WO2024059715A3 - Microbulles et leurs procédés de fabrication - Google Patents

Microbulles et leurs procédés de fabrication Download PDF

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Publication number
WO2024059715A3
WO2024059715A3 PCT/US2023/074198 US2023074198W WO2024059715A3 WO 2024059715 A3 WO2024059715 A3 WO 2024059715A3 US 2023074198 W US2023074198 W US 2023074198W WO 2024059715 A3 WO2024059715 A3 WO 2024059715A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbubbles
providing
methods
surfactant
making same
Prior art date
Application number
PCT/US2023/074198
Other languages
English (en)
Other versions
WO2024059715A2 (fr
Inventor
Brian Oeffinger
Margaret Wheatley
Original Assignee
Drexel University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University filed Critical Drexel University
Publication of WO2024059715A2 publication Critical patent/WO2024059715A2/fr
Publication of WO2024059715A3 publication Critical patent/WO2024059715A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/237—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media
    • B01F23/2373—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media for obtaining fine bubbles, i.e. bubbles with a size below 100 µm
    • B01F23/2375—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media for obtaining fine bubbles, i.e. bubbles with a size below 100 µm for obtaining bubbles with a size below 1 µm

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

La présente invention concerne des procédés de préparation de microbulles acoustiquement sensibles. Le procédé comprend les étapes consistant à fournir un premier système comprenant au moins un tensioactif soluble dans l'eau ; fournir un second système comprenant au moins un tensioactif insoluble dans l'eau, la fourniture du second système comprenant éventuellement l'étape d'autoclavage du second système et éventuellement le refroidissement du système autoclavé obtenu ; et mettre en contact le premier système et le second système à la température inférieure au point de fusion du second tensioactif, de façon à produire un mélange comprenant des microbulles.
PCT/US2023/074198 2022-09-14 2023-09-14 Microbulles et leurs procédés de fabrication WO2024059715A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263406607P 2022-09-14 2022-09-14
US63/406,607 2022-09-14

Publications (2)

Publication Number Publication Date
WO2024059715A2 WO2024059715A2 (fr) 2024-03-21
WO2024059715A3 true WO2024059715A3 (fr) 2024-05-10

Family

ID=90275911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/074198 WO2024059715A2 (fr) 2022-09-14 2023-09-14 Microbulles et leurs procédés de fabrication

Country Status (1)

Country Link
WO (1) WO2024059715A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110150778A1 (en) * 2003-12-22 2011-06-23 Bracco Research S.A. Assembly of Gas-Filled Microvesicle With Active Component For Contrast Imaging
US20150342854A1 (en) * 2012-12-27 2015-12-03 Hayashibara Co., Ltd. External dermal composition for anti-ageing and method for producing the same
US20160059036A1 (en) * 2014-08-26 2016-03-03 Drexel University Surfactant microbubbles and process for preparing and methods of using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110150778A1 (en) * 2003-12-22 2011-06-23 Bracco Research S.A. Assembly of Gas-Filled Microvesicle With Active Component For Contrast Imaging
US20150342854A1 (en) * 2012-12-27 2015-12-03 Hayashibara Co., Ltd. External dermal composition for anti-ageing and method for producing the same
US20160059036A1 (en) * 2014-08-26 2016-03-03 Drexel University Surfactant microbubbles and process for preparing and methods of using the same

Also Published As

Publication number Publication date
WO2024059715A2 (fr) 2024-03-21

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