WO2023187412A1 - Produit comprenant un récipient perméable et un extrait séché à partir d'un matériau végétal et ses utilisations - Google Patents

Produit comprenant un récipient perméable et un extrait séché à partir d'un matériau végétal et ses utilisations Download PDF

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Publication number
WO2023187412A1
WO2023187412A1 PCT/GB2023/050864 GB2023050864W WO2023187412A1 WO 2023187412 A1 WO2023187412 A1 WO 2023187412A1 GB 2023050864 W GB2023050864 W GB 2023050864W WO 2023187412 A1 WO2023187412 A1 WO 2023187412A1
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WO
WIPO (PCT)
Prior art keywords
flavour
aerosol
active
product
composition
Prior art date
Application number
PCT/GB2023/050864
Other languages
English (en)
Inventor
Stuart Martin
John Richardson
Original Assignee
Nicoventures Trading Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicoventures Trading Limited filed Critical Nicoventures Trading Limited
Publication of WO2023187412A1 publication Critical patent/WO2023187412A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A24B15/303—Plant extracts other than tobacco
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges

Definitions

  • a product comprising a permeable container and a dried extract from a plant material and uses thereof
  • the invention relates to a product comprising a permeable container and a dried extract from a plant material, methods of manufacturing the product and uses thereof.
  • Materials for use in delivery systems for delivering active substances and/or flavours may be derived from plant materials or extracts from plant materials. Factors such as the concentration of the active and/or flavour components in the materials for use in the delivery systems, and the stability of these materials, will influence the delivery of the desired components. Summary
  • a product comprising a permeable container holding a flavour- and/or active-delivering composition comprising a dried extract from a flavour- and/or active-containing plant material.
  • the flavour- and/or active-delivering composition consists of a dried extract from a flavour- and/or active-containing plant material.
  • the container is a wrapper, bag, pouch, pod, capsule or cartridge.
  • the flavour- and/or active-delivering composition is formed by drying a precursor composition comprising the extract from a flavour- and/or activecontaining plant material.
  • flavour- and/or active-delivering composition and/or the precursor composition comprises an aerosol-former material.
  • the aerosol-former material is glycerol. In some embodiments, the precursor material is dried to a moisture content of from o to about 5% (calculated on a wet weight basis).
  • the precursor material comprises from about to to about 95% by weight extract from a flavour- or active-containing plant material.
  • the precursor material comprises from about 1 to about 36 wt% aerosol-former material. In some embodiments, the precursor material comprises from o to about 40% by weight of an excipient.
  • the flavour- and/or active-delivering composition comprises from about 45 to about 99% by weight dried extract from the flavour- or active- containing plant material.
  • the flavour- and/or active-delivering composition comprises from about 1 to about 34% by weight of an aerosol-former material. In some embodiments, the flavour- and/ or active-delivering composition comprises from o to about 25% by weight of an excipient.
  • the plant material is selected from the group consisting of tobacco, eucalyptus, star anise, cocoa and hemp.
  • the extract from a flavour- or active-containing plant material is an aqueous extract.
  • the extract from a flavour- or active-containing plant material is an aqueous tobacco extract.
  • the flavour- and/or active-delivering composition comprises from about 40 to about 99% by weight tobacco solids. In some embodiments, the flavour- and/or active-delivering composition is in the form of one or more selected from the group consisting of discrete particles, agglomerates or tablets. In some embodiments, the product is for use in an aerosol provision system.
  • the product is for use in an aerosol-free delivery system or for use as an aerosol-free delivery system. In some embodiments, the product is for oral use.
  • a noncombustible aerosol-provision system comprising a product according to the first aspect, and a non-combustible aerosol provision device.
  • the system is configured to heat the flavour- and/or activedelivering composition to form a vapour and/or aerosol.
  • the system further comprises a further aerosol-generating material which is to be heated to form an aerosol and/ or vapour, optionally wherein the further aerosol-generating material is a liquid.
  • flavour- and/or active-delivering composition is heated by the aerosol and/or vapour generated from the further aerosol-generating material.
  • the system includes a means for heating the further aerosolgenerating material to form a vapour, but not including a separate means for heating the flavour- and/or active-delivering composition.
  • an aerosolgenerating device comprising an area for receiving one or more products according to the first aspect, and configured to heat the one or more products in the area.
  • the area is configured to be opened to allow the user to insert the product and then close the area to retain the product.
  • the device comprises a means for holding or gripping the product located within the area of the device.
  • the area is surrounded by a heat source.
  • heat from a remote source within the device may be transferred to the product within the area.
  • a method for providing a product according to the first aspect comprising: drying a precursor material comprising an extract from a flavour- and/or active-containing plant material; and placing the flavour- and/or active-delivering composition in a container.
  • the precursor material is dried by spray-diying or freeze-diying.
  • a method for providing a product according to the first aspect comprising: placing a precursor material comprising an extract from a flavour- and/or active-containing plant material in a container; and drying the precursor material in the container to form the flavour- and/or active-delivering composition in a container.
  • the precursor material is frozen prior to being dried.
  • Figure 1 is schematic representation of a permeable container holding a dried extract from a plant material.
  • Figure 2 is a schematic cross-sectional view of a non-combustible aerosol provision device for generating aerosol from a permeable container holding a dried extract from a plant material.
  • Figure 3 is a schematic cross-sectional view of a Hybrid device for generating aerosol from a permeable container holding a dried extract from a plant material and a further vapour source.
  • the present invention relates to products comprising a permeable container holding a dried or dehydrated flavour- and/ or active-delivering composition formed from an extract from a flavour- and/or active-containing plant material.
  • the extract is a liquid solution or suspension and it may be dried or dehydrated using a process such as spray-drying or freeze-diying.
  • the dried or dehydrated flavour- and/or active-delivering composition may be formed from a precursor material comprising the extract from a flavour- and/or active-containing plant material and an aerosol-former material.
  • the flavour- and/or active-delivering composition comprising the dried extract from a flavour- and/or active-containing plant material comprises a high concentration of the flavour and/or active, with little or no material that does not contribute to the aerosol generated from the dried aerosol-generating material. As such, very small amounts of the flavour- and/or active-delivering composition are sufficient to deliver the desired active and flavour content. Further, the flavour- and/or active may be quickly and efficiently released by the composition.
  • the dried aerosol-generating material has a moisture content of from o to about 10%, or from o to about 5% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer titration.
  • the moisture content of the dried aerosolgenerating material is less than about 3 wt%, for example from about o to about 3 wt%, or from about 0.5 to about 2.5 wt %.
  • Karl Fischer titration is a classic method of chemical analysis for reliably determining the amount of water in a sample, and even just trace amounts. The method can be readily carried out using an automated Karl Fischer titrator. Similarly, the use of GC- TCD is also a well-established method for reliably determining the water content in a sample.
  • references to moisture content herein are references to the moisture content as measured by Karl Fischer titration.
  • a product comprising a permeable container containing the flavour- and/or active-delivering composition.
  • the container allows exposure of the flavour- and/or active-delivering composition to air flow and to moisture.
  • the container also allows the flavour- and/or active-components released by the composition to exit the container so that they may be delivered to a user.
  • the step of packaging a portion of the flavour- and/ or activedelivering composition in a permeable container is carried out in a controlled low- humidity environment to minimise the moisture absorbed by the flavour- and/or active-delivering composition.
  • flavour- and/or active-delivering composition does not need to be protected from moisture once packaged in the container because its absorption of moisture once inside the container will be less detrimental, and may even be beneficial in some embodiments discussed herein.
  • permeable containers comprising a flavour- and/or activedelivering composition comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material.
  • the hygroscopic flavour- and/or active-delivering composition has a moisture content of no greater than about 10% or no greater than about 5% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer titration.
  • GC-TCD gas chromatography-thermal conductivity detector
  • Karl Fischer titration This moisture content is stable, meaning that the moisture content of the flavour- and/or active-delivering composition is within this range not only when it is first prepared, but also after incorporation into an article and following transport and storage. This stable moisture content is observed despite the fact that the hygroscopic flavour- and/or activedelivering composition would rapidly absorb moisture if exposed to the environment, even under “normal” humidity conditions.
  • flavour- and/or activedelivering composition when described as hygroscopic, this means that it will rapidly absorb water from the surrounding environment to significantly increase its water content.
  • the moisture content upon exposure of the flavour- and/or active-delivering composition to the environment (for example, upon storage in an open container or the like), the moisture content rapidly increases to above 20% or above 25% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer titration.
  • GC-TCD gas chromatography-thermal conductivity detector
  • Karl Fischer titration Karl Fischer titration.
  • the permeable containers disclosed herein provide a moisture and air permeable barrier around the flavour- and/or active-delivering composition formed by diying an extract from a flavour- and/or active-containing plant material.
  • the permeable container may provide a precise dose or amount of the flavour- and/ or active-delivering composition.
  • the permeable container may be rigid or non-rigid.
  • the permeable container is a wrapper, bag or pouch.
  • the container may be a pod, capsule or cartridge.
  • a wrapper, bag or pouch may be flexible, for example formed from one or more sheets.
  • the sheets may be bonded to one another to seal the wrapper, bag or pouch once the portion of flavour- and/or active-delivering composition has been added.
  • the wrapper, bag or pouch forms a chamber within which the flavour- and/ or active-delivering composition is sealed.
  • the sheets are formed from or consist of a moisture impermeable material, such as a polymeric sheet, a metal foil or laminate sheet, which is perforated to render it permeable.
  • the sheet material comprises a permeable or porous material, such as a porous paper, a fabric or a fleece.
  • the sheets comprise a woven or non-woven fabric or fleece comprising a plurality of fibres.
  • the fleece or fabric is manufactured by a dry-laid process, an air-laid process, a wet-laid process, a spun melt process, a melt blown process or the like to entangle fibres or filaments into a web in a manner that does not involve weaving or knitting.
  • the fabrics may comprise fibres formed from materials including cellulose fibres, viscose fibres, regenerated cellulose fibres, wood fibres, cotton fibres, wool fibres, or other fleece forming polymers, such as polyglycolic acid fibres, polylactic acid fibres, polyhydroxyalkanoate fibres, polycaprolactone fibres, polybutylene succinate fibres, polybutylene succinate adipate fibres, and combinations thereof.
  • the fibres are thermostable and/or biodegradable.
  • the pouch may be provided as a single pouch or as a series of connected pouches, each pouch holding flavour- and/or active-delivering composition.
  • the plurality of pouches may all hold the same flavour- and/or active-delivering composition or two or more different flavour- and/or active-delivering compositions.
  • the series of connected pouches may be configured to allow a single pouch to be separated from the rest and used. Alternatively, in some embodiments, the series of pouches may remain connected and may be sequentially used.
  • the pouch 1 comprises two sheets 2 of porous material. These sheets are fused or adhered along their edges to form a chamber within which a flavour- and/ or active-delivering composition 3 is sealed.
  • the dried flavour- and/or active-delivering composition is placed inside a container which has already been formed. In other embodiments.
  • the flavour- and/or active-delivering composition is added as the container is being formed. This may be an attractive option where the container is a bag or pouch.
  • the precursor material may be added to the container and is then dried inside the container to form the flavour- and/ or active-delivering composition.
  • This option may be attractive where the container is rigid, such as a pod, capsule or cartridge, and so is suited to hold a liquid or slurry.
  • the material of the container must also be compatible with the drying process that is used to dry the precursor.
  • the precursor material may be frozen, for example by snap-freezing by exposure to liquid nitrogen before being added to the container or whilst in the container. The frozen precursor is then dried to form the flavour- and/or active-delivering composition.
  • the flavour- and/or active-delivering composition comprises a dried extract from a flavour- and/or active-containing plant material.
  • the flavour- and/or active-delivering composition is formed by drying a precursor material comprising an extract from a flavour- and/or active- containing plant material.
  • the drying process is selected to retain the desired components of the precursor material and, therefore, the flavour- and/or activedelivering material may comprise one or more active substances and/or flavours.
  • the extract from a flavour- or active-substance containing plant material is an extract derived by contacting the plant material with a suitable solvent, such as an aqueous solvent or an alcohol such as ethanol.
  • a suitable solvent such as an aqueous solvent or an alcohol such as ethanol.
  • the liquid portion comprising the solvent and any dissolved plant components may then be separated or partially separated from the remaining solid plant material to provide the extract to be included in the precursor composition and dried.
  • the precursor material may also optionally include one or more other functional materials. Additionally or alternatively, one or more functional materials may be added to the dried precursor material to provide a flavour- and/or active-delivering material with the desired components and properties.
  • At least some embodiments of the invention enjoy the advantage of a flavour- and/or active-delivering composition that is has a long shelflife and may be easily transported and stored. Without wishing to be bound by any particular theory, it is hypothesised that the low water content of the flavour- and/or active-delivering composition reduces evaporation over time of other solvents, and reduces degradation of active substances, such as nicotine, flavours and/or other volatile compounds.
  • compositions may be stored at temperatures in the range of o-35°C. In some embodiments, the compositions may be stored at a relative humidity of up to about 30%, or even as high as 50%, prior to use.
  • flavour- and/or active-delivering compositions may also have the advantage of having a high concentration of the desired components. This means that relatively small amounts of the compositions are required and the desired components are quickly and readily released upon use.
  • the extract from a flavour- or active-substance containing plant material is an extract derived from tobacco material.
  • the compositions provide an authentic tobacco taste of reasonable strength.
  • the tobacco extract or material may be from or may be any type of tobacco and any part of the tobacco plant, including tobacco lamina, stem, stalk, ribs, scraps and shorts or mixtures of two or more thereof. Suitable tobacco extracts or materials include the following types: Virginia or flue-cured tobacco, Burley tobacco, Oriental tobacco, or blends of tobacco materials, optionally including those listed here.
  • the tobacco may be expanded, such as dry-ice expanded tobacco (DIET), or processed by any other means.
  • the tobacco material may be reconstituted tobacco material.
  • the tobacco may be pre-processed or unprocessed, and may be, for instance, solid stems (SS); shredded dried stems (SDS); steam treated stems (STS); or any combination thereof.
  • the tobacco material may be fermented, cured, uncured, toasted, or otherwise pre-treated.
  • the tobacco material may be provided in the form of cut rag tobacco.
  • the cut rag tobacco can have a cut width of at least 15 cuts per inch (about 5.9 cuts per cm, equivalent to a cut width of about 1.7 mm) for example.
  • the cut rag tobacco can be formed from a mixture of forms of tobacco material, for instance a mixture of one or more of paper reconstituted tobacco, leaf tobacco, extruded tobacco and bandcast tobacco.
  • the precursor material which is dried to form the flavour- and/or active-delivering composition may comprise at least about 10 wt%, at least about 15 wt%, at least about 20 wt%, at least about 25 wt%, at least about 30 wt%, at least about 35 wt%, or at least about 40 wt% tobacco solids (calculated on a wet weight basis). Additionally or alternatively, the precursor material may comprise up to about 60 wt%, up to about 55 wt%, up to about 50 wt%, up to about 45 wt%, or up to about 40 wt% tobacco solids (calculated on a wet weight basis) . In some embodiments, the precursor material comprises from about 20 wt% to about 40 wt% tobacco solids (calculated on a wet weight basis).
  • the precursor material comprises at least about 10 wt%, about 20 wt%, at least about 30 wt%, at least about 40 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, or at least about 90 wt% extract from a tobacco or other flavour- or active-substance containing plant material (calculated on a wet weight basis).
  • precursor material may comprise up to about 99 wt%, up to about 90 wt%, up to about 80 wt%, up to about 70 wt% or up to about 60 wt% extract from tobacco or other flavour- or activesubstance containing plant material (calculated on a wet weight basis).
  • the precursor material comprises around 50 wt% tobacco extract (calculated on a wet weight basis).
  • the aerosol-generating material may comprise at least about 45 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, at least about 90 wt%, or at least about 95 wt% tobacco material or tobacco extract, or flavour- or active-substance containing plant material extract (calculated on a diy weight basis). In some embodiments, the aerosol-generating material may comprise about 60 to about 80 wt% tobacco extract (calculated on a diy weight basis).
  • the dried flavour- and/or active-delivering composition may comprise from about 2 wt% to about 10 wt% of nicotine, or from about 3 to about 6 wt% of nicotine (calculated on a dry weight basis).
  • the precursor material comprises around 50 v/v% tobacco extract. Where the precursor material comprises around 50 v/v% tobacco extract and the tobacco extract has a tobacco solid content of between about 55 and about 60 v/v%, the overall tobacco solid content of the precursor material is from about 27.5 to about 30 v/v%.
  • the tobacco extract has a solids content of between about 40 and about 65 wt%, between about 45 and about 65 wt%, or between about 40 and about 60 wt% (calculated on a wet weight basis).
  • the water content of the tobacco extract is between about 35 wt% and about 65 wt%, or between about 35 and about 55 wt% (calculated on a wet weight basis).
  • the nicotine content of the tobacco extract is between about 1 wt% and about 5 wt% (calculated on a wet weight basis).
  • the dried flavour- and/or active-delivering composition may comprise at least about 45 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, at least about 90 wt%, or at least about 95 wt% tobacco solids (calculated on a dry weight basis). Additionally or alternatively, the flavour- and/or active-delivering composition may comprise up to about 99 wt%, up to about 98 wt%, up to about 95 wt%, up to about 90 wt% or up to about 80 wt%.
  • the dried flavour- and/or active-delivering composition may comprise about 60 to about 80 wt% tobacco solids (calculated on a diy weight basis).
  • the tobacco extract is an aqueous tobacco extract.
  • the tobacco extract may be concentrated and subsequently diluted before being added to the precursor material and dried. In other embodiments, the tobacco extract is not concentrated and may be used directly in the precursor material.
  • the precursor material may be in the form of a sluriy, a suspension, a gel, a liquid or a solid, but in some embodiments which may be preferred, it is in the form of a suspension or liquid. In some embodiments, particles of solid material may be removed from the extract and/ or from the precursor material by filtration and/ or centrifugation.
  • any particles in the precursor composition may be desirable for any particles in the precursor composition to have an average particle size of no greater than about 3 mm, of no greater than 1 mm, of no greater than about 0.5 mm, or to have an average particle size of no greater than about 0.3 mm, when measured by sieving or by observing the size of the particles by SEM.
  • the water content of the precursor material may be at least about 20 wt%, at least about 30 wt%, at least about 40 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, or at least about 90 wt% on a wet weight basis.
  • the water content of the precursor material may be up to about 95 wt%, up to about 90 wt%, up to about 85 wt%, up to about 80 wt%, up to about 75 wt%, up to about 70 wt%, up to about 65 wt%, up to about 60 wt%, up to about 55 wt% or up to about 50 wt% on a wet weight basis.
  • the water content of the precursor material is between about 40 and about 50 wt % on a wet weight basis (50% and 60 v/v%). When the precursor material has a lower water content, the spray/freeze-diying process is quicker, as there is less water to remove.
  • the dried flavour- and/or active-delivering composition and/or the precursor material comprises one or more active substance.
  • This may be derived from the extract or it may be added.
  • the extract from a flavour- or active-substance containing plant material comprises an active substance.
  • the active substance may be a physiologically active material, which is a material intended to achieve or enhance a physiological response.
  • the active substance may for example be selected from nutraceuticals, nootropics and psychoactives.
  • the active substance may comprise, for example, nicotine, caffeine, taurine, theine, vitamins such as B6 or B12 or C, melatonin, cannabinoids, or constituents, derivatives, or combinations thereof.
  • the active substance may comprise one or more constituents, derivatives or extracts of tobacco, cannabis or another botanical.
  • the active substance comprises nicotine.
  • the active substance comprises caffeine, melatonin or vitamin B12.
  • the precursor material may comprise an extract from other botanical source(s) along with or instead of the tobacco extract.
  • the extract may comprise or be derived from one or more botanicals or constituents, derivatives or extracts thereof.
  • botanical includes any material derived from plants including, but not limited to, extracts, leaves, bark, fibres, stems, roots, seeds, flowers, fruits, pollen, husk, shells or the like.
  • the extract may comprise or be derived from botanicals in the form of liquid, gas, solid, powder, dust, crushed particles, granules, pellets, shreds, strips, sheets, or the like.
  • Example botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel, licorice (liquorice), matcha, mate, orange skin, papaya, rose, sage, tea such as green tea or black tea, thyme, clove, cinnamon, coffee, aniseed (anise), basil, bay leaves, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, beefsteak plant, curcuma, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian, pimento, mace, damien, maijoram, olive, lemon
  • the mint may be chosen from the following mint varieties: Mentha Arventis, Mentha c.v., Mentha niliaca, Mentha piperita, Mentha piperita citrata c.v., Mentha piperita c.v., Mentha spicata crispa, Mentha cardifolia, Mentha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata c.v. and Mentha suaveolens
  • the extract comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof selected from eucalyptus, star anise, cocoa and hemp.
  • the extract comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof selected from rooibos and fennel.
  • the flavour- and/or active-delivering composition and/or the precursor material comprises one or more cannabinoid compounds selected from the group consisting of: cannabidiol (CBD), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM) and cannabielsoin (CBE), cannabicitran (CBT).
  • CBD cannabidiol
  • THC tetrahydrocannabinol
  • THCA te
  • the flavour- and/or active-delivering composition and/or the precursor material may comprise one or more cannabinoid compounds selected from the group consisting of cannabidiol (CBD) and THC (tetrahydrocannabinol).
  • CBD cannabidiol
  • THC tetrahydrocannabinol
  • flavour- and/or active-delivering composition and/or the precursor material may comprise cannabidiol (CBD).
  • the flavour- and/or active-delivering composition and/or the precursor material may comprise nicotine and cannabidiol (CBD).
  • the flavour- and/or active-delivering composition and/or the precursor material may comprise nicotine, cannabidiol (CBD), and THC (tetrahydrocannabinol).
  • CBD cannabidiol
  • THC tetrahydrocannabinol
  • the flavour- and/ or active-delivering composition and/ or the precursor material further comprises one or more excipients.
  • the excipient stabilises and preserves the precursor material and the inventors have found the inclusion of an excipient especially important for stability when the precursor material comprises glycerol.
  • the excipient may also act as a bulking agent or a filler material.
  • the inclusion of an excipient may also improve the handleability of the dried material, helping it to retain its granular form by helping to reduce moisture uptake and the resulting increase in tackiness of the material.
  • the presence of an excipient may also have an effect on the speed of (freeze) drying.
  • Suitable excipients include mannitol, sucrose, trehalose, lactose, sorbitol, raffinose, maltose, dextrans such as Dextran to, Dextran 70, Dextran 90, maltodextrin, gelatin, agar, cyclodextrins, and polyethylene glycols such as PEG 2000-6000, and polyvinylpyrrolidone (PVP 10).
  • the flavour- and/or active-delivering composition and/or the precursor material comprises one or more excipients in an amount of from o to about 40 wt% on a wet weight basis.
  • the precursor material may comprise at least about 1 wt%, at least about 10 wt%, at least about 20 wt%, at least about 30 wt%, and/or up to about 40 wt%, up to about 30%, up to about 20 wt%, or up to about 10 wt% excipient on a wet weight basis.
  • the flavour- and/or active-delivering composition may comprise at least about 0.1 wt%, at least about 10 wt%, at least about 20 wt%, or at least about 25 wt% excipient (calculated on a dry weight basis). In some embodiments, the flavour- and/or active-delivering composition may comprise up to about 25%, up to about 20 wt%, up to about 15 wt%, or up to about 10 wt% excipient (calculated on a dry weight basis).
  • the flavour- and/or active-delivering composition comprises about 36 wt% glycerol, about 45 wt% tobacco extract, and about 19 wt% excipient on a diy weight basis.
  • the flavour- and/or active-delivering composition comprises from about 17 to about 39 wt% glycerol, from about 41 to about 76 wt% tobacco extract, and from o to about 28 wt% excipient on a dry weight basis.
  • the precursor material may comprise about o wt%, about 5 wt%, or about 10 wt% agar.
  • the precursor material comprises about 50 wt% tobacco extract, from o to about 36 wt% aerosol forming agent (for example, from o to about 15 v/v%) and from o to about 40 wt% (for example, about 37.5 v/v%) excipient.
  • the tobacco extract may comprise about 55 wt% tobacco solids and the overall tobacco solids content of the precursor material is about 27.5 wt%.
  • the precursor material comprises about 50 wt% tobacco extract, up to about 36 wt% (for example, about 15 v/v%) glycerol and from o to about 40 wt% (for example, about 37.5 v/v%) excipient.
  • the tobacco extract may comprise about 55 wt% tobacco solids and the overall tobacco solids content of the precursor material is about 27.5 wt%.
  • glycerol typically from about 80 to 89% of the glycerol is retained following the drying.
  • Glycerol may be used as an aerosol -former material, but can be replaced or partially replaced with one or more other aerosol-former material such as those disclosed herein.
  • the excipient used may be a dextran such as Dextran 70. Again, this may be replaced or partially replaced with alternative excipients, such as those disclosed herein.
  • Table 1 The percentage content of nicotine in the formulation will depend on the type of tobacco used, and the presence of other components, i.e. the aerosol-former and the excipient.
  • the flavour- and/or active-delivering composition and/or the precursor material comprises one or more binders.
  • the one or more binder is selected from the group consisting of: thermoreversible gelling agents, such as gelatin; starches; polysaccharides; pectins; celluloses; cellulose derivatives, such as carboxymethylcellulose; and alginates.
  • the flavour- and/ or active-delivering composition and/ or the precursor material comprises one or more flavour-modifier, flavour or flavourant. This may be derived from the extract or it may be added.
  • flavour and “flavourant” refer to materials which, where local regulations permit, may be used to create a desired taste, aroma or other somatosensorial sensation in a product for adult consumers. They may include naturally occurring flavour materials, botanicals, extracts of botanicals, synthetically obtained materials, or combinations thereof (e.g., tobacco, cannabis, licorice (liquorice), hydrangea, eugenol, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, maple, matcha, menthol, Japanese mint, aniseed (anise), cinnamon, turmeric, Indian spices, Asian spices, herb, wintergreen, cherry, berry, red berry, cranberry, peach, apple, orange, mango, clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruits, Drambuie, bourbon, scotch,
  • the flavour comprises flavour components of cucumber, blueberry, citrus fruits and/or redberry. In some embodiments, the flavour comprises eugenol. In some embodiments, the flavour comprises flavour components extracted from tobacco. In some embodiments, the flavour comprises flavour components extracted from cannabis.
  • the flavour may comprise a sensate, which is intended to achieve a somatosensorial sensation which are usually chemically induced and perceived by the stimulation of the fifth cranial nerve (trigeminal nerve), in addition to or in place of aroma or taste nerves, and these may include agents providing heating, cooling, tingling, numbing effect.
  • a suitable heat effect agent may be, but is not limited to, vanillyl ethyl ether and a suitable cooling agent may be, but not limited to eucolyptol, WS-3.
  • flavour- and/or active-delivering composition and/or the precursor material comprises one or more other functional materials, which may comprise one or more of pH regulators, colouring agents, preservatives, fillers, stabilizers, and/or antioxidants.
  • the flavour- and/or active-delivering composition and/or the precursor material contains a filler component.
  • the filler component is generally a non-tobacco component, that is, a component that does not include ingredients originating from tobacco.
  • the precursor material comprises less than 60 wt% of a filler, such as from 1 wt% to 60 wt%, or 5 wt% to 50 wt%, or 5 wt% to 30 wt%, or 10 wt% to 20 wt% on a wet weight basis.
  • the filler may comprise one or more inorganic filler materials such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulphate, magnesium carbonate, and suitable inorganic sorbents, such as molecular sieves.
  • the filler may comprise one or more organic filler materials such as wood pulp, hemp fibre, cellulose and cellulose derivatives.
  • the flavour- and/or active-delivering composition is in the form of a gel.
  • a gelling agent may be added to the flavour- and/or active-delivering composition, the precursor material or may be optionally omitted.
  • the gelling agent may comprise one or more compounds selected from cellulosic gelling agents, non- cellulosic gelling agents, guar gum, acacia gum and mixtures thereof.
  • the cellulosic gelling agent is selected from the group consisting of: hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), cellulose acetate propionate (CAP) and combinations thereof.
  • the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose, guar gum, or acacia gum.
  • the gelling agent comprises (or is) one or more non-cellulosic gelling agents, including, but not limited to, agar, xanthan gum, gum Arabic, guar gum, locust bean gum, pectin, carrageenan, starch, alginate, and combinations thereof.
  • the non-cellulose based gelling agent is alginate or agar.
  • the flavour- and/or active-delivering composition and/or the precursor material may comprise an acid.
  • the acid may be an organic acid.
  • the acid may be at least one of a monoprotic acid, a diprotic acid and a triprotic acid.
  • the acid may contain at least one carboxyl functional group.
  • the acid may be at least one of an alpha-hydroxy acid, carboxylic acid, dicarboxylic acid, tricarboxylic acid and keto acid. In some such embodiments, the acid may be an alpha-keto acid.
  • the acid may be at least one of succinic acid, lactic acid, benzoic acid, citric acid, tartaric acid, fumaric acid, levulinic acid, acetic acid, malic acid, formic acid, sorbic acid, benzoic acid, propanoic and pyruvic acid.
  • the acid is selected from one of lactic acid, benzoic acid and levulinic acid.
  • the acid may be an inorganic acid. In some of these embodiments the acid may be a mineral acid. In some such embodiments, the acid may be at least one of sulphuric acid, hydrochloric acid, boric acid and phosphoric acid.
  • the inclusion of an acid is may be beneficial in embodiments in which the flavour- and/or active-delivering composition and/or the precursor material comprises nicotine.
  • the presence of an acid may stabilise dissolved species in the slurry from which the aerosol-generating material is formed. The presence of the acid may reduce or substantially prevent evaporation of nicotine during diying of the sluriy, thereby reducing loss of nicotine during manufacturing.
  • the flavour- and/or active-delivering composition comprises a gelling agent comprising a cellulosic gelling agent and/or a non-cellulosic gelling agent, an active substance and an acid.
  • the dried flavour- and/or active-delivering composition may be in any solid form.
  • the flavour- and/ or active-delivering composition may be in the form of particles, granules or powder.
  • the flavour- and/or active-delivering composition may be in the form of a monolithic form, tablet, agglomerate or “cake”.
  • the flavour- and/or active-delivering composition is formed by freeze- or spray-diying and is then processed with other suitable steps as required and known to the person skilled in the art to provide the dried material in the desired form, for example in the form of particles of the desired size(s).
  • the flavour- and/or active-delivering composition is in the form of granules.
  • the granules may be of any size, cross-sectional shape or mass.
  • the flavour- and/or active-delivering composition in the form of granules is advantageous due to the high surface area to volume ratio, which positively impacts the release of components including the flavour and/ or active from the material.
  • the flavour- and/or active-delivering composition is free- flowing and non-sticky, and this aids the further processing and handling of the flavour- and/or active-delivering composition.
  • Smaller granules and particles have a greater surface area to volume ratio and they may therefore exhibit enhanced release of constituents compared to particles of larger sizes.
  • the particles in the precursor composition may be desirable for the particles in the precursor composition, to have an average particle size of no greater than about 3 mm, no greater than 1 mm, no greater than 500 pm, no greater than about 200 pm, no greater than too
  • the average particle size is within the range of from about 0.1 pm to about 1 mm, from about 1 pm to about 500 pm, from about 10 pm to about 200 pm, from aboutio pm to about too pm, or in the range of from about 10 pm to about 50 pm.
  • at least about 90% of the particles of the precursor composition will have a particle size within the range of from about 1 pm to about 1 mm, or from about 10 to about 500 pm, or from about 50 to about 200 pm.
  • at least about 90% of the tobacco particles of the precursor composition will have a particle size within the range of from about 1 pm to about 1 mm, or from about 10 to about 500 pm, or from about 50 to about 200 pm.
  • At least about 90% of the tobacco particles of the precursor composition will have a particle size within the range of from about 1 pm to about 1 mm, or from about 10 to about 500 pm, or from about 50 to about 200 pm. In some embodiments, at least about 90% of the tobacco particles of the precursor composition will have a particle size within the range of from about 1 pm to about 1 mm, or from about 10 to about 500 pm, or from about 50 to about 200 pm. In some embodiments, none of the particles in the precursor composition have a particle size greater than 1 mm, greater than 0.5 mm, greater than 0.2 mm, greater than 0.15 mm, or greater than about 0.1 mm. In some embodiments, the average particle size is less than 50 pm.
  • the particle size of any solid material present may be reduced by grinding, shredding, cutting or crushing plant material.
  • Suitable machinery to create such plant particles includes, for example, shredders, cutters, or mills, such as hammer mills, roller mills or other types of commercially available milling machinery.
  • the size of the plant particles is selected to provide particles which can be readily prepared from a variety of different types of plant material, having the properties described herein, and which provide a source of plant constituents that are readily released.
  • Particles of the flavour- and/or active-delivering composition of a smaller size may be advantageous for releasing the flavour- and/or active.
  • smaller particles may have a greater surface area to volume ratio, which may improve release.
  • the dried flavour- and/or active- delivering composition readily forms particles with an average size of smaller than 1 mm.
  • the particles may be as small as to pm or even as small as 1 pm. The size of the particles may be determined by sieving or by observing the particles by SEM.
  • the freeze dried precursor material is ground into particles and may be sieved to exclude particles that are considered too small or too large to be used as flavour- and/or active-delivering composition.
  • the flavour- and/ or active-delivering composition used in the present invention has a particle size distribution Dio from about 5 to about 25 pm (meaning that 10% of the particles in the tested sample are smaller than the value), a particle size distribution D50 from about 30 to about 200 pm (meaning that 50% of the particles in the tested sample are smaller than the value), and a particle size distribution D90 from about 500 to about 2500 pm (meaning that 90% of the particles in the tested sample are smaller than the value). These values are determined using particle size analyser Microtrac CamSizer® X2. Percentages referred to here are volume percentages.
  • the freeze dried material used as the flavour- and/or activedelivering composition according to the present invention has a particle size distribution Dio from about 8 to about 15 pm, a particle size distribution D50 from about 50 to about 150 pm, and a particle size distribution D90 from about 900 to about 1700 pm.
  • the Dio mean is from about 10 to about 15 pm, the D50 mean from about 40 to about 140 pm and the D90 mean from about 800 to about 1600 pm.
  • the drying methods used to diy the precursor material may be any suitable drying process, including freeze-drying or spray-drying processes.
  • the drying process used must be compatible with the precursor material and the desired make-up of the flavour- and/or active-delivering composition.
  • it may be desirable for the flavour- and/or active-delivering composition to include active and/or flavour substances derived from the extract in the precursor material it is important to select a drying method that will retain a sufficient amount of these components.
  • the precursor material is freeze-dried using freeze-drying microscopy, for example using a Lyostat freeze-drying microscope.
  • a spray-drying process the precursor material is sprayed and rapidly dried using a hot gas.
  • the dry particle size can be controlled and may be consistent; tobacco or flavour extracts or materials are heat sensitive but can still be spray-dried at relatively high inlet temperatures; a short residence time in the spray-diying equipment is required; and minimal loss of flavour/volatiles. This makes the process adaptable to reduce loss of volatile compounds and maintain the desired flavour of the flavour- and/or activedelivering composition.
  • Freeze-drying also known as lyophilisation or cryodesiccation, is a process in which the precursor material is frozen, the temperature lowered and the water is removed via sublimation under reduced pressure conditions. Without wishing to be bound by any specific theory, it is believed that the low processing temperatures and rapid water loss via sublimation avoid changes in the flavour- and/or active-delivering composition’s characteristics. This process preserves the structure of the precursor material, and reduces the loss and decomposition of volatile flavour compounds.
  • the dried flavour- and/or active-delivering composition has a lower water content than the precursor material.
  • the water content of the flavour- and/or active-delivering composition may be at most about 0.5 wt%, about 1 wt%, about 2%, about 5 wt%, about 10 wt%, or about 20 wt% (calculated on a wet weight basis).
  • the water content of the dried flavour- and/or active-delivering composition may be reduced from the precursor material by at least about 50 wt%, about 60 wt%, about 70 wt%, about 80 wt%, about 90 wt%, about 95 wt%, about 98 wt%, or by about too wt%.
  • the dried flavour- and/or active-delivering composition has a water content of less than about 5 wt%, less than about 4 wt%, less than about 3 wt%, less than about 2 wt% or less than about 1 wt% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer measurement.
  • the precursor material comprises Burley tobacco extract and a water content of 60 wt%. After the freeze-drying operation described herein, the dried flavour- and/or active-delivering composition has a water content of 3 wt%.
  • a lower water content of the dried flavour- and/or active-delivering composition is associated with longer shelf-life and stability. However, very low water content may be associated be a brittle structure and a smaller particle size, as well as taking longer to process.
  • the material is also very hygroscopic. If the water content of the dried flavour- and/or active-delivering composition is too high on the other hand, the desired increased stability may not be achieved.
  • the dried flavour- and/or active-delivering composition may also not be as easy to handle with higher water content, with the material becoming sticky.
  • the precursor material comprises an excipient
  • the precursor material may be better suited to being dried via spray-drying (compared to a precursor material without an excipient).
  • increasing the amount of the excipient in the precursor material raises the glass transition temperature to above too°C and this affects the physical properties of the material, making it more suitable for spray diying. Aerosol generation
  • the permeable containers containing flavour- and/or active-delivering compositions as disclosed herein may be used for generating an aerosol.
  • An aerosol-generating material is a material that is capable of generating aerosol, for example when heated, irradiated or energized in any other way.
  • Conventional aerosol-generating materials which comprise tobacco material or a tobacco extract may be used in combustible and non-combustible aerosol-generating devices, including hybrid devices and tobacco heating products, to provide the user with an aerosol with an authentic tobacco taste and texture.
  • One issue encountered with such materials is that the flavour, other volatile compound and nicotine content decreases with storage of the aerosol-generating material, dropping off particularly towards the end of the life of the material. This is because the more volatile components, including nicotine and many flavours and aromas, are readily released from the material.
  • the moisture content of the aerosol-generating material increases through moisture absorption, the release of substances such as nicotine and flavours is negatively impacted. Aerosol-generating materials that are produced using conventional methods and procedures commonly need to be used within one to three days of production. There is therefore a need to improve the shelf life of the aerosol generating material.
  • a further issue associated with conventional aerosol-generating materials comprising tobacco material or a tobacco extract is that the concentration of the desired components such as nicotine and flavours is relatively low. This limits the concentration of these desired components in the aerosol generated. Additionally, this means that a relatively large amount of the aerosol-generating material is needed and, accordingly, high amounts of energy are required to heat the aerosol-generating material in order to release the desired components.
  • flavour- and/or active-delivering composition disclosed herein being used as a solid substrate for aerosol generation is that the low water content reduces issues associated with “hot puff’, which are known in the art.
  • the permeable container holding a flavour- and/or activedelivering composition is used to generate an aerosol for inhalation by a user.
  • An advantage of the permeable containers holding the flavour- and/or active-delivering composition is that they may be used as a solid aerosol-generating substrate in Hybrid systems or Tobacco Heating Products (THPs). This makes the invention versatile enough to be used in a range of products without the need for further processing.
  • THPs Tobacco Heating Products
  • the composition may comprise an aerosol-former material.
  • this aerosol-former material is included in the precursor material.
  • the aerosol-former material may be added to the dried flavour- and/or active-delivering composition.
  • the aerosol-former material may comprise one or more constituents capable of forming an aerosol.
  • the aerosol-former maybe, for instance, a polyol aerosol generator or a non-polyol aerosol generator. It may be a solid or liquid at room temperature, but preferably is a liquid at room temperature.
  • the aerosol-former material may comprise one or more of glycerine, glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Eiythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauiyl acetate, lauric acid, myristic acid, and propylene carbonate.
  • the aerosol former comprises one or more polyhydric alcohols, such as propylene glycol, triethylene glycol, 1 ,3-butanediol and glycerin; esters of polyhydric alcohols, such as glycerol mono-, di- or triacetate; and/or aliphatic esters of mono-, di- or polycarboxylic acids, such as dimethyl dodecanedioate and dimethyl tetradecanedioate.
  • polyhydric alcohols such as propylene glycol, triethylene glycol, 1 ,3-butanediol and glycerin
  • esters of polyhydric alcohols such as glycerol mono-, di- or triacetate
  • aliphatic esters of mono-, di- or polycarboxylic acids such as dimethyl dodecanedioate and dimethyl tetradecanedioate.
  • the aerosol-former material comprises one or more compounds selected from eiythritol, propylene glycol, glycerol, vegetable glycerine (VG), triacetin, sorbitol and xylitol.
  • the aerosol-former material comprises, consists essentially of or consists of glycerol.
  • Glycerol provides a visible aerosol when the aerosol-generation device is used. It is common that consumers like the aerosol generating device to provide a visible aerosol, as this enables the consumer to visualise the product and what they are consuming. This makes glycerol a desirable choice for aerosol former material.
  • Propylene glycol has the benefit that it is a better flavour carrier than glycerol.
  • a combination of two or more aerosol forming agents may be used, in equal or differing proportions.
  • the precursor material comprises at least about 1 wt%, at least about 5 wt%, at least about 10 wt%, or at least about 20 wt%, aerosol-former material (calculated on a wet weight basis). Additionally or alternatively, the precursor material may comprise up to about 40 wt%, up to about 35, up to about 30 wt%, up to about 25 wt%, up to about 20 wt%, or up to about 10 wt% aerosol-former material (calculated on a wet weight basis).
  • the precursor material may comprise at most 36 wt% of glycerol.
  • the inventors have demonstrated that dry weight inclusion levels up to 36 wt% (calculated on a dry weight basis) of aerosol-former material are possible.
  • the amount of glycerol in the precursor material, and therefore the dried flavour- and/or active-delivering composition, is important because it is both an aerosol-former material and also a plasticizer. If the concentration of glycerol it too high, it may be detrimental to a critical temperature of the product during the freeze-drying process and may result in collapse of the product if the critical temperature of the formulation is exceeded.
  • glycerol should be included to provide the consumer with an adequate and pleasing aerosol.
  • glycerol and some other aerosol-former materials are considered to have anti-freeze properties, it is particularly surprising that it is possible to freeze-dry a precursor material comprising such materials. Nevertheless, the inventors have discovered that precursor materials comprising glycerol may be freeze dried to form a highly useful flavour- and/or active-delivering composition.
  • the dried flavour- and/or active-delivering composition may comprise at least about 1 wt%, at least about 5 wt%, at least about 10 wt%, at least about 20 wt%, at least about 30 wt%, or at least about 40 wt% aerosol-former material (calculated on a dry weight basis).
  • the dried flavour- and/or active-delivering composition may comprise from about 1 to about 34 wt%, or from about 17 to about 34 wt% aerosolformer material (calculated on a dry weight basis).
  • the aerosol-former material is glycerol
  • the dried flavour- and/or active-delivering composition may comprise from about 13 to about 34 wt% glycerol (calculated on a diy weight basis).
  • the flavour- and/or active-delivering composition may comprise from about 17 to about 36 wt% of glycerol.
  • the amount of glycerol in the flavour- and/or active-delivering composition is important because it is both an aerosol-forming material and a plasticizer. If the concentration of glycerol is too high, it may be detrimental to the critical temperature of the product during the freeze-drying process and may result in collapse of the product if a critical temperature of the formulation is exceeded. On the other hand, sufficient glycerol should be included to provide the consumer with an adequate and pleasing aerosol.
  • flavour- and/or active-delivering composition and/or the precursor material further comprises one or more excipients
  • the excipient stabilises and preserves the precursor material and the inventors have found the inclusion of an excipient especially important for stability when the precursor material comprised glycerol as the aerosol-forming material.
  • the container and/or the flavour- and/or active-delivering composition comprises one or more additives that are released upon heating the flavour- and/or active-delivering composition and which therefore contribute to the generated aerosol.
  • the total weight of the flavour- and/or active-delivering composition to be included in the container is up to about 200 mg, up to about 190 mg, up to about 180 mg, up to about 170 mg, up to about 160 mg, up to about 150 mg, up to about 140 mg, up to about 130 mg, up to about 120 mg, up to about no mg, up to about too mg, up to about 90 mg, up to about 80 mg, up to about 70 mg, up to about 60 mg, or up to about 50 mg.
  • the total mass of the flavour- and/or active-delivering composition included may be at least about 5 mg, at least about 10 mg, at least about 15 mg, at least about 20 mg, at least about 25 mg, at least about 30 mg, at least about 35 mg, at least about 40 mg, at least about 45 mg, or at least about 50 mg.
  • the total mass of the flavour- and/or active-delivering composition is sufficient to provide aerosol, for example, for up to about 10 puffs to be generated in a single session or over a series of multiple sessions.
  • the total mass of the dried aerosol-generating material provided is from about 10 to too mg, or from about 25 to about 50 mg.
  • the containers will have suitable dimensions to accommodate this amount of flavour- and/or active-delivering composition, whilst also being of a size that is easy to manufacture and handle.
  • the flavour- and/or active-delivering composition may be incorporated into the container in the absence of any carrier or other substrate material that would need to be heated.
  • the flavour- and/or active-delivering composition may be combined with a carrier or substrate before being placed in the container.
  • the flavour- and/or active-delivering composition is combined with a further aerosol-generating material, such as a material comprising tobacco.
  • the flavour- and/ or active-delivering composition may be combined with tobacco material.
  • the tobacco may be pre-processed or unprocessed, and may be, for instance, solid stems (SS); shredded dried stems (SDS); steam treated stems (STS); or any combination thereof.
  • the tobacco material may be fermented, cured, uncured, toasted, or otherwise pre-treated.
  • the tobacco material may be provided in the form of cut rag tobacco.
  • the cut rag tobacco can have a cut width of at least 15 cuts per inch (about 5.9 cuts per cm, equivalent to a cut width of about 1.7 mm) for example.
  • the cut rag tobacco can be formed from a mixture of forms of tobacco material, for instance a mixture of one or more of paper reconstituted tobacco, leaf tobacco, extruded tobacco and bandcast tobacco.
  • flavour- and/or active-delivering composition may be combined with a further aerosol-generating material that comprises an amorphous solid such as a dried composition comprising a gelling agent, an aerosol former and one or more flavour and/ or active.
  • a further aerosol-generating material that comprises an amorphous solid such as a dried composition comprising a gelling agent, an aerosol former and one or more flavour and/ or active.
  • the container contains and/or the flavour- and/or activedelivering composition comprises a heating material.
  • the heating material comprises one or more materials selected from the group consisting of: an electrically-conductive material, a magnetic material, and a magnetic electrically-conductive material.
  • the heating material may comprise a metal or a metal alloy.
  • the heating material may comprise one or more materials selected from the group consisting of: aluminium, gold, iron, nickel, cobalt, conductive carbon, graphite, plain-carbon steel, stainless steel, ferritic stainless steel, copper, and bronze.
  • the heating material may be heated by induction heating.
  • Induction heating is a process in which an electrically-conductive object is heated by penetrating the object with a varying magnetic field.
  • the heating material may be heated by resistive heating.
  • the heating material is connected to a power supply.
  • the heating may be microwave heating or infrared heating.
  • the heating material is surrounded by the flavour- and/or active-delivering composition.
  • the heating material is in the form of a mesh or a perforated sheet, a strip or ribbon.
  • the heating material is in particulate form.
  • the heating material is a coating on the flavour- and/or active-delivering composition or on the container. It may be preferable for the heating material to be in contact with the flavour- and/or active-delivering composition.
  • the products comprising a container containing the flavour- and/or active-delivering composition may be used in combustible or non-combustible aerosol provision systems.
  • the products are used as a consumable or are included in a consumable.
  • the high concentration of flavour and/ or active provided by the flavour- and/ or activedelivering composition of the present disclosure means that, upon heating, the composition is able to provide an aerosol comprising a high concentration of these desirable components.
  • the small quantity of the composition required means that the aerosol can be generated rapidly once the heating has started, as the mass of composition to be heated is very small.
  • the heating of these compositions is veiy energy efficient as there may be little material in the compositions that does not contribute to the aerosol.
  • a consumable is an article comprising an aerosol-generating material, part or all of which is intended to be consumed during use by a user.
  • aerosol-generating material or at least part of the aerosol -generating material is the flavour- and/or activedelivering composition, and is provided in a container as disclosed herein. Further aerosol-generating material may be provided in the container or elsewhere in the consumable.
  • the flavour- and/or active-delivering composition may be used as or referred to as an aerosol-generating material.
  • a consumable may comprise one or more other components, such as an aerosol- generating material storage area, an aerosol-generating material transfer component, an aerosol generation area, a housing, a wrapper, a mouthpiece, a filter and/or an aerosol-modifying agent.
  • a consumable may also comprise an aerosol generator, such as a heater, that emits heat to cause the aerosol-generating material to generate aerosol in use.
  • the heater may, for example, comprise a material heatable by electrical conduction, or a susceptor.
  • the heater may, in some embodiments, be provided within the container with the flavour- and/or active-delivering composition. In some embodiments, the heater may form part of the container.
  • the permeable nature of the container may assist the transfer heat from a heat source outside the container to the composition held within the container.
  • at least part of the container comprises a thermally conductive material to enhance the heating of the flavour- and/or active-delivering composition held within it.
  • a heating material or heated may be provided in the container with the flavour- and/or active-delivering composition.
  • the consumable may be any shape or size that is appropriate to the aerosol-generating device.
  • the consumable is a rod shape.
  • the container comprising a flavour- and/or active-delivering composition is provided in an aerosol-generating device such as a tobacco-heating product (THP) or hybrid e-cigarette product.
  • an aerosol-generating device such as a tobacco-heating product (THP) or hybrid e-cigarette product.
  • THP tobacco-heating product
  • the container may be used directly as a solid substrate and the container is directly heated without burning to provide an inhalable aerosol.
  • heating the container will first cause the flavour- and/or activedelivering composition to be heated and will volatilise or aerosolise components thereof, including the flavour- and/or active-components that are to be delivered. Then, the aerosolised components, for example the glycerol, nicotine and/ or tobacco flavour, will be released.
  • the delivery systems described herein can be combustible aerosol provision systems or non-combustible aerosol provision systems.
  • the term “delivery system” is intended to encompass systems that deliver at least one substance to a user, and includes: combustible aerosol provision systems, such as cigarettes, cigarillos, cigars, and tobacco for pipes or for roll-your-own or for make-your-own cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes or other smokable material); and non-combustible aerosol provision systems that release compounds from an aerosol-generating material without combusting the aerosol-generating material, such as electronic cigarettes, tobacco heating products, and hybrid systems to generate aerosol using a combination of aerosol-generating materials.
  • combustible aerosol provision systems such as cigarettes, cigarillos, cigars, and tobacco for pipes or for roll-your-own or for make-your-own cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes or other smokable material
  • non-combustible aerosol provision systems that release compounds from an aerosol-generating material without combus
  • a “combustible” aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is combusted or burned during use in order to facilitate deliveiy of at least one substance to a user.
  • the delivery system is a combustible aerosol provision system, such as a system selected from the group consisting of a cigarette, a cigarillo and a cigar.
  • the disclosure relates to a component for use in a combustible aerosol provision system, such as a filter, a filter rod, a filter segment, a tobacco rod, a spill, an aerosol-modifying agent release component such as a capsule, a thread, or a bead, or a paper such as a plug wrap, a tipping paper or a cigarette paper.
  • a “non-combustible” aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is not combusted or burned in order to facilitate delivery of at least one substance to a user.
  • the delivery system is a non-combustible aerosol provision system, such as a powered non-combustible aerosol provision system.
  • the non-combustible aerosol provision system is an electronic cigarette, also known as a vaping device or electronic nicotine delivery system (END), although it is noted that the presence of nicotine in the aerosol-generating material is not a requirement.
  • the non-combustible aerosol provision system is an aerosolgenerating material heating system, also known as a heat-not-burn system.
  • An example of such a system is a tobacco heating system.
  • the non-combustible aerosol provision system may comprise a non- combustible aerosol provision device and a consumable for use with the non- combustible aerosol provision device.
  • the disclosure relates to consumables comprising a container comprising an aerosol-generating material and configured to be used with non- combustible aerosol provision devices. These consumables are sometimes referred to as articles throughout the disclosure.
  • the non-combustible aerosol provision system such as a non- combustible aerosol provision device thereof, may comprise a power source and a controller.
  • the power source may, for example, be an electric power source or an exothermic power source.
  • the exothermic power source comprises a carbon substrate which may be energised so as to distribute power in the form of heat to a composition comprising an aerosol -generating material and a moisture impermeable coating or to a heat transfer material in proximity to the exothermic power source.
  • the non-combustible aerosol provision system may comprise an area or a chamber for receiving the consumable, an aerosol generator, an aerosol generation area, a housing, a mouthpiece, a filter and/or an aerosol -modifying agent.
  • the present invention also relates to a device with a chamber for receiving one or more comsumables.
  • This chamber may, for example, be opened to allow the user to insert the consumable and then closed or sealed to prevent the consumable from falling out of the chamber.
  • the device may comprise a mechanism for holding or gripping the consumable once it is located within a receiving area or chamber of the device.
  • the area or chamber for receiving the consumable may be surrounded by a heat source, so that heat is transferred to the consumable and the aerosol-generating material held therein.
  • heat from another source within the device may be transferred to the consumable within the chamber or area.
  • the consumable for use with the non-combustible aerosol provision device may comprise a composition comprising an aerosol-generating material and a moisture impermeable coating, an aerosol-generating material storage area, an aerosol-generating material transfer component, an aerosol generator, an aerosol generation area, a housing, a wrapper, a filter, a mouthpiece, and/or an aerosolmodifying agent.
  • the substance to be delivered may be an aerosol-generating material provided within a container, and optionally another aerosol-generating material that may or may not be heated.
  • the aerosol-generating material in the container and any other aerosol-generating material may comprise one or more active constituents, one or more flavours, one or more aerosol-former materials, and/or one or more other functional materials.
  • the permeable container containing a flavour- and/or activedelivering composition is used to provide the aerosol-generating material is a tobacco heating system. This may be instead of or in addition to another aerosol-generating material, such as a tobacco composition.
  • the container and or the flavour- and/or active-delivering composition may be heated directly or indirectly to generate an aerosol from the flavour- and/or active-delivering composition.
  • the permeable nature of the container means that this does not need to be removed or opened prior to use.
  • the contents of the container may be sufficient to provide aerosol for a single puff or for a series of puffs.
  • the contents of the container provides 6 to 9 puffs of aerosol when heated.
  • the flavour- and/or activedelivering composition generates an aerosol with a high concentration of flavour and/or active. This can provide an authentic tobacco taste and nicotine delivery.
  • the very small size of the container and the veiy concentrated nature of the flavour- and/or active-delivering composition means that the aerosol provision system may be designed to be small and discreet. As discussed above, the amount of energy required to operate the system is much smaller than the energy required by conventional tobacco heating devices. Further, the aerosol generated is much more satisfying with the high concentration of flavour and/or active.
  • Figure 2 shows a cross-sectional view of an example of a tobacco heating product for heating an aerosol-generating material.
  • the apparatus n has a heating chamber 14 which in use contains the permeable container 13 containing the flavour- and/ or activedelivering composition to be heated and volatilised.
  • the apparatus 11 of Figure 2 further has an electronics/power chamber 16 which may, for example, contain electrical control circuitiy and/or a power source (not shown).
  • the electrical control circuitry may include a controller, such as a microprocessor arrangement, configured and arranged to control the heating of the smokable material via a heating element (not shown).
  • the electrical control circuitry may in use receive a signal from, for example, a puff-actuated sensor which is sensitive to for example changes in pressure or changes in rate of air flow that occur upon initiation of a draw on the apparatus 11 by a user.
  • the electrical control circuitiy can then operate so as to cause heating of the flavour- and/or active-delivering composition “on demand”.
  • a puff-actuated sensor including for example a thermistor, an electro-mechanical device, a mechanical device, an optical device, an opto-mechanical device and a micro electro mechanical systems (MEMS) based sensor.
  • the apparatus may have a manually operable switch for a user to initiate a puff.
  • the heating chamber 14 is contained within the housing 12. There may be a support and/or insulating means (not shown) positioned between the heating chamber 14 and the housing 12, for example to assist in heat -insulating the housing 12 from the heating chamber 14, so that the housing 12 does not become hot or at least too hot to touch during use.
  • the housing 12 includes an inlet 15 through which air is drawn into the apparatus.
  • the housing 12 also includes an outlet 17 at a mouthpiece 18 of the apparatus 11. Air is drawn into the apparatus 11 through the inlet 15, travels through the apparatus and through the container 13, picking up the aerosol released by the flavour- and/ or activedelivering composition. The resulting aerosol generated by the apparatus 11 leaves the apparatus 11 through the outlet 19 and is inhaled by the user.
  • the non-combustible aerosol provision system is a hybrid system to generate aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated and may be a composition comprising an aerosolgenerating material and a moisture impermeable coating.
  • Each of the aerosolgenerating materials may be, for example, in the form of a solid, liquid or gel and may or may not contain nicotine.
  • the hybrid system comprises a liquid or gel aerosol-generating material and a solid aerosol-generating material.
  • the solid aerosol-generating material may comprise, for example, tobacco or a non-tobacco product.
  • the permeable container containing a flavour- and/or activedelivering composition is used in a hybrid system and the flavour- and/or activedelivering composition is heated by a vapour that is generated by the system and is drawn through the permeable container. Additionally or alternatively, the flavour- and/or active-delivering composition may be directly heated by a further heat source. In such embodiments, the flavour- and/ or active-delivering composition adds concentrated flavour and/or active to the aerosol, such as an authentic tobacco taste and nicotine deliveiy.
  • FIG. 3 shows a cross-sectional view of an example of a Hybrid product for heating a flavour- and/or active-delivering composition and a liquid.
  • the apparatus 21 has a housing 22 containing a chamber 24 which in use contains a container containing the flavour- and/or active-delivering composition 23 to be heated and volatilised.
  • the housing 22 also contains a liquid reservoir 25 containing a liquid 26 to be heated to form a vapour.
  • the apparatus 21 further has an electronics/power chamber 27 which may, for example, contain electrical control circuitiy and/or a power source (not shown).
  • the electrical control circuitry may include a controller, such as a microprocessor arrangement, configured and arranged to control the heating of the container 23 and/or its contents, and of the liquid 26 via one or more heating elements (not shown).
  • the electrical control circuitiy may allow the apparatus 21 to be puff-actuated, so as to cause heating “on demand”.
  • the apparatus 22 may have a manually operable switch for a user to initiate a puff.
  • the housing 22 also includes an inlet 28 through which air is drawn into the apparatus.
  • the housing 22 also includes an outlet 29 at a mouthpiece 30 of the apparatus 21. Air is drawn into the apparatus 21 through the inlet 28, travels through the apparatus picking up the vapour created by heating the liquid 26 in the liquid reservoir 25, and flavour and/or active components released by the container 23, and the resulting aerosol generated by the apparatus 21 leaves the apparatus 21 through the outlet 29 and is inhaled by the user.
  • the Hybrid device 21 shown schematically in Figure 3 represents just one possible configuration of such an apparatus.
  • the relative positions of the liquid reservoir 25 and the chamber 24 for holding the container 23 can be changed, as can the path of the air flowing through the apparatus.
  • the liquid reservoir is positioned upstream of the smokable material to be volatilised.
  • the liquid reservoir may be positioned downstream of the smokable material to be volatilised.
  • the two sources of aerosol in the apparatus may be arranged side-by-side, etc.
  • the products comprising a permeable container containing a flavour- and/or activedelivering composition may be used in an aerosol-free deliveiy system or as an aerosol- free delivery system.
  • Aerosol-free delivery systems are those that deliver at least one substance to a user orally, nasally, transdermally or in another way without forming an aerosol, including but not limited to, lozenges, gums, patches, articles comprising inhalable powders, and oral products such as oral tobacco which includes snus or moist snuff, wherein the at least one substance may or may not comprise nicotine.
  • the permeable container is provided in a form such that during oral use, saliva in the mouth of the user enters through the permeable container and contacts the flavour- and/or active-delivering composition.
  • the saliva causes the flavour and/or active components to be released from the flavour- and/or active- delivering composition, and saliva containing the released components is able to pass out of the container, so that they may be perceived in the mouth and/or absorbed into the bloodstream, either via the mucosal membranes in the oral cavity or by being swallowed by the user.
  • the permeable container comprises or consists of a water- permeable pouch.
  • the highly concentrated nature of the flavour- and/or activedelivering composition means that the container can be veiy small, such as a “micro pouch” with dimensions that are smaller than the conventional pouches provided for oral use, such as snus or moist snuff. As a result, these tiny pouches are discreet and can be more comfortable for use. Also, the amount of saliva required to release the flavour and/or active components may be much smaller than in conventional products. This means that the release of the components may be much faster, providing a more rapid effect for the user.
  • the release of the components may commence as soon as within less than about 5 minutes, less than about 4 minutes, less than about 3 minutes, less than about 2 minutes, less than about 1 minute, or less than about 30 seconds from placing the product in the mouth. Further, use of the product may, in some embodiments, be much more satisfying with the high concentration of flavour and/or active.
  • the container holds not only the flavour- and/or activedelivering composition but also an additional flavour and/or active source, such as a tobacco formulation.
  • the tobacco formulation may be a formulation similar to one used in know oral tobacco products.
  • the flavour- and/or activedelivering composition provides an additional release of flavour and/or active component(s), in addition to the components delivered by the tobacco formulation.
  • the flavour- and/or active-delivering composition may provide an initial “hit” of flavour and/or active, in advance of the slower and more sustained release form the tobacco formulation.
  • the product comprises a moisture impermeable coating that surrounds but which may be separate from the flavour- and/or active-delivering composition.
  • the moisture impermeable coating may surround the flavour- and/or active-delivering composition.
  • the moisture impermeable coating may be provided as a film or wrapper, optionally being deposited on a moisture permeable carrier.
  • the product comprises a sorbent or desiccant material. The sorbent or desiccant material may be provided in the flavour- and/or active-delivering composition as discussed above.
  • these components may be provided separately in the product, but in such a manner that the sorbent still competes with the flavour- and/or active-delivering composition for the moisture in the environment and therefore reduces the amount of moisture absorbed by the flavour- and/ or activedelivering composition.
  • the sorbent may be provided in or on a wrapper that surrounds the flavour- and/or active-delivering composition in the product.
  • the sorbent may be incorporated into a separate section of the product to the flavour- and/or active-delivering composition. Where the product is to be heated to generate an aerosol, this may have the benefit of reducing the exposure of the sorbent to the high temperatures that the aerosol-generating material is heated to upon use.
  • the sorbent may be located in an adjacent section of the product which is not directly heated. This may be downstream or upstream of the aerosol-generating material. In some embodiments, the sorbent is included in one or more sections of the product that does not include the aerosol-generating material, such as a cooling element section, or a filter section.
  • the sorbent may be separated or removed from the flavour- and/or active-delivering composition and/or from the product before it is used.
  • the sorbent may be located in the packaging within which the product is held prior to use. In some embodiments, this packaging may be a wrapper, a box or other container.
  • the sorbent may be incorporated into the packaging material or part thereof.
  • the sorbent may be provided in a separate article, such as a sachet or sheet, located with the product within the packaging.
  • the invention enjoys the advantage of longer shelflife than other tobacco extracts.
  • the nicotine content of the precursor and flavour- and/or active-delivering composition after the freeze drying process has been calculated, providing an indication of the amount of nicotine retained following the processing.
  • the nicotine recovery of the dried flavour- and/or active-delivering composition is at least about 76 wt% on a dry weight basis.
  • the nicotine recoveiy of the dried flavour- and/or active-delivering composition compared to the original tobacco extract maybe at least about 60%, at least about 70%, at least about 75%, at least about 80%, or at least about 90% on a dry weight basis.
  • the glycerol content of the precursor and dried flavour- and/or active-delivering composition after the freeze drying process has been calculated, providing an indication of the amount of glycerol retained following the processing.
  • the glycerol recoveiy of the dried flavour- and/ or active-delivering composition is at least about 85%.
  • the glycerol recovery of the dried flavour- and/or active-delivering composition compared to the precursor material may be at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90% at least about 95% on a dry weight basis.
  • the precursor material comprised essentially of aqueous tobacco extract, and glycerol.
  • the aqueous tobacco extract was diluted further with glycerol up to about 24 wt% (calculated on a dry weight basis).
  • the Burley aqueous tobacco extract had a tobacco solid content of about 40 wt%, and a water content of about 60 wt%.
  • the precursor material was dried via freeze drying.
  • the precursor material comprised essentially of aqueous tobacco extract, glycerol and Dextran 70.
  • the glycerol content was about o to about 15 v/v%, or up to about 36 wt% calculated on a diy weight basis.
  • the precursor material was dried via freeze drying.
  • Example 3 The freeze-dried material of Example 1 or Example 2 is ground to provide a loose powder with an average size of from about 10 pm to about 50 pm. 50 mg of the powder is then placed in a fleece pouch to provide an oral product for releasing the flavour- and/or active upon contact with salvia in the user’s mouth.
  • Example 4 The freeze-dried aerosol-generating material of Example 1 or Example 2 is ground to provide a loose powder with an average size of from about 500 pm to about 1000 pm. 200 mg of the powder is then placed in a permeable pod, together with a susceptor comprising a metal mesh to provide a consumable for use in an aerosol generation system to provide aerosol for a series of puff or sessions of puffs.

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Abstract

L'invention concerne un produit comprenant un récipient perméable contenant une composition de distribution d'arôme et/ou d'agent actif comprenant un extrait séché obtenu à partir d'un matériau végétal contenant un arôme et/ou un agent actif. Les produits peuvent être utilisés pour générer un aérosol ou peuvent être destinés à une utilisation orale. L'invention concerne également des systèmes de distribution comprenant les produits, et des procédés de fourniture des produits.
PCT/GB2023/050864 2022-04-01 2023-03-31 Produit comprenant un récipient perméable et un extrait séché à partir d'un matériau végétal et ses utilisations WO2023187412A1 (fr)

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GB2204840.9 2022-04-01
GBGB2204840.9A GB202204840D0 (en) 2022-04-01 2022-04-01 A product comprising a permeable container and a dried extract from a plant material and uses thereof

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2048976B1 (fr) * 2006-08-01 2010-12-01 R. J. Reynolds Tobacco Company Tabac sans fumée
US20170157106A1 (en) * 2015-12-03 2017-06-08 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
EP2173200B1 (fr) * 2007-07-23 2017-11-15 R.J.Reynolds Tobacco Company Composition de tabac sans fumée, et procédés pour traiter le tabac destiné à y être utilisé
US20200359703A1 (en) * 2019-05-17 2020-11-19 Rai Strategic Holdings, Inc. Age verification with registered cartridges for an aerosol delivery device
US20210352954A1 (en) * 2006-10-18 2021-11-18 Rai Strategic Holdings, Inc. Tobacco-containing smoking article

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2048976B1 (fr) * 2006-08-01 2010-12-01 R. J. Reynolds Tobacco Company Tabac sans fumée
US20210352954A1 (en) * 2006-10-18 2021-11-18 Rai Strategic Holdings, Inc. Tobacco-containing smoking article
EP2173200B1 (fr) * 2007-07-23 2017-11-15 R.J.Reynolds Tobacco Company Composition de tabac sans fumée, et procédés pour traiter le tabac destiné à y être utilisé
US20170157106A1 (en) * 2015-12-03 2017-06-08 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20200359703A1 (en) * 2019-05-17 2020-11-19 Rai Strategic Holdings, Inc. Age verification with registered cartridges for an aerosol delivery device

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