WO2024040922A1 - Dispositif de test de plaquettes - Google Patents

Dispositif de test de plaquettes Download PDF

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Publication number
WO2024040922A1
WO2024040922A1 PCT/CN2023/080565 CN2023080565W WO2024040922A1 WO 2024040922 A1 WO2024040922 A1 WO 2024040922A1 CN 2023080565 W CN2023080565 W CN 2023080565W WO 2024040922 A1 WO2024040922 A1 WO 2024040922A1
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WIPO (PCT)
Prior art keywords
carrier
detection device
sample
platelet
assembly
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PCT/CN2023/080565
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English (en)
Chinese (zh)
Inventor
张传国
强勇平
李运奇
赖鹏飞
郑凯
谢明君
Original Assignee
深圳市爱康生物科技股份有限公司
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Application filed by 深圳市爱康生物科技股份有限公司 filed Critical 深圳市爱康生物科技股份有限公司
Publication of WO2024040922A1 publication Critical patent/WO2024040922A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

Definitions

  • the present application relates to the technical field of medical devices, and in particular to a platelet detection device.
  • Platelet transfusion is an effective measure to prevent and treat bleeding caused by thrombocytopenia or functional defects, and to reduce the mortality rate of bleeding caused by thrombocytopenia after radiotherapy and chemotherapy.
  • the ineffectiveness of platelet transfusion has gradually attracted people's attention.
  • platelet detection methods generally include antibody detection and cross-matching.
  • the platelet antibody detection antigen can help doctors find out the reasons for ineffective platelet transfusion; it can also guide doctors to choose appropriate platelet transfusion plans for patients to rationally and effectively utilize precious blood resources; it can also help diagnose repeated transfusions.
  • the corresponding antibodies in their serum should be measured regularly to predict the effect of platelet transfusion and promptly discover immune factors that lead to ineffective platelet transfusion.
  • Cross-matching can distinguish the type of platelet antibodies in patients; it can also select corresponding antigen-negative platelets for transfusion to improve the effect of platelet transfusion.
  • this application proposes a platelet detection device that can perform both platelet antibody detection experiments and platelet cross-matching experiments, thereby Reduce the cost of platelet testing.
  • the platelet detection device includes: a turntable mechanism on which a carrier assembly is detachably provided.
  • the carrier assembly includes a first carrier assembly or a second carrier assembly, and a test tube hole is provided on the carrier assembly. , the test tube hole is used to place reagent bottles loaded with samples or corresponding types of reagents; wherein, the first carrier component is used to perform antibody detection experiments, and the second carrier component is used to perform cross-matching experiments; centrifugal incubation mechanism , is arranged on one side of the turntable mechanism.
  • the centrifugal incubation mechanism includes a centrifuge and an incubator.
  • the incubator is provided with micro-slats.
  • the centrifuge is provided inside the incubator.
  • the centrifuge is connected to the micro-slats.
  • the micro-slats are provided with There are multiple microplate holes.
  • the centrifuge is used to centrifuge the samples in the microplate holes.
  • the incubator is used to incubate the samples in the microplate holes.
  • a first window is provided at the upper end of the incubator.
  • the sample adding mechanism is set on the turntable mechanism. Above, the sample adding mechanism includes a first driving component and a sample adding needle.
  • the first driving component is used to drive the sample adding needle to add sample into the hole;
  • the interpretation mechanism is set above the turntable mechanism, and the interpretation mechanism is used to analyze the experimental results of the sample. Perform interpretation.
  • the platelet detection device has at least the following beneficial effects: when performing an antibody detection experiment, the first carrier component can be placed on the turntable mechanism, and the antibodies can be placed at different positions of the first carrier component Samples and reagents required for detection experiments are used to conduct antibody detection experiments; when performing cross-matching experiments, a second carrier component can be placed on the turntable mechanism, and cross-matching laboratories are placed at different positions of the second carrier component Required samples and reagents to perform cross-matching experiments.
  • this application can effectively be compatible with antibody detection experiments and cross-matching experiments, thereby reducing the cost of platelet detection.
  • the turntable mechanism is an annular hollow structure
  • the turntable mechanism is provided with a first drive unit and a second drive unit
  • the carrier assembly is disposed on the outer ring of the turntable mechanism
  • the first drive unit and the second drive unit Both are connected to the carrier assembly.
  • the incubator is arranged in the middle of the turntable mechanism.
  • the first drive unit is used to drive the turntable mechanism to drive the carrier assembly to rotate to a preset position.
  • the second drive unit is used to drive the reagent bottle to rotate and shake evenly.
  • the first driving unit drives the outer ring of the turntable mechanism to rotate and rotates the corresponding sample position to the preset position so that the sample can be processed accordingly.
  • the second driving unit is used to drive the reagent bottle loaded with the reagent to be mixed for rotation and mixing. uniform.
  • the first carrier assembly includes a reagent carrier and a sample carrier.
  • the reagent carrier and sample carrier required for antibody detection are placed on the outer ring of the turntable mechanism, so that the sample carrier and reagent carrier are rotated to the bottom of the sample loading mechanism respectively, and the samples and reagents are sequentially added to the centrifuge incubator through the sample adding needle. organization to take the next step.
  • the first carrier assembly includes 4 sample carriers and 1 reagent carrier. By setting 4 sample carriers and 1 reagent carrier, multiple samples can be tested in each batch, effectively improving detection efficiency. efficiency.
  • the second carrier assembly includes a sample carrier, a reagent carrier and a mixing carrier, and the mixing carrier is connected to the second driving unit.
  • the reagent carrier, sample carrier and mixing carrier required for cross-matching are placed on the outer ring of the turntable mechanism.
  • the mixing carrier is connected to the second drive unit, and the second drive unit drives the mixing carrier to be placed on the outer ring of the turntable mechanism. After the reagents are mixed, the mixed reagents and samples are moved to the centrifugal incubation mechanism for the next step.
  • the second carrier assembly includes a sample carrier, a reagent carrier, an eight-position mixing carrier and two four-position mixing carriers.
  • the sampling mechanism is provided with two groups of sampling channels, each group of sampling channels is provided with at least one sampling needle and one driving unit, and the two groups of sampling channels are independently lifted and lowered in the vertical direction. sports. By setting up two sets of independently ascending and descending loading channels, two sample positions can be loaded at the same time, thereby improving the loading efficiency and improving the experimental efficiency of platelet antibody detection and/or cross-matching.
  • the interpretation mechanism is connected to the sample adding mechanism, and the interpretation mechanism includes a fifth driving unit, and the fifth driving unit is used to drive the interpretation mechanism to move in the vertical direction.
  • the platelet detection device further includes a lever, which is connected to the fifth driving unit, and the lever is used to open or close the first window.
  • a magnet is provided at the lower end of the lever, and a blocking piece is provided at the upper end of the first window. The magnet is used to cooperate with the blocking piece to open or close the first window.
  • a sensing component is provided on the interpretation mechanism, and the sensing component is used to sense the spatial position of the interpretation mechanism.
  • the interpretation mechanism can be accurately positioned to avoid the problem of low interpretation accuracy caused by the failure of the interpretation mechanism to be aligned.
  • the interpretation mechanism also includes a camera, a camera box and a light-shielding sleeve.
  • the camera is arranged in the middle of the camera box, and the light-shielding sleeve is arranged at the lower end of the camera box. Installing a light-shielding sleeve at the lower end of the camera box can effectively avoid interference from ambient light and improve the accuracy of interpretation of experimental results.
  • the platelet detection device further includes a plate washing mechanism.
  • the plate washing mechanism includes a plate washing head assembly and a second driving assembly.
  • the second driving assembly is used to drive the plate washing head assembly to perform lifting movements.
  • the board washing head assembly includes at least a set of liquid injection needles and liquid suction needles.
  • the liquid injection needle and the liquid suction needle are provided at the lower end of the board washing head assembly.
  • the liquid injection needle and/or the liquid suction needle are provided with an escape portion. Bend the end toward the middle of the injection needle and the aspiration needle.
  • a maintenance pool is also provided on one side of the second driving assembly, and the maintenance pool is used for cleaning and maintenance of the washing head assembly.
  • the washing mechanism also includes a washing head hanger and a washing head hanger.
  • the upper end of the washing head assembly is also provided with a first fixing hole and a first adjustment hole.
  • the washing head assembly passes through the first fixing hole and the first adjustment hole.
  • the hole is fixedly connected to the washing head pendant, and the first adjustment hole is used to adjust the angle of the washing head assembly in the horizontal direction.
  • Figure 1 is a schematic diagram of the overall structure of a platelet detection device according to an embodiment of the present application
  • Figure 2 is a schematic structural diagram of the turntable mechanism of the platelet detection device according to the embodiment of the present application.
  • Figure 3 is a schematic structural diagram of the turntable mechanism of the platelet detection device according to another embodiment of the present application.
  • Figure 4 is a partial structural schematic diagram of the turntable mechanism of the platelet detection device according to the embodiment of the present application.
  • Figure 5 is a schematic structural diagram of the sample adding mechanism and the interpretation mechanism of the platelet detection device according to the embodiment of the present application;
  • Figure 6 is an exploded view of the interpretation mechanism of the platelet detection device according to the embodiment of the present application.
  • Figure 7 is a schematic structural diagram of the plate washing mechanism of the platelet detection device according to the embodiment of the present application.
  • Figure 8 is a schematic structural diagram of the plate washing mechanism of the platelet detection device according to another embodiment of the present application.
  • Figure 9 is a schematic structural diagram of the plate washing head assembly of the platelet detection device according to the embodiment of the present application.
  • Figure 10 is a cross-sectional view of the plate washing head assembly of the platelet detection device according to the embodiment of the present application.
  • Figure 11 is a top view of the plate washing head assembly of the platelet detection device according to the embodiment of the present application.
  • platelet antibody detection and cross-matching are generally used to determine the antibody type of platelets to avoid ineffective transfusion. These two experiments require It is performed on the corresponding antibody detection device and cross-matching device respectively. In order to meet different detection needs, it is necessary to have both platelet antibody detection and cross-matching. This will significantly increase the cost of platelet detection.
  • this application proposal proposes a platelet detection device that can perform both platelet antibody detection experiments and platelet cross-matching experiments, thereby reducing the risk of platelet loss. Testing costs.
  • a platelet detection device including: a turntable mechanism 100, on which a carrier assembly is detachably provided.
  • the carrier assembly includes a first carrier assembly or a second carrier assembly.
  • the carrier component is provided with test tube holes, and the test tube holes are used to place reagent bottles loaded with samples or corresponding types of reagents; wherein the first carrier component is used for antibody detection experiments, and the second carrier component is used for cross Matching experiment;
  • the centrifugal incubation mechanism 200 is arranged on one side of the turntable mechanism 100.
  • the centrifugal incubation mechanism 200 includes a centrifuge and an incubator 210.
  • the incubator 210 is provided with micro-slats.
  • the centrifuge is arranged inside the incubator 210.
  • the centrifuge The machine is connected to the microplate strip.
  • a plurality of microplate holes are provided on the microplate strip.
  • the centrifuge is used to centrifuge the samples in the microplate holes.
  • the incubator 210 is used to incubate the samples in the microplate holes.
  • the incubator A first window 211 is opened at the upper end of 210; the sample adding mechanism 300 is arranged above the turntable mechanism 100.
  • the sample adding mechanism 300 includes a first driving component and a sample adding needle.
  • the first driving component is used to drive the sample adding needle to add the sample into the hole.
  • the interpretation mechanism 400 is arranged above the turntable mechanism 100, and the interpretation mechanism 400 is used to interpret the experimental results of the sample.
  • the first carrier component when performing an antibody detection experiment, can be placed on the turntable mechanism 100, and the samples and reagents required for the antibody detection experiment can be placed in different positions of the first carrier component to perform the antibody detection experiment;
  • a second carrier assembly can be placed on the turntable mechanism 100, and the samples and reagents required for the cross-matching experiment can be placed at different positions of the second carrier assembly to perform the cross-matching experiment. That is, the solution of this application can effectively be compatible with platelet antibody detection experiments and cross-matching experiments by arranging detachable first carrier components and second carrier components, so as to meet different platelet detection needs and reduce platelet detection costs.
  • the turntable mechanism 100 is an annular hollow structure, the turntable mechanism 100 is provided with a first driving unit and a second driving unit 133, and the carrier assembly is provided outside the turntable mechanism 100. Circle, the first driving unit and the second driving unit 133 are both connected to the carrier assembly.
  • the incubator 210 is disposed in the middle of the turntable mechanism 100.
  • the first drive unit is used to drive the turntable mechanism 100 to drive the carrier assembly to rotate to a preset position.
  • the second driving unit 133 is used to drive the reagent bottle to rotate and mix.
  • the first driving unit drives the outer ring of the turntable mechanism 100 to rotate and rotate the corresponding sample position to a preset position so that the sample can be processed accordingly.
  • the second driving unit 133 is used to drive the reagent bottle loaded with the reagent to be mixed to rotate and mix.
  • the turntable mechanism 100 is also provided with a carrier base 160 and a turntable base 150.
  • a support column 190 is connected between the turntable base 150 and the carrier base 160.
  • the turntable base 150 is connected to the first driving unit, and the first driving unit drives the turntable.
  • the base 150 rotates, thereby driving the carrier base 160 and the carrier assembly to rotate along the center of the annular hollow structure.
  • the first drive unit can be set as a stepper motor, and the system controls the rotation angle of the motor to control the carrier assembly to rotate to the preset position. to the sample adding position and perform subsequent sample adding actions.
  • the first carrier assembly includes a reagent carrier 110 and a sample carrier 120 .
  • the reagent carrier 110 and sample carrier 120 required for antibody detection are placed on the outer ring of the turntable mechanism 100, so that the sample carrier 120 and the reagent carrier 110 can be rotated to the bottom of the sample loading mechanism 300 respectively, and the sample can be transferred through the sample needle. and reagents are sequentially added to the centrifugal incubation mechanism 200, and the next step is performed.
  • the first carrier assembly includes 4 sample carriers 120 and 1 reagent carrier 110.
  • 4 sample carriers 120 and 1 reagent carrier 110 By arranging 4 sample carriers 120 and 1 reagent carrier 110, multiple samples can be placed at one time to avoid multiple samples.
  • the action of placing samples on the outer ring of the turntable mechanism 100 can also complete the detection of multiple samples in each batch, thereby effectively improving detection efficiency.
  • the number of sample carriers 120 and reagent carriers 110 at this time is related to the specifications and models of the sample carriers 120 and reagent carriers 110 and the outer ring diameter of the turntable mechanism 100.
  • the sample carrier 120 and the reagent carrier 110 can be spread all over the outer ring of the turntable mechanism 100 . Therefore, other numbers of sample carriers 120 and reagent carriers 110 can also be provided in conjunction with the turntable mechanism 100 .
  • the second carrier assembly includes a sample carrier 120 , a reagent carrier 110 and a mixing carrier 130 , and the mixing carrier 130 is connected to the second driving unit 133 .
  • the reagent carrier 110, sample carrier 120 and mixing carrier 130 required for cross-matching are placed on the outer ring of the turntable mechanism 100.
  • the mixing carrier 130 is connected to the second driving unit 133, and the second driving unit 133 drives Mixing carrier 130 After the reagents placed therein are mixed, the mixed reagents and samples are moved to the centrifugal incubation mechanism 200 for the next step.
  • the second carrier assembly includes a sample carrier 120 , a reagent carrier 110 , an eight-position mixing carrier 131 and two four-position mixing carriers 132 .
  • a sample carrier 120 a sample carrier 120
  • a reagent carrier 110 an eight-position mixing carrier 131 and two four-position mixing carriers 132 .
  • eight-position mixing carrier 131 and two four-position mixing carriers 132 By arranging one eight-position mixing carrier 131 and two four-position mixing carriers 132, multiple sets of reagents can be mixed at the same time, thereby improving the mixing efficiency and thereby improving the experimental efficiency of cross-matching.
  • the specifications and quantities of the sample carrier 120 , the reagent carrier 110 and the mixing carrier 130 at this time are different from the specifications and models of the sample carrier 120 , the reagent carrier 110 and the mixing carrier 130 and the turntable mechanism 100 is related to the diameter of the outer ring.
  • the sample carrier 120, the reagent carrier 110 and the mixing carrier 130 can be placed all over the outer ring of the turntable mechanism 100. Therefore, other numbers of sample carriers 120 , reagent carriers 110 and mixing carriers 130 can also be provided in conjunction with the turntable mechanism 100 .
  • a positioning column 170 and an anti-fool column 180 can be provided on the carrier base 160.
  • the positioning column 170 is used for positioning the carrier assembly to prevent the positioning of the carrier assembly.
  • the dead column 180 is used for position limiting to prevent the carrier assembly from being placed in the wrong position.
  • a handheld portion 140 can be provided on the sample carrier 120 , the reagent carrier 110 and the mixing carrier 130 .
  • the sample adding mechanism 300 is provided with two groups of sample adding channels. Each group of sample added channels is provided with at least one sample adding needle and one driving unit. The two groups of sample added The channels move independently in the vertical direction. By setting up two sets of independently ascending and descending loading channels, two sample positions can be loaded at the same time, thereby improving the loading efficiency and improving the experimental efficiency of platelet antibody detection and/or cross-matching.
  • the two groups of sampling channels are respectively a first sampling channel 310 and a second sampling channel 320.
  • the first sampling channel 310 is provided with a first sampling needle 31
  • the second sampling channel 320 is provided with a first sampling needle 311.
  • Two sampling needles 321, the first sampling needle 311 is driven by the third driving unit 312 to drive the corresponding synchronous wheel and timing belt
  • the first screw 350 and the second sampling needle 321 are driven by the fourth driving unit 322 through the corresponding synchronization
  • the wheel and the synchronous belt drive the screw to rotate.
  • the third driving unit 312 and the fourth driving unit 322 can be motors.
  • a first linear guide 330 can also be provided on the first sampling channel 310, and on the second sampling channel 330 can be provided.
  • a second linear guide rail 327 is provided on 320 to respectively limit the movement of the first sample adding needle 311 and the second sample adding needle 321 in the vertical direction.
  • sampling mechanism 300 can also be provided with three groups of sampling channels, or even more, but its structure and principle are similar to the foregoing contents, and are regarded as the essence of the sampling mechanism 300 with the two groups of sampling channels mentioned above. same. No further details will be given here.
  • the interpretation mechanism 400 is connected to the sample adding mechanism.
  • the interpretation mechanism 400 includes a fifth driving unit 328.
  • the fifth driving unit 328 is used to drive the interpretation mechanism 400 to move in the vertical direction.
  • the interpretation mechanism 400 includes a camera 410 and a camera box 420 that protects the camera 410.
  • a light-shielding sleeve 430 is connected to the lower end of the camera box 420.
  • the first driving component drives the interpretation mechanism 400 through the first window 211 and descends to the incubator 210.
  • the lower end of the light-shielding sleeve is in contact with the microplate hole, or is separated from the microplate hole by a first preset distance.
  • the camera 410 captures the experimental results in the microplate hole, it can almost completely isolate the outside.
  • the interference of ambient light can effectively improve the accuracy of the interpretation of experimental results by the interpretation mechanism 400.
  • the platelet detection device further includes a lever 360, which is connected to the fifth driving unit 328.
  • the lever 360 is used to open or close the first window 211.
  • a magnet 361 is provided at the lower end of the lever 360, and a blocking piece is provided at the upper end of the first window 211.
  • the magnet 361 is used to cooperate with the blocking piece to open or close the first window 211.
  • the fifth driving unit 328 is fixedly connected to the first fixing part 323, and the first fixing part 323 is fixedly connected to the second fixing part 324.
  • the lever 360 is movably connected to the second fixing member 324 through the second adjustment hole provided.
  • the second adjustment hole is a waist-shaped hole.
  • the limiting nail 363 passes through the second adjustment hole provided on the lever 360 and is connected to the second fixing member 324 .
  • 324 is fixedly connected, and the lever 360 is provided with a second connector 362.
  • the second connector 362 is connected to the interpretation mechanism 400. As the interpretation mechanism 400 moves in the vertical direction, the amplitude of the rise or fall of the lever 360 is the second Adjust the length of the hole.
  • a first adapter 326 is provided at the lower end of the fifth drive unit 328.
  • the first adapter 326 is fixedly connected to the shaft end of the fifth drive unit 328, and the first adapter 326 is fixedly connected to the third connecting member 325.
  • a third fixing part 470 is fixedly provided on the third connecting part 325.
  • the third fixing part 470 is connected to the camera pendant 440.
  • the lower end of the camera pendant 440 is connected to the cover plate 450.
  • the cover plate 450 is fixed to the camera 410. connect.
  • a sensing component 460 is provided on the interpretation mechanism 400, which can accurately sense the movement of the interpretation mechanism 400.
  • the spatial position realizes the precise positioning of the interpretation mechanism 400 with a descending distance in the horizontal direction.
  • the sensing component 460 includes a vertical direction sensing unit to accurately sense the position of the interpretation mechanism 400 in the vertical direction, thereby achieving precise positioning of the interpretation mechanism 400 in the vertical direction and improving the accuracy of interpretation.
  • the vertical direction sensing unit includes a positioning sensor 461 and a sensing piece 462.
  • the positioning sensor 461 is arranged in a U-shape or a ring shape, so that the sensing piece 462 passes through the middle of the positioning sensor 461, and the positioning sensor 461 senses the sensing piece 462. The distance by which the sensing and interpretation mechanism 400 rises or falls through the distance.
  • the platelet detection device further includes a plate washing mechanism 500.
  • the plate washing mechanism 500 includes a plate washing head assembly 510 and a second driving assembly 520.
  • the second driving assembly 520 is used to drive the plate washing.
  • the head assembly 510 performs lifting and lowering movements.
  • the board washing head assembly 510 includes at least a set of liquid injection needles 511 and liquid suction needles 512.
  • the liquid injection needle 511 and the liquid suction needle 512 are provided at the lower end of the board washing head assembly 510.
  • the needle 511 and/or the liquid aspiration needle 512 is provided with an escape portion 513, and the escape portion 513 is bent toward the middle of the liquid injection needle 511 and the liquid aspiration needle 512.
  • the avoidance part 513 is provided at the preset position of the injection needle 511 and/or the suction needle 512, and the avoidance part 513 is bent toward the middle of the injection needle 511 and the suction needle 512, thereby effectively avoiding the impact of the needle. risks of.
  • a maintenance pool 560 is provided on one side of the second driving assembly 520 .
  • the maintenance pool 560 is used for cleaning and maintenance of the washing head assembly 510 .
  • the plate washer head assembly 510 can be cleaned and maintained in a timely manner to avoid cross-contamination of samples and at the same time improve the service life of the plate washer head assembly 510.
  • the washing mechanism 500 further includes a washing head hanger 580 and a washing head hanger 590.
  • the upper end of the washing head assembly 510 is also provided with a first fixing hole 515 and a first adjustment hole 514.
  • the washing head assembly 510 is fixedly connected to the washing head hanger 560 through the first fixing hole 515 and the first adjustment hole 514.
  • the first adjustment hole 514 is used to adjust the angle of the washing head assembly 510 in the horizontal direction.
  • the position of the washing head assembly 510 in the horizontal direction can be accurately adjusted, thereby achieving precise positioning of the washing head assembly 510 and the microplate well, which can avoid The positioning is not accurate and the corresponding microplate hole cannot be inserted or there is a problem with the striker.
  • the washer head hanger 580 is fixedly connected to the washer head assembly 510.
  • the washer head hanger 590 is provided with a U-shaped groove 591.
  • the U-shaped groove 591 is used to restrict the washer head hanger 580 from sliding in the vertical direction.
  • the three holes are arranged in a triangular shape. The screws pass through the first fixing hole 515 of the washing head hanger 580 and are fixedly connected to the washing head assembly 510.
  • the washing head pendant 580 and the washing head assembly 510 are fixedly connected along the first fixing hole 515;
  • the first adjustment hole 514 is set as a waist-shaped hole, which can adjust the rotation angle of the washing head assembly 510 in the horizontal direction, that is, with The first fixing hole 515 is used as the base point. Rotate and adjust the position of the washing head assembly 510. After the adjustment is in place, tighten the screw passing through the first adjustment hole 514 to fix the position of the washing head pendant 580 and the washing head assembly 510. , thereby enabling the washing head assembly 510 to be positioned more accurately.
  • adjustable waist-shaped holes while achieving precise positioning, the processing accuracy of other matching parts can also be reduced, ultimately achieving the purpose of reducing costs.
  • the washing mechanism 500 also includes a bracket 570 , which is used to support the washing head assembly 510 and the maintenance tank 560 .
  • the second driving assembly 520 also includes a motor, a third linear guide 530, a second screw 540 and a hub 550.
  • the motor drives the second screw 540 along the third straight line through the synchronous wheel and synchronous belt connected thereto.
  • the guide rail 530 moves in the vertical direction, and the washing head hanger 590 is fixedly connected to the second driving assembly 520, thereby driving the washing head assembly 510 to move in the vertical direction.
  • a hub 550 is used to organize and collect them, which can not only increase the service life of the wire connections, but also improve the overall aesthetics of the platelet detection device.
  • the experimental process of platelet antibody detection is:
  • the corresponding sample carrier 120 and the reagent carrier 110 are placed on the turntable mechanism 100, and the corresponding microplate strips are placed in the incubator 210; wherein, there are four sample carriers and microplate strips, and each sample carrier There are 8 holes on both the rack and the microstrip.
  • the platelet suspension, indicator red blood cells, negative control, positive control, low ionic strength solution, and anti-human IgG solution are placed on the reagent carrier in sequence;
  • the reagent bottles containing red blood cells and platelets are connected to the second driving unit 133.
  • the second driving unit 133 drives the reagent bottle containing platelets and the reagent bottle indicating red blood cells to rotate and mix them;
  • the fifth driving unit 328 drives the lever 360 downward, and cooperates with the stopper at the upper end of the first window 211. After opening the first window 211, the fifth driving unit 328 rises and returns to its original position;
  • the fifth driving unit 328 drives the lever 360 downward, cooperates with the baffle at the upper end of the first window 211, closes the first window 211 and rises back to the original position;
  • the fifth driving unit 328 drives the lever 360 downward, and cooperates with the stopper at the upper end of the first window 211. After opening the first window 211, the fifth driving unit 328 rises and returns to its original position;
  • the fifth driving unit 328 drives the lever 360 again to open the incubator 210, and drives the interpretation mechanism 400 to descend a preset distance (the light-shielding sleeve 430 is in contact with the upper end of the microplate hole, or is separated by a preset distance), and the microplate is The experimental results in the wells are interpreted to obtain the platelet antibody detection results.
  • the corresponding sample carrier 120, the reagent carrier 110 and the mixing carrier 130 are placed on the turntable mechanism 100, and the corresponding microslats are placed in the incubator 210; wherein, the anti-human IgG solution is placed on the reagent carrier in sequence. , positive control, negative control, low ionic strength solution; the indicator red blood cells are placed in the designated holes on the mixing carrier 130;
  • the fifth driving unit 328 drives the lever 360 downward, and cooperates with the stopper at the upper end of the first window 211. After opening the first window 211, the fifth driving unit 328 rises and returns to its original position;
  • the fifth driving unit 328 drives the lever 360 downward, cooperates with the baffle at the upper end of the first window 211, closes the first window 211 and rises back to the original position;
  • the fifth driving unit 328 drives the lever 360 downward, and cooperates with the stopper at the upper end of the first window 211. After opening the first window 211, the fifth driving unit 328 rises and returns to its original position;
  • the fifth driving unit 328 drives the lever 360 again to open the incubator 210, and drives the interpretation mechanism 400 to descend a preset distance (the light-shielding sleeve 430 is in contact with the upper end of the microplate hole, or is separated by a preset distance), and the experiment in the microplate hole is The results are interpreted and the platelet antibody test results are obtained.

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  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Est divulgué dans la présente demande un dispositif de test de plaquettes, comprenant : un mécanisme de plateau rotatif sur lequel un ensemble de support est agencé amovible, l'ensemble de support comprenant un premier ensemble de support ou un second ensemble de support, l'ensemble de support étant utilisé pour transporter un flacon de réactif contenant un échantillon ou un type correspondant de réactif, le premier ensemble de support étant utilisé pour effectuer une expérience de test d'anticorps, et le second ensemble de support étant utilisé pour effectuer une expérience d'épreuve croisée ; un mécanisme d'incubation centrifuge, qui est disposé sur un côté du mécanisme de plateau rotatif, le mécanisme d'incubation centrifuge comprenant une machine centrifuge et un incubateur, la machine centrifuge étant utilisée pour centrifuger des échantillons dans des trous de microplaques, l'incubateur étant utilisé pour incuber les échantillons dans les trous de microplaques, et une première fenêtre étant formée dans l'extrémité supérieure de l'incubateur ; un mécanisme d'injection d'échantillon, comprenant un premier ensemble d'entraînement et une aiguille d'injection d'échantillon, le premier ensemble d'entraînement étant utilisé pour entraîner l'aiguille d'injection d'échantillon pour l'amener à injecter des échantillons dans les trous ; et un mécanisme de détermination. La présente invention permet de réaliser efficacement à la fois l'expérience de test d'anticorps et l'expérience d'épreuve croisée par agencement de l'ensemble support amovible, ce qui permet de réduire le coût de test des plaquettes.
PCT/CN2023/080565 2022-08-24 2023-03-09 Dispositif de test de plaquettes WO2024040922A1 (fr)

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