WO2024098453A1 - 一种颈静脉置管 - Google Patents

一种颈静脉置管 Download PDF

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Publication number
WO2024098453A1
WO2024098453A1 PCT/CN2022/132951 CN2022132951W WO2024098453A1 WO 2024098453 A1 WO2024098453 A1 WO 2024098453A1 CN 2022132951 W CN2022132951 W CN 2022132951W WO 2024098453 A1 WO2024098453 A1 WO 2024098453A1
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WO
WIPO (PCT)
Prior art keywords
hose
jugular vein
tube
hard tube
vein catheter
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PCT/CN2022/132951
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English (en)
French (fr)
Inventor
朱英杰
徐薇
Original Assignee
中国科学院深圳先进技术研究院
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Publication of WO2024098453A1 publication Critical patent/WO2024098453A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters

Definitions

  • the utility model relates to the technical field of medical equipment, in particular to a jugular vein catheter.
  • mice and rats are the most commonly used experimental animals in life science and medical research. In the evaluation of pharmacodynamics and drug safety, it is often necessary to administer drugs and take samples from different parts of the animal to observe drug metabolism in a timely manner.
  • Common methods of administration include tail vein administration, cardiac puncture administration, and jugular vein catheterization administration.
  • the tail vein has thin blood vessels and is not suitable for long-term administration; cardiac puncture administration causes excessive damage to animals and is not in line with animal ethics.
  • Jugular vein catheterization is convenient for long-term continuous drug administration or blood sampling to monitor metabolism. It has little stimulation to animals during drug administration and is an important test method for pharmacological experiments.
  • One type has a puncture needle at the front end, which can easily puncture blood vessels during use, causing catheterization failure; the other type has all catheters made of silicone hoses.
  • the advantage is that the catheter will not damage the blood vessels after implantation, but this type of catheter is difficult to place and takes a long time to place, resulting in a low success rate of placement.
  • the technical problem to be solved by the utility model is that, in view of the above-mentioned defects of the prior art, a jugular vein catheter is provided, aiming to solve the problem of low catheterization success rate of the jugular vein catheter made of silicone hose in the prior art.
  • a jugular vein catheter comprising:
  • a connecting component is provided with a channel
  • a first hose is connected to the channel; wherein the jugular vein catheter further comprises:
  • a second hose connected to the hard tube
  • the hardness of the first hose and the hardness of the second hose are both smaller than the hardness of the hard tube.
  • the jugular vein catheter is configured such that the first soft tube and the second soft tube are respectively sleeved on the outside of both ends of the hard tube.
  • the jugular vein catheter wherein the first hose and the second hose are connected to each other and formed in one piece.
  • the jugular vein catheterization wherein the jugular vein catheterization further comprises:
  • the connecting bead is located at the position of the hard tube and is sleeved outside the first hose and the second hose.
  • the jugular vein catheter wherein the outer diameter of the connecting bead gradually increases and then decreases in the direction from the first hose to the second hose, and the position of the maximum outer diameter of the connecting bead is close to the second hose; and/or
  • the hard tube extends toward one end of the second hose to the outside of the connecting bead to form a fixed position.
  • the jugular vein catheter wherein the first hose, the second hose, the hard tube and the connecting bead are integrally injection molded.
  • the jugular vein catheter wherein the length of the first hose is less than the length of the second hose;
  • the length of the first hose is 1-3 cm; and/or
  • the length of the second hose is 3-5 cm; and/or
  • the first hose and the second hose are both made of silicone tubes; and/or
  • the hard pipe is a polyethylene pipe.
  • connection assembly comprises:
  • a base provided with a through hole
  • a tube body arranged on one side of the base
  • a connecting pipe is arranged on the other side of the base
  • a catheter cap threadedly connected to the tube body
  • a blocking column is arranged in the catheter cap and inserted into the tube body
  • the tube body, the through hole and the connecting tube are connected to form the channel
  • the connecting pipe is connected to the second hose.
  • the jugular vein catheterization wherein the connecting tube is L-shaped; and/or
  • the base is a tissue compatible mesh base.
  • the jugular vein catheterization is characterized in that the end of the first soft tube facing away from the hard tube forms a wedge-shaped structure.
  • FIG1 is a first structural schematic diagram of the jugular vein catheterization in the present invention.
  • FIG. 2 is a second structural schematic diagram of the jugular vein catheterization in the present invention.
  • FIG. 3 is an exploded view of the jugular vein catheterization in the present invention.
  • FIG. 4 is a cross-sectional view of the jugular vein catheterization in the present invention.
  • FIG. 5 is an exploded cross-sectional view of the jugular vein catheter of the present invention.
  • FIG. 6 is a graph showing the results of a methamphetamine self-administration experiment in mice in the present invention.
  • the utility model provides some preferred embodiments of jugular vein catheterization.
  • jugular vein cannulation involves:
  • a connecting component 10 is provided with a channel 11;
  • a second hose 40 connected to the hard tube 30;
  • the hardness of the first hose 20 and the hardness of the second hose 40 are both smaller than the hardness of the hard tube 30 .
  • the entire length of the intravenous catheter is a soft tube, and there is no fulcrum during catheterization, which makes catheterization difficult and takes a long time, resulting in a high failure rate of catheterization.
  • the second soft tube 40 is connected to the hard tube 30, a fulcrum can be formed, which is convenient for clamping or holding, so that it is easier to put into the blood vessel, thereby improving the success rate of catheterization.
  • the hard tube 30 is also connected to the first soft tube 20, it can be prevented that the hard tube 30 damages the blood vessel.
  • the first hose 20, the hard tube 30 and the second hose 40 are located in the blood vessel, and the connecting assembly 10 is located outside the blood vessel and in the subcutaneous tissue.
  • the drug solution is injected into the channel 11 so that the drug solution enters the blood vessel from the channel 11.
  • blood can also be sampled from the channel 11.
  • the first hose 20 and the second hose 40 are respectively sleeved on the outer sides of both ends of the hard tube 30 .
  • the first soft tube 20 and the second soft tube 40 are respectively sleeved on the outside of both ends of the hard tube 30 .
  • first hose 20 and the second hose 40 are connected to each other and formed in one piece.
  • the first hose 20 and the second hose 40 when the first hose 20 and the second hose 40 are both sleeved outside the hard tube 30, the first hose 20 and the second hose 40 can be connected to each other and formed as one piece, that is, the hard tube 30 is inserted into the hose, and the hose is divided into two parts according to the position of the hard tube 30, one part is the first hose 20, and the other part is the second hose 40.
  • the jugular vein catheter further comprises:
  • the connecting bead 50 is located at the position of the hard tube 30 and is sleeved outside the first hose 20 and the second hose 40 .
  • a connecting bead 50 is arranged outside the hard tube 30, and is sleeved outside the first hose 20 and the second hose 40.
  • the size of the connecting bead 50 is set according to the inner diameter of the blood vessel. After the connecting bead 50 is located in the blood vessel, the connecting bead 50 abuts against the inner wall of the blood vessel, which can fix the hard tube 30 to a certain extent and prevent the first hose 20, the hard tube 30 and the second hose 40 from falling off from each other.
  • the fixing force of the pure hose is not easy to control.
  • the blood vessel is tied with a line to fix the pure hose, it is easy to cause the hose to be blocked if it is tied tightly, and it is easy to fall off if it is tied loosely.
  • the column hard tube 30 can be fixed to prevent the first hose 20, the hard tube 30 and the second hose 40 from falling off under constant shaking.
  • the connecting bead 50 can also effectively seal the connection between the first hose 20 and the hard tube 30 , and effectively seal the connection between the second hose 40 and the hard tube 30 , to avoid leakage.
  • connection bead 50 is a teardrop-shaped connection bead 50 having a large end with a larger outer diameter and a small end with a smaller outer diameter. The small end is close to the first hose 20 and the large end is close to the second hose 40 .
  • the hard tube 30 extends toward one end of the second soft tube 40 to the outside of the connecting bead 50 to form a fixed position.
  • the hard tube 30 is longer and extends outside the connecting bead 50 to form a fixing position, which is used to fix with the blood vessel to ensure that the first hose 20, the hard tube 30 and the second hose 40 fall off in the vein.
  • the first hose 20, the second hose 40, the hard tube 30 and the connecting bead 50 are integrally injection molded.
  • the first hose 20, the second hose 40, the hard tube 30 and the connecting bead 50 are integrally injection molded.
  • the length of the first hose 20 is smaller than the length of the second hose 40 .
  • the first hose 20 is shorter and the second hose 40 is longer, that is, the hard tube 30 is located close to the end of the first hose 20 .
  • the length of the first hose 20 is 1-3 cm, and the length of the second hose 40 is 3-5 cm.
  • the lengths of the first hose 20 and the second hose 40 can be set as needed.
  • both the first hose 20 and the second hose 40 are made of silicone hose.
  • first hose 20 and the second hose 40 can be made of silicone tubes.
  • first hose 20 and the second hose 40 can also be made of other materials as needed.
  • the hard tube 30 is a polyethylene tube.
  • the hard tube 30 can be a polyethylene tube.
  • the hard tube 30 can also be made of other materials as needed.
  • connection assembly 10 includes:
  • the base 12 is provided with a through hole 121;
  • the tube body 13 is arranged on one side of the base 12;
  • a connecting pipe 14 is provided on the other side of the base 12;
  • a catheter cap 15 threadedly connected to the tube body 13;
  • a blocking column 16 is disposed in the catheter cap 15 and inserted into the tube body 13;
  • the tube body 13, the through hole 121 and the connecting tube 14 are connected to form the channel 11;
  • the connecting pipe 14 is connected to the second hose 40 .
  • the base 12 is relatively large, which is conducive to fixing the connection assembly 10 in the subcutaneous tissue.
  • the catheter cap 15 can be a lightweight catheter cap 15 to prevent the connection assembly 10 from falling off and reduce the burden on the animal.
  • the silicone tube, polyethylene tube and connection assembly 10 of the present application are all commercially available products, and the materials can be purchased at an affordable price, which greatly reduces the cost of drug administration.
  • the connecting pipe 14 is L-shaped. Specifically, the connecting pipe 14 is L-shaped, which is convenient for connecting the second hose 40 and the base 12.
  • the base 12 is a tissue-compatible mesh base 12 .
  • tissue-compatible mesh base 12 is used to facilitate long-term storage in the subcutaneous tissue of an animal.
  • the end of the first hose 20 away from the hard tube 30 forms a wedge-shaped structure.
  • the port of the first hose 20 forms a wedge-shaped structure, similar to the end of a needle, which is conducive to expanding the aperture of the port and avoiding blockage.
  • the jugular vein catheter of the utility model has a simple structure and is easy to manufacture, which is convenient for popularization and application.
  • the utility model adopts a hose-hard tube-soft tube mode, and the part entering the blood vessel is a hose, which will not damage the inner wall of the blood vessel or even puncture the blood vessel.
  • the hard tube in the middle helps to improve the success rate of intubation and improve the efficiency of intubation.
  • the hose and the connector are placed in the middle of the scapula on both sides of the shoulder of the mouse or rat to prevent the animal from scratching the catheter and the connector, ensuring that the experiment can proceed smoothly for a long time.
  • the utility model adopts a water drop-shaped connecting bead, which can effectively prevent the first soft tube, the hard tube and the second hard tube from slipping out of the blood vessel.
  • the tube body used in the connection assembly of the utility model matches the commercial catheter cap and the inner insertion needle, and can effectively perform subsequent blood collection, drug administration and other operations.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

一种颈静脉置管，包括：连接组件(10)，设置有通道(11)；第一软管(20)，与通道(11)连通：硬管(30)，与第一软管(20)连通：第二软管(40)，与硬管(30)连通：其中，第一软管(20)的硬度和第二软管(40)的硬度均小于硬管(30)的硬度。颈静脉置管在置管过程中，由于第二软管(40)上连接有硬管(30)，可以形成着力点，便于夹住或握持，从而更容易放入血管中，提高了置管成功率。由于硬管(30)上还连接有第一软管(20)，可以避免硬管(30)损伤血管。

Description

一种颈静脉置管 技术领域
本实用新型涉及医疗器械技术领域，尤其涉及的是一种颈静脉置管。
背景技术
大小鼠是生命科学和医学科研最常用的实验动物。在进行药效学和药物安全性评价中，常需要对动物不同补位进行给药以及取材，及时观察药物代谢情况。常用的给药方式有尾静脉给药、心脏穿刺给药以及颈静脉置管给药。尾静脉血管较细，不适合长期给药；心脏穿刺给药对动物的损伤过大，不符合动物伦理学。
颈静脉置管便于长时间连续给药或者采血监测代谢，给药时对动物刺激小，是药理学实验的重要试验方法。现有技术中，目前市场上现有导管成品主要有两种，一种前端为穿刺针，这种在使用过程中容易刺破血管，造成置管失败；另一种全部导管均为硅胶软管，优点是导管植入后不会损伤血管，但这种导管置管难度高且置管用时长，导致置管成功率低。
因此，现有技术还有待于改进和发展。
实用新型内容
本实用新型要解决的技术问题在于，针对现有技术的上述缺陷，提供一种颈静脉置管，旨在解决现有技术中硅胶软管制成的颈静脉置管的置管成功率低的问题。
本实用新型解决技术问题所采用的技术方案如下：
一种颈静脉置管，包括：
连接组件，设置有通道；
第一软管，与所述通道连通；其中，所述颈静脉置管还包括：
硬管，与所述第一软管连通；
第二软管，与所述硬管连通；
其中，所述第一软管的硬度和所述第二软管的硬度均小于所述硬管的硬度。
所述的颈静脉置管，其中，所述第一软管和所述第二软管分别套设在所述硬管的两端的外侧。
所述的颈静脉置管，其中，所述第一软管和所述第二软管相互连接且一体成型。
所述的颈静脉置管，其中，所述颈静脉置管还包括：
连接珠，位于所述硬管位置，并套设在所述第一软管和所述第二软管外。
所述的颈静脉置管，其中，自所述第一软管朝所述第二软管的方向上，所述连接珠的外径逐渐增大后减小，且所述连接珠的最大外径的位置靠近所述第二软管；和/或
所述硬管朝向所述第二软管的一端延伸至所述连接珠外形成固定位。
所述的颈静脉置管，其中，所述第一软管、所述第二软管、所述硬管以及所述连接珠一体注塑成型。
所述的颈静脉置管，其中，所述第一软管的长度小于所述第二软管的长度；和/或
所述第一软管的长度为1-3cm；和/或
所述第二软管的长度为3-5cm；和/或
所述第一软管和所述第二软管均采用硅胶管；和/或
所述硬管采用聚乙烯管。
所述的颈静脉置管，其中，所述连接组件包括：
底座，设置有通孔；
管体，设置于所述底座的一侧；
连接管，设置于所述底座的另一侧；
导管帽，与所述管体螺纹连接；
封堵柱，设置于所述导管帽内，并插入所述管体；
其中，所述管体、所述通孔以及所述连接管连通形成所述通道；
所述连接管与所述第二软管连接。
所述的颈静脉置管，其中，所述连接管呈L形；和/或
所述底座为组织相容性网面底座。
所述的颈静脉置管，其中，所述第一软管背离所述硬管的一端形成楔形结构。
有益效果：本申请的颈静脉置管在置管过程中，由于第二软管上连接有硬管，可以形成着力点，便于夹住或握持，从而更容易放入血管中，提高了置管成功率。当然，由于硬管上还连接有第一软管，可以避免硬管损伤血管。
附图说明
图1是本实用新型中颈静脉置管的第一结构示意图。
图2是本实用新型中颈静脉置管的第二结构示意图。
图3是本实用新型中颈静脉置管的爆炸图。
图4是本实用新型中颈静脉置管的截面图。
图5是本实用新型中颈静脉置管的截面爆炸图。
图6是本实用新型中小鼠甲基苯丙胺自给药实验结果图。
附图标记说明：
10、连接组件；11、通道；12、底座；121、通孔；13、管体；14、连接管；15、导管帽；16、封堵柱；20、第一软管；30、硬管；40、第二软管；50、连接珠。
具体实施方式
为使本实用新型的目的、技术方案及优点更加清楚、明确，以下参照附图并举实施例对本实用新型进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本实用新型，并不用于限定本实用新型。
请同时参阅图1-图6，本实用新型提供了一种颈静脉置管的一些较佳实施例。
如图1和4所示，颈静脉置管包括：
连接组件10，设置有通道11；
第一软管20，与所述通道11连通；
硬管30，与所述第一软管20连通；
第二软管40，与所述硬管30连通；
其中，所述第一软管20的硬度和所述第二软管40的硬度均小于所述硬管30的硬度。
值得说明的是，现有技术中静脉置管全长均为软管，在置管时无着力点，导致置管难度大且置管手术时间长，造成置管失败率高。本申请的颈静脉置管在置管过程中，由于第二软管40上连接有硬管30，可以形成着力点，便于夹住或握持，从而更容易放入血管中，提高了置管成功率。当然，由于硬管30上还连接有第一软管20，可以避免硬管30损伤血管。
本申请的颈静脉置管置管后，第一软管20、硬管30以及第二软管40位于血管内，连接组件10位于血管外且位于皮下组织内。在需要给药时，将药液注入通道11，使得药液自通道11进入血管。在需要采血时，也可以从通道11采血。
在本实用新型的一个较佳实施例中，请同时参阅图2和图4，所述第一软管20和所述第二软管40分别套设在所述硬管30的两端的外侧。
具体地，为了避免硬管30损伤血管，第一软管20和第二软管40分别套设在硬管30的两端的外侧。
在本实用新型的一个较佳实施例中，所述第一软管20和所述第二软管40相互连接且一体成型。
具体地，当第一软管20和第二软管40均套设在硬管30外时，第一软管20和第二软管40可以相互连接且一体成型，也就是说，将硬管30插入到软管内，软管按照硬管30的位置划分为两部分，一部分为第一软管20，另一部分为第二软管40。
在本实用新型的一个较佳实施例中，请同时参阅图3-图5，所述颈静脉置管还包括：
连接珠50，位于所述硬管30位置，并套设在所述第一软管20和所述第二软管40外。
具体地，为了进一步第一软管20、硬管30以及第二软管40在静脉血管中脱落，需要进行固定，在硬管30外设置连接珠50，并套设在第一软管20和第二软管40外。连接珠50的尺寸根据血管的内径设置。连接珠50位于血管内后，连接珠50抵接在血管的内壁上，可以在一定程度上固定硬管30，避免第一软管20、硬管30以及第二软管40 的相互脱落。与现有技术相比，纯软管固定力度不易控制，若采用线将血管捆绑以固定纯软管，捆紧了容易造成软管堵塞，捆松了纯软管容易脱落。而本申请中，由于设置了硬管30以及连接珠50，则可以固定柱硬管30，避免第一软管20、硬管30以及第二软管40在不断晃动下而脱落。
连接珠50还可以对第一软管20与硬管30的连接处进行有效密封，对第二软管40与硬管30的连接处进行有效密封，避免漏液。
在本实用新型的一个较佳实施例中，请同时参阅图3-图5，自所述第一软管20朝所述第二软管40的方向上，所述连接珠50的外径逐渐增大后减小，且所述连接珠50的最大外径的位置靠近所述第二软管40。
具体地，连接珠50采用水滴形连接珠50，水滴形连接珠50具有外径较大的大端和外径较小的小端，小端靠近第一软管20，大端靠近第二软管40。
在本实用新型的一个较佳实施例中，请同时参阅图1和图4，所述硬管30朝向所述第二软管40的一端延伸至所述连接珠50外形成固定位。
具体地，为了进一步固定，硬管30的长度较长，延伸至连接珠50外，形成固定位，固定位用于与血管固定，确保第一软管20、硬管30以及第二软管40在静脉血管中脱落。
在本实用新型的一个较佳实施例中，所述第一软管20、所述第二软管40、所述硬管30以及所述连接珠50一体注塑成型。具体地，第一软管20、第二软管40、硬管30以及连接珠50采用一体注塑成型。
在本实用新型的一个较佳实施例中，请同时参阅图1-图3，所述第一软管20的长度小于所述第二软管40的长度。
具体地，第一软管20的长度较小，第二软管40的长度较长，也就是说，硬管30位于靠近第一软管20的端口的位置。
在本实用新型的一个较佳实施例中，请同时参阅图1-图3，所述第一软管20的长度为1-3cm。所述第二软管40的长度为3-5cm。
具体地，第一软管20和第二软管40的长度可以根据需要进行设置。
在本实用新型的一个较佳实施例中，所述第一软管20和所述第二软管40均采用硅 胶管。
具体地，第一软管20和第二软管40可以采用硅胶管。当然还可以根据需要采用其它材料制成第一软管20和第二软管40。
在本实用新型的一个较佳实施例中，所述硬管30采用聚乙烯管。
具体地，硬管30可以采用聚乙烯管。当然还可以根据需要采用其它材料制成硬管30。
在本实用新型的一个较佳实施例中，请同时参阅图3-图5，所述连接组件10包括：
底座12，设置有通孔121；
管体13，设置于所述底座12的一侧；
连接管14，设置于所述底座12的另一侧；
导管帽15，与所述管体13螺纹连接；
封堵柱16，设置于所述导管帽15内，并插入所述管体13；
其中，所述管体13、所述通孔121以及所述连接管14连通形成所述通道11；
所述连接管14与所述第二软管40连接。
具体地，底座12的尺寸较大，有利于将连接组件10固定在皮下组织内。当然，导管帽15可以采用轻质导管帽15，避免连接组件10脱落，也可以降低动物的负担。本申请的硅胶管、聚乙烯管以及连接组件10均为市售产品，可购买材料且价格实惠，极大地降低了给药成本。
在本实用新型的一个较佳实施例中，请同时参阅图3-图5，所述连接管14呈L形。具体地，连接管14呈L形，便于连接第二软管40和底座12。
在本实用新型的一个较佳实施例中，所述底座12为组织相容性网面底座12。
具体地，采用组织相容性网面底座12，便于长期存于动物的皮下组织内。
在本实用新型的一个较佳实施例中，请同时参阅图1-图3，所述第一软管20背离所述硬管30的一端形成楔形结构。
具体地，第一软管20的端口形成楔形结构，类似针头的端部，有利于扩大端口的孔径，避免堵塞。
本实用新型的有益效果是：
本实用新型的颈静脉置管结构简单、制作简便，便于普及应用。本实用新型采用软管-硬管-软管模式，进入血管部分为软管，不会损伤血管内壁甚至刺破血管。中间的硬管有助于提高插管成功率，提升插管效率。通过皮下隧道的方式，将软管和连接件置于小鼠或者大鼠肩两侧胛骨中间，避免动物抓咬导管和连接件，保障实验能长期顺利进行。
本实用新型采用水滴形连接珠，可有效防止第一软管、硬管以及第二硬管滑出血管。
本实用新型连接组件所用管体，匹配商品化导管帽和内插针，可有效进行后续采血、给药等操作。
经过实验，采用本申请的颈静脉置管进行小鼠颈静脉插管成功率超过90％。运用本静脉装置进行小鼠甲基苯丙胺自给药实验，小鼠成功建立自身给药行为(图6)，表明本申请的颈静脉置管不易脱落失效，可靠性高。
应当理解的是，本实用新型的应用不限于上述的举例，对本领域普通技术人员来说，可以根据上述说明加以改进或变换，所有这些改进和变换都应属于本实用新型所附权利要求的保护范围。

Claims (10)

  1. 一种颈静脉置管，包括：
    连接组件，设置有通道；
    第一软管，与所述通道连通；其特征在于，所述颈静脉置管还包括：
    硬管，与所述第一软管连通；
    第二软管，与所述硬管连通；
    其中，所述第一软管的硬度和所述第二软管的硬度均小于所述硬管的硬度。
  2. 根据权利要求1所述的颈静脉置管，其特征在于，所述第一软管和所述第二软管分别套设在所述硬管的两端的外侧。
  3. 根据权利要求2所述的颈静脉置管，其特征在于，所述第一软管和所述第二软管相互连接且一体成型。
  4. 根据权利要求2所述的颈静脉置管，其特征在于，所述颈静脉置管还包括：
    连接珠，位于所述硬管位置，并套设在所述第一软管和所述第二软管外。
  5. 根据权利要求4所述的颈静脉置管，其特征在于，自所述第一软管朝所述第二软管的方向上，所述连接珠的外径逐渐增大后减小，且所述连接珠的最大外径的位置靠近所述第二软管；和/或
    所述硬管朝向所述第二软管的一端延伸至所述连接珠外形成固定位。
  6. 根据权利要求4所述的颈静脉置管，其特征在于，所述第一软管、所述第二软管、所述硬管以及所述连接珠一体注塑成型。
  7. 根据权利要求1所述的颈静脉置管，其特征在于，所述第一软管的长度小于所述第二软管的长度；和/或
    所述第一软管的长度为1-3cm；和/或
    所述第二软管的长度为3-5cm；和/或
    所述第一软管和所述第二软管均采用硅胶管；和/或
    所述硬管采用聚乙烯管。
  8. 根据权利要求1-7任意一项所述的颈静脉置管，其特征在于，所述连接组件包括：
    底座，设置有通孔；
    管体，设置于所述底座的一侧；
    连接管，设置于所述底座的另一侧；
    导管帽，与所述管体螺纹连接；
    封堵柱，设置于所述导管帽内，并插入所述管体；
    其中，所述管体、所述通孔以及所述连接管连通形成所述通道；
    所述连接管与所述第二软管连接。
  9. 根据权利要求8所述的颈静脉置管，其特征在于，所述连接管呈L形；和/或
    所述底座为组织相容性网面底座。
  10. 根据权利要求1-7任意一项所述的颈静脉置管，其特征在于，所述第一软管背离所述硬管的一端形成楔形结构。
PCT/CN2022/132951 2022-11-12 2022-11-18 一种颈静脉置管 WO2024098453A1 (zh)

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Publication number Priority date Publication date Assignee Title
US6533770B1 (en) * 1998-01-21 2003-03-18 Heartport, Inc. Cannula and method of manufacture and use
JP2002017865A (ja) * 2000-07-11 2002-01-22 Fuji Systems Kk 血管挿入用カニューレ
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