WO2024028898A1 - A synergistic fungicidal composition - Google Patents

Abstract

The invention relates to a synergistic fungicidal composition for controlling fungal disease in plants, more particularly to a synergistic composition comprising at least three active ingredients. The composition overcomes the fungal infections much more efficiently and provides the advantages of increased resistance to fungal disease, improved shelf life, better crop quality and enhanced efficacy.

Description

INDOFIL- 202221044240 1 TITLE OF THE INVENTION A SYNERGISTIC FUNGICIDAL COMPOSITION FIELD OF THE INVENTION [001] The invention relates to a synergistic fungicidal composition for controlling fungal disease in plants, more particularly to a synergistic composition comprising at least three active ingredients. BACKGROUND OF THE INVENTION [002] The control of plant diseases caused by fungal plant pathogens is extremely important in achieving high crop efficiency. The control of fungi is important since fungal growth on plants or on parts of plants inhibits production of foliage, fruit or seed, and the overall quality of a cultivated crop. [003] Due to the vast economic ramifications of fungal propagation in agricultural and horticultural cultivations, a broad spectrum of fungicidal and fungistatic products have been developed for general and specific applications. Fungicides that effectively control plant fungi are constantly being sought by growers. Combinations of fungicides are often used to promote disease control and to delay the formation of resistance. It is desirable to use a mixture of active ingredients that have a therapeutic effect on plant pathogens and provide a combination of invasive and prophylactic controls to improve the range and effect of disease control. [004] Moreover, it is always desirable to be able to reduce the content of chemicals released into the environment while effectively protecting crops from diseases caused by plant pathogens. Mixtures of fungicides can provide significantly better disease control than would be expected based on the activity of the individual components. [005] Several patents exist in this field. IN202034023458 discloses the use of multi-site contact fungicides for prevention and treatment of fungal leaf spot diseases caused by Zymoseptoria infection in plants. [006] IN202032011752 discloses the use of multi-site contact fungicides and systemic fungicides for treatment of soybean rust in host leguminous plant by treating plant at locus of infection. This patent teaches prior, subsequent, and concurrent treatment by two types of fungicides. at least one copper fungicide and at least two systemic fungicides selected from a quinone outside inhibitor, a quinone inside inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor. Also disclosed is a method for treating soybean rust in a host leguminous plant by fungicidal composition. [007] IN201731033800 discloses a combination containing a diamide insecticide and a silicic INDOFIL- 202221044240 2 acid-based plant health promoting additive for control of fungal diseases, resistance management in crops, preventing resistance in fungi and controlling insect pest. [008] IN201921043214 discloses the management of Asian soyabean rust by treatment using fungicide composition including fungicide and adjuvants such as surfactant and polymer. [009] US6090415 discloses a pesticidal composition consisting of granulated sulphur and pyrethroid and process for preparation of the same. [010] IN201811003095 (Indian Patent 372477) discloses a synergistic fungicidal composition comprising sulphur and propineb for controlling and preventing fungus in cereals, fruits, vegetables, and ornamental crops, particularly in paddy, apple, pomegranate, chili, grape, tomato, and groundnut. [011] While many products are commercially available for this purpose, there is still a need for new mixtures and compositions that are more effective, less expensive, less toxic, more environmentally safe and have various mechanisms of action. The use of multiple such pesticides in a synergistic manner gives users the ability to provide fungicidal control for managing the fungus attack on the crops without the risk of increased resistance being developed in the target pest population. [012] There is a continuing need to provide pesticidal compositions, which provide improved, biological properties, synergistic properties, especially for controlling pathogens and/or pests in useful plants grown from treated plant propagation material. OBJECT OF THE INVENTION [013] Object of the present invention is to provide a synergistic fungicidal composition that results into reduced fungal disease incidence in the crops to which it is applied. [014] Another object of the present invention is to provide a synergistic fungicidal composition that achieves increased yield in the crops to which it is applied. [015] Another object of the present invention provides a process preparation of a synergistic fungicidal composition. [016] Yet another object of the present invention is to provide a method of treatment for plants. [017] Another object of the present invention to provide a view to effective resistance management and reducing the application rates and broadening the activity spectrum of the known compounds and show improved activity against important harmful fungi. SUMMARY OF THE INVENTION [018] One aspect of the present invention relates to a synergistic fungicidal composition comprising at least two multi-site contact fungicides (A) and (B) in an amount from 1wt% to 90 INDOFIL- 202221044240 3 wt% of the total composition; at least one fungicide (C) selected from DMI-fungicide (demethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide in an amount from 1wt% to 90 wt% of the total composition; and at least one agrochemically acceptable excipient. [019] Another aspect of the present invention is to provide the method for controlling phytopathogenic harmful fungi, which method comprises treating the fungi, their habitat or the plants to be protected against fungal attack, the soil, seed, areas, materials or spaces the soil or the plants to be protected against fungal attack with an effective amount of synergistic fungicidal composition. DETAILED DESCRIPTION OF THE INVENTION [020] The present invention is directed towards a synergistic composition for inhibiting or minimizing the growth of fungi that can damage the plant. Further, use of this synergistic composition reduces the number of applications of various individual fungicidal components thus providing a cost-effective solution. [021] In one aspect of the present invention, a synergistic composition comprising at least two multi-site contact fungicides (A) & (B); at least one fungicide (C) selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides; and at least one agrochemically acceptable excipient. [022] In one embodiment, the synergistic fungicidal composition comprising: - at least two multi-site contact fungicides (A) and (B) in an amount from 1wt% to 90 wt% of the total composition; - at least one fungicide (C) selected from DMI-fungicide (demethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide in an amount from 1wt% to 90 wt% of the total composition; and - at least one agrochemically acceptable excipient. [023] In one embodiment, multi-site contact fungicides (A) & (B) inhibit fungal growth through multiple sites of action and have contact and preventive activity. Suitable multi-site contact fungicides can be selected from, such as but not limited to, inorganic fungicide, dithiocarbamate fungicide, phthalimide fungicide, and chloronitrile fungicide. [024] In one embodiment, the inorganic fungicide is selected from copper fungicide including copper (II) hydroxide, copper oxychloride, copper (II) sulphate, basic copper sulphate, Bordeaux mixture, copper salicylate, cuprous oxide and sulphur. The sulphur is a natural element that is essential for plant health and has fungicidal properties. [025] In one embodiment, the dithiocarbamate of the present invention comprises broad INDOFIL- 202221044240 4 spectrum, non-systemic contact fungicide including their derivatives which have activity against phytopathogenic fungi, they are useful in control of many fungal disease in a wide range of field crops, fruits. In one embodiment, the dithiocarbamate is selected from, but not limited to, amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb. [026] In one embodiment, the inorganic fungicide is selected from copper (II) hydroxide, copper oxychloride, copper (II) sulfate, basic copper sulfate, Bordeaux mixture, copper salicylate, cuprous oxide and sulphur; the dithiocarbamate fungicide is selected from amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb; and the phthalimide fungicide is selected from captan, captafol and folpet; and the chloronitrile fungicide is chlorothalonil. [027] In one embodiment, mancozeb is an ethylene bisdithiocarbamate (EBDC) fungicide, belonging to the group of dithiocarbamates, having a mode of action group M (Multi-site Action). It is a contact fungicide, acting on the surface of plants. Mancozeb reacts with, and inactivates, the sulfhydryl groups of amino acids and enzymes within fungal cells, resulting in disruption of lipid metabolism, respiration, and production of adenosine triphosphate. Mancozeb [CAS NO. 8018- 01-7] is a common name for zinc; manganese (2+); N-[2-(sulfidocarbothioylamino) ethyl] carbamodithioate (also known as ethylene bis dithiocarbamate manganese-zinc) and possesses the following structure:

[028] In one embodiment, propineb is also known as Zinc 1-methylethylenbisdithiocarbamate, is a fungicide used to combat fungal diseases such as powdery mildew, scab, etc. It also prevents spore germination. It possesses the following structure:

[029] In one embodiment, the Zineb is also known as zinc ethane-1,2-diylbis(dithiocarbamate), is polymeric complex. It is primarily used to control downy mildews, rusts, and redfire disease. It possesses the following structure: INDOFIL- 202221044240

[030] In one embodiment, the phthalimide fungicide contain a phthalimide molecular moiety. In one embodiment, the phthalimide fungicide is be selected from captan, captafol and folpet. [031] In one embodiment, the chloronitrile fungicides comprise an aromatic ring substituted with chloro- and cyano-substituents. In one embodiment, the chloronitrile fungicide is chlorothalonil. [032] In an embodiment, the fungicide (C) is selected from at least one of a fungicide selected from, but not limited to, DMI-fungicide (DeMethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide. [033] In one embodiment, DMI-fungicides (Demethylation Inhibitors) are a class of fungicides having broad spectrum activity with protective, curative translaminar and systemic properties. They inhibit spore germination and mycelial growth and also show anti-sporulant activity. In one embodiment, DMI-fungicide (Demethylation Inhibitors) is selected from piperazine, pyridine, pyrimidine, imidazole and triazole. [034] In one embodiment, piperazine is triforine. In one embodiment, pyridine is pyrifenox or pyrisoxazole. In one embodiment, pyrimidine is fenarimol or nuarimol. In one embodiment, imidazole is selected from imazalil, oxpoconazole, pefurazoate, prochloraz and triflumizole. [035] In one embodiment, the triazole is selected from azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole and prothioconazole. [036] In one embodiment, the methyl benzimidazole carbamate fungicide control fungal pathogens such as Botrytis cinerea, Cercospora, powdery mildew and eyespot. The methyl benzimidazole carbamate fungicide is selected from class of benzimidazole and thiophanate. In one embodiment, the benzimidazole is selected from benomyl, carbendazim, fuberidazole and thiabendazole. In one embodiment, the thiophanate is thiophanate or thiophanate-methyl. The thiophanate is member of the class of thiourea that is the diethyl ester of (1,2- phenylenedicarbamothioyl) biscarbamic acid. It is effective against a broad spectrum of diseases in fruit, vegetables, turf, and other crops including eyespot, scab, powdery mildew and grey mould. In one embodiment, the methyl benzimidazole carbamate fungicide is selected from benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate and thiophanate-methyl. [037] In one embodiment, the carbendazim is also known as Methyl 1H-benzimidazol-2-yl INDOFIL- 202221044240 6 carbamate. It is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. The fungicide is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It possesses the following structure:

[038] In one embodiment, the thiophanate-methyl is a systemic fungicide with protective and curative action. It is being absorbed by leaves and roots. Thiophanate-methyl [CAS NO.23564- 05-8] is a common name for Dimethyl 4, 4′-(o-phenylene) bis (3-thioallophanate) and possesses the following structure:

[039] In one embodiment, the quinone outside inhibitors (QOI) fungicide is selected from, such as but not limited to, strobilurin, methoxy-acrylates, methoxy-acetamide, methoxy carbamate, oximino-acetate, oximino-acetamide, oxazolidine-dione, dihydro-dioxazines, imidazolinone, benzyl-carbamate, azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, fenamidone and pyribencarb. [040] In one embodiment, the azoxystrobin (CAS No. 131860-33-8) is the common name for Methyl (2E)-2-(2-{[6-(2-cyanophenoxy) pyrimidin-4-yl] oxy} phenyl)-3-methoxyacrylate and is represented as

[041] In one embodiment, the azoxystrobin is a commercial fungicide with protectant, curative, eradicant, translaminar and systemic properties. Typically, azoxystrobin inhibits spore germination and mycelial growth and also shows antisporulant activity. [042] In one embodiment, the picoxystrobin [CAS no.: 117428-22-5] is a common name for methyl (2E)-3-methoxy-2-{2-[6-(trifluoromethyl)-2-pyridyloxymethyl] phenyl} acrylate. INDOFIL- 202221044240 7 Picoxystrobin is a broad spectrum fungicide, which can be applied as a foliar spray or a soil- treatment prior to planting, as it has a residual effect. It acts as a systemic fungicide which has curative, translaminar and preventative action. Picoxystrobin is represented as:

[043] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) is present in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; preferably 1 wt% to 75 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is present in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition, preferably 1 wt% to 75 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is present in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; preferably 1 wt% to 75 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [044] In one embodiment of the present invention, a synergistic composition comprising at least two multi-site contact fungicides (A) & (B) selected from inorganic fungicide, dithiocarbamate fungicide, phthalimide fungicide, and chloronitrile fungicide; at least one fungicide (C) selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides; and at least one agrochemically acceptable excipient. [045] In one embodiment, the synergistic composition comprising: - at least two multi-site contact fungicides (A) & (B) selected from dithiocarbamate, inorganic fungicide, phthalimide fungicide and chloronitrile fungicide in an amount from 1wt% to 90 wt% of the total composition; - at least one fungicide (C) selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides in an amount from 1wt% to 90 wt% of the total composition; and - at least one agrochemically acceptable excipient. [046] In one embodiment, the synergistic composition of the present invention comprises the INDOFIL- 202221044240 8 multi-site contact fungicide (A) is the inorganic fungicide selected from copper fungicide including copper (II) hydroxide, copper oxychloride, copper (II) sulphate, basic copper sulphate, Bordeaux mixture, copper salicylate, cuprous oxide and sulphur in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate selected from amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is at least one fungicide selected from DMI-fungicide (DeMethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [047] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) is the inorganic fungicide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is DMI-fungicide (DeMethylation Inhibitor) in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [048] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) is the inorganic fungicide in an amount from 1 wt% to 70 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 75 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [049] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) is the inorganic fungicide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; and INDOFIL- 202221044240 9 the fungicide (C) is methyl benzimidazole carbamate fungicide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [050] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) is the inorganic fungicide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is Quinone outside inhibitor (QoI) in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [051] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) the inorganic fungicide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is thiazole carboxamide in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. [052] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) sulphur in an amount from 1 wt% to 90 wt% of the total weight of the composition; the multi-site contact fungicide (B) is selected from dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the composition; and the fungicide (C) is at least one fungicide selected from DMI-fungicide (DeMethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide in an amount from 1 wt% to 90 wt% of the total weight of the composition and at least one agrochemically acceptable excipient. [053] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) sulphur in an amount from 1 wt% to 90 wt% of the total weight of the composition; the multi-site contact fungicide (B) is selected from dithiocarbamate in an amount from 1 wt% to 90 wt% of the total weight of the composition; and the fungicide (C) is at least one fungicide selected triazole, thifluzamide, methyl benzimidazole carbamate, or strobilurin in an amount from 1 wt% to 90 wt% of the total weight of the composition and at least one agrochemically acceptable excipient. INDOFIL- 202221044240 10 [054] In one embodiment, the synergistic composition of the present invention comprises the multi-site contact fungicide (A) sulphur in an amount from 1 wt% to 90 wt% of the total weight of the composition; the multi-site contact fungicide (B) is selected from mancozeb and zineb in an amount from 1 wt% to 90 wt% of the total weight of the composition; and the fungicide (C) is at least one fungicide selected difenoconazole, hexaconazole, thifluzamide, carbendazim, thiophanate methyl or picoxystrobin in an amount from 1 wt% to 90 wt% of the total weight of the composition and at least one agrochemically acceptable excipient. [055] In accordance with an embodiment of the present invention, the agrochemically acceptable excipients are present in an amount in the range of 1% to 90% of the total weight of the composition, preferably from 1% to 80% of the total weight of the composition. [056] In one embodiment, the agrochemically acceptable excipient includes but are not limited to customary formulation adjuvants or components, such as organic solvent, stabilizer, anti-foam, emulsifier, antifreeze agent, preservative, antioxidant, colorant, thickener, dispersing agent, wetting agent, polymeric film forming agent, diluent, inert filler, binder and rheology modifier. [057] In one embodiment, the stabilizing agent is at least one selected from the group, consisting of Hexamethylene tetra amine, sodium bi sulphite, phosphoric acid monoesters, phosphoric acid diesters, phosphoric acid mono- and di- ester mixture, sodium phosphates, butylated hydroxytoluene, castor oil ethoxylate, ethoxylated hydrogenated castor oil, vegetable oil and epoxidized soyabean oil or combinations thereof. [058] In one embodiment, the antifoam includes to silicon emulsions, poly dimethyl siloxanes. [059] In one embodiment, the emulsifiers includes Polyoxyethylene alkylamine, Polyoxyethylene linear alkyl ether, Ethoxylated Castor Oil, Epoxidized soyabean oil, Polyoxyethyene alkylamine quaternary, Polyoxyethyene tallow ethylmonium ethosulfate, Glycerol monostearate, Glycerol monooleate, ethoxylated monostearate / distearate / tri stearate ethoxylated monooleate / trioleate, Polyoxyethylene branched tridecyl Phosphate, Polyoxyethylene branched tridecyl phosphate neutralised, Polyoxyethylene alkyl ether phosphate, ethoxylated propoxylated sorbitan mono esters, Tallow amine ethoxylate. [060] In one embodiment, the dispersing agent includes, but is not limited to, Anionic graft polymer, Kraft lignin Polymer, Napthalene sulphonate formaldehyde condensate, Amine alkyl benzenesulfonate, Sodium Ligno Sulphonate, Blend of Naphthalene sulphonate sodium salts, Blend of Lignin sulphonates sodium salts, Ethoxylated Lignin sulphonates, Linear alkyl benzene sulphonate, tri stearyl phenol ethoxylates, Acrylic copolymer solution, Modified styrene acrylic polymer, Ammonium distyrylphenyl ether sulphate, salts of polystyrene sulphonic acids. [061] In one embodiment, the wetting agent includes Polyalkylene oxide block copolymer, Salts INDOFIL- 202221044240 11 of Di-octyl sulfosuccinate, Alcohol alkoxylate diester, Sodium N-methyl oleoyl taurate, Sodium cocoyl sarcosinate, sodium lauryl sulphate, Sodium dioctyl sulfosuccinate, alkyl polyglucoside, Naphthalenesulfonic acids, branched and linear Butyl derivatives sodium salts, Sodium Lauryl sulphate. [062] In one embodiment, the antifreeze agents include Propylene glycol, 1 methoxyl 2 propoanol, Butyl cellosolve, ethylene glycol. [063] The preservatives include, but is not limited to, 1-2-benziisothiazolin-3-one, 5-Chloro-2- methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one. [064] The rheology modifiers include Polyester block co-polymer, Poly saccharides, Polyamide, Clay, xanthum gum, Silicates. [065] The binder / film-forming agent is at least one selected from the group consisting of hydrophilic polymers, hydrobhobic polymers, Poly(vinylpyrrolidone), vinypyrrolidone- vinylacetate and the filler, at least one selected from the group consisting of lactose, glucose, fructose, mannose, mannitol, sucrose, and the like, can also act as binding agent. [066] The disintegrating agent is selected from the group consisting of sodium chloride, sodium sulphate, ammonium sulphate, sodium carbonate, sodium bicarbonate, sodium tripolyphosphate (STPP), Crosslinked carboxyl methyl cellulose, crosslinked PVA, crosslinked starch, crosslinked alginic acid and Ca silicate, etc. Also, hydrocarbons such as lactose, sucrose, dextrose. [067] The filler and/or diluent is selected from the group consisting of starches and their derivatives, sugars and sugar alcohols, silicates, calcium phosphates, calcium sulfate, dextrates, kaolin clay, bentonite clay, attapulgite, diatomaceous earth, magnesium carbonate, polymethacrylates, talc, or salts. [068] Water is used as a diluent to dilute the active ingredient to a desired concentration. The water used is purified water and selected from the group consisting of deionized water and distilled water. [069] In another aspect, the invention relates to a process for preparation of a synergistic fungicidal composition comprising the steps of: • Mixing at least one multi-site (A) and triazole fungicide (C) with water, dispersants / wetting agents / anti freezing agent/ Defoaming agent; • Wet milling to the desired particle size; Mixing the wet milled material with second muti-site fungicide (B), defoamer, preservatives, thickener and or stabilizers with balance quantity of water to obtain the synergistic fungicidal composition in suspension form. [070] In another aspect, the invention relates to a process for preparation of a synergistic INDOFIL- 202221044240 12 fungicidal composition comprising the steps of: Pre-blending: Mixing the formulation components to a blender and mix until uniform. Milling: Process the blended formulation through an air jet mill to achieve the desired particle size, preferably d (90) < 10 µm. Post-blending: Mix the milled formulation to ensure even distribution of components in the powder. The above premix is converted to dough, which is then extruded via extruder. The received granules are subjected to fluid bed drier to get the dried the free-flowing granules. The granules are analysed for parameters as per specification. These formulations, which can be prepared in any manner known by the skilled person, also form part of the invention. [071] In another embodiment, the composition is formulated as a formulation selected from water dispersible granules, wettable powder, capsule suspension, soluble (liquid) concentrates or suspension concentrate, suspo-emulsion, water dispersible powder, combination of capsule suspension & suspension concentrate, combination of capsule suspension & oil in emulsion, combination of capsule suspension of suspo emulsion. [072] The fungicidal composition of the present disclosure may further comprise one or more excipients. The employment of excipients used in the composition will depend upon the type of formulation and/or the manner in which the formulation is to be applied by the end user. [073] The formulations can be of any type known in the sector that is suitable for application onto all types of cultures or crops. These formulations, which can be prepared in any manner known by the skilled person, also form part of the invention. [074] In one embodiment, for optimal results, preventive applications may also be carried out. Having curative activity, the composition can also be applied after the infection, but the treatments will be carried out in the initial or first stages of development of the fungus. The interval between treatments is adjusted according to the pressure of infection, the development of culture and climatic conditions. The fungi which are combated with the composition of the invention include Sheath blight, Grain discoloration, False smut, Downy mildew, Anthracnose, Rust, Scab, premature leaf fall, Cercospora leaf spot, Leaf spot , Grey Mildew, Anthracnose, Boll rot, Late blight, Early blight, Soft rots, Purple blotch, Stem rot, Alternaria Blight, Powdery mildew, Blister blight, Powdery mildew, Die-back, Anthracnose, Red Rust, Grey blight, Thielaviopsis rot, Leaf & Fruit rot, Banded sheath blight & Charcoal rot. [075] Under specific conditions, for example according to the nature of the phytopathogenic fungi or insect to control, a lower dose may offer adequate protection. Certain climatic conditions, resistance or other factors like the nature of the phytopathogenic fungi or damaging insect to be INDOFIL- 202221044240 13 eliminated or the degree of infestation, for example, of the plants with these fungi, may require higher doses of combined active ingredients. [076] The synergistic composition of the present invention has uses for controlling variety of Fungal action on various crops such as Rice, Grapes, Apple, Black gram, Banana Ground Nut, Cotton, Citrus, Ginger, Onion, Potato, Tomato, Cumin, Tea, Chilli, Pome, Mango, Pineapple, Wheat and Maize. [077] In one embodiment, relates to a method for controlling pests, the method comprising the step of applying a synergistic pesticidal composition to a plant or a plant part or the locus thereof. [078] A composition according to the present invention shall encompass a tank mix or a combipack. EXAMPLES [079] The present invention is more particularly described in the following examples that are intended as illustration only, since numerous modifications and variations within the scope of the present invention will be apparent to those skilled in the art. Unless otherwise noted, all parts, percentages and ratios reported in the following examples are on a weight basis, and all reagents used in the examples were obtained or are available from the chemical suppliers. [080] The following examples illustrate the basic methodology and versatility of the present invention. Examples of fungicidal composition development [081] In this experiment, different compositions were developed using multi-contact fungicides sulphur (99%) [Component A] and (Component B) Zineb (75%) or MAN - Mancozeb (85%) and using a variety of systemic fungicides (Component C). [082] The systemic fungicides were selected from amongst the following – HEX - Hexaconazole (92%); THI - Thifluzamide (97%); CAR - carbendazim (98%); TPM - Thiophanate methyl (97%); AZO - Azoxystrobin (98%); PIC - Picoxystrobin (98%); and DIF - Difenoconazole (98%). [083] Table 1- Unit-g

INDOFIL- 202221044240 14

INDOFIL- 202221044240 15

[084] The total volume of the composition was made up to 200g using deionised water (DIW). The physical properties of each composition were analysed at both room temperature and high temperature for the standard tests given below – a. Rod test: + implies rod enters easily into mixture. b. Separation: B – Brown layer separation, L – lump formation c. Settling d. Colour: Cr – Creamy; Y - Yellow Examples 1 to 8 were found to be stable in terms of Rod test, no colour change, settling and separation was observed. 1. ACCELERATED STORAGE STABILITY STUDY The compositions formulated in the above Examples 1 to 8 are subjected to accelerated storage stability study at 54 °C for a period of 14 days. The compositions were analysed for physico- chemical property study. The results are shown in Table No.1.

⁸ T 9 ⁸ _. 6 1 ⁸ _. 1 7 0_. 0 e_l D H 1 1 1 9 0 1 p ^{+ m} _a ^Z _e x ⁺ 5 E S 7 g T 2 0 ⁹ _. 6 9 3 9 0 0 ^a _r 1 _t

m_a ^Z n x ⁺ 7 S T ³ _. 4 7 3 3 4 0 ^a E R 0 _. 3 5 ⁰ _.2 9 ⁰ _.0 1 ^e _lb^a _t T ³ _. 5 ^s 2 7 0 ^e _r 2 F H 9 ⁰ _. 2 ⁹ _.2 9 ⁰ _. 1 ^{a e} _l H 1 1 0 ⁸- p T 1 m_a + _s x Z+ 8 5 T 1 ⁶ _. 9 ^e _lp E S R ³ _. 0 ¹ _. ⁰ _. 3 ⁰ _. 01 2 21 3 9 0 ^m _ax E ¹ T ⁴ _. 8 8 ^t _a 3 ¹ _. ² _. 1 ⁰ _. 0 h e_lp H H 2 21 1 9 0 1 + _t ^{t d} _e m_a Z ^s _e + 8 6 9 ^{t v} _r x S T ⁴ _. ² _. ^{3 9} _. 0 ^e _v ^e _s E R 42 21 _.1 2 ⁰ _. 1 9 0 ^e _i b s ^{o t} _e ^s _{i I ) .} µ w _t ⁱ A 5 l ^{4 )} _{l -} T_S ^{1 e} _{l I I I.} y ^w _/ n m h ^{o (} W ^b _{a . . I. I.} ^A I ^e _l ^A A ^{A t e} _e ^I _. ^w n m ^t l m _e ^{o m A %} o n_i y ^{i t} _s ao m n ^{F o} _r A _. ^{o i d} _{i z} ^e _t b _i ^l _i ^e F s _I i _. b s y_l ^{A e} _z A _z o _r a _z n a a d m n an ^o _r b _t ^{e i e} _{r c} n c u oc ⁿ _e ^a _z ^o _c a o h ^t _{s s} ⁽ a p y ⁿ _e ^t _s a ^b _e n h p_l a x ^b _r ^u _l ^f _i ⁿ _e ^o _i xo ^p _s ^{T S i} _s n ⁿ A _i a _e a h ^f _i h Z M u S H C T D T ^c _i ^r P u S W _e P no _s ⁱ _t n k n ^& _e ^r _{e . )} ⁱ _e h w ^a _{l s} ^o _i o ^t _{a a} T P ^w T_. o^l _e o^c p ^r _t ⁽ C ^{W s} _e d^{l b} _i d_i ⁸ y m n ^{E % d} _{i e} ⁱ _f ^{4 h} _c ^r _e ^r _e ^a _r o ^{e c} _cn % 0 ^c _{i e} ^e _l ^{a l} _a o ^c 5 4 2 _r g u n h u ^{t b} _{a r} vo ^t _f p ^{s a} _l ^{a d} _r ⁱ _f ^T o d d n _c ^{n i} _e ^e _l h ^a _t ^p _r ^r _t ^e _t 3 l _e ⁱ n ⁱ o n a _fo^s _e ^v _i o g p _t ^z _a u h ^e _s d ^p _s o e a n S ^{T a o} _, ^. _{t e} ^e _t ^{o C r} _{t s}y % % % u ^s _i n^e _c r n a 5 9 7_eh ^d _{e c} P o ^N d _s % U d 8 6 7 e _e ^tt _a ^t _s ⁿ _e ^W d _{f r} ^C ₍ n ^{o p} _{t f} y h ^{e t} _{t e} ^f _i %5 u n ^e _r o ^r _e o ^a _r g ^{r n} _e ^D _i ^{+ 7 o b} _r o G ⁱ _t ^{a p y} _s ^t _{f f} a _{s I} y p ^s _{) ) )} 7 ⁷ _. ⁴ _. ^t w _{a ,} P _e n ^c _{i f} ^a _{i e} o ^t _i h ^a _e a _i ^. d _t ^{8 W} ₎ n ^l D ^{d d} _r 7 6_. 5 ^{6 1} _.3 1 0 8 u ^{e n} _l ^Z _i ^{, i} T_. P 8 3 6 ₍ 1 ² ₍ 1 ¹ ₍ N p %5 _. ^{a e} _l y h . o ^t _i ^e _s ^{l a} _ra ^r _f y _su d ^m _a ^{7 i c} _i ^w _e s_i ^e _e ^t o ^a _r ^h _t nu x ^b _e ^s _e ^d _i d_, ^{d h e} _t d a _{f s} p _{) ) ) e} k a_I y ^{s 4} _. 3 ^{7 1}d ^o _r ^Eh ⁿ _{i i} c _{c i} ^a _r ^a _i ^h _t ^k _i a D ^d d 7 6_. 2 ³ _{. .}8 7 6 _{. .} 8^o _i G_f ^t _i ^Z g ^t _i w ^, ₎ n ^a n _f ^{T o t} _s P 8 n 2 4 ¹ ₍ 01 ¹ ₍ 9 ¹ ₍ ^r _e ^x _i u ^a _r ^{i n} _{i e}

h ^t a ^h _t ⁿ _f Z_{, a i} k ^{g e} _t ^t _i d ^p _l ^/ _. ^{3 5} _. 2+ ^{+ k} _i o_s ^. _e % _a ._i 5 _l ^{f e} _t a_e u ^e _s ⁱ _. + o ^a 5 2 5 5 6 2 2_{e .} n _{a s} ² o^{r r} _e ^r _t ^S D ^g ₍ 2 1 1^{s e} _l ^{T e} _r ^b _a ^t _s oⁱ _t n ^e _{l t} i ^o _i o n y n ⁺ 6 + 1 1 o ^a _rp ^u % ^c _e ^t _s ⁿ _{i s} a o ^t _a ^z _a ^C d _e ^{S t} _s 5 0 _t ^{r n} _e g p a m ⁿ _i n b ^o _c d^e _t ^k _{c .} ^l n a ⁱ _a ² + 4 b_e % C _ru _a ^c _i ^w y o d ^c m o o ⁿ _e ^a _e ^r _t ^a _s ^{v p} _r g e ^f _t ^{a n} _i 51_r ^S h C p_l ^E _i ^e _r n ^u _s ^u _t ^{l s} _a d_i ^{c f x} _{i i} n _{a i} ^{D U} n ^{n K} _i ^d _{e s} ^t Z a _{f s} uh ^% u ^{o l} _i ^p _l ⁵ _. u 2 ^S ₎ %5^g o ^{y s l} _{c c} ^c _i d ^{y l s} _l a u ^{+ x} _i ^{+ 2}o ^s _i a gn ^mk ⁺ P n ^a h^t _{i a} d _a v a^{i t} _e ^{S e} _lo P ^m P ^e _lo ⁿ d_t ^c _i ^f _f ^u _f ⁿ c _a ^{t W} C ^{w 8} _{e r} D t _e ^t _t ^{+ z} _a ^W k n_a ^{W z} _{a )} ^s _a n^{e e}- ⁱ _t ^e _l ^{% E} y^a _{r a e} ^r _e ^y _c ⁿ _e % n 5 ^o %5 T % n 5 ^{o x} _iw _{s e} ^e _r ^o _i ^s _ig ^b _i s 0 % 4 5 p w a s n _s ^c _i ^m _t ² _co ^{7 (} P ⁷ _co ^m _e ^{B r} _s ² o ^t _l ^f _f a ^b _e ^{n b b n} k^r p h _e ^– _e o _r ^r _a d ^. _t ^e _{e e e e} ⁿ _a ^{t h} _t 2 n t ^y _s ^p u y h ^e _lo ⁱ _{l e} o ^{r u} _{s e} ^{e e} - _r ^o _i u _r T ⁿ _i ^f _i Z D ⁿ _i ^W Z % ⁿ _i ^f _i Z D ^{T t} _{( a f} h ^{o n} _{e e a} ^p _l h ^w u ^z _{a f} n _s w _e ^{B N} d _. T _s h T o ^S _. ^d _e ^m _i ^{o a} T ^– n o w & _c g o y ^{r d n} _i ¹ u o ^N d _ap ^r _e p _]5 ^th ₎ x_i ⁿ _{e e} ⁱ _l y _] ^e _{l r} ^. p ^a _r 6 b G _r 1 2 3u^{t e} _r x 8 ^t _i ^f _i ^p 8 a _f T T T T _s p E ⁰ _[ w M D _a ^p _s ⁰ _[ T o 5 01 ^a n o

)0 _{) ) ) ) )} 5 ^, _. o ^e _s 0_. 0 0 0 0 0 0 0 0 ^{2 e} _. ^t d b 0 _{. . . (} ⁰ _. ⁰ _. S S 0 ⁰ ₍ 0 ⁰ ₍ 0 ⁰ ₍ 0 ⁰ ₍ 0 ⁰ ₍ N N ^{@ i} C ⁾ _I nu ^o o ^s _a S DP ^{f w % (} C y e 0 0 0 0 ⁵ _{. c} S ^t _i n ^{% c} _ix 0 0 5 5 0 2 5 5 1 6 0 ² _e 5 05 ^e _l d ⁵ _. ^o _t o ^{i z} _{c a} n ^{2 i e} _l ^o _ty n ^e o h 57 ^{o 3} _{c s} ^z _a ^Po + ⁵ _. o ^{a n} _e n 5 2 5 _e ^s _i ^o _c ^N. 2 2 06 5 ^f _i d_{t .} o _t s 6 ⁶ + 11 22 21 ^D n ^s _t ⁿ _{e e}v + ^e _c ⁿ % ^r _e ^f _i ^{r D} _{a e} ^m _t ^h + 5 C 1 ^p 7 ^a _e + ^{t r} _{a t} % _s C %5 S E 1 _t C _ru ⁶ _{. e} 51 ^r _{e r} ^l _/ ^E h ^t % u ^{g p} _l ⁶ h ^h _{t r}u _s u 5 h ⁵ _. % u ^t _{i f}o h _l c ^{2 p} _l ² P 5 2 ^S w_{t t} s ^p _lu d e_l u ^e _l P ^{W e} _l ⁺ u _e ^{r S} op o ^{S z} _a ⁺ o^{z W %} o %5 ^{N o} _t ⁺ _tu n ₎ o_c ^x _a ^z i % n ₎ 0 _a ² dn _r % n o d 5 ^x _i % n 5 4 ^b u ^o _i 5 n o ^{m 2} _c n o ^{m 7} _ru ^o _co _lo %5 _{e e} k ⁿ _i ^o _r ^r _e ² u G p ^{b o} _{r i} ^{b f n} _{a e} ^{n n} _{i e} k f_i ⁿ _a ^b _e h n_i ^p _l ⁿ _e ^{r f} _{t i} n @ o ^m D C _e D ^Z S C - _f u o ^s _e n_i ^gd D ^T ₍ Z D ^T ₍ Z u S ^t _lu ₎ ^s _a ^Z o s_e ^a _l o o ^w 1 h _t ^g R ^c _i ^c _i ⁿ _e y d h ^r _e 5 6 7 8 9 _{] i} m v T T T T T 7 ^h 8 _c ^{w t} _{a e} 0 _[ ^a _r d ^e a ⁿ _{a r} ^v T _a h 5 INDOFIL- 202221044240 19 TO STUDY THE EFFECT OF THE TEST FUNGICIDES ON THE YIELD PARAMETERS OF GROUNDNUT [088] Individual plot wise yield was recorded and calculated treatment wise yield and converted into yield per hectare (T/ha) at harvest and statistically analyzed the data. Table 2: Effect of different fungicides treatments on Yield parameters of Groundnut

[089] The results presented in Table 2 show that all the treatments significantly increase the yield than Untreated Control (17.50 q/ha). The highest yield was observed in treatment T1 (35 q/ha), The lowest yield was observed in T7 (20 q/ha) and T6 (22.50 q/ha). The test fungicide treatment T1 was significantly superior over solo fungicide treatments (T6 to T8) and two-way tank mix combination treatments (T2 to T4). The lowest yield was recorded in Untreated Control (17.50 q/ha). TO STUDY THE PHYTOTOXICITY EFFECT OF TEST FUNGICIDES ON GROUNDNUT [090] Observations were taken on damage caused to plants, if any, by the application of different treatments taking into the account phytotoxic symptoms viz. leaf injury on tips and leaf surface, INDOFIL- 202221044240 20 wilting, vein clearing, necrosis, epinasty and hyponasty on ten plants per plot. The observations were recorded before treatment and 1, 3, 5, 7^th 10 & 15th day after treatment. For Phytotoxicity study of leaf injury on tips and leaf surface the Scale (0-10) used is given below. Phytotoxicity Rating Scale (PRS) Crop response/ Crop injury Rating 0-00 0 1-10% 1 11-20% 2 21-30% 3 31-40% 4 41-50% 5 51-60% 6 61-70% 7 71-80% 8 81-90% 9 91-100% 10 Table 3: Phyto-toxicity effect of different Insecticide treatments on Groundnut

*For phototoxic symptoms- Leaf injury on tips and Leaf surface, Wilting, Vein Clearing, Necrosis, INDOFIL- 202221044240 21 Epinasty and Hyponasty. [091] As illustrated in Table 3, the Fungicide ready formulation was sprayed at doses X 2500g/ha and 2X 5000g/ha to check the phytotoxic effects like leaf injury on tips/surface, vein clearing, wilting, necrosis, hyponasty and epinasty on the Groundnut crop. The observations on these phytotoxicity parameters were observed on before spray and at 1, 3, 5, 7, 10 and 15 days after application. But there was no any phytotoxicity observed on Groundnut crop after seed treatment in any treatment. Even there was no any adverse effect noticed on Groundnut crop in the field applied with this fungicidescombinations at highest dose. [092] Overall, the three way combination test T1 showed synergistic effect for controlling the diseases and pests. Also for prolong the effectiveness of fungicides liable to encounter resistance problems and to limit crop losses, the test fungicides can be used effectively and safely for the management of diseases than solo and their two way possible tank mix combinations. CONCLUSION: [093] Comparatively, efficacy of readymade test synergistic fungicide combinations is far better than market standards and possible Tank mixtures. [094] Overall, the test fungicides show synergistic effect for controlling of Tikka early leaf spot of groundnut. [095] The present invention advantageously provides a fungicidal composition which is high- performing in particular as regards its efficacy against pests and the perenniallity of this efficacy so as to be able to reduce the doses of chemical products spread in the environment for combating pest damages or attacks of plants or crops. [096] Advantageously, the present invention provides a composition that comprises at least three active ingredients, where the composition overcomes the fungal infections much more efficiently when compared with the individual application. The composition provides the advantages of increased resistance to fungal disease, improved shelf life, better crop quality and enhanced efficacy. [097] The foregoing description of the invention has been set merely to illustrate the invention and is not intended to be limiting. While the present invention has been described with respect to certain embodiments, it will be apparent to those skilled in the art that various changes and modification may be made without departing from the scope of the invention as defined in the following claims.

Claims

INDOFIL- 202221044240 22 CLAIMS: 1. A synergistic fungicidal composition comprising: - at least two multi-site contact fungicides (A) and (B) in an amount from 1wt% to 90 wt% of the total composition; - at least one fungicide (C) selected from DMI-fungicide (demethylation Inhibitor), methyl benzimidazole carbamate fungicide, Quinone outside inhibitor (QoI) and thiazole carboxamide in an amount from 1wt% to 90 wt% of the total composition; and - at least one agrochemically acceptable excipient. 2. The synergistic fungicidal composition as claimed in claim 1, wherein the multi-site contact fungicides (A) and (B) are selected from inorganic fungicide, dithiocarbamate fungicide, phthalimide fungicide and chloronitrile fungicide. 3.. The synergistic fungicidal composition as claimed in claim 2, wherein the inorganic fungicide is selected from copper (II) hydroxide, copper oxychloride, copper (II) sulfate, basic copper sulfate, Bordeaux mixture, copper salicylate, cuprous oxide and sulphur; the dithiocarbamate fungicide is selected from amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb; the phthalimide fungicide is selected from captan, captafol and folpet; and the chloronitrile fungicide is chlorothalonil. 4. The synergistic fungicidal composition as claimed in claim 1, wherein the DMI-fungicide (Demethylation Inhibitor) is selected from piperazines, pyridines, pyrimidines, imidazoles and triazoles. .5. The synergistic fungicidal composition as claimed in claim 1, wherein the methyl benzimidazole carbamate fungicide is selected from benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate and thiophanate-methyl; the quinone outside inhibitor (QoI) is selected from strobilurins, methoxy- acrylate, methoxy- acetamide, methoxy carbamate, oximino-acetate, oximino- acetamide, oxazolidine-dione, dihydro-dioxazine, imidazolinone, benzyl-carbamate, azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, fenamidone and pyribencarb; and the thiazole carboxamide is thifluzamide. 6. The synergistic fungicidal composition as claimed in claim 1, wherein the agrochemically INDOFIL- 202221044240 23 acceptable excipient is a customary formulation adjuvant or component selected from organic solvent, stabilizer, anti-foam, emulsifier, antifreeze agent, preservative, antioxidant, colorant, thickener, dispersing agent, wetting agent, polymeric film forming agent, diluent, inert filler, binder and rheology modifier. 7. The synergistic fungicidal composition as claimed in claim 1, wherein the composition is formulated as a formulation selected from water dispersible granule, wettable powder, soluble (liquid) concentrates, suspension concentrates, oil in water emulsion, water in oil emulsion, oil dispersions, capsule suspension, suspension concentrate, emulsifiable concentrates, suspoemulsion, water dispersible powder, combination of capsule suspension & suspension concentrate, combination of capsule suspension & oil in emulsion, combination of capsule suspension of suspo emulsion. 8. The synergistic fungicidal composition as claimed in claim 1, comprising - at least two multi-site contact fungicides (A) & (B) selected from dithiocarbamate, inorganic fungicide, phthalimide fungicide and chloronitrile fungicide in an amount from 1wt% to 90 wt% of the total composition; - at least one fungicide (C) selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides in an amount from 1wt% to 90 wt% of the total composition; and - at least one agrochemically acceptable excipient. 9. The synergistic fungicidal composition as claimed in claim 8, wherein the multi-site contact fungicide (A) is the inorganic fungicide in an amount from 1 wt% to 70 wt% of the total weight of the synergistic fungicidal composition; the multi-site contact fungicide (B) is dithiocarbamate in an amount from 1 wt% to 75 wt% of the total weight of the synergistic fungicidal composition; and the fungicide (C) is selected from DMI-fungicides (DeMethylation Inhibitors), methyl benzimidazoles carbamates fungicides, Quinone outside inhibitors (QoI) and thiazole carboxamides in an amount from 1 wt% to 90 wt% of the total weight of the synergistic fungicidal composition and at least one agrochemically acceptable excipient. 10. A method for controlling phytopathogenic harmful fungi, which method comprises treating the fungi, their habitat or the plants to be protected against fungal attack, the soil, seed, areas, materials or spaces the soil or the plants to be protected against fungal attack with an effective amount of synergistic composition according to claim 1.