WO2023217234A1 - Composition d'anticorps liquide et son utilisation - Google Patents
Composition d'anticorps liquide et son utilisation Download PDFInfo
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- WO2023217234A1 WO2023217234A1 PCT/CN2023/093543 CN2023093543W WO2023217234A1 WO 2023217234 A1 WO2023217234 A1 WO 2023217234A1 CN 2023093543 W CN2023093543 W CN 2023093543W WO 2023217234 A1 WO2023217234 A1 WO 2023217234A1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
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Abstract
La présente invention concerne une composition d'anticorps liquide et son utilisation. La composition d'anticorps liquide comprend un anticorps bispécifique ciblant PD-L1 et CD47, une solution tampon acide, un stabilisant de saccharide et un tensioactif de polysorbate, et présente un pH de 5,5 à 6,5, de préférence de 5,5 à 6,0. La composition présente une bonne stabilité dans les conditions d'un anticorps bispécifique à haute concentration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210511286 | 2022-05-11 | ||
| CN202210511286.4 | 2022-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023217234A1 true WO2023217234A1 (fr) | 2023-11-16 |
Family
ID=88729742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2023/093543 WO2023217234A1 (fr) | 2022-05-11 | 2023-05-11 | Composition d'anticorps liquide et son utilisation |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN117731771A (fr) |
| WO (1) | WO2023217234A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113121686A (zh) * | 2019-12-31 | 2021-07-16 | 迈威(上海)生物科技股份有限公司 | 抗pd-l1抗体及其应用 |
| CN114040777A (zh) * | 2019-06-25 | 2022-02-11 | 信达生物制药(苏州)有限公司 | 包含抗cd47/pd-l1双特异性抗体的制剂及其制备方法和用途 |
-
2023
- 2023-05-11 WO PCT/CN2023/093543 patent/WO2023217234A1/fr unknown
- 2023-05-11 CN CN202310528584.9A patent/CN117731771A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114040777A (zh) * | 2019-06-25 | 2022-02-11 | 信达生物制药(苏州)有限公司 | 包含抗cd47/pd-l1双特异性抗体的制剂及其制备方法和用途 |
| CN113121686A (zh) * | 2019-12-31 | 2021-07-16 | 迈威(上海)生物科技股份有限公司 | 抗pd-l1抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117731771A (zh) | 2024-03-22 |
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