WO2023284900A3 - 重组人胶原蛋白多肽及其应用 - Google Patents
重组人胶原蛋白多肽及其应用 Download PDFInfo
- Publication number
- WO2023284900A3 WO2023284900A3 PCT/CN2022/118748 CN2022118748W WO2023284900A3 WO 2023284900 A3 WO2023284900 A3 WO 2023284900A3 CN 2022118748 W CN2022118748 W CN 2022118748W WO 2023284900 A3 WO2023284900 A3 WO 2023284900A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- recombinant human
- human collagen
- collagen polypeptide
- seq
- amino acid
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 4
- 108010035532 Collagen Proteins 0.000 title abstract 4
- 229920001436 collagen Polymers 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000003556 vascular endothelial cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Birds (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
公开了一种重组人胶原蛋白多肽及其应用。所述的重组人胶原蛋白多肽的氨基酸序列如SEQ ID NO:2所示或者与SEQ ID NO:2具有至少90％同一性的氨基酸序列。所述的重组人胶原蛋白多肽可以用于抑制血管内皮细胞的生长，可以促进细胞增殖和促进细胞粘附。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110802458.9 | 2021-07-15 | ||
| CN202110802458.9A CN113444167B (zh) | 2021-07-15 | 2021-07-15 | 重组人胶原蛋白多肽及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2023284900A2 WO2023284900A2 (zh) | 2023-01-19 |
| WO2023284900A3 true WO2023284900A3 (zh) | 2023-03-09 |
Family
ID=77816373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2022/118748 WO2023284900A2 (zh) | 2021-07-15 | 2022-09-14 | 重组人胶原蛋白多肽及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113444167B (zh) |
| WO (1) | WO2023284900A2 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113444167B (zh) * | 2021-07-15 | 2022-09-30 | 陕西巨子生物技术有限公司 | 重组人胶原蛋白多肽及其应用 |
| CN113735966B (zh) * | 2021-09-29 | 2022-11-01 | 陕西巨子生物技术有限公司 | 一种抗肿瘤重组胶原蛋白及其制备方法和应用 |
| CN114316030B (zh) * | 2022-01-27 | 2023-06-30 | 西安巨子生物基因技术股份有限公司 | 一种透皮吸收性的i型重组胶原蛋白及其用途 |
| CN116478274B (zh) * | 2022-07-19 | 2023-12-15 | 山西锦波生物医药股份有限公司 | 一种生物合成人体结构性材料的制备方法 |
| CN117229386A (zh) * | 2023-03-16 | 2023-12-15 | 山西锦波生物医药股份有限公司 | 一种具有164.88°三螺旋结构低分子量胶原蛋白 |
| CN117003857B (zh) * | 2023-09-28 | 2024-01-05 | 英特菲尔(成都)生物制品有限责任公司 | 一种具有透皮吸收性能的胶原蛋白及其制备方法与应用 |
| CN117304306B (zh) * | 2023-09-28 | 2024-06-04 | 广东普言生物科技有限公司 | 一种重组Ⅲ型胶原蛋白Pro.C3及其制备方法和应用 |
| CN117285616B (zh) * | 2023-10-07 | 2024-02-27 | 广东省卓肽医药有限公司 | 一种重组人源化i+iii型胶原蛋白及应用 |
| CN117603343B (zh) * | 2024-01-19 | 2024-04-26 | 四川大学 | 阻断bFGF的胶原来源天然短肽及应用 |
| CN117801096B (zh) * | 2024-01-29 | 2024-07-02 | 河北纳科生物科技有限公司 | 一种水溶性重组人ⅹⅶ型胶原蛋白及其制备方法和应用 |
| CN118271425B (zh) * | 2024-03-29 | 2024-10-18 | 湖南丽赛药业有限公司 | 一种用于创面修复的重组ⅲ型人源化胶原蛋白及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130084638A1 (en) * | 2011-09-29 | 2013-04-04 | Fujifilm Corporation | Scaffold for vascular endothelial cell migration |
| CN107857812A (zh) * | 2017-11-17 | 2018-03-30 | 杭州惠博士生物科技有限公司 | 一种同人源胶原蛋白氨基酸、基因序列及蛋白氨基酸的制备方法 |
| CN111944057A (zh) * | 2020-07-23 | 2020-11-17 | 广州启妆生物科技有限公司 | 一种重组人胶原蛋白肽及其应用 |
| CN113444167A (zh) * | 2021-07-15 | 2021-09-28 | 陕西巨子生物技术有限公司 | 重组人胶原蛋白多肽及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69636122T2 (de) * | 1995-11-13 | 2006-12-07 | Takara Bio Inc., Otsu | Verfahren zum gentransfer in zielzellen mit einem retrovirus |
| CN106554410B (zh) * | 2016-06-02 | 2019-11-26 | 陕西东大生化科技有限责任公司 | 一种重组人源胶原蛋白及其编码基因和制备方法 |
| CN109022464A (zh) * | 2018-07-02 | 2018-12-18 | 西安巨子生物基因技术股份有限公司 | 重组人源型胶原蛋白的羟基化方法 |
| JP2022527082A (ja) * | 2019-03-27 | 2022-05-30 | フェニックス ティシュー リペア インコーポレイテッド | コラーゲン７組成物を産生するための系および方法 |
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2021
- 2021-07-15 CN CN202110802458.9A patent/CN113444167B/zh active Active
-
2022
- 2022-09-14 WO PCT/CN2022/118748 patent/WO2023284900A2/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130084638A1 (en) * | 2011-09-29 | 2013-04-04 | Fujifilm Corporation | Scaffold for vascular endothelial cell migration |
| CN107857812A (zh) * | 2017-11-17 | 2018-03-30 | 杭州惠博士生物科技有限公司 | 一种同人源胶原蛋白氨基酸、基因序列及蛋白氨基酸的制备方法 |
| CN111944057A (zh) * | 2020-07-23 | 2020-11-17 | 广州启妆生物科技有限公司 | 一种重组人胶原蛋白肽及其应用 |
| CN113444167A (zh) * | 2021-07-15 | 2021-09-28 | 陕西巨子生物技术有限公司 | 重组人胶原蛋白多肽及其应用 |
Non-Patent Citations (3)
| Title |
|---|
| FUSHIMI HIDEO, HIRATSUKA TAKAHIRO, OKAMURA AI, ONO YOSHITAKA, OGURA IZUMI, NISHIMURA ICHIRO: "Recombinant collagen polypeptide as a versatile bone graft biomaterial", COMMUNICATIONS MATERIALS, vol. 1, no. 1, 20 November 2020 (2020-11-20), pages 87 - 13, XP093041501, ISSN: 2662-4443, DOI: 10.1038/s43246-020-00089-9 * |
| TANG YUN-PING, ZHENG QIANG; HU BIN; CAI JIN; HUANG LEI; XU ZHI-NAN: "Ｒesearch progress on preparation and application of recombinant collagens", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, GAI KAN BIANJIBU , BEIJING, CN, vol. 37, no. 18, 1 January 2016 (2016-01-01), CN , pages 384 - 386, XP093041525, ISSN: 1002-0306, DOI: 10.13386/j.issn1002-0306.2016.18.065 * |
| WEI CHUN, LIU CHUN; LIU XINYU; ZHANG XUCHU; WANG HUAN: "Research progress on the production of recombinant collagen by genetic engineering", BULLETIN OF FERMENTATION SCIENCE AND TECHNOLOGY, ZHEJIANG UNIVERSITY OF TECHNOLOGY, CN, vol. 50, no. 1, 1 March 2021 (2021-03-01), CN , pages 1 - 5, XP093041515, ISSN: 1674-2214, DOI: 10.16774/j.cnki.issn.1674-2214.2021.01.001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113444167A (zh) | 2021-09-28 |
| WO2023284900A2 (zh) | 2023-01-19 |
| CN113444167B (zh) | 2022-09-30 |
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