual color change of the target color block 99 of the first dry chemical test paper 91 according to the image taken at the shooting moment and part or all of the images of the first dry chemical test paper 91 taken before the shooting moment, including: obtaining the test paper area 20 where the first dry chemical test paper 91 is located; according to the test paper area 20 where the first dry chemical test paper 91 is located, determining the target local camera 53 from the at least two local cameras included in the imaging component 50; for any i-th shooting moment, according to the position of the target color block 99 on the first dry chemical test paper 91, determine the color block information of the target color block 99 from the image taken by the target local camera 53 at the i-th shooting moment.
  • the dry chemical test paper 90 includes not only the first dry chemical test paper 91 but also the second dry chemical test paper 92.
  • the second dry chemical test paper 92 has one or more color blocks 99, and each color block 99 corresponds to a test item.
  • the global camera 51 also captures a fourth image. The first image, the second image, and the fourth image are all captured at different times. It can be seen from the description in this article that the detection result of the test item corresponding to the target color block 99 of the first dry chemical test paper 91 can be calculated based on at least the first image and the second image; in addition to the first dry chemical test paper 91, the first image and the second image may also have other dry chemical test papers 90.
  • the dry chemical detection method may further include the steps of: determining the color block information of a color block 99 of the second dry chemical test paper 92 at different times based on at least the first image and the fourth image, and calculating the detection result of the test item corresponding to the color block 99 based on the color block information of the color block 99 at different times.
  • the dry chemical detection method may further include the steps of: determining the color block information of a color block 99 of the second dry chemical test paper 92 at different times based on at least the second image and the fourth image, and calculating the detection result of the test item corresponding to the color block 99 based on the color block information of the color block 99 at different times. It can be understood that at this time, the detection result of the test item corresponding to the color block 99 is calculated based on the color block information of the color block 99 of the second dry chemical test paper 92 at at least two moments.
  • the color block information may be relevant information representing the color. Therefore, referring to FIG. 16 , the dry chemical detection method of some embodiments includes the following steps:
  • Step 1300 driving the carrying component 10 by the driving component 10 a so that the dry chemical test paper 90 placed on the carrying component 10 is transported in a plurality of test paper areas 20 along a preset direction; the plurality of test paper areas 20 include a sample adding area 21 .
  • Step 1310 adding the biological sample to be tested to the target color block 99 in the first dry chemical test paper 91 transported to the sample adding area 21 through the sample adding component 30 .
  • Step 1320 photographing the first dry chemical test paper 91 through the global camera 51 after the sample adding component 30 adds the biological sample to the target color block 99 of the first dry chemical test paper 91 to obtain at least two images of the first dry chemical test paper 91 at different shooting times.
  • Step 1330 Obtain the actual colors of the target color block 99 at different times based on at least two images of the first dry chemical test paper 91 taken at different times.
  • step 1330 can be performed in the following way to obtain the actual color of the target color block 99 at different times based on at least two images of the first dry chemical test paper 91 taken at different times: for an image at any shooting time i in the at least two images taken at different times, determine the position of the first dry chemical test paper 91 in the image at any shooting time i based on the second preset cycle, the any shooting time i and the position of the sample adding area 21, and obtain the actual color of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i based on the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91.
  • step 1330 can be performed as follows to obtain the actual color of the target color block 99 at different times based on at least two images of the first dry chemical test paper 91 taken at different times: for an image at any shooting time i in the at least two images taken at different times, determine the position of the first dry chemical test paper 91 in the image at any shooting time i based on the test paper mark of the first dry chemical test paper 91, obtain the position of the target color block 99 on the first dry chemical test paper 91, and obtain the actual color of the target color block 99 in the first dry chemical test paper 91 from the image at any shooting time i based on the position of the first dry chemical test paper 91 in the image at any shooting time i and the position of the target color block 99 on the first dry chemical test paper 91.
  • Step 1340 Calculate the test results of the test items corresponding to the target color block 99 according to the actual colors of the target color block 99 at different times and multiple sets of standard colors.
  • Each set of standard colors corresponding to the standard test results of the test items corresponding to the target color block is pre-established and includes at least two standard colors at different reaction times.
  • step 1340 can calculate the test results of the test items corresponding to the target color block 99 according to the actual colors of the target color block 99 at different times and multiple sets of standard colors, wherein each set of standard colors is pre-established corresponding to the standard test results of the test items corresponding to the target color block 99, and includes at least two standard colors at different reaction times. That is, for each of the multiple standard test results of the test items corresponding to the target color block 99, the biological sample with the corresponding standard test result is added to the target color block 99 and reacted, thereby forming a standard color at different reaction times during the reaction process, and the standard colors at different reaction times during the reaction process corresponding to the same standard test result form a set of standard colors.
  • each set of standard colors includes the standard colors at multiple different reaction times during the reaction process corresponding to a corresponding standard test result.
  • a set of standard colors can be a standard color group; when presented in a continuous state, a set of standard colors can be a standard color curve, which is further described below.
  • step 1340 calculates the actual color curve of the target color block 99 that changes with time based on the actual color of the target color block 99 at different times, and compares the actual color curve with a plurality of standard color curves, wherein the plurality of standard color curves are pre-established corresponding to standard test results of the test items corresponding to the target color block 99; determines the test results of the test items corresponding to the target color block 99 based on the comparison results, for example, determining the standard test results corresponding to the standard color curve with the highest similarity to the actual color curve among the plurality of standard color curves as the test results of the test items corresponding to the target color block 99.
  • step 1340 compares the actual color of the target color block 99 at different times with a plurality of standard color groups, each standard color group including the standard color of the reaction time corresponding to the different times; each standard color group is pre-established corresponding to the standard test result of the test item corresponding to the target color block 99; and the test result of the test item corresponding to the target color block 99 is determined according to the comparison result.
  • each standard color group is also a group of time series data groups, which reflects a group of data groups that change with time during the reaction process after the biological sample with the corresponding standard test result is added to the target color block 99, and can be equivalently considered as a discretization of a continuous reaction curve.
  • the color block in the dry chemical test paper 90 is calculated based on the color block information or actual color of the color block at at least two moments to obtain the test result of the test item corresponding to the color block.
  • the specific calculation method can be, for example, the above-mentioned method of calculating the test result by calculating the similarity between the actual color curve and the standard color curve; in some embodiments, it can also be calculated by artificial intelligence AI.
  • the detection results of the test items corresponding to the target color block 99 are calculated, including: inputting the color block information of the target color block 99 at different times into a pre-established machine learning model to obtain the detection results of the test items corresponding to the target color block 99 through the machine learning model.
  • training can be performed using training sets, and test sets can be used to fine-tune parameters; the data sets of both training and test sets can be color block information at different times (i.e., a time series data set consisting of color block information at at least two times), and the labels of the data sets can be the corresponding test results.
  • different machine learning models can be introduced for different types of color blocks (mainly distinguished by test items and reagents of the color blocks).
  • all or part of the embodiments may be implemented by software, hardware, firmware, or any combination thereof.
  • the principles of the present invention may be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with a computer-readable program code.
  • Any tangible, non-temporary computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD to ROM, DVD, Blu-Ray disks, etc.), flash memory, and/or the like.
  • These computer program instructions may be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing device to form a machine, so that these instructions executed on a computer or other programmable data processing device may generate a device that implements a specified function.
  • These computer program instructions may also be stored in a computer-readable memory, which may instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory may form a manufactured product, including an implementation device that implements a specified function.
  • the computer program instructions may also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to produce a computer-implemented process, so that the instructions executed on the computer or other programmable device may provide steps for implementing a specified function.

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Abstract

La présente invention concerne un appareil de test chimique à sec et un procédé de test chimique à sec. Le procédé comprend les étapes suivantes : après qu'un échantillon biologique à tester a été ajouté à un bloc de couleur cible (99) d'une première bande de test chimique sèche (91) par un composant d'ajout d'échantillon (30), photographier, par un composant d'imagerie (50), la première bande de test chimique sèche (91) pour obtenir une pluralité d'images, la pluralité d'images comprenant au moins une première image et une seconde image, les moments auxquels la première image et la seconde image sont capturées étant différents ; et déterminer des informations de bloc de couleur du bloc de couleur cible (99) de la première bande de test chimique sèche (91) à différents moments au moins en fonction de la première image et de la seconde image, et, sur la base des informations de bloc de couleur du bloc de couleur cible (99) à différents moments, effectuer un calcul pour obtenir le résultat de test d'un élément de test correspondant au bloc de couleur cible (99). Ainsi, le résultat de test est plus précis.
PCT/CN2022/134492 2022-11-25 2022-11-25 Appareil et procédé de test chimique à sec WO2024108597A1 (fr)

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US20150241358A1 (en) * 2012-08-08 2015-08-27 Scanadu Incorporated Method and apparatus for determining analyte concentration by quantifying and interpreting color information captured in a continuous or periodic manner
WO2015134820A1 (fr) * 2014-03-05 2015-09-11 Scanadu Incorporated Concentration en analytes par quantification et interprétation de couleur
US20210004995A1 (en) * 2014-03-31 2021-01-07 Healthy .Io Ltd. Methods and apparatus for enhancing color vision and quantifying color interpretation
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