WO2023243448A1 - 二次流れ形成装置、固液分離装置及び固液分離システム - Google Patents

二次流れ形成装置、固液分離装置及び固液分離システム Download PDF

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Publication number
WO2023243448A1
WO2023243448A1 PCT/JP2023/020685 JP2023020685W WO2023243448A1 WO 2023243448 A1 WO2023243448 A1 WO 2023243448A1 JP 2023020685 W JP2023020685 W JP 2023020685W WO 2023243448 A1 WO2023243448 A1 WO 2023243448A1
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Prior art keywords
flow path
height
fluid
baffle plate
solid
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PCT/JP2023/020685
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English (en)
French (fr)
Japanese (ja)
Inventor
諒介 池田
達也 山下
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株式会社Ihi
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Priority to JP2024528713A priority Critical patent/JPWO2023243448A1/ja
Publication of WO2023243448A1 publication Critical patent/WO2023243448A1/ja

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
    • B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00—Influencing flow of fluids
    • F15D1/02—Influencing flow of fluids in pipes or conduits

Definitions

  • the present disclosure relates to a secondary flow forming device, a solid-liquid separation device, and a solid-liquid separation system.
  • solid-liquid separation techniques include centrifugation, membrane separation, sedimentation separation, and the like.
  • solid-liquid separation technology is also applied to microfluidic devices having microchannels whose cross-sectional sizes are defined on the scale of mm or ⁇ m.
  • Patent Document 1 discloses a technology related to a liquid sending device that sends liquid to a microchannel and performs solid-liquid separation by sedimentation.
  • a pattern is formed on the inner wall or partition of the microchannel to generate an upward flow in the vertical direction at the center of the cross section of the microchannel. This pattern generates a flow in the opposite direction to the displacement flow that occurs as the solid particles settle, thereby canceling out the displacement flow and, as a result, contributing to obtaining a stable sedimentation rate.
  • solid-liquid separation technology is also known that applies the tubular pinch effect, in which solid particles are concentrated at a specific position in a flow channel due to the lift or drag force that solid particles receive from the fluid and the inner wall of the flow channel.
  • the tubular pinch effect in which solid particles are concentrated at a specific position in a flow channel due to the lift or drag force that solid particles receive from the fluid and the inner wall of the flow channel.
  • a particle concentration region with a ring-shaped cross section is formed in the channel.
  • the tubular pinch effect affects the left and right ends of the channel in the span direction, there is a region in the center of the channel where the tubular pinch effect does not affect. It is possible. Therefore, it is conceivable to expand the range of the tubular pinch effect by forming a secondary flow in the cross-sectional direction in a channel having a rectangular cross-section.
  • Patent Document 1 Even if the patterns disclosed in Patent Document 1 are applied as obstacles, for example, these patterns are applied to a liquid feeding device that performs solid-liquid separation by sedimentation. Therefore, when performing solid-liquid separation using the tubular pinch effect, it is not always possible to generate the desired secondary flow.
  • an object of the present disclosure is to provide a secondary flow forming device, a solid-liquid separation device, and a solid-liquid separation system that stably form a secondary flow while simplifying the structure.
  • One aspect of the present disclosure is a secondary flow forming device that causes a fluid in which solid particles are dispersed to flow through a flow path to form a secondary flow in a cross-sectional direction in the fluid, the flow path portion having a flow path. and a plurality of baffles formed in the flow path, the flow path having a rectangular cross section with an aspect ratio of the flow path width divided by the flow path height ranging from 3 to 100.
  • the inner wall constituting the flow path includes a first wall and a second wall that face each other in a direction in which the height of the flow path is defined, and each of the plurality of baffle plates protrudes toward the first wall.
  • the extending direction of the baffle plate is parallel to the second wall and is inclined at a constant angle with respect to the extending direction of the flow path.
  • the height of the baffle plate may be half the height of the channel.
  • the height of the baffle plate is lower than half of the channel height
  • the inclination angle of the baffle plate is ⁇
  • the channel width is w
  • the channel height is h
  • the pitch related to the arrangement of the baffle plate is
  • the height of the baffle plate is higher than half of the channel height
  • the inclination angle of the baffle plate is ⁇
  • the channel width is w
  • the channel height is h
  • the pitch related to the arrangement of the baffle plate is
  • the width of the baffle plate be w p
  • the channel width be w
  • the channel height be h
  • the pitch related to the baffle plate arrangement be P i
  • the number of baffle plates in an arbitrary cross section be m.
  • the inclination angle of the baffle plate may be in a range of 1° or more and 45° or less. If the length of the baffle plate in the stretching direction is LP , the number of baffle plates installed is n, and the channel height is h, the following condition of equation (4) may be satisfied.
  • the inner wall constituting the flow path includes a third wall and a fourth wall that face each other in the direction in which the flow path width is defined, and the length component of the baffle plate along the direction of the flow path width is
  • the baffle plate may be shorter than the road width and may be in non-contact with the third wall and the fourth wall. Furthermore, the distance between the rearmost end of the baffle plate that is the most downstream among the plurality of baffle plates and the third or fourth wall to which the rearmost end is closest is 0, where w is the channel width. It may be in the range of .35w or more and 0.65w or less.
  • Another aspect of the present disclosure is a solid-liquid separator that separates solid particles from a fluid in which the solid particles are dispersed, and includes a secondary flow forming device that forms a secondary flow in a cross-sectional direction in the fluid.
  • the secondary flow forming device is the above-mentioned secondary flow forming device, and separates solid particles from the fluid while forming a secondary flow in the fluid.
  • the solid-liquid separator described above includes a fluid outlet portion having at least three outlet passages that communicate with the downstream side of the flow passage of the secondary flow forming device, and the at least three outlet passages are arranged in a direction in which the width of the passage is defined. may diverge from each other.
  • the inlet width of each of the two outlet channels located at both ends in the direction in which the channel width is defined is set to a size that is at least twice the channel height and 45% or less of the channel width. may be done.
  • a solid-liquid separation system includes a solid-liquid separation device that separates solid particles from a fluid in which the solid particles are dispersed, a storage tank that stores the fluid, and a solid-liquid separation device that separates the solid particles from the storage tank.
  • the solid-liquid separator includes a liquid sending section that sends fluid to the liquid sending section, and a control section that adjusts at least the flow rate or speed of the fluid by controlling the operation of the liquid sending section. be.
  • FIG. 1 is a perspective view showing the configuration of a secondary flow forming device according to an embodiment.
  • FIG. 2 is a partially cutaway sectional view of the flow path section corresponding to the II-II cross section in FIG.
  • FIG. 3 is a schematic diagram for explaining the shape and arrangement of baffle plates.
  • FIG. 4 is a fluid image showing the behavior of solid particles in a fluid that has passed through a plurality of baffles.
  • FIG. 5 is a sectional view showing the configuration of a solid-liquid separator according to one embodiment.
  • FIG. 6A is a cross-sectional view showing the shape of a first example of a fluid outlet in a solid-liquid separator.
  • FIG. 6B is a cross-sectional view showing the shape of a second example of a fluid outlet in the solid-liquid separator.
  • FIG. 7A is a schematic diagram showing the configuration of a cell culture device according to one embodiment.
  • FIG. 7B is a schematic diagram showing the configuration of a precipitation apparatus according to one embodiment.
  • FIG. 1 is a perspective view showing the configuration of a secondary flow forming device 1 according to an embodiment.
  • the secondary flow forming device 1 is used, for example, in a solid-liquid separation device that separates solid particles from a fluid in which the solid particles are dispersed.
  • the secondary flow forming device 1 generates a secondary flow in the cross-sectional direction in the fluid flowing through the flow path 7, and concentrates solid particles at a specific position within the flow path 7 by the tubular pinch effect. .
  • the fluid in which solid particles are dispersed refers to a liquid (particle dispersion) that includes a large number of solid particles.
  • solid-liquid separation is based on the premise that solid particles of various particle sizes are dispersed in the fluid, and basically, solid particles of a specific particle size are selected from among them. Separation of particles.
  • fine particles having a particle size in the range of 1 ⁇ m to 1 mm are assumed.
  • the secondary flow forming device 1 includes a flow path portion 2 as a block body having a flow path 7 through which fluid is introduced and circulated.
  • the flow path portion 2 may be a microfluidic device in which the cross section of the flow path 7 is defined on the scale of mm or ⁇ m.
  • the direction of fluid introduction (IN) into the flow path 7 and the direction of fluid discharge from the flow path 7 (OUT) are indicated by white arrows.
  • the flow path 7 extends linearly.
  • linear means that the extending direction of the flow path 7 is along the X direction in the figure, which is an example of one direction.
  • it is not limited to a strictly straight line, and some bending is allowed as long as the desired action on the fluid by the baffle plate 5, which will be explained in detail below, can be obtained.
  • the cross section of the flow path 7 is rectangular.
  • the rectangle referred to here is not a shape that is strictly interpreted geometrically, but allows for the existence of a slight bend in the sides themselves or a slight curved part in a continuous portion of the sides.
  • the cross section of the flow path 7 is a YZ cross section.
  • the long side of the flow path 7 in the cross section is along the Y direction, and is hereinafter defined as the flow path width w.
  • the short side of the flow path 7 in the cross section is along the Z direction, and is hereinafter defined as the flow path height h.
  • the channel height h is perpendicular to the channel width w on the cross section.
  • the Y direction may be expressed as the channel width direction
  • the Z direction may be expressed as the channel height direction.
  • the Z direction is assumed to be a direction parallel to the vertical direction, and the Z direction may be appropriately expressed as "up” or "down”.
  • the flow path section 2 is formed, for example, by overlapping two flat plates, the first flat plate 3 and the second flat plate 4, in the Z direction.
  • the lower second flat plate 4 has three inner walls defining the shape of the flow path 7, namely, a first side wall 4a, a second side wall 4b, and a bottom wall 4c, as grooves on the upper surface side facing the first flat plate 3.
  • the first side wall 4a and the second side wall 4b are side walls that face each other in the Y direction and correspond to the respective short sides in the cross section.
  • the first flat plate 3 on the upper stage is a so-called lid, and is joined to the second flat plate 4 so as to cover the flow path 7 with its lower surface.
  • the wall portion of the first flat plate 3 that faces the bottom wall 4c of the second flat plate 4 serves as the remaining inner wall that defines the shape of the flow path 7.
  • This is the upper wall 3a.
  • the top wall 3a and the bottom wall 4c are side walls that face each other in the Z direction and correspond to the respective long sides in the cross section.
  • the first flat plate 3 is drawn with a chain double-dashed line in order to clearly show the overall shape of the flow path 7.
  • the secondary flow forming device 1 has a plurality of baffle plates 5 in the flow path section 2.
  • the baffle plate 5 in this embodiment is a protrusion that protrudes from the bottom wall 4c of the second flat plate 4 toward the lower surface of the first flat plate 3.
  • the upper surface of the baffle plate 5 does not come into contact with the first flat plate 3.
  • the plurality of baffle plates 5 have the same shape and are arranged in the flow path 7 with a certain regularity as will be explained in detail below.
  • six baffle plates 5 are illustrated as a first plate 5a, a second plate 5b, a third plate 5c, a fourth plate 5d, a fifth plate 5e, and a sixth plate 5f.
  • FIG. 1 six baffle plates 5 are illustrated as a first plate 5a, a second plate 5b, a third plate 5c, a fourth plate 5d, a fifth plate 5e, and a sixth plate 5f.
  • the baffle plate 5 that intersects with the inlet or outlet of the secondary flow forming device 1 is, as a drawing example, a part that goes outward of the secondary flow forming device 1 from the intersecting position or the vicinity thereof. is represented by a shape that does not exist.
  • FIG. 2 is a sectional view of a part of the secondary flow forming device 1 cut along a plane perpendicular to the X direction, which is the extending direction of the flow path 7, corresponding to the II-II cross section in FIG.
  • FIG. 2 the state of the flow of the fluid flowing in the flow path 7 at the relevant cut plane is illustrated by vectors.
  • FIG. 3 is a schematic diagram for explaining the shape of the baffle plates 5 and the arrangement relationship of the baffle plates 5, when the baffle plates 5 are viewed along the Z direction.
  • FIG. 3 is expressed as a partial cross-sectional view in which a part of the flow path portion 2 is cut along an arbitrary XY plane.
  • the baffle plate 5 is a rod-shaped portion whose extending direction is parallel to the bottom wall 4c along the XY plane and inclined at an inclination angle ⁇ with respect to the X direction. However, both ends of each baffle plate 5 may be cut out along the XZ plane. If the length of the baffle plate 5 in the stretching direction is the baffle plate length LP , then the length of the baffle plate 5 in the Y direction, which is the direction in which the channel width w is defined (hereinafter referred to as the "channel width direction"). The length component L Y is represented by L P sin ⁇ and is shorter than the channel width w. Further, the baffle plate 5 is not in contact with either the first side wall 4a or the second side wall 4b. In the flow path 7, n baffle plates 5 having such a shape are arranged along the X direction at equal intervals of a pitch P i .
  • the shape of the cross section perpendicular to the extending direction of the baffle plate 5 is approximately rectangular.
  • the height of the baffle plate 5 will be expressed as a baffle plate height hP
  • the width of the baffle plate 5 will be expressed as a baffle plate width wp , respectively.
  • the baffle plate height hP is set as follows, for example, based on the channel height h of the channel 7.
  • the flow velocity of the fluid flowing through the flow path 7 is defined as follows.
  • V 0 is the mainstream flow velocity of the fluid introduced into the flow path 7 along the X direction, which is the direction in which the flow path 7 extends.
  • V 1 is the first flow velocity in the direction along the stretching direction of the baffle plate 5 .
  • V 2 is the second flow velocity in the Y direction, which is the channel width direction, and is expressed by equation (5) using the mainstream velocity V 0 .
  • the baffle plate height hP is half the height of the flow path height h, that is, 0.5h, the plurality of baffle plates 5 most efficiently direct the secondary flow. can be generated.
  • equation (1) By substituting and rearranging equations (5) and (6) into equation (8), equation (1) already mentioned is derived.
  • the baffle height hP is lower than 0.5h
  • the baffle is The pitch P i related to the arrangement of the plates 5, the number n of baffle plates 5 installed, and the baffle plate height h P may be set.
  • equation (2) By substituting equation (5) and equation (6) into equation (9) and sorting it out, equation (2) already mentioned is derived.
  • the baffle plate height hP is higher than 0.5h
  • the baffle is The pitch P i related to the arrangement of the plates 5, the number n of baffle plates 5 installed, and the baffle plate height h P may be set.
  • the upper limit value of the baffle plate height h P is defined based on formula (2), and the lower limit value of the baffle plate height h P is determined based on formula (1). may be defined based on
  • the baffle width wp is determined, for example, based on the condition that in order to reduce the pressure loss within the flow path 7, it is desirable that the blockage rate of the cross section of the flow path 7 is 0.5 or less. It is set as follows. The cross section of the channel 7 assuming that the baffle plate 5 does not exist is expressed as (channel width w x channel height h). Therefore, if the number of baffle plates 5 in a certain cross section is m, in order to satisfy the condition that the blockage rate is 0.5 or less, the upper limit value of the baffle plate width w p can be determined using the equation (3) given above. Just set it so that it satisfies. On the other hand, it is desirable that the lower limit of the baffle plate width wp be set as small as possible.
  • the inclination angle ⁇ of the baffle plate 5 may be determined by determining a range defined by an upper limit value and a lower limit value based on equations (1) and (2), and may be set to a value included in the range. However, if the inclination angle ⁇ is too large, flow separation may occur, which may result in unintended secondary flow. On the other hand, from the viewpoint of similarly suppressing flow separation, it is desirable that the inclination angle ⁇ is as small as possible; however, if it is too small, the value of tan ⁇ becomes small, and as a result, the baffle plate 5 referred to in equation (1) etc. It may be necessary to set the pitch P i or the number n of baffle plates 5 to be large.
  • the inclination angle ⁇ is at least 1° or more. Therefore, the inclination angle ⁇ is preferably in the range of 1° or more and 45° or less, and more preferably 1° or more and 30° or less.
  • FIG. 4 is a fluid image showing the behavior of solid particles p in the fluid that has passed through the flow path 7. Note that the behavior of solid particles in the fluid while passing through the flow path 7 may also be similar to the behavior shown in FIG. 4 .
  • the fluid image shown in FIG. 4 is obtained by photographing the fluid flowing through a part of the flow path 7 along the Z direction.
  • the plurality of baffle plates 5 are arranged from the upstream side to the downstream side of the flow path 7 along the X direction.
  • the approximate position of the baffle plate 5 with respect to the position in the flow path 7 where the fluid image was acquired is shown by a two-dot chain line adjacent to the fluid image.
  • the solid particles p can be captured at least near the first side wall 4a or the second side wall 4b. Recognize.
  • the particle concentration at the inlet region RIN of the channel 7 was 0.55 vol%.
  • the particle concentration in the high concentration region R H where the solid particles p gathered on the outlet side of the flow path 7 was 1.33 vol %.
  • the particle concentration in the low concentration region R L with few solid particles p was 0.11 vol %.
  • the secondary flow forming device 1 moves the solid particles p not only in the vicinity of the first side wall 4a or the second side wall 4b but also in the flow path 7 as shown in FIG. It can also be trapped in the central region in the width direction of the channel.
  • the baffle plate length LP is a condition for trapping the solid particles p in the central region of the flow path 7 in the width direction of the flow path.
  • the solid particles p In order to trap the solid particles p in the central region in this way, it is necessary to produce a tubular pinch effect as an action of the plurality of baffles 5.
  • the solid particles p In other words, the solid particles p must move along the baffles 5 to some extent. It is necessary to flow the distance. This distance needs to be at least 100 times the channel height h. Therefore, it is only necessary to satisfy the conditions of the equation (4) above using the baffle plate length L P , the number n of baffle plates installed, and the channel height h.
  • the baffle plate 5 located on the most downstream side among the plurality of baffle plates 5 corresponds to the sixth plate 5f.
  • the rearmost end be located as close to the center of the channel 7 in the channel width direction as possible.
  • the distance e between the rearmost end of the baffle plate 5 that is the most downstream among the plurality of baffle plates 5 and the first side wall 4a or second side wall 4b to which the rearmost end is closest is determined by the flow path width. Assuming that w is in the range of 0.35w or more and 0.65w or less, it is desirable. Referring to FIG. 3, the distance e corresponds to the distance between the rearmost end of the baffle plate 5, which may correspond to the sixth plate 5f, and the first side wall 4a.
  • the secondary flow forming device 1 is configured to cause a fluid in which solid particles p are dispersed to flow through a channel 7 to form a secondary flow in the cross-sectional direction of the fluid, and includes a channel section having the channel 7. 2, and a plurality of baffle plates 5 formed in the flow path section 2.
  • the channel 7 has a rectangular cross section with an aspect ratio A R in the range of 3 to 100, which is the channel width w divided by the channel height h.
  • the inner walls forming the flow path 7 include a first wall and a second wall that face each other in the direction in which the flow path height h is defined.
  • Each of the plurality of baffle plates 5 is a rod-shaped portion arranged on the second wall so as to protrude toward the first wall.
  • the direction in which each baffle plate 5 extends is parallel to the second wall and is inclined at a constant angle with respect to the direction in which the flow path 7 extends.
  • the first wall corresponds to the upper wall 3a of the first flat plate 3 that constitutes a part of the flow path section 2, and the second wall constitutes another part of the flow path section 2. This corresponds to the bottom wall 4c of the second flat plate 4.
  • the flow path 7 is defined as having a rectangular cross section with an aspect ratio AR in the range of 3 to 100. This causes a tubular pinch effect on the fluid flowing in the flow path 7, and the solid particles p dispersed in the fluid are removed from at least the first side walls, which are inner walls facing each other in the width direction of the flow path. 4a or near the second side wall 4b.
  • the secondary flow forming device 1 is provided with a plurality of baffle plates 5, it is possible to form a secondary flow in the fluid flowing through the flow path 7.
  • a secondary flow occurs, the solid particles p dispersed in the fluid are subjected to a drag force induced by the secondary flow.
  • the separation efficiency can be improved compared to the case of separation.
  • the shape and arrangement of the plurality of baffle plates 5 defined as above it is possible to suppress an increase in the blockage rate of the flow path 7 and, as a result, suppress pressure loss in the flow path 7.
  • a secondary flow can be stably formed over a long distance in the main flow direction of the flow path 7.
  • the secondary flow forming device 1 since the plurality of baffle plates 5 are positioned as a so-called passive type secondary flow forming mechanism that does not utilize external power, the secondary flow forming device 1 as a whole can have a simple structure.
  • the secondary flow forming device 1 that stably forms a secondary flow while simplifying the structure.
  • the height hP of the baffle plate 5 may be half of the channel height h.
  • the plurality of baffle plates 5 can generate the secondary flow most efficiently.
  • the height hP of the baffle plate 5 may be lower than half of the channel height h.
  • the inclination angle of the baffle plate 5 is ⁇
  • the channel width is w
  • the channel height is h
  • the pitch related to the arrangement of the baffle plate 5 is P i
  • the number of baffle plates 5 installed is n.
  • the height of the baffle plate 5 is hP .
  • the pitch P i the number n of baffle plates 5 installed, and , the height hP of the baffle plate 5 may be set.
  • the dimensions of each part can be set assuming in advance that the flow rate of the secondary flow will decrease proportionally as the baffle plate height hP becomes lower. It is possible to suppress a decrease in the generation efficiency of the next flow.
  • the height hP of the baffle plate 5 may be higher than half of the channel height h.
  • the inclination angle of the baffle plate 5 is ⁇
  • the channel width is w
  • the channel height is h
  • the pitch related to the arrangement of the baffle plate 5 is P i
  • the number of baffle plates 5 installed is n.
  • the height of the baffle plate 5 is hP .
  • the pitch P i the number n of baffle plates 5 installed, and , the height hP of the baffle plate 5 may be set.
  • the flow rate of the secondary flow also decreases when the height h P of the baffle plate is higher than 0.5 h.
  • the dimensions of each part can be set assuming in advance that the flow rate of the secondary flow will decrease proportionally as the baffle plate height hP increases. It is possible to suppress a decrease in the generation efficiency of the next flow.
  • the width of the baffle plate 5 is w p
  • the flow path width is w
  • the flow path height is h
  • the pitch related to the arrangement of the baffle plate 5 is P i
  • the number of baffle plates 5 in an arbitrary cross section Let m be the height of the baffle plate 5, and let hP be the height of the baffle plate 5.
  • the upper limit value of the width wp of the baffle plate 5 may satisfy the condition of the above equation (3).
  • the condition that the blockage rate is 0.5 or less can be satisfied, and as a result, the pressure loss in the flow path 7 can be further reduced.
  • the inclination angle ⁇ of the baffle plate 5 may be in the range of 1° or more and 45° or less.
  • separation of the flow within the flow path 7 can be suppressed, and in turn, an increase in pressure loss within the flow path 7 can be suppressed.
  • the length of the baffle plate 5 in the stretching direction is LP
  • the number of installed baffle plates 5 is n
  • the height of the flow path is h
  • the solid particles p dispersed in the fluid can be simply captured in the vicinity of the first side wall 4a or the second side wall 4b, which are inner walls facing each other in the channel width direction. Instead, it can be captured in the central region of the flow path 7 in the width direction of the flow path.
  • the inner wall forming the flow path 7 includes a third wall and a fourth wall that face each other in the direction in which the flow path width w is defined.
  • the length component LY of the baffle plate 5 along the direction of the flow path width w is shorter than the flow path width w, and the baffle plate 5 is It may not be in contact with the wall.
  • the third wall corresponds to the first side wall 4a of the second flat plate 4 that constitutes a part of the flow path section 2
  • the fourth wall corresponds to the second side wall 4b of the second flat plate 4. Equivalent to.
  • the flow in the width direction of the flow path can more easily circulate in the cross section of the flow path 7, so that the secondary flow can be generated more stably over a long distance in the main flow direction of the flow path 7.
  • a flow can be formed.
  • the distance e between the rearmost end of the baffle plate 5 that is the most downstream among the plurality of baffle plates 5 and the third or fourth wall to which the rearmost end is closest may be in the range of 0.35w or more and 0.65w or less, where w is the channel width.
  • the solid particles p dispersed in the fluid can be simply captured in the vicinity of the first side wall 4a or the second side wall 4b, which are inner walls facing each other in the channel width direction. Instead, it can be captured in the central region of the flow path 7 in the width direction of the flow path.
  • the plurality of baffle plates 5 are provided on the bottom wall 4c of the second flat plate 4, and protrude from the bottom wall 4c toward the top wall 3a of the first flat plate 3. That is, the first wall corresponds to the top wall 3a, and the second wall corresponds to the bottom wall 4c.
  • the plurality of baffle plates 5 may be provided on the top wall 3a and protrude from the top wall 3a toward the bottom wall 4c. That is, the first wall may correspond to the bottom wall 4c, and the second wall may correspond to the top wall 3a.
  • the plurality of baffle plates 5 may be provided on both the top wall 3a and the bottom wall 4c so as to face each other without contacting each other.
  • the plurality of baffle plates 5 are arranged at a pitch P i of one value throughout the flow path 7 in the extending direction.
  • the plurality of baffle plates 5 are arranged at pitches P i of a plurality of values throughout the extending direction of the flow path 7, that is, the values of the pitches P i are changed in the middle of the arrangement. It may be something that is done. However, if the value of the pitch P i is too small, the viscous resistance will increase, so it is desirable that the value of the pitch P i be set larger than the channel height h.
  • the plurality of baffle plates 5 are provided at the center of the channel width w of the channel 7. That is, in the channel width direction, the distance from the baffle plate 5 to the first side wall 4a and the distance from the baffle plate 5 to the second side wall 4b are the same.
  • the plurality of baffle plates 5 may be provided closer to the first side wall 4a than the second side wall 4b in the channel width direction, or conversely, the baffle plates 5 may be provided closer to the first side wall 4a than the second side wall 4b. It may be provided so as to be closer to the second side wall 4b than the side.
  • the flow path portion 2 is constituted by a combination of two flat plates, the first flat plate 3 and the second flat plate 4, is illustrated.
  • the flow path portion 2 may be integrally formed, for example, by using three-dimensional metal additive manufacturing technology.
  • Solid-liquid separator Next, a solid-liquid separation device using the secondary flow forming device 1 will be explained.
  • FIG. 5 is a schematic cross-sectional view showing the configuration of the solid-liquid separator 10 according to one embodiment.
  • the overall configuration of the solid-liquid separation device 10 is drawn in accordance with the cross-sectional view of FIG. 3 used in the explanation regarding the secondary flow forming device 1.
  • the solid-liquid separator 10 separates solid particles from a fluid in which solid particles are dispersed based on a desired standard, and leads out each fluid containing solid particles sorted based on the standard.
  • the criterion here is, for example, the particle diameter of solid particles.
  • the solid-liquid separation device 10 includes the secondary flow forming device 1 described above, a fluid introduction section 11, and a fluid outlet section 12.
  • the fluid introduction section 11 is connected to the upstream side of the secondary flow forming device 1, and introduces fluid into the flow path 7 in accordance with the fluid introduction direction ("IN" in FIG. 1).
  • the fluid introduction part 11 is, for example, a block body having a flow path 11a in accordance with the shape of the upstream side of the secondary flow forming device 1.
  • the fluid introduction part 11 may be a part that is integrated with the secondary flow forming device 1 in advance.
  • the fluid introduction section 11 may be manufactured separately from the secondary flow forming device 1 and then connected to the secondary flow forming device 1.
  • the flow path 11a has a first inlet 11b that serves as a fluid introduction side, and a first outlet 11c that serves as a fluid outlet side.
  • the first introduction port 11b communicates with a supply mechanism (not shown) that supplies fluid to the fluid introduction section 11.
  • the number of first inlet ports 11b installed is one in this embodiment, but is not limited to this, and a plurality of first inlet ports 11b may be provided so as to individually introduce fluid into the same channel 11a from a plurality of supply mechanisms. Good too. That is, in the fluid introduction section 11, there is at least one first introduction port 11b.
  • the first outlet 11c communicates with the second inlet 8a, which is the fluid inlet side of the flow path 7 of the secondary flow forming device 1. That is, the cross section of the flow path 11a at least at the first outlet 11c connected to the second inlet 8a has the same shape as the cross section of the flow path 7 of the secondary flow forming device 1.
  • the fluid derivation unit 12 is connected to the downstream side of the secondary flow forming device 1, and after introducing the fluid from the flow path 7 in accordance with the fluid discharge direction (“OUT” in FIG. 1), the fluid is distributed to a plurality of portions and discharged to the outside. It is derived as follows.
  • the fluid lead-out section 12 is, for example, a block body having at least three lead-out passages, matching the shape of the downstream side of the secondary flow forming device 1 .
  • the fluid outlet portion 12 may be a portion integrated with the secondary flow forming device 1 in advance, as shown in FIG. 5 . Alternatively, the fluid outlet portion 12 may be manufactured separately from the secondary flow forming device 1 and then connected to the secondary flow forming device 1.
  • the fluid derivation section 12 at least three derivation paths are set in advance for each fluid containing solid particles distributed in the flow path 7 of the secondary flow forming device 1.
  • the solid particles p dispersed in the fluid are located near the first side wall 4a or the second side wall 4b, which are inner walls facing each other in the width direction of the flow path 7.
  • the third introduction port 12d which communicates with the second outlet port 8b on the fluid outlet side of the flow path 7, branches into at least three outlet paths in the width direction of the flow path.
  • the fluid lead-out section 12 has three lead-out paths: a first lead-out path 12a, a second lead-out path 12b, and a third lead-out path 12c.
  • FIG. 6A is an enlarged cross-sectional view of the fluid outlet portion 12, which is partially extracted from the cross-sectional view of the solid-liquid separator 10 shown in FIG.
  • the cross-sectional shapes of the first lead-out path 12a, the second lead-out path 12b, and the third lead-out path 12c are each rectangular, and regarding the shape of the opening of each part, the length along the Y direction is defined as ⁇ opening''. "width" and the length along the Z direction is "opening height.”
  • the first outlet path 12a is a flow path intended to flow a fluid containing solid particles captured near the first side wall 4a in the flow path 7 of the secondary flow forming device 1.
  • the opening on the fluid introduction side of the first outlet path 12a is the first branch port 12h, and faces the third introduction port 12d.
  • the opening on the fluid outlet side of the first outlet path 12a is the first outlet 12e.
  • the second outlet path 12b is a flow path intended to flow a fluid containing solid particles captured near the second side wall 4b in the flow path 7 of the secondary flow forming device 1.
  • the opening on the fluid introduction side of the second outlet path 12b is the second branch port 12i, and faces the third introduction port 12d.
  • the opening on the fluid outlet side of the second outlet path 12b is the third outlet 12g.
  • the central region in the channel width direction in the channel 7 of the secondary flow forming device 1 is a region shown as a low concentration region R L in FIG.
  • This flow path is designed to flow a fluid with a small content of particles p.
  • the central region in the channel width direction of the channel 7 is a region shown as a high concentration region R H in FIG.
  • This is a flow path designed to allow fluid to flow through it.
  • the opening on the fluid introduction side of the third outlet path 12c is the third branch port 12j, and faces the third introduction port 12d.
  • the opening on the fluid outlet side of the third outlet path 12c is the second outlet 12f.
  • the entire cross section of the third inlet 12d has the same shape as the cross section of the flow path 7 of the secondary flow forming device 1.
  • the first branch port 12h, the second branch port 12i, and the third branch port 12j are arranged along the Y direction in the figure corresponding to the flow path width direction.
  • the branch port 12j and the second branch port 12i are arranged in this order.
  • the opening width hereinafter referred to as "inlet width”
  • the entrance width w1 of the first branch port 12h and the second branch port 12i is the same, and A case where the width is larger than the entrance width of the three-branch port 12j is illustrated.
  • each of the first outlet path 12a, the second outlet path 12b, and the third outlet path 12c is the same as the channel height h of the channel 7 as a whole.
  • the first discharge port 12e, the second discharge port 12f, and the third discharge port 12g are also lined up in that order along the Y direction.
  • FIG. 6A illustrates a case where the opening width and opening height of each of the first discharge port 12e, the second discharge port 12f, and the third discharge port 12g are the same.
  • the solid-liquid separator 10 may include a fluid outlet section 22 as a second example having four outlet paths instead of the fluid outlet section 12 as the first example.
  • FIG. 6B is an enlarged cross-sectional view of the fluid outlet portion 22 drawn corresponding to FIG. 6A.
  • the fluid lead-out section 22 has four lead-out paths: a first lead-out path 22a, a second lead-out path 22b, a third lead-out path 22c, and a fourth lead-out path 22d.
  • the first outlet path 22a is a flow path designed to flow a fluid containing solid particles captured near the first side wall 4a in the flow path 7 of the secondary flow forming device 1.
  • the opening on the fluid introduction side of the first outlet path 22a is the first branch port 22j, and faces the third introduction port 22e.
  • the opening on the fluid outlet side of the first outlet path 22a is the first outlet 22f.
  • the second outlet path 22b may be a flow path intended to flow a fluid containing solid particles captured in the central region in the width direction of the flow path in the flow path 7 of the secondary flow forming device 1.
  • the second outlet path 22b may be a flow path intended to flow a fluid with a low content of solid particles p in the low concentration region RL .
  • the opening on the fluid introduction side of the second outlet path 22b is the second branch port 22m, and faces the third introduction port 22e.
  • the opening on the fluid outlet side of the second outlet path 22b is the second outlet 22g.
  • the third outlet path 22c is a flow path assumed to be similar to the second outlet path 22b.
  • the opening on the fluid introduction side of the third outlet path 22c is the third branch port 22n, and faces the third introduction port 22e.
  • the opening on the fluid outlet side of the third outlet path 22c is the third outlet 22h.
  • the fourth outlet path 22d is a flow path designed to flow a fluid containing solid particles captured near the second side wall 4b in the flow path 7 of the secondary flow forming device 1.
  • the opening on the fluid introduction side of the fourth outlet path 22d is the fourth branch port 22k, and faces the third introduction port 22e.
  • the opening on the fluid outlet side of the fourth outlet path 22d is the fourth outlet 22i.
  • the entire cross section of the third inlet 22e has the same shape as the cross section of the flow path 7 of the secondary flow forming device 1.
  • the first branch port 22j, the second branch port 22m, the third branch port 22n, and the fourth branch port 22k are arranged in that order along the Y direction in the figure corresponding to the channel width direction. line up.
  • the inlet width w2 of the first branch port 22j and the fourth branch port 22k in the third introduction port 22e is the same and wider than the inlet widths of the second branch port 22m and the third branch port 22n.
  • the example shows a large case.
  • each of the first outlet path 22a, the second outlet path 22b, the third outlet path 22c, and the fourth outlet path 22d is the same as the channel height h of the channel 7 as a whole.
  • the first discharge port 22f, the second discharge port 22g, the third discharge port 22h, and the fourth discharge port 22i are also lined up in that order along the Y direction.
  • FIG. 6B illustrates a case where the opening width and opening height of each of the first discharge port 22f, the second discharge port 22g, the third discharge port 22h, and the fourth discharge port 22i are the same.
  • the solid-liquid separation device 10 may include an intermediate flow path portion 13 between the secondary flow forming device 1 and the fluid outlet portion 12.
  • the intermediate flow path portion 13 is a block body provided to match the shape of the flow path portion 2 of the secondary flow forming device 1.
  • the intermediate flow path section 13 is not provided with a portion like the baffle plate 5 that the flow path section 2 has. Note that, as shown in FIG. 5, the intermediate flow path portion 13 may be a portion integrated with the secondary flow forming device 1 in advance. Alternatively, the intermediate flow path portion 13 may be manufactured separately from the secondary flow forming device 1 and then connected to the secondary flow forming device 1.
  • the intermediate flow path section 13 has a flow path 13a whose cross section is the same as the cross section of the flow path 7 of the secondary flow forming device 1.
  • the flow path 13a has a fourth inlet 13b that serves as a fluid introduction side, and a fourth outlet 13c that serves as a fluid outlet side.
  • the fourth inlet 13b communicates with the second outlet 8b on the side of the secondary flow forming device 1
  • the fourth outlet 13c communicates with the fluid outlet 12. It communicates with the third inlet 12d on the side. That is, the second outlet port 8b on the side of the secondary flow forming device 1 and the third inlet port 12d on the side of the fluid outlet section 12 communicate with each other via the channel 13a of the intermediate channel section 13.
  • the solid-liquid separator 10 includes the intermediate flow path section 13
  • the fluid that has passed through the flow path 7 of the secondary flow forming device 1 is prevented from tubular pinch in the flow path 13a of the intermediate flow path section 13. effect can be produced. Thereby, there is a possibility that the separation efficiency can be improved more than when using the secondary flow forming device 1 alone.
  • the solid-liquid separator 10 separates solid particles from a fluid in which solid particles are dispersed, and includes a secondary flow forming device that forms a secondary flow in the cross-sectional direction of the fluid.
  • the secondary flow forming device is the above-mentioned secondary flow forming device 1, which separates solid particles from the fluid while forming a secondary flow in the fluid.
  • this solid-liquid separator 10 since it is equipped with the above-mentioned secondary flow forming device 1, it is possible to form a secondary flow stably while simplifying the structure. Separation efficiency can be improved by widening the range.
  • the solid-liquid separation device 10 may include a fluid outlet portion having at least three outlet paths communicating with the downstream side of the flow path 7 of the secondary flow forming device 1.
  • the at least three lead-out paths may diverge from each other in the direction in which the channel width w is defined.
  • the at least three lead-out paths correspond to the first lead-out path 12a, the second lead-out path 12b, and the third lead-out path 12c.
  • the at least three outlet paths include a first outlet path 22a, a second outlet path 22b, a third outlet path 22c, and a fourth outlet path. This corresponds to the road 22d.
  • the fluid outlet section 12 and the like separate solid particles according to a desired standard in accordance with each position where solid particles are captured in the channel width direction in the channel 7 of the secondary flow forming device 1.
  • Each fluid containing solid particles can be introduced into a desired outlet path.
  • the inlet width of each of the two outlet channels located at both ends in the direction in which the channel width w is defined is at least twice the channel height h, and The dimensions may be set within a range of 45% or less.
  • the entrance width here corresponds to the entrance width w1 of each of the first branch port 12h and the second branch port 12i, and according to the example of FIG. This corresponds to the entrance width w2 of each of the fourth branch ports 22k.
  • the fluid containing the high concentration region RH and the fluid containing the low concentration region RL can be further separated. It can be efficiently branched and derived.
  • the fluid introduction section 11, the fluid outlet section 12, or the intermediate flow path section 13 may each be configured by a combination of two flat plates, similarly to the flow path section 2 of the secondary flow forming device 1.
  • the solid-liquid separation device 10 including the secondary flow forming device 1, the fluid introduction section 11, the fluid outlet section 12, and the intermediate flow path section 13 is integrally formed. may be done. By shaping the solid-liquid separator 10 in this manner, the solid-liquid separator 10 can be mass-produced at low cost.
  • FIGS. 7A and 7B are schematic diagrams showing a configuration example of a solid-liquid separation system including the solid-liquid separation device 10 described above.
  • FIG. 7A is a diagram showing a cell culture device (an animal cell continuous culture device) 100 as an example of the solid-liquid separation system according to the present embodiment.
  • a culture solution is assumed to be the fluid in which solid particles are dispersed.
  • the cell culture device 100 includes a culture tank 102 as a storage tank that stores a culture medium, and a pump 106a as a liquid feeding unit that sends the culture solution from the culture tank 102 to the solid-liquid separation device 10.
  • the culture medium is supplied to the culture tank 102 via a culture medium addition pipe 104 that includes a first supply valve 104a.
  • the culture tank 102 is equipped with a stirrer 102a and is used to culture a medium.
  • the culture solution in the culture tank 102 is supplied to the solid-liquid separation device 10 via a culture solution supply pipe 106 connected to a pump 106a.
  • the solid-liquid separator 10 is capable of separating the culture solution introduced into the channel 7 into a concentrated liquid as a fluid containing a high concentration region RH and a clarified liquid as a fluid containing a low concentration region RL . can.
  • the clear liquid is recovered as is.
  • the concentrated liquid is returned to the culture tank 102 via a concentrated liquid return pipe 108 that includes a second supply valve 108a.
  • the cell culture device 100 includes a control unit 110 that adjusts at least the flow rate or speed of the culture solution by controlling at least the operation of the pump 106a.
  • the control unit 110 may also control the operation of the stirrer 102a, the opening/closing operation of the first supply valve 104a or the second supply valve 108a, and the like.
  • FIG. 7B is a diagram showing a precipitation apparatus 200 as an example of the solid-liquid separation system according to the present embodiment.
  • the fluid in which the solid particles p are dispersed is assumed to be a fluid containing crystallized large-diameter particles and small-diameter particles.
  • the precipitation apparatus 200 is separated by a precipitation tank 202 as a storage tank for storing a precipitation liquid, a pump 206a as a liquid feeding section that sends fluid from the precipitation tank 202 to the solid-liquid separation apparatus 10, and a solid-liquid separation apparatus 10. It includes a separation membrane 207a that extracts only large-diameter particles from the concentrated liquid.
  • the precipitation liquid is supplied to the precipitation tank 202 via a precipitation liquid addition pipe 204 that includes a first supply valve 204a.
  • the precipitation tank 202 is equipped with a stirrer 202a to promote precipitation.
  • the fluid in the precipitation tank 202 is supplied to the solid-liquid separator 10 via a fluid supply pipe 206 connected to a pump 206a.
  • the solid-liquid separator 10 can separate the fluid introduced into the flow path 7 into a concentrated liquid mainly containing large-diameter particles and a clear liquid mainly containing small-diameter particles.
  • the concentrated liquid is sent to the separation membrane 207a via the concentrated liquid supply piping 207.
  • the large diameter particles extracted from the concentrate by the separation membrane 207a are recovered as they are.
  • the precipitation apparatus 200 also includes a control unit 210 that adjusts at least the flow rate or speed of the fluid by controlling at least the operation of the pump 206a.
  • the control unit 210 may also control the operation of the stirrer 202a, the opening/closing operation of the first supply valve 204a or the second supply valve 209a, and the like.
  • the solid-liquid separation system includes a solid-liquid separation device that separates solid particles from a fluid in which the solid particles are dispersed.
  • the solid-liquid separation system includes a storage tank that stores fluid, a liquid sending unit that sends the fluid from the storage tank to the solid-liquid separator, and at least a flow rate or speed of the fluid by controlling the operation of the liquid sending unit. and a control section that adjusts the.
  • the solid-liquid separator is the solid-liquid separator 10 described above.
  • this solid-liquid separation system since it includes the solid-liquid separation device 10 described above, it is possible to form a secondary flow stably while simplifying the structure, thereby improving separation efficiency or processing. It is possible to easily obtain the desired resolution while maintaining the amount.
  • the solid-liquid separation system according to this embodiment is not limited to the cell culture device 100 or the precipitation device 200 as described above.
  • the solid-liquid separation system according to the present embodiment converts solid particles dispersed in a fluid into cells or cell aggregates dispersed in a suspension, and extracts cells or cell aggregates from the suspension according to size. It may also be a cell screening device that sorts cells.
  • the solid-liquid separation system according to the present embodiment is a microorganism screening device that classifies solid particles dispersed in a fluid as microorganisms dispersed in a suspension from a suspension according to size. It may be.

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PCT/JP2023/020685 2022-06-13 2023-06-02 二次流れ形成装置、固液分離装置及び固液分離システム WO2023243448A1 (ja)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6494084B1 (en) * 2001-09-19 2002-12-17 Sandia Corporation Adjustable shear stress erosion and transport flume
JP2011067785A (ja) * 2009-09-28 2011-04-07 Fuji Xerox Co Ltd 送液装置、分級装置及び分級方法
JP2012076016A (ja) * 2010-10-01 2012-04-19 Chiba Univ 連続的２次元粒子分離装置および粒子分離方法
JP2015051430A (ja) * 2013-08-06 2015-03-19 旭化成株式会社 マイクロ流路構造体及び粒子の分離方法
JP2019502936A (ja) * 2015-12-31 2019-01-31 クリオシス・カンパニー・リミテッドＣｕｒｉｏｓｉｓ Ｃｏ．， Ｌｔｄ． 微細粒子分離または整列装置およびこれを用いた微細粒子分離または整列方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6494084B1 (en) * 2001-09-19 2002-12-17 Sandia Corporation Adjustable shear stress erosion and transport flume
JP2011067785A (ja) * 2009-09-28 2011-04-07 Fuji Xerox Co Ltd 送液装置、分級装置及び分級方法
JP2012076016A (ja) * 2010-10-01 2012-04-19 Chiba Univ 連続的２次元粒子分離装置および粒子分離方法
JP2015051430A (ja) * 2013-08-06 2015-03-19 旭化成株式会社 マイクロ流路構造体及び粒子の分離方法
JP2019502936A (ja) * 2015-12-31 2019-01-31 クリオシス・カンパニー・リミテッドＣｕｒｉｏｓｉｓ Ｃｏ．， Ｌｔｄ． 微細粒子分離または整列装置およびこれを用いた微細粒子分離または整列方法

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