WO2024010313A1 - Appareil de thérapie pour animaux combinant la radiothérapie et la thérapie thermique magnétique - Google Patents

Appareil de thérapie pour animaux combinant la radiothérapie et la thérapie thermique magnétique Download PDF

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Publication number
WO2024010313A1
WO2024010313A1 PCT/KR2023/009350 KR2023009350W WO2024010313A1 WO 2024010313 A1 WO2024010313 A1 WO 2024010313A1 KR 2023009350 W KR2023009350 W KR 2023009350W WO 2024010313 A1 WO2024010313 A1 WO 2024010313A1
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Prior art keywords
radiation
magnetic heat
gantry
treatment device
animals
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PCT/KR2023/009350
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English (en)
Korean (ko)
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허윤정
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주식회사 이노비오젠
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Publication of WO2024010313A1 publication Critical patent/WO2024010313A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
    • A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1069—Target adjustment, e.g. moving the patient support
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1022—Generators, e.g. X-ray tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/105—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using a laser alignment system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation

Definitions

  • the present invention relates to an animal-specific medical device for performing radiation and magnetic heat treatment on animals. More specifically, the radiation generating module, which is easy to move and located within a circular gantry, rotates 360° and is directed to the tumor site of the animal. It relates to a radiation and magnetic heat fusion treatment device for animals that can treat .
  • the radiation therapy device of Patent Document 1 includes a treatment unit including a receiving space for placing an animal, an electron generator, and one side of the electron generator, and is disposed in a direction perpendicular to the treatment unit to irradiate radiation toward the treatment unit.
  • An irradiation unit including an accelerator, and an image acquisition unit located at a preset interval from the treatment unit along the irradiation direction of the radiation and acquiring an image of the irradiation area when the radiation is irradiated, so that the radiation is transmitted to the animal.
  • the output of the radiation is set to 1 to 2 MeV so that it is irradiated to the affected area located at a predetermined distance from the epidermis.
  • Conventional radiation therapy devices for companion animals consist of a fixed table for placing the companion animal to be treated and a radiation irradiation device located on the upper side of the table, making it difficult to accurately control the irradiation angle, which reduces the treatment effect.
  • the present invention was proposed to solve this problem, and the problem to be solved by the present invention is to make it easy to move and include a radiation generating module in a circular gantry, so that the rail inside the gantry can be easily moved.
  • the aim is to provide a radiation and magnetic heat fusion treatment device for animals that can rotate 360° and accurately treat tumor areas in animals.
  • Another object of the present invention is to provide a radiation and magnetic heat fusion treatment device for animals that can perform radiation therapy and magnetic heat therapy simultaneously or separately, allowing selection of appropriate treatment according to the tumor condition.
  • Another object of the present invention is to provide a radiation and magnetic heat fusion treatment device for animals that allows the table to be stably moved in and out of the treatment module.
  • Another object of the present invention is to provide a radiation and magnetic heat fusion treatment device for animals that can prevent radiation intensity from being attenuated by a table.
  • Another object of the present invention is to provide a radiation and magnetic heat fusion treatment device for animals that can perform radiation therapy as well as CT imaging with a single facility.
  • Another object of the present invention is to provide a radiation and magnetic heat fusion treatment device for animals that can easily adjust the size and appropriate radiation intensity to treat companion animals.
  • the apparatus of this embodiment includes a radiation therapy device for treating a tumor of an animal patient to be treated with radiation, a magnetic heat treatment device for treating an animal patient with magnetic heat, a patient table for placing an animal patient, and an animal on the patient table. It may include an operation panel that controls the radiation therapy device and the magnetic heat treatment device to treat the patient with radiation and/or magnetic heat.
  • the radiation therapy device includes a gantry that forms a gantry aperture for accommodating a patient table inside and forms a radiation beam according to a control signal and emits it toward the gantry aperture, the gantry aperture A table gear installed on the floor to move the patient table forward and backward, a reference laser attached to the front of the gantry to remember the position of the patient table and move the patient table to the gantry aperture radiation area, And it may include a radiation body for supporting the gantry.
  • the radiation generator includes a radiation generator body having a radiation discharge port formed in the center and a through hole communicating with the radiation discharge port from one side, an isotope injection port for injecting radioactive isotope material, and an isotope injection port formed in the through hole of the body.
  • a radiation isotope injection rod that is inserted to direct the radiation injection hole toward the radiation discharge port, a primary beam collimator installed in the x-axis direction of the radiation discharge port to primarily adjust the generation range, and a primary beam collimator of the radiation discharge port. It may be installed in the y-axis direction and include a collimator to adjust the shape of the radiation beam according to the shape of the animal patient's tumor.
  • the radioactive isotope material may be any one of Sr-90, Cs-137, and Co-60.
  • the magnetic heat therapy device includes a gantry aperture for accommodating a patient table inside, a magnetic field gantry that forms magnetic heat according to a control signal and radiates it toward the gantry aperture, and a magnetic field gantry for supporting the magnetic field gantry. It may include a magnetic field body, a magnetic field generating coil provided inside the magnetic field gantry and for generating an alternating magnetic field according to power supply, and a connector formed on one side of the magnetic field body for connecting to the radiation therapy machine.
  • Wheels for moving the magnetic heat therapy device may be attached to the bottom of the magnetic field body.
  • the device of this embodiment includes a radiation therapy device for treating a tumor of an animal patient that is a treatment target with radiation, a magnetic heat therapy device disposed adjacent to the radiation therapy device for treating an animal patient with magnetic heat, and a patient table for placing the animal patient. , and may include a moving unit for moving the patient table to the radiation therapy device and the magnetic heat therapy device.
  • the moving part includes a lower body placed on the ground in front of the radiation therapy machine, an upper body movable up and down on top of the lower body, and an upper body formed on the upper body and extending in the axial direction of the gantry aperture of the radiation therapy machine. It may include a rail portion that slideably supports the table, and a control panel provided on one side of the upper body to control up and down and/or forward and backward movement of the table.
  • the moving unit may further include a support bar disposed between the adjacent radiation therapy device and the magnetic heat therapy device or behind the magnetic heat therapy device to movably support the table.
  • the support includes a lower support body placed on the ground, an upper support body movably installed on top of the lower support body, and an upper support body extending in the direction of movement of the table and slidingly supporting the table. It may include a support rail part, which is provided on one side of the lower support body, and a connector for connecting to the control panel of the moving part.
  • the moving unit may further include a plurality of auxiliary wheels installed on the bottom of the upper body or the upper support body and rotated in contact with the lower part of the table.
  • the table may have a mesh structure installed on the front.
  • the radiation therapy machine includes a gantry that forms a gantry aperture for accommodating a patient table inside, forms a radiation beam according to a control signal and emits it toward the gantry aperture, and a gantry on the front of the gantry. It may include a reference laser that is attached and installed to remember the position of the patient table and move the patient table to the gantry aperture radiation irradiation area, and a radiation body to support the gantry.
  • the radiation therapy device may further include a CT imaging device provided in the gantry.
  • the CT imaging diagnostic device may include a diagnostic radiation generator installed on the annular support frame of the gantry to generate radiation for CT images, and a detector located in a diagonal direction of the diagnostic radiation generator to detect radiation from the diagnostic radiation generator. there is.
  • the CT diagnostic device may have a cone beam computed tomography (cone beam CT) structure.
  • the radiation generator may be an x-ray generator that generates radiation for treatment.
  • the radiation and magnetic heat fusion treatment device for animals can be constructed at a cost that is about 5 to 10 times lower than that of the treatment device for humans.
  • radiation and magnetic heat therapy can be performed simultaneously or separately in one device by using the radiation therapy device alone or by combining it with an alternating magnetic field generator for magnetic heat treatment, allowing you to select the appropriate treatment according to the tumor condition. It is expected to increase the treatment effect of tumors, shorten the treatment period, and reduce costs.
  • the table can be moved stably in and out of the treatment machine, increasing convenience of use and maximizing the treatment effect by placing the patient in a more accurate position.
  • the table has a mesh structure, which prevents the intensity of radiation from being attenuated by the table.
  • It is equipped with a therapeutic radiation generator and a CT imaging diagnostic device that rotates 360 degrees through a guide rail provided within the circular gantry, enabling the treatment effect to be increased by obtaining anatomical images for animal diagnosis as well as radiation therapy.
  • the treatment effect can be improved by adjusting the shape of the radiation beam according to the shape of the pet's tumor.
  • Figure 2 is an operation flow chart of the radiation and magnetic heat fusion treatment device for animals according to the first embodiment of the present invention
  • Figure 3 is a perspective view showing a radiation therapy device according to a first embodiment of the present invention.
  • FIG. 4 is a right side view of the radiation therapy device according to the first embodiment of the present invention.
  • FIG. 5 is a plan view of a radiation therapy device according to a first embodiment of the present invention.
  • Figure 7 is a schematic diagram showing a state in which the patient table is inserted in the radiation therapy machine according to the first embodiment of the present invention.
  • Figure 8 is a schematic diagram showing a state in which the patient table and gantry cover are removed from the radiation therapy device according to the first embodiment of the present invention
  • Figure 9 is an enlarged view of the radiation generator and shield according to the first embodiment of the present invention.
  • Figure 15 is a perspective view of a magnetic heat treatment device according to the first embodiment of the present invention.
  • Figure 17 is an exemplary view of the coil shape inside the gantry of the magnetic heat therapy device according to the first embodiment of the present invention.
  • Figure 18 is a schematic diagram showing a radiation and magnetic heat fusion treatment device for animals according to a second embodiment of the present invention.
  • 19 to 21 are schematic diagrams showing the moving part of the radiation and magnetic heat fusion treatment device for animals according to the second embodiment of the present invention.
  • 22 to 24 are schematic diagrams showing the radiation therapy device of the radiation and magnetic heat fusion treatment device for animals according to the second embodiment of the present invention.
  • Figure 1 is a schematic diagram showing a radiation and magnetic heat fusion treatment device for animals according to an embodiment of the present invention.
  • Animals subject to treatment according to an embodiment of the present invention may include various companion animals such as dogs and cats.
  • animals with diseases that need to be treated such as tumors, will be collectively referred to as 'animal patients.
  • the radiation and magnetic heat fusion treatment device 100 for animals includes a radiation therapy device 10 for treating a tumor of an animal patient with radiation, and a magnetic heat treatment for the animal patient.
  • a magnetic heat therapy device (20) for treatment with radiation a patient table (30) for placing an animal patient, and a radiation therapy device (10) for treating the animal patient on the patient table (30) with radiation and/or magnetic heat. It may include an operation panel 40 that controls the magnetic heat therapy device 20.
  • the radiation therapy device 10 forms a radiation beam with a radiation intensity and shape set under the control of the operation panel 40, and then irradiates the radiation beam to the treatment area for a set time, as will be discussed in detail later. This allows radiation treatment to take place.
  • the magnetic heat therapy device 20 generates an alternating magnetic field with a magnetic field intensity set according to the control of the operation panel 40 and then irradiates the alternating magnetic field to the treatment area for a set time to perform magnetic heat treatment.
  • the patient table 30 is detachably installed on the gantry aperture 112 of the radiation therapy machine 10 and can be moved forward or backward.
  • the operation panel 40 is composed of a touch-type display and a controller attached to one side of the radiation therapy machine 10, and is capable of selecting a treatment mode or setting various parameters according to the symptoms of the animal patient.
  • Figure 2 is a flowchart of the operation of a radiation and magnetic heat fusion treatment device for animals according to an embodiment of the present invention.
  • the radiation therapy device 10 and the magnetic heat therapy device 20 can be coupled and separated through the module connectors 11 and 21. there is.
  • the operation panel 40 and the patient table 30 are installed on the side of the radiation therapy device 10, so that in some cases, the radiation therapy device can be operated independently and operated only as a radiation therapy device.
  • a 'radiation therapy mode' using only the radiation therapy device to independently operate and use it for radiation treatment is called a 'radiation therapy mode'
  • a 'magnetic heat treatment mode' using only the magnetic heat treatment device to operate and use it for magnetic heat treatment is called a 'magnetic heat treatment mode'.
  • Combining magnetic heat (heat) treatment with radiation therapy is called ‘fusion treatment mode’ (simply referred to as ‘fusion mode’).
  • the operating state of the device is determined through self-diagnosis, and the magnetic heat treatment device 20 is After determining whether the module connectors 11 and 21 are connected properly, an initial screen such as the operation status, whether the magnetic heat therapy device is connected, and various setting menus is displayed on the touch-type display (S101 to S103).
  • radiation parameters such as radiation intensity, beam shape, irradiation time or cycle, etc. can be set, and the radiation beam can be irradiated to the treatment area of the animal patient.
  • the set radiation beam is irradiated to the treatment area (S111 to S114).
  • the screen returns to the initial screen (S115).
  • magnetic heat parameters such as magnetic field strength, temperature, time, or cycle of the magnetic heat therapy device 20 can be set, and the animal patient's After adjusting the position of the patient table 30 to emit magnetic heat to the treatment area, the set magnetic heat is applied to the treatment area (S121 to S124). When magnetic heat treatment is completed, the screen returns to the initial screen (S125).
  • the connection status of the magnetic heat treatment device 20 is checked, various parameters for radiation treatment are set, and various parameters for magnetic heat treatment are set (S131 to S133).
  • radiation treatment is performed by irradiating the radiation beam set to the treatment area (S134, S135).
  • the patient table 30 is moved to the gantry aperture side of the magnetic heat therapy device 20 and an alternating magnetic field is generated to treat the treatment area of the animal patient with magnetic heat (S136 to S138).
  • the screen returns to the initial screen (S139).
  • the radiation therapy device 10 is used alone, only the magnetic heat therapy device 20 is used, or the radiation therapy device 10 and the magnetic heat therapy device 20 for magnetic heat treatment are combined to form a single device. Since the device can perform radiation and magnetic heat treatment at the same time, it is possible to select the appropriate treatment according to the tumor condition, thereby increasing the tumor treatment effect, shortening the treatment period, and reducing costs.
  • FIG. 3 is a perspective view showing a radiation therapy device according to an embodiment of the present invention
  • Figure 4 is a right side view of the radiation therapy device according to an embodiment of the present invention
  • Figure 5 is a top view of the radiation therapy device according to an embodiment of the present invention
  • FIG. 6 is a rear view of a radiation therapy machine according to an embodiment of the present invention
  • FIG. 7 is a schematic diagram showing a state in which a patient table is inserted in the radiation therapy machine according to an embodiment of the present invention.
  • the radiation therapy device 10 accommodates a patient table 30 inside and has a gantry aperture (112) for the radiation area. It may include a gantry 110 that irradiates a radiation beam, a table gear 102, reference lasers 104-1 to 104-3, and a radiation body 106.
  • a patient table 30 is detachably attached within the gantry aperture 112, the front top of the gantry aperture 112, and Reference lasers (104-1 to 104-3) are installed on the left and right sides.
  • the position of the patient table (30) is remembered by the reference laser (reference laser (104-1 ⁇ 104-3)), and the patient table (table) is moved to the radiation irradiation area in the center of the gantry aperture (112). 30) can be moved precisely.
  • a module connector 11 is attached to the rear of the radiation therapy device 10 for connection to the magnetic heat therapy device 20.
  • the table gear 102 is installed on the bottom of the gantry aperture 112 and transports the patient table 30 forward and backward by a motor controlled by the operation panel 40.
  • Anteroposterior can mean front or rear.
  • Reference lasers 104-1 to 104-3 are attached to the front of the gantry and are used to detect the position of the patient table 30.
  • reference lasers 104-1 to 104-3 are installed on the upper, left, and right sides of the table, respectively, and the detected table position signal is transmitted to the operation panel 40.
  • the radiation body 106 is intended to surround and support the gantry 110, and an operation panel 40 is attached to one side.
  • Figure 8 is a schematic diagram showing a state in which the patient table and gantry cover are removed from the radiation therapy device according to an embodiment of the present invention
  • Figure 9 is an enlarged view of the radiation generator and shield according to an embodiment of the present invention.
  • the gantry 110 of the radiation therapy device includes a gantry aperture 112, a gantry body 114, a gantry cover 115, and a guide rail ( 116), an annular support frame 118, a radiation generator 120, and a radiation shield 130.
  • the gantry aperture 112 accommodates a patient table 30 and forms an irradiation area.
  • a table gear 102 is attached to the bottom of the gantry aperture 112 to move the patient table 30 forward or backward.
  • the gantry body 114 has an inner cylinder 114a and an outer cylinder 114b and is shaped like a donut with one side open, and the open side is closed by the gantry cover 115.
  • a gantry aperture 112 is formed in the center of the inner cylinder 114a, and a radiation generator 120 and a radiation shield 130 are installed in the empty space between the inner cylinder 114a and the outer cylinder 114b. °It is accommodated so that it can rotate.
  • the radiation generator 120 is for generating radiation and forming a radiation beam for treatment, and the radiation shield 130 is located diagonally opposite the radiation generator 120, that is, in the radiation generator 120. It primarily shields the generated radiation.
  • the radiation generator 120 and the radiation shield 130 are arranged diagonally to face each other by a pair of annular support frames 118.
  • a guide rail 116 is formed as a circular groove in the inner cylinder 114a of the gantry body 114 to support the radiation generator 120 and the radiation shield 130 so that they can rotate 360° while maintaining the diagonal directions. .
  • the radiation generator 120 and the radiation shield 130 are each formed with guide protrusions 120a and 130a inserted into the guide rail 116.
  • the radiation generator 120 and the radiation shield 130 rotate 360° in the space inside the gantry through the guide rail 116 and radiate radiation to the gantry aperture (112).
  • the radiation shield 130 located on the opposite side (180° position) of the radiation generator 120 is capable of primarily shielding the radiation generated from the radiation generator 120.
  • Figures 10 to 14 are enlarged views of a radiation generator according to an embodiment of the present invention.
  • Figure 10 shows the radioactive isotope injection rod exposed
  • Figure 11 shows the radioactive isotope injection rod entering the inside of the generator body
  • Figure 10 shows the radioactive isotope injection rod exposed.
  • 12 is a top view of the radiation generator
  • Figure 13 is a side cross-sectional view of the radiation generator
  • Figure 14 shows the collimator.
  • the radiation generator 120 may include a radiation generator body 123, a radioisotope injection rod 124, and a collimator 126.
  • the radiation generator body 123 has a radiation discharge port 121 formed in the center between a pair of guide protrusions 120a, and a through hole 122 communicating with the radiation discharge port 121 from one side is formed. and a radioisotope injection rod 124 is fitted into the through hole 122.
  • the radioisotope injection rod 124 is fitted into the through hole 122 of the generator body 123, and when injecting radioactive isotope material, the injection rod 124 is exposed to the outside as shown in FIG. 10, and the isotope injection hole ( After injecting the radioactive isotope material through 125), the injection rod 124 is inserted into the through hole 122 as shown in FIG. 11 so that the isotope injection port 125 is located at the radiation emission port 121. .
  • the radiation generator may be an x-ray generator that generates radiation for treatment.
  • Figure 14 shows the structure of a collimator according to this embodiment.
  • the collimator 126 has a pair of large tungsten leaves 127 installed on the left and right sides of the radiation outlet 121 along the X-axis direction, and 10 pairs along the y-axis direction.
  • Small tungsten leaves (128) are installed on the left and right sides of the discharge port (121).
  • the radiation generated from radioactive isotopes is primarily controlled in its range through a pair of large tungsten ribs 126 arranged in the x-axis direction, and secondarily its beam shape is adjusted through 10 pairs of tungsten ribs 128. Adjust it.
  • a pair of large tungsten ribs 127 and 10 pairs of small tungsten ribs 128 each move to change the shape of the discharge port, thereby adjusting the radiation beam shape to suit the shape of the animal patient's tumor.
  • the tungsten ribs 127 in the x-axis direction and the 10 pairs of tungsten ribs 128 in the y-axis direction can be controlled by the operation of the motor 140, respectively.
  • a rack gear 141 is installed to extend at the tip of each tungsten rib 127 and 128, and a pinion gear 142 that engages the rack gear 141 is installed on the rotation axis of the motor 140 and can be coupled to each other. Accordingly, when the motor 140 is driven forward or backward, the pinion gear 142 rotates, and the tungsten ribs 126 and 128 connected to the pinion gear 142 through the rack gear 141 are moved, making it possible to adjust the beam shape.
  • the operation panel 40 can control each motor 140 to adjust the shape of the radiation beam according to the shape of the patient's tumor.
  • any one of Sr-90, Cs-137, and Co-60 can be used as the radioisotope material.
  • Figure 15 is a perspective view of a magnetic heat therapy device according to an embodiment of the present invention
  • Figure 16 is a front view of the magnetic heat therapy device according to an embodiment of the present invention
  • Figure 17 is a rear view of the magnetic heat therapy device according to an embodiment of the present invention. And this is an example of the coil shape inside the gantry.
  • the magnetic heat therapy device 20 includes a magnetic field generating coil 24 for generating an alternating magnetic field when power is supplied, and a gantry aperture of the radiation therapy device. It has a gantry aperture 23 of the same size as (112), a magnetic field gantry 22 for accommodating the magnetic field generating coil 24 therein, and a magnetic field body for supporting the magnetic field gantry 22 ( 25) and a module connector 21 formed on one side of the magnetic body 25 and connected to the radiation therapy device 10.
  • the magnetic field body 25 has wheels 26 attached to the bottom surface for easily moving the magnetic heat therapy device 20.
  • the magnetic heat therapy device 20 consists of a donut-shaped gantry 22 and a magnetic field body 25 for supporting the gantry 22, and a module connector located at the bottom of the magnetic field body 25. It is connected to the radiation therapy device (10) through 21). In addition, it can be easily moved through the wheels 26 located at the bottom of the magnetic field body 25, and the gantry 22 includes a coil 24 for generating a magnetic field, and the magnetic field body 25 includes a coil 24 for generating a magnetic field.
  • a circuit and a heat radiation device for generating a magnetic field may be installed.
  • the magnetic heat therapy device 20 has a gantry aperture (23) of the same size as the radiation therapy device (10), and uses a coil (24) for generating a magnetic field within the gantry (22).
  • An alternating magnetic field is formed in the gantry aperture (23).
  • Figure 18 shows another embodiment of a radiation and magnetic heat fusion treatment device for animals.
  • the device 100 of this embodiment is a radiation therapy device 10 for treating a tumor of an animal patient, which is the target of treatment, with radiation, and is disposed adjacent to the radiation therapy device 10 to treat the animal patient with magnetic heat.
  • a magnetic heat therapy device (20) for treatment with radiation, a patient table (30) for placing an animal patient, and a moving unit (50) for moving the patient table (30) to the radiation therapy device (10) and the magnetic heat therapy device (20). ) may include.
  • the magnetic heat therapy device 20 generates an alternating magnetic field in response to power supply and can treat an animal patient placed on the patient table 30 with magnetic heat.
  • the magnetic heat therapy device 20 includes a magnetic field gantry 22 and a magnetic field body 25 supporting the magnetic field gantry 22.
  • the magnetic heat therapy device 20 of this embodiment may further include a separate control panel 27 for operating the magnetic heat therapy device 20. Accordingly, the magnetic heat therapy machine 20 can be individually driven by manipulating the control panel 27 separately from the control of the radiation therapy machine 10.
  • the patient table 30 may have a mesh structure 32 installed on the front. Accordingly, the radiation intensity can be prevented from being attenuated by the table 30.
  • the moving unit 50 is disposed on the front side separately from the radiation therapy device 10.
  • the moving unit 50 can selectively move the patient table 30 to the radiation therapy machine 10 disposed at the rear or the magnetic heat therapy machine 20 disposed adjacent to the rear of the radiation therapy machine only when necessary.
  • the moving part 50 includes a lower body 52 placed on the ground in front of the radiation therapy device 10, and an upper body installed to be movable up and down on top of the lower body 52. (54), a rail portion (56) formed on the top of the upper body (54), extending in the axial direction of the gantry aperture (112) of the radiation therapy device (10), and slidingly supporting the patient table (30), upper body (54) It may include a control panel 58 provided on one side to control the up and down and/or forward and backward movement of the patient table 30.
  • the patient table 30 is installed to be slidable in engagement with the rail portion 56.
  • a plurality of auxiliary wheels 59 that rotate in contact with the lower part of the patient table 30 may be further installed on the upper bottom surface of the upper body 54.
  • a plurality of auxiliary wheels 59 are arranged at regular intervals and rotatably installed on the bottom surface of the rail unit 56.
  • the auxiliary wheel 59 supports the patient table 30 and assists the patient table 30 to move more smoothly along the rail portion 56.
  • the upper body 54 is moved up and down with respect to the lower body 52 to adjust the height of the patient table 30, and the rail portion 56 of the upper body 54
  • the patient table 30 moves forward and backward along . Accordingly, the patient table 30 can be moved to the radiation therapy machine 10 while supported by the rail portion 56 or to the magnetic heat therapy machine 20 disposed at the rear.
  • the height of the patient table 30 can be lowered by placing it outside the radiation therapy machine 10, making it possible to easily place an animal patient on the table and move it while minimizing interference with the radiation therapy machine 10.
  • the moving unit 50 is disposed between the adjacent radiation therapy machine 10 and the magnetic heat therapy machine 20 or/and behind the magnetic heat therapy machine 20 to movably support the patient table 30. It may further include a support 60.
  • the support 60 of this embodiment includes a lower support body 62 placed on the ground, an upper support body 64 movable up and down installed on the lower support body 62, and an upper support body 60.
  • a support rail portion 66 is formed at the top of the body 64, extends in the moving direction of the patient table 30, and slideably supports the patient table 30, and is provided on one side of the lower support body 62 and controls the moving portion. It may include a connector 68 for connection to the panel 58.
  • a plurality of auxiliary wheels 69 that rotate in contact with the lower part of the patient table 30 may be further installed on the upper bottom surface of the upper support body 54.
  • the auxiliary wheel 59 supports the patient table 30 and assists the patient table 30 to move more smoothly along the support rail portion 66.
  • the support rail part 66 has the same structure as the rail part 56 of the moving part 50 and can slideably support the patient table 30.
  • the upper support body 64 is moved up and down with respect to the lower support body 62, so that the height of the support rail portion 66 can be accurately adjusted to the height of the patient table 30.
  • the support 60 disposed at the rear of the radiation therapy machine 10 moves rearward from the upper body 52 of the moving unit 50 and supports the front end of the patient table 30 that has passed the radiation therapy machine 10. Since the patient table 30 is supported by the support 60, it does not sag down due to its own weight even if it is moved outward from the moving unit 50.
  • the patient table 30 is supported at both ends by the upper body 52 of the movable part and the upper support body 64 of the support 60. Accordingly, the patient table 30 can pass through the gantry aperture 112 of the radiation therapy machine 10 and be stably supported in a non-contact state with the gantry 110.
  • the support 60 disposed at the rear of the magnetic heat therapy device 20 also supports the front end of the patient table 30 that has passed through the magnetic heat therapy device, thereby preventing the patient table 30 from sagging due to its own weight. Accordingly, the patient table 30 can be positioned within the magnetic heat therapy device 30 as long as it maintains a non-contact state with respect to the magnetic heat therapy device 20 .
  • a connector 68 may be provided on the lower support body 62 of the support 60.
  • the connector 68 for example, has a male connector structure that protrudes outward, and can be easily electrically connected by being inserted into a female connector provided in the radiation therapy device 10 or the magnetic heat therapy device 20.
  • the support 60 is connected to the control panel 58 of the moving part, which is electrically connected to the radiation therapy machine 10 through the connector 58, and can be driven under the control of the control panel 58.
  • the upper support of the support 60 is adjusted according to the amount of vertical movement of the upper body 54.
  • the body 64 is also moved up and down with respect to the lower support body 62. Therefore, the height of the support rail portion 66 of the support 60 matches the height of the patient table 30, so that the patient table 30 is smoothly engaged with the support rail portion 66 of the support and moves along the support rail portion 66. can be moved
  • Figures 22 to 24 show the radiation therapy device of this embodiment.
  • the radiation therapy machine 10 forms a gantry aperture 112 to accommodate the patient table 30 inside, forms a radiation beam according to a control signal, and emits it toward the gantry aperture 112. It may include a gantry 110 and a radiation body 106 for supporting the gantry 110.
  • a radiation generator 120, a radiation shield 130, and a CT imaging device may be provided inside the gantry body 114.
  • a CT imaging device provides diagnostic CT images for animal patients.
  • the radiation generator 120 may have an x-ray generator structure that generates radiation for treatment.
  • the CT imaging diagnostic device is installed on the annular support frame 118 of the gantry 110 and includes a diagnostic radiation generator 135 that generates radiation for CT images, and a diagnostic radiation generator located diagonally from the diagnostic radiation generator 135 ( It may include a detector 137 that detects radiation 135).
  • the annular support frame 118 is rotatably coupled to the inner cylinder 114a of the gantry 110 and rotates along the circumferential surface of the inner cylinder 114a.
  • the annular support frame 118 has a radiation generator 120 and a diagnostic radiation generator 135 installed at a predetermined angle along the circumferential direction, and the radiation generator 120 and the diagnostic radiation generator 135 are installed on opposite sides of the radiation generator 120 and the diagnostic radiation generator 135, respectively.
  • a waste 130 and a detector 137 are installed.
  • the radiation generator 120 and the diagnostic radiation generator 135 may be arranged, for example, at 90-degree intervals along the circumferential direction.
  • the annular support frame 118 rotates 360° around the inner cylinder 114a while maintaining the radiation generator 120, the radiation shield 130, the diagnostic radiation generator 135, and the detector 137 in diagonal directions. .
  • the CT diagnostic device may have a cone beam computed tomography (cone beam CT) diagnostic structure.
  • the cone beam CT diagnostic structure captures images by emitting x-rays in a cone shape, and the diagnostic radiation generator 135 generates a cone-shaped beam.
  • a detector 137 is provided diagonally opposite the diagnostic radiation generator 135 to detect radiation emitted from the diagnostic radiation generator 135 and obtain an image.
  • the gantry is equipped with a therapeutic radiation generator and a CT imaging device that rotates 360 degrees, so that the treatment effect can be increased by obtaining anatomical images for diagnosis of animals as well as radiation therapy.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L'invention concerne un appareil de thérapie pour animaux combinant la radiothérapie et la thérapie thermique magnétique, conçu de telle sorte qu'un module générateur de rayonnement mobile situé à l'intérieur d'un portique circulaire peut traiter un site tumoral chez un animal tout en tournant sur 360°. Ledit appareil comprend : un dispositif de radiothérapie servant à traiter une tumeur chez un patient animal par radiation ; un dispositif de thérapie thermique magnétique servant à traiter le patient animal par la chaleur magnétique ; une table pour le patient, sur laquelle le patient animal est installé ; et un panneau de commande permettant de commander le dispositif de radiothérapie et le dispositif de thérapie thermique magnétique afin de traiter le patient animal sur la table par radiation et/ou par la chaleur magnétique.
PCT/KR2023/009350 2022-07-04 2023-07-03 Appareil de thérapie pour animaux combinant la radiothérapie et la thérapie thermique magnétique WO2024010313A1 (fr)

Applications Claiming Priority (2)

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KR10-2022-0082016 2022-07-04
KR20220082016 2022-07-04

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WO2024010313A1 true WO2024010313A1 (fr) 2024-01-11

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2691632Y (zh) * 2003-12-03 2005-04-13 朱宏 肿瘤磁热疗治疗仪
CN200987837Y (zh) * 2006-04-05 2007-12-12 林思清 一种环形聚焦、多辅助治疗手段的放疗装置
JP2010519965A (ja) * 2007-02-28 2010-06-10 ユニバーシティ オブ メリーランド，ボルチモア 画像誘導型立体位置放射線手術を乳癌に行う方法およびそれに用いる機器
US20170135599A1 (en) * 2014-06-25 2017-05-18 Elekta Ab (Publ) Control of Breathing During MRI-Based Procedures
KR20200065477A (ko) * 2018-11-30 2020-06-09 (주)아우라케어 방사선 촬영 및 치료 장치

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Publication number Priority date Publication date Assignee Title
KR102068326B1 (ko) 2018-06-27 2020-01-20 한국원자력의학원 동물용 방사선 치료기
KR200490657Y1 (ko) 2019-09-16 2019-12-12 고려대학교 산학협력단 Kilovoltage X-ray를 이용한 반려동물 방사선 치료 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2691632Y (zh) * 2003-12-03 2005-04-13 朱宏 肿瘤磁热疗治疗仪
CN200987837Y (zh) * 2006-04-05 2007-12-12 林思清 一种环形聚焦、多辅助治疗手段的放疗装置
JP2010519965A (ja) * 2007-02-28 2010-06-10 ユニバーシティ オブ メリーランド，ボルチモア 画像誘導型立体位置放射線手術を乳癌に行う方法およびそれに用いる機器
US20170135599A1 (en) * 2014-06-25 2017-05-18 Elekta Ab (Publ) Control of Breathing During MRI-Based Procedures
KR20200065477A (ko) * 2018-11-30 2020-06-09 (주)아우라케어 방사선 촬영 및 치료 장치

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