WO2023207172A1 - 一种酸、精油、酶及益生菌复合制剂及其制备方法 - Google Patents
一种酸、精油、酶及益生菌复合制剂及其制备方法 Download PDFInfo
- Publication number
- WO2023207172A1 WO2023207172A1 PCT/CN2022/141887 CN2022141887W WO2023207172A1 WO 2023207172 A1 WO2023207172 A1 WO 2023207172A1 CN 2022141887 W CN2022141887 W CN 2022141887W WO 2023207172 A1 WO2023207172 A1 WO 2023207172A1
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- WIPO (PCT)
- Prior art keywords
- acid
- preparation
- enzyme
- essential oil
- adsorbent
- Prior art date
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 23
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 23
- 239000006041 probiotic Substances 0.000 title claims abstract description 19
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 19
- 239000002253 acid Substances 0.000 title claims abstract description 14
- 150000001875 compounds Chemical class 0.000 title claims abstract description 14
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 18
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 16
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- 150000007524 organic acids Chemical class 0.000 claims abstract description 11
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 10
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 8
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- 239000005022 packaging material Substances 0.000 claims abstract description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 7
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000011090 malic acid Nutrition 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
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- 239000005844 Thymol Substances 0.000 claims abstract description 5
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 5
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 5
- 229940117916 cinnamic aldehyde Drugs 0.000 claims abstract description 5
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001530 fumaric acid Substances 0.000 claims abstract description 5
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001630 malic acid Substances 0.000 claims abstract description 5
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 4
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- 235000019325 ethyl cellulose Nutrition 0.000 claims description 4
- 229920001249 ethyl cellulose Polymers 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/225—Faecalis
Definitions
- the invention belongs to the technical field of feed additives, and in particular relates to a compound preparation of acid, essential oil, enzyme and probiotics and a preparation method thereof.
- Acidifiers, plant essential oils and enzyme preparations are recognized as typical representatives of non-toxic, harmless and pollution-free green additives, and are one of the focuses and hot spots of current research.
- Compound acidifiers are commonly used in farmed animals. They can make up for the lack of physiological acid production in weaned piglets, thereby alleviating problems such as maldigestion and absorption, nutritional diarrhea, and feed waste in piglets.
- the exposed acid due to the simple mixing or adsorption process used in ordinary acidifiers, the exposed acid easily reacts with the alkaline substances in the feed and loses its antibacterial and other effects; plant essential oils have good antibacterial and antiviral properties, regardless of whether they are alone Adding or combining it with antibiotics can improve the antibacterial effect.
- plant essential oils have shortcomings such as easy oxidation and volatilization, it is difficult to achieve corresponding effects by simply mixing plant essential oils due to instability; therefore, it is necessary to explore the preparation of acidifiers, plant essential oils and enzyme preparations, as well as the processing methods during preparation, so as to make the three Maximizing the effectiveness of the drug is the problem that compound preparations need to solve.
- the purpose of the present invention is to provide a compound preparation of acid, essential oil, enzyme and probiotics and a preparation method thereof, which can protect the stability of organic acids and essential oils, help digestion and absorption, and can pass gastric acid, slowly release in the intestinal tract of animals, and enhance The antibacterial effect of plant essential oils also improves intestinal flora.
- a compound preparation of acids, essential oils, enzymes and probiotics made of raw materials with the following mass percentages: organic acids: sorbic acid 5-20%, citric acid 5-15%, malic acid 2-10%, fumaric acid 10% -20%, benzoic acid 0-10%, medium chain fatty acids 1-10%; plant essential oils: either cinnamaldehyde or carvacrol, mass percentage 0.5-3%, thymol 0.5-5%, aroma Lansu 0.5-5%; adsorbent 3-6%, emulsification blocker 0.1-10%, lubricant 0.5-2%, packaging material 10-30%, enzyme preparation 0.005-3%, probiotics 0.005-3% .
- the adsorbent is one of silica or montmorillonite;
- the emulsification blocking agent is maltodextrin, gelatinized starch, microcrystalline cellulose, ethyl cellulose, or hydroxypropyl methylcellulose.
- the ratio of maltodextrin: gelatinized starch: microcrystalline cellulose: ethyl cellulose: hydroxypropyl methylcellulose is (0-2): 1: (0-0.2 ): 0.1: (0-0.2)
- the lubricant is any one of silica, talc or magnesium stearate
- the packaging material is hydrogenated fat
- the enzyme preparation is cellulase, xylanase, ⁇ - At least one of glucanase and mannanase, if more than one, the ratio of cellulase:xylanase: ⁇ -glucanase:mannanase is (0-2): (0-1): (0-0.3): 0.2: (0-0.5);
- the probiotic is at least one of Lactobacillus, Streptococcus faecalis, Bacillus, and Saccharomyces.
- Lactobacillus The ratio of Streptococcus faecalis: Bacillus: Yeast is (10-100): 1:10:1. Except for Bacillus, the probability of other bacteria surviving in gastric acid is very small. After the compound bacteria are processed, the bacteria can play their role in the intestines as much as possible.
- a method for preparing a compound preparation of acids, essential oils, enzymes and probiotics including the following steps: adsorbing plant essential oils and medium-chain fatty acids with an adsorbent and mixing them with other solid organic acids in a mixer, then adding lubricants. During the mixing process Add emulsification blocker to adjust the viscosity, perform granulation in a rotary extrusion or swing granulator, and then enter the rounding process for rounding at a rotation speed of 50 rpm. Collect the samples and dry and coat them in a fluidized bed granulation drying and coating machine. Control the inlet air temperature of the fluidized bed to 45°C, the fan frequency to 30HZ, and the spray gun pressure to 0.1-0.2Mpa. After completion, it is mixed with enzyme preparations and probiotic granules in a mixer and then screened and packaged for storage.
- the present invention adds benzoic acid to the existing formula, which has broad spectrum antibacterial properties, can effectively control diarrhea and promote growth, and is used together with essential oils to enhance the antibacterial effect.
- Benzoic acid exerts antibacterial properties in the form of molecules. After being processed through coating technology, it is ensured that benzoic acid exists in more molecular forms in the intestines, which effectively exerts the potency of benzoic acid.
- Medium-chain fatty acids are also added to the existing formula.
- MCFA Medium-chain fatty acids refer to saturated fatty acids containing 6-12 carbon atoms. They have shorter carbon chains, smaller molecules, polarity and High water solubility and other characteristics. It has unique characteristics in digestion, absorption, transport, and oxidation in animals.
- MCFA is oxidized in liver cells to produce a large amount of acetyl CoA.
- Acetyl CoA can be used together with citric acid and L-malic acid in the formula to perform the tricarboxylic acid cycle in the mitochondria, rapidly oxidizing it for energy, and also generating ketone bodies into the blood, making the blood.
- the content of ketone bodies in the body increases.
- Ketone bodies can be used as energy substances by tissues such as cardiac muscle, skeletal muscle, and brain. Therefore, they can reduce the consumption of glycogen and protein in the body and reduce nitrogen excretion.
- MCFA is rarely re-esterified into MCT. Therefore, direct MCFA supplementation will not affect the fatty acid composition of animal body fat. Due to its unique antibacterial principle, MCFA makes it difficult for bacteria to develop drug resistance. Using MCFA to replace antibiotics may become one of the important ways in the future. Medium-chain fatty acids work best when synergized with other acids and essential oils in the formula.
- the formula and preparation method of the present invention increase the added value of the product. It can not only protect the stability of organic acids and essential oils and help digestion and absorption, but also can pass gastric acid and be slowly released in the animal intestines to enhance the antibacterial effect of plant essential oils. At the same time, the intestinal flora is improved, and the actual use effect is excellent. In practical applications, while the feed-to-meat ratio decreases, the average daily weight gain of animals increases significantly;
- the enzyme catalysis in the present invention has the advantages of high efficiency, specificity, mild conditions, controllable catalytic activity, etc.
- the protein with catalytic activity in the enzyme is produced by active cells and exists in animals, microorganisms and plants.
- Feed enzymes The preparation can effectively improve the utilization rate of feed, promote the growth, development and production performance of animals. It is a green and environmentally friendly feed additive. Adding exogenous enzyme preparations to feed can also make up for the serious shortage of endogenous enzymes and quickly improve the quality of animals.
- Digestive capacity improve the utilization of complete feed, and improve its production performance under basic stress conditions. It can also feed back the results to actively promote the cell secretion and cell activity of endogenous enzymes, and can also eliminate some special Anti-supplementary nutritional factors, reducing the utilization of concentrated nutrients.
- a compound preparation of acids, essential oils, enzymes and probiotics made of raw materials with the following mass percentages: organic acids: sorbic acid 5-20%, citric acid 5-15%, malic acid 2-10%, fumaric acid 10% -20%, benzoic acid 0-10%, medium chain fatty acids 1-10%; plant essential oil: either cinnamaldehyde or carvacrol, mass percentage 0.5-3%, thymol 0.5-5%, aroma Lansu 0.5-5%; adsorbent 3-6%, emulsification blocker 0.1-10%, lubricant 0.5-2%, packaging material 10-30%, enzyme preparation 0.005-3%, probiotics 0.005-3% ;
- the adsorbent is one of silica or montmorillonite; the emulsification blocker is gelatinized starch, microcrystalline cellulose, ethyl cellulose, hydroxypropyl methylcellulose, the ratio is 10:1 :1:1.
- the lubricant is any one of silica, talc or magnesium stearate; the packaging material is hydrogenated fat; the enzyme preparation is cellulase, xylanase, B-glucanase, mannanase, The ratio is 1:1:0.2:0.2:0.1; the probiotics are Lactobacillus, Streptococcus faecalis, Bacillus, and Yeast, and the colony number ratio is approximately: 80:1:10:1.
- a method for preparing a compound preparation of acids, essential oils, enzymes and probiotics including the following steps: adsorbing plant essential oils and medium-chain fatty acids with an adsorbent and mixing them with other solid organic acids in a mixer, then adding lubricants. During the mixing process Add emulsification blocker to adjust the viscosity, perform granulation in a rotary extrusion or swing granulator, and then enter the rounding process for rounding at a rotation speed of 50 rpm. Collect the samples and dry and coat them in a fluidized bed granulation drying and coating machine. Control the inlet air temperature of the fluidized bed to 45°C, the fan frequency to 30HZ, and the spray gun pressure to 0.1-0.2Mpa. After completion, it is mixed with enzyme preparations and probiotic granules in a mixer and then screened and packaged for storage.
- 30-day-old weaned piglets that are healthy, have normal feed intake, are of the same breed, and have similar initial weights are selected and divided into a control group and an experimental group.
- the control group is fed the control group feed
- the experimental group is fed the feed of the embodiment of this application.
- During the test Pigs were weighed at the beginning and at the end. Used to calculate average daily gain and feed conversion efficiency. Diarrhea, illnesses, treatments and deaths were recorded daily.
- the test period is 10 days; the feed formula of the control group is: organic acid raw materials: sorbic acid 5-20%, citric acid 5-15%, malic acid 2-10%, fumaric acid 10-20%; plant essential oil raw materials : Any one of cinnamic aldehyde or vanillin or carvacrol, mass content is 1-5%, thymol 2-5%; adsorbent: silica, silica, vermiculite or sepiolite Any one of them, with a mass content of 2-8%; Binder: any one or more of dextrin lactose or gelatinized starch or cellulose, with a mass content of 2-5%; Lubricant: white carbon Any one of black, talc or magnesium stearate, mass percentage is 1-3%; packaging material: hydrogenated fat 10-30%. Granules are made by wet granulation to have a sustained-release effect; the control group and the feed prepared in the embodiment of the present application are fed at the same time. The experimental results are shown in Table 1
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Abstract
本发明属于饲料添加剂技术领域，尤其涉及一种酸、精油、酶及益生菌复合制剂及其制备方法，由以下质量百分比的原料制成：有机酸：山梨酸5-20％、柠檬酸5-15％、苹果酸2-10％、富马酸10-20％，苯甲酸0-10％；植物精油：肉桂醛或香芹酚中的任一一种，质量百分比为0.5-3％、百里香酚0.5-5％、香兰素0.5-5％；吸附剂3-6％、乳化阻断剂0.1-10％、润滑剂0.5-2％、包材10-30％、酶制剂0.005-3％、益生菌0.005-3％，本发明饲料增加了产品附加值，不仅能够保护有机酸和精油的稳定性，帮助消化吸收，而且能过胃酸，在动物肠道中缓慢释放，增强植物精油的抑菌效果同时改善肠道菌群。
Description
本发明属于饲料添加剂技术领域，尤其涉及一种酸、精油、酶及益生菌复合制剂及其制备方法。
酸化剂、植物精油和酶制剂被公认为是无毒、无害、无污染的绿色添加剂的典型代表，是目前研究的重点和热点之一。复合酸化剂普遍运用在养殖动物中，其能弥补断奶仔猪生理性产酸不足，进而缓解仔猪的消化吸收不良、营养性腹泻、饲料浪费等问题。但普通酸化剂由于采用的是简单的混合或吸附工艺，裸露的酸易于与饲料中的碱性物质发生反应，而失去抑菌等作用；植物精油具有较好的抗菌、抗病毒特性，无论单独添加或是与抗生素联合使用均可提高抑菌效果。由于植物精油具有易氧化、易挥发等缺点，简单混合的植物精油由于不稳定很难达到相应的效果；因此，探究酸化剂、植物精油和酶制剂的调配以及制备时的处理形式，使其三者发挥最大的功效是复合制剂所要解决的问题。
发明内容
本发明的目的是提供一种酸、精油、酶及益生菌复合制剂及其制备方法，能够保护有机酸和精油的稳定性，帮助消化吸收，而且能过胃酸，在动物肠道中缓慢释放，增强植物精油的抑菌效果同时改善肠道菌群。
为达到上述目的，本发明采用的技术方案是：
一种酸、精油、酶及益生菌复合制剂，由以下质量百分比的原料制成：有机酸：山梨酸5-20％、柠檬酸5-15％、苹果酸2-10％、富马酸10-20％，苯甲酸0-10％、中链脂肪酸1-10％；植物精油：肉桂醛或香芹酚中的任一种，质量百分比为0.5-3％、百里香酚0.5-5％、香兰素0.5-5％；吸附剂3-6％、乳化阻断剂0.1-10％、润滑剂0.5-2％、包材10-30％、酶制剂0.005-3％、益生菌0.005-3％。
进一步的，所述吸附剂为白炭黑或蒙脱石中的一种；乳化阻断剂为麦芽糊精、胶化淀粉、微晶纤维素、乙基纤维素、羟丙基甲基纤维素至少一种，若为多种时，麦芽糊精：胶化淀粉：微晶纤维素：乙基纤维素：羟丙基甲基纤维素的比例为(0-2)：1：(0-0.2)：0.1：(0-0.2)，润滑剂为白炭黑、滑石粉或硬脂酸镁中的任意一种；包材为氢化脂肪；酶制剂为纤维素酶、木聚糖酶、β-葡聚糖酶、甘露聚糖酶中的至少一种，若为多种时，纤维素酶：木聚糖酶：β-葡聚糖酶：甘露聚糖酶的比例为(0-2)：(0-1)：(0-0.3)：0.2：(0-0.5)； 益生菌为乳酸杆菌、粪链球菌、芽孢杆菌、酵母菌中的至少一种，若为多种时，乳酸杆菌：粪链球菌：芽孢杆菌：酵母菌的比例为(10-100)：1：10：1。除芽孢杆菌外其余菌体在胃酸中存活的概率很小，复合菌经过处理后使菌体尽可能的在肠道内发挥作用。
一种酸、精油、酶及益生菌复合制剂的制备方法，包括以下步骤：将植物精油和中链脂肪酸用吸附剂吸附后与其他固态有机酸在混合机混合后，加入润滑剂，混合过程中加入乳化阻断剂调整粘度，在旋转挤压或摇摆制粒机进行制粒，然后进入抛圆工序进行抛圆，转速50rpm，收集样品在流化床制粒干燥包衣机中干燥包衣，控制流化床进风温度45℃，风机频率30HZ,喷枪压力0.1-0.2Mpa，完成后在混合机中与酶制剂、益生菌颗粒混合后筛分包装入库。
本发明在现有配方中加入了苯甲酸，其广谱抑菌，可有效控制腹泻并促生长，与精油同时使用增强抑菌效果。苯甲酸以分子形式发挥抑菌性能，通过包被技术处理后，保证苯甲酸在肠道更多以分子形式存在，高效了发挥苯甲酸的效价。在现有配方中还加入了中链脂肪酸，中链脂肪酸(Medium-chain fatty acid，MCFA)是指含有6-12个碳原子的饱和脂肪酸，具有碳链较短、分子较小、极性和水溶性较高等特点。其在动物体内的消化、吸收、转运、氧化等都具有特点，可以起到迅速供能、改善脂肪沉积、改善胰岛素敏感性、提高畜产品品质、抑菌及调整肠道菌群和结构等作用。MCFA在肝细胞中氧化产生大量的乙酰CoA，乙酰CoA可以与配方中柠檬酸，L-苹果酸一起在线粒体内进行三羧酸循环，快速氧化供能，同时也生成酮体进入血液，使血液中酮体含量升高，酮体能够被心肌、骨骼肌及大脑等组织作为能源物质利用，因此可以减少体内糖原和蛋白质的消耗，减少氮排出量，而MCFA很少重新酯化为MCT，因此直接补饲MCFA也不会影响动物体脂脂肪酸的组成。MCFA由于其独特的抑菌原理，使细菌不易产生耐药性，利用其替代抗生素将来亦或成为重要的途径之一。中链脂肪酸与配方中的其他酸和精油协同作用下，效果最佳。
本发明具有的优点是：
1.本发明的配方及制备方法增加了产品的附加值，不仅能够保护有机酸和精油的稳定性，帮助消化吸收，而且能过胃酸，在动物肠道中缓慢释放，增强植物精油的抑菌效果同时改善肠道菌群，实际使用效果优异，在实际应用中，料肉比下降的同时，动物平均日增重明显上升；
2.本发明中酶催化作用具有高效、专一、条件温和、催化活性可控等优点，酶中具有催化活性的蛋白质是由活性细胞产生的，存在于动物、微生物以及植物体内，饲用酶制剂能有效提升饲料的利用率，促进动物的生长发育和生产性能发挥，是一种绿色环保型的饲料添加 剂，在饲料中添加外源酶制剂还可以弥补内源酶的严重不足，迅速改善动物的消化能力，提高全价饲料的利用率，并提高其在基本胁迫条件下的生产性能，它还可以反馈结果，以积极促进内源性酶的细胞分泌和细胞活性，还可以消除一些特殊的抗补充营养因子，降低浓缩营养素的利用率。
实施例
一种酸、精油、酶及益生菌复合制剂，由以下质量百分比的原料制成：有机酸：山梨酸5-20％、柠檬酸5-15％、苹果酸2-10％、富马酸10-20％、苯甲酸0-10％、中链脂肪酸1-10％；植物精油：肉桂醛或香芹酚中的任一种，质量百分比为0.5-3％、百里香酚0.5-5％、香兰素0.5-5％；吸附剂3-6％、乳化阻断剂0.1-10％、润滑剂0.5-2％、包材10-30％、酶制剂0.005-3％、益生菌0.005-3％；所述吸附剂为白炭黑或蒙脱石中的一种；乳化阻断剂为胶化淀粉、微晶纤维素、乙基纤维素、羟丙基甲基纤维素，比例为10：1：1：1。润滑剂为白炭黑、滑石粉或硬脂酸镁中的任意一种；包材为氢化脂肪；酶制剂为纤维素酶、木聚糖酶、B一葡聚糖酶、甘露聚糖酶，比例为1：1：0.2：0.2：0.1；益生菌为乳酸杆菌、粪链球菌、芽孢杆菌、酵母菌，菌落数比值约为：80：1：10：1。
一种酸、精油、酶及益生菌复合制剂的制备方法，包括以下步骤：将植物精油和中链脂肪酸用吸附剂吸附后与其他固态有机酸在混合机混合后，加入润滑剂，混合过程中加入乳化阻断剂调整粘度，在旋转挤压或摇摆制粒机进行制粒，然后进入抛圆工序进行抛圆，转速50rpm，收集样品在流化床制粒干燥包衣机中干燥包衣，控制流化床进风温度45℃，风机频率30HZ,喷枪压力0.1-0.2Mpa，完成后在混合机中与酶制剂、益生菌颗粒混合后筛分包装入库。
应用效果实验
根据国家标准要求，选择健康、采食正常、品种一致、初始体重相近的30日龄断奶仔猪分成对照组和实验组，对照组饲喂对照组饲料，实验组喂养本申请实施例饲料，在试验开始和结束时对猪进行称重。用于计算平均日增重和饲料转化效率。每天记录腹泻、疾病、治疗和死淘情况。试验周期为10天；对照组饲喂饲料配方为：有机酸原料：山梨酸5-20％、柠檬酸5-15％、苹果酸2-10％、富马酸10-20％；植物精油原料：肉桂醛或香兰素或香芹酚中的任意一种，质量含量为1-5％、百里香酚2-5％；吸附剂：二氧化硅或白炭黑或蛭石或海泡石中的任意一种，质量含量为2-8％；粘合剂：糊精乳糖或胶化淀粉或纤维素中的任意一种或多种，质量含量百分比为2-5％；润滑剂：白炭黑、滑石粉或硬脂酸镁中的任意一种，质 量百分比为1-3％；包材：氢化脂肪10-30％。通过湿法制粒制成颗粒，使其具有缓释效果；将对照组与本申请实施例制备的饲料同时饲喂，实验结果见表1：
| 项目 | 平均日增重(kg) | 料肉比(kg) | 腹泻率(％) |
| 对照组 | 0.489±0.04 | 1.42±0.03 | 8.38±0.23 |
| 试验组 | 0.523±0.05 | 1.34±0.02 | 7.56±0.19 |
Claims (3)
- 一种酸、精油、酶及益生菌复合制剂，其特征在于，由以下质量百分比的原料制成：有机酸：山梨酸5-20％、柠檬酸5-15％、苹果酸2-10％、富马酸10-20％，苯甲酸0-10％、中链脂肪酸1-10％；植物精油：肉桂醛或香芹酚中的任一种，质量百分比为0.5-3％、百里香酚0.5-5％、香兰素0.5-5％；吸附剂3-6％、乳化阻断剂0.1-10％、润滑剂0.5-2％、包材10-30％、酶制剂0.005-3％、益生菌0.005-3％。
- 如权利要求1所述的酸、精油及酶复合制剂，其特征在于：所述吸附剂为白炭黑或蒙脱石中的一种；乳化阻断剂为麦芽糊精、胶化淀粉、微晶纤维素、乙基纤维素、羟丙基甲基纤维素中的至少一种，润滑剂为白炭黑、滑石粉或硬脂酸镁中的任意一种；包材为氢化脂肪；酶制剂为纤维素酶、木聚糖酶、β-葡聚糖酶、甘露聚糖酶中的至少一种；益生菌为乳酸杆菌、粪链球菌、芽孢杆菌、酵母菌中的至少一种。
- 如权利要求1-2任一所述的酸、精油及酶复合制剂的制备方法，其特征在于，包括以下步骤：将植物精油和中链脂肪酸用吸附剂吸附后与其他固态有机酸在混合机混合后，加入润滑剂，混合过程中加入乳化阻断剂调整粘度，在旋转挤压或摇摆制粒机进行制粒，然后进入抛圆工序进行抛圆，转速50rpm，收集样品在流化床制粒干燥包衣机中干燥包衣，控制流化床进风温度45℃，风机频率30HZ,喷枪压力0.1-0.2Mpa，完成后在混合机中与酶制剂、益生菌颗粒混合后筛分包装入库。
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| CN114344356A (zh) * | 2021-12-31 | 2022-04-15 | 福建傲农生物科技集团股份有限公司 | 一种抑菌型复合活性物质微胶囊颗粒及其制备方法与应用 |
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| CN107156455A (zh) * | 2017-07-19 | 2017-09-15 | 浙江万方生物科技有限公司 | 一种酸加精油复合制剂及其制备方法 |
| CN107950792A (zh) * | 2017-12-12 | 2018-04-24 | 生物源生物技术（深圳）股份有限公司 | 一种新型复合饲料添加剂及其制备方法和用途 |
| CN108174978A (zh) * | 2017-12-26 | 2018-06-19 | 广州美瑞泰科生物工程技术有限公司 | 一种调节肠胃健康的酸化剂及其制备方法 |
| CN108813123A (zh) * | 2018-05-30 | 2018-11-16 | 上海新邦生物科技有限公司 | 一种提高仔猪肠道健康的肠道营养包及应用 |
| CN113812528A (zh) * | 2021-09-23 | 2021-12-21 | 广州市信农生物科技有限公司 | 一种改善畜禽肠道健康的植物提取物添加剂 |
| CN114601027A (zh) * | 2022-04-26 | 2022-06-10 | 驻马店华中正大有限公司 | 一种酸、精油、酶及益生菌复合制剂及其制备方法 |
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