IL293169A - Consumable comprising two different aerosol-generating materials for non-combustible aerosol provision device - Google Patents
Consumable comprising two different aerosol-generating materials for non-combustible aerosol provision deviceInfo
- Publication number
- IL293169A IL293169A IL293169A IL29316922A IL293169A IL 293169 A IL293169 A IL 293169A IL 293169 A IL293169 A IL 293169A IL 29316922 A IL29316922 A IL 29316922A IL 293169 A IL293169 A IL 293169A
- Authority
- IL
- Israel
- Prior art keywords
- aerosol
- amorphous solid
- generating material
- acid
- consumable
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims description 512
- 239000000443 aerosol Substances 0.000 title claims description 116
- 239000007787 solid Substances 0.000 claims description 385
- 239000013543 active substance Substances 0.000 claims description 161
- 239000000796 flavoring agent Substances 0.000 claims description 145
- 239000002253 acid Substances 0.000 claims description 142
- 239000003349 gelling agent Substances 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 61
- 238000004519 manufacturing process Methods 0.000 claims description 14
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002002 slurry Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 125000000524 functional group Chemical group 0.000 claims description 7
- 239000005711 Benzoic acid Substances 0.000 claims description 6
- 235000010233 benzoic acid Nutrition 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 238000000151 deposition Methods 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 238000001816 cooling Methods 0.000 description 59
- 241000208125 Nicotiana Species 0.000 description 39
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 39
- 238000010438 heat treatment Methods 0.000 description 37
- 238000009423 ventilation Methods 0.000 description 34
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 33
- 229960002715 nicotine Drugs 0.000 description 33
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 33
- 239000003795 chemical substances by application Substances 0.000 description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- 239000000945 filler Substances 0.000 description 19
- 239000000123 paper Substances 0.000 description 17
- 235000019634 flavors Nutrition 0.000 description 15
- 235000010443 alginic acid Nutrition 0.000 description 14
- 229920000615 alginic acid Polymers 0.000 description 14
- 239000000284 extract Substances 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 13
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 229940072056 alginate Drugs 0.000 description 12
- 239000000499 gel Substances 0.000 description 11
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 10
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 description 10
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 description 10
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 description 10
- 229950011318 cannabidiol Drugs 0.000 description 10
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 description 10
- 239000011888 foil Substances 0.000 description 10
- 235000011187 glycerol Nutrition 0.000 description 9
- 229960005150 glycerol Drugs 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000000470 constituent Substances 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 7
- 235000002899 Mentha suaveolens Nutrition 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 6
- 235000004357 Mentha x piperita Nutrition 0.000 description 6
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 6
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 6
- 244000269722 Thea sinensis Species 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 235000010980 cellulose Nutrition 0.000 description 6
- 229920002678 cellulose Polymers 0.000 description 6
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 6
- 229960004242 dronabinol Drugs 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 6
- 239000012212 insulator Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 235000010987 pectin Nutrition 0.000 description 6
- 229920001277 pectin Polymers 0.000 description 6
- 239000001814 pectin Substances 0.000 description 6
- 235000006679 Mentha X verticillata Nutrition 0.000 description 5
- 235000014749 Mentha crispa Nutrition 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- -1 but not limited to Substances 0.000 description 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- AAXZFUQLLRMVOG-UHFFFAOYSA-N 2-methyl-2-(4-methylpent-3-enyl)-7-propylchromen-5-ol Chemical compound C1=CC(C)(CCC=C(C)C)OC2=CC(CCC)=CC(O)=C21 AAXZFUQLLRMVOG-UHFFFAOYSA-N 0.000 description 4
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 4
- 241000218236 Cannabis Species 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 4
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 4
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 4
- 240000004160 Capsicum annuum Species 0.000 description 4
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 4
- 244000018436 Coriandrum sativum Species 0.000 description 4
- 244000163122 Curcuma domestica Species 0.000 description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 description 4
- 229920002907 Guar gum Polymers 0.000 description 4
- 229920000084 Gum arabic Polymers 0.000 description 4
- 235000014435 Mentha Nutrition 0.000 description 4
- 241001072983 Mentha Species 0.000 description 4
- 244000246386 Mentha pulegium Species 0.000 description 4
- 235000016257 Mentha pulegium Nutrition 0.000 description 4
- 235000009421 Myristica fragrans Nutrition 0.000 description 4
- 235000012550 Pimpinella anisum Nutrition 0.000 description 4
- 240000004760 Pimpinella anisum Species 0.000 description 4
- 235000010489 acacia gum Nutrition 0.000 description 4
- 239000000205 acacia gum Substances 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 235000010216 calcium carbonate Nutrition 0.000 description 4
- 239000004281 calcium formate Substances 0.000 description 4
- 235000019255 calcium formate Nutrition 0.000 description 4
- 229940044172 calcium formate Drugs 0.000 description 4
- 235000009120 camo Nutrition 0.000 description 4
- 229920002301 cellulose acetate Polymers 0.000 description 4
- 239000000919 ceramic Substances 0.000 description 4
- 235000005607 chanvre indien Nutrition 0.000 description 4
- ZDJFDFNNEAPGOP-UHFFFAOYSA-N dimethyl tetradecanedioate Chemical compound COC(=O)CCCCCCCCCCCCC(=O)OC ZDJFDFNNEAPGOP-UHFFFAOYSA-N 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 239000002657 fibrous material Substances 0.000 description 4
- 239000000665 guar gum Substances 0.000 description 4
- 235000010417 guar gum Nutrition 0.000 description 4
- 229960002154 guar gum Drugs 0.000 description 4
- 239000011487 hemp Substances 0.000 description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229920000609 methyl cellulose Polymers 0.000 description 4
- 235000010981 methylcellulose Nutrition 0.000 description 4
- 239000001923 methylcellulose Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- 229960004063 propylene glycol Drugs 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- 150000005846 sugar alcohols Polymers 0.000 description 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 240000006914 Aspalathus linearis Species 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 3
- 244000131522 Citrus pyriformis Species 0.000 description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
- 244000004281 Eucalyptus maculata Species 0.000 description 3
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 3
- 240000006927 Foeniculum vulgare Species 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 235000008227 Illicium verum Nutrition 0.000 description 3
- 240000007232 Illicium verum Species 0.000 description 3
- 244000078639 Mentha spicata Species 0.000 description 3
- 241001479543 Mentha x piperita Species 0.000 description 3
- 235000009470 Theobroma cacao Nutrition 0.000 description 3
- 244000299461 Theobroma cacao Species 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000003557 cannabinoid Substances 0.000 description 3
- 229930003827 cannabinoid Natural products 0.000 description 3
- 239000011111 cardboard Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 235000019504 cigarettes Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 235000001050 hortel pimenta Nutrition 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000001771 mentha piperita Substances 0.000 description 3
- 229940041616 menthol Drugs 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- RBEAVAMWZAJWOI-MTOHEIAKSA-N (5as,6s,9r,9ar)-6-methyl-3-pentyl-9-prop-1-en-2-yl-7,8,9,9a-tetrahydro-5ah-dibenzofuran-1,6-diol Chemical compound C1=2C(O)=CC(CCCCC)=CC=2O[C@H]2[C@@H]1[C@H](C(C)=C)CC[C@]2(C)O RBEAVAMWZAJWOI-MTOHEIAKSA-N 0.000 description 2
- ZROLHBHDLIHEMS-HUUCEWRRSA-N (6ar,10ar)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCC)=CC(O)=C3[C@@H]21 ZROLHBHDLIHEMS-HUUCEWRRSA-N 0.000 description 2
- IXJXRDCCQRZSDV-GCKMJXCFSA-N (6ar,9r,10as)-6,6,9-trimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydro-6h-1,9-epoxybenzo[c]chromene Chemical compound C1C[C@@H](C(O2)(C)C)[C@@H]3C[C@]1(C)OC1=C3C2=CC(CCCCC)=C1 IXJXRDCCQRZSDV-GCKMJXCFSA-N 0.000 description 2
- YJYIDZLGVYOPGU-XNTDXEJSSA-N 2-[(2e)-3,7-dimethylocta-2,6-dienyl]-5-propylbenzene-1,3-diol Chemical compound CCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 YJYIDZLGVYOPGU-XNTDXEJSSA-N 0.000 description 2
- KOCVACNWDMSLBM-UHFFFAOYSA-N 4-(Ethoxymethyl)-2-methoxyphenol Chemical compound CCOCC1=CC=C(O)C(OC)=C1 KOCVACNWDMSLBM-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241001280436 Allium schoenoprasum Species 0.000 description 2
- 235000001270 Allium sibiricum Nutrition 0.000 description 2
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 2
- 240000001851 Artemisia dracunculus Species 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 2
- KASVLYINZPAMNS-UHFFFAOYSA-N Cannabigerol monomethylether Natural products CCCCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(OC)=C1 KASVLYINZPAMNS-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 235000009467 Carica papaya Nutrition 0.000 description 2
- 240000006432 Carica papaya Species 0.000 description 2
- 229920008347 Cellulose acetate propionate Polymers 0.000 description 2
- 240000003538 Chamaemelum nobile Species 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- 240000007154 Coffea arabica Species 0.000 description 2
- 235000002787 Coriandrum sativum Nutrition 0.000 description 2
- 235000001543 Corylus americana Nutrition 0.000 description 2
- 240000007582 Corylus avellana Species 0.000 description 2
- 235000007466 Corylus avellana Nutrition 0.000 description 2
- 235000015655 Crocus sativus Nutrition 0.000 description 2
- 244000124209 Crocus sativus Species 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
- 235000007129 Cuminum cyminum Nutrition 0.000 description 2
- 244000304337 Cuminum cyminum Species 0.000 description 2
- 235000014375 Curcuma Nutrition 0.000 description 2
- 235000003392 Curcuma domestica Nutrition 0.000 description 2
- 240000004784 Cymbopogon citratus Species 0.000 description 2
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 description 2
- ZROLHBHDLIHEMS-UHFFFAOYSA-N Delta9 tetrahydrocannabivarin Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCC)=CC(O)=C3C21 ZROLHBHDLIHEMS-UHFFFAOYSA-N 0.000 description 2
- VZWGRQBCURJOMT-UHFFFAOYSA-N Dodecyl acetate Chemical compound CCCCCCCCCCCCOC(C)=O VZWGRQBCURJOMT-UHFFFAOYSA-N 0.000 description 2
- 240000002943 Elettaria cardamomum Species 0.000 description 2
- MWAYRGBWOVHDDZ-UHFFFAOYSA-N Ethyl vanillate Chemical compound CCOC(=O)C1=CC=C(O)C(OC)=C1 MWAYRGBWOVHDDZ-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 240000001238 Gaultheria procumbens Species 0.000 description 2
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 2
- 241000208152 Geranium Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 235000005206 Hibiscus Nutrition 0.000 description 2
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 2
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- 241000721662 Juniperus Species 0.000 description 2
- 235000013628 Lantana involucrata Nutrition 0.000 description 2
- 240000005183 Lantana involucrata Species 0.000 description 2
- 235000017858 Laurus nobilis Nutrition 0.000 description 2
- 244000165082 Lavanda vera Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- 235000004431 Linum usitatissimum Nutrition 0.000 description 2
- 240000006240 Linum usitatissimum Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 2
- 235000010654 Melissa officinalis Nutrition 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 244000182807 Mentha suaveolens Species 0.000 description 2
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 2
- 244000179970 Monarda didyma Species 0.000 description 2
- 235000010672 Monarda didyma Nutrition 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 244000270834 Myristica fragrans Species 0.000 description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 description 2
- 240000005125 Myrtus communis Species 0.000 description 2
- 235000013418 Myrtus communis Nutrition 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 241001529734 Ocimum Species 0.000 description 2
- 240000004737 Ocimum americanum Species 0.000 description 2
- 235000010676 Ocimum basilicum Nutrition 0.000 description 2
- 235000004195 Ocimum x citriodorum Nutrition 0.000 description 2
- 240000007817 Olea europaea Species 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 2
- 240000000783 Origanum majorana Species 0.000 description 2
- 244000124853 Perilla frutescens Species 0.000 description 2
- 235000016374 Perilla frutescens var crispa Nutrition 0.000 description 2
- 235000015640 Perilla frutescens var frutescens Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 229920001131 Pulp (paper) Polymers 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 235000011552 Rhamnus crocea Nutrition 0.000 description 2
- 235000001466 Ribes nigrum Nutrition 0.000 description 2
- 241001312569 Ribes nigrum Species 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 240000000513 Santalum album Species 0.000 description 2
- 235000008632 Santalum album Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 2
- 244000125380 Terminalia tomentosa Species 0.000 description 2
- 235000006468 Thea sinensis Nutrition 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 description 2
- 240000000851 Vaccinium corymbosum Species 0.000 description 2
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 2
- 235000013832 Valeriana officinalis Nutrition 0.000 description 2
- 244000126014 Valeriana officinalis Species 0.000 description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 description 2
- 244000263375 Vanilla tahitensis Species 0.000 description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 2
- 241000759263 Ventia crocea Species 0.000 description 2
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 2
- 240000001519 Verbena officinalis Species 0.000 description 2
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 2
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 2
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 235000020279 black tea Nutrition 0.000 description 2
- 235000021014 blueberries Nutrition 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- YJYIDZLGVYOPGU-UHFFFAOYSA-N cannabigeroldivarin Natural products CCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(O)=C1 YJYIDZLGVYOPGU-UHFFFAOYSA-N 0.000 description 2
- 239000001511 capsicum annuum Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 235000005300 cardamomo Nutrition 0.000 description 2
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 235000019506 cigar Nutrition 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 235000016213 coffee Nutrition 0.000 description 2
- 235000013353 coffee beverage Nutrition 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 235000003373 curcuma longa Nutrition 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- IZMOTZDBVPMOFE-UHFFFAOYSA-N dimethyl dodecanedioate Chemical compound COC(=O)CCCCCCCCCCC(=O)OC IZMOTZDBVPMOFE-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000003571 electronic cigarette Substances 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 235000008995 european elder Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 235000013773 glyceryl triacetate Nutrition 0.000 description 2
- 239000001087 glyceryl triacetate Substances 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- 229940040102 levulinic acid Drugs 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 235000011477 liquorice Nutrition 0.000 description 2
- 239000001115 mace Substances 0.000 description 2
- 239000008204 material by function Substances 0.000 description 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 2
- 229960003987 melatonin Drugs 0.000 description 2
- 239000001220 mentha spicata Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 239000001702 nutmeg Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000012766 organic filler Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 2
- 239000004248 saffron Substances 0.000 description 2
- 235000013974 saffron Nutrition 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 239000002594 sorbent Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 229960002920 sorbitol Drugs 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 2
- 229960002622 triacetin Drugs 0.000 description 2
- 235000013976 turmeric Nutrition 0.000 description 2
- 235000016788 valerian Nutrition 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- QGDOQULISIQFHQ-UHFFFAOYSA-N 1,3,7,9-tetramethyluric acid Chemical compound CN1C(=O)N(C)C(=O)C2=C1N(C)C(=O)N2C QGDOQULISIQFHQ-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical group CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 235000003320 Adansonia digitata Nutrition 0.000 description 1
- 244000056971 Adansonia gregorii Species 0.000 description 1
- 235000003319 Adansonia gregorii Nutrition 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229910017083 AlN Inorganic materials 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 239000009405 Ashwagandha Substances 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- UVOLYTDXHDXWJU-UHFFFAOYSA-N Cannabichromene Chemical compound C1=CC(C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-UHFFFAOYSA-N 0.000 description 1
- REOZWEGFPHTFEI-JKSUJKDBSA-N Cannabidivarin Chemical compound OC1=CC(CCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 REOZWEGFPHTFEI-JKSUJKDBSA-N 0.000 description 1
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 240000007681 Catha edulis Species 0.000 description 1
- 235000006696 Catha edulis Nutrition 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 235000006025 Durio zibethinus Nutrition 0.000 description 1
- 240000000716 Durio zibethinus Species 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004348 Glyceryl diacetate Substances 0.000 description 1
- 244000267823 Hydrangea macrophylla Species 0.000 description 1
- 235000014486 Hydrangea macrophylla Nutrition 0.000 description 1
- 235000018481 Hylocereus undatus Nutrition 0.000 description 1
- 244000157072 Hylocereus undatus Species 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 244000255365 Kaskarillabaum Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 240000000759 Lepidium meyenii Species 0.000 description 1
- 235000000421 Lepidium meyenii Nutrition 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241000768444 Magnolia obovata Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 235000016278 Mentha canadensis Nutrition 0.000 description 1
- 244000245214 Mentha canadensis Species 0.000 description 1
- 241000531303 Mentha x rotundifolia Species 0.000 description 1
- 235000009665 Mentha x villosa Nutrition 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- IGHTZQUIFGUJTG-QSMXQIJUSA-N O1C2=CC(CCCCC)=CC(O)=C2[C@H]2C(C)(C)[C@@H]3[C@H]2[C@@]1(C)CC3 Chemical compound O1C2=CC(CCCCC)=CC(O)=C2[C@H]2C(C)(C)[C@@H]3[C@H]2[C@@]1(C)CC3 IGHTZQUIFGUJTG-QSMXQIJUSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000000556 Paullinia cupana Nutrition 0.000 description 1
- 240000003444 Paullinia cupana Species 0.000 description 1
- MIYFJEKZLFWKLZ-UHFFFAOYSA-N Phenylmethyl benzeneacetate Chemical compound C=1C=CC=CC=1COC(=O)CC1=CC=CC=C1 MIYFJEKZLFWKLZ-UHFFFAOYSA-N 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000008180 Piper betle Nutrition 0.000 description 1
- 240000008154 Piper betle Species 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 244000299790 Rheum rhabarbarum Species 0.000 description 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N Tetraethylene glycol, Natural products OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- 240000000143 Turnera diffusa Species 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 244000002783 Vanda tricolor Species 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 102100029469 WD repeat and HMG-box DNA-binding protein 1 Human genes 0.000 description 1
- 101710097421 WD repeat and HMG-box DNA-binding protein 1 Proteins 0.000 description 1
- 244000195452 Wasabia japonica Species 0.000 description 1
- 235000000760 Wasabia japonica Nutrition 0.000 description 1
- 235000001978 Withania somnifera Nutrition 0.000 description 1
- 240000004482 Withania somnifera Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 235000019647 acidic taste Nutrition 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 150000004716 alpha keto acids Chemical class 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- OJIJEKBXJYRIBZ-UHFFFAOYSA-N cadmium nickel Chemical compound [Ni].[Cd] OJIJEKBXJYRIBZ-UHFFFAOYSA-N 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 description 1
- 229940065144 cannabinoids Drugs 0.000 description 1
- SVTKBAIRFMXQQF-UHFFFAOYSA-N cannabivarin Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCC)C=C3OC(C)(C)C2=C1 SVTKBAIRFMXQQF-UHFFFAOYSA-N 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- HKQOBOMRSSHSTC-UHFFFAOYSA-N cellulose acetate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 HKQOBOMRSSHSTC-UHFFFAOYSA-N 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 235000020057 cognac Nutrition 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- PEUGOJXLBSIJQS-UHFFFAOYSA-N diethyl octanedioate Chemical compound CCOC(=O)CCCCCCC(=O)OCC PEUGOJXLBSIJQS-UHFFFAOYSA-N 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 150000007520 diprotic acids Chemical class 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012765 fibrous filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000013531 gin Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000019443 glyceryl diacetate Nutrition 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000010903 husk Substances 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000012902 lepidium meyenii Nutrition 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 150000007518 monoprotic acids Chemical class 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 229910001120 nichrome Inorganic materials 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000011087 paperboard Substances 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000010451 perlite Substances 0.000 description 1
- 235000019362 perlite Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001296 polysiloxane Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 235000013533 rum Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000019794 sodium silicate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 235000021092 sugar substitutes Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 235000013529 tequila Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 210000003901 trigeminal nerve Anatomy 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- 150000007521 triprotic acids Chemical class 0.000 description 1
- 235000004952 turnera diffusa Nutrition 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 235000019354 vermiculite Nutrition 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- DBRXOUCRJQVYJQ-CKNDUULBSA-N withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/12—Chemical features of tobacco products or tobacco substitutes of reconstituted tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/183—Treatment of tobacco products or tobacco substitutes sterilization, preservation or biological decontamination
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24C—MACHINES FOR MAKING CIGARS OR CIGARETTES
- A24C5/00—Making cigarettes; Making tipping materials for, or attaching filters or mouthpieces to, cigars or cigarettes
- A24C5/01—Making cigarettes for simulated smoking devices
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/20—Cigarettes specially adapted for simulated smoking devices
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/20—Devices using solid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Manufacture Of Tobacco Products (AREA)
- Cigarettes, Filters, And Manufacturing Of Filters (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
WO 2021/105449 PCT/EP2020/083764 CONSUMABLE COMPRISING TWO DIFFERENT AEROSOL-GENERATING MATERIALS FOR NON-COMBUSTIBLE AEROSOL PROVISION DEVICE Technical FieldThe present invention relates to consumables for use with a non- combustible aerosol provision device, the consumables comprising an aerosol- generating material comprising an amorphous solid.
BackgroundSmoking consumables such as cigarettes, cigars and the like bum tobacco during use to create tobacco smoke. Alternatives to these types of consumables release an inhalable aerosol or vapour by releasing compounds from a substrate material by heating without burning. These may be referred to as non-combustible smoking consumables or aerosol generating assemblies.
One example of such a product is a heating device which releases compounds by heating, but not burning, a solid aerosol-generating material. This solid aerosol- generating material may, in some cases, comprise a tobacco material. The heating volatilises at least one component of the material, typically forming an inhalable aerosol. These products may be referred to as heat-not-bum devices, tobacco heating devices or tobacco heating products. Various different arrangements for volatilising at least one component of the solid aerosol-generating material are known.
As another example, there are hybrid devices. These comprise a liquid source (which may or may not comprise nicotine) which is vaporised by heating to produce an inhalable vapour or aerosol. The device additionally comprises a solid aerosol- generating material (which may or may not comprise a tobacco material) and components of this material are entrained in the inhalable vapour or aerosol to produce the inhaled medium.
SummaryThe invention provides a consumable for use with a non-combustible aerosol provision device, the consumable comprising: WO 2021/105449 PCT/EP2020/083764 a first aerosol-generating material; anda second aerosol-generating material,wherein each of the first and second aerosol-generating materials comprise an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material has a composition different from a composition of the amorphous solid of the second aerosol-generating material.
The invention also provides a method of manufacturing a consumable for use with a non-combustible aerosol provision device, the method comprising:providing a support;depositing on the support at least two discrete portions of slurry comprising a gelling agent, an aerosol former material and at least one of an active substance, flavourant and an acid;drying the at least two discrete portions of slurry to provide a first aerosol- generating material and a second aerosol-generating material, wherein the first and second aerosol-generating materials are attached to the support;forming the consumable;wherein each of the first and second aerosol-generating materials comprise an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material has a composition different from a composition of the amorphous solid of the second aerosol-generating material.
In a further aspect of the invention, there is provided a non-combustible aerosol provision system comprising a consumable of the invention and a non-combustible WO 2021/105449 PCT/EP2020/083764 aerosol provision device, the non-combustible aerosol provision device comprising an aerosol-generation device arranged to generate aerosol from the consumable when the consumable is used with the non-combustible aerosol provision device.
The invention also pertains to a use of a consumable as described herein in a non-combustible aerosol provision device, wherein the device is arranged to generate aerosol from the consumable when the consumable is used with the non-combustible aerosol provision device.
Further features and advantages of the invention will become apparent from the following description of preferred embodiments of the invention, given by way of example only, which is made with reference to the accompanying drawings.
Brief Description of the DrawingsFigure 1 shows a section view of an example of a consumable.Figure 2 shows a perspective view of the consumable of Figure 1.Figure 3 shows a sectional elevation of an example of a consumable.Figure 4 shows a perspective view of the consumable of Figure 3.Figure 5 shows a perspective view of an example of a non-combustible aerosol provision system.Figure 6 shows a section view of an example of a non-combustible aerosol provision system.Figure 7 shows a perspective view of an example of a non-combustible aerosol provision system.
Detailed DescriptionAs discussed above, one aspect of the invention provides a consumable for use with a non-combustible aerosol provision device, the consumable comprising:a first aerosol-generating material; anda second aerosol-generating material,wherein each of the first and second aerosol-generating materials comprises an amorphous solid, the amorphous solid comprising: WO 2021/105449 PCT/EP2020/083764 - 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material has a composition different from a composition of the amorphous solid of the second aerosol-generating material.
In this aspect of the invention the percentage by weight of the at least one active substance, flavourant and acid represents the combined total weight of any combination of active substance, flavourant and acid described herein.
In one embodiment the amorphous solid of the first aerosol-generating material comprises the active substance and the amorphous solid of the second aerosol- generating material comprises the flavourant. In certain such cases, the amorphous solid of the first aerosol-generating material is free from the flavourant and the acid. In some embodiments the amorphous solid of the first aerosol-generating material does not comprise the flavourant contained in the second aerosol-generating material and does not comprise the acid. In other embodiments the amorphous solid of the first aerosol-generating material also comprises the flavourant and/or the acid. In some cases, the amorphous solid of the second aerosol-generating material is free from the active substance and the acid. In some embodiments the amorphous solid of the second aerosol-generating material does not comprise the active substance contained in the first aerosol-generating material and does not comprise the acid. In alternative embodiments, the amorphous solid of the second aerosol-generating material also comprises the active substance and/or the acid.
WO 2021/105449 PCT/EP2020/083764 In these embodiments, the amorphous solid of the first aerosol-generating material, comprising the active substance comprises:- 0.5-60 wt% of a gelling agent;- 5-80 wt% of an aerosol-former material; and - 0.1 -60 wt% of at least one active substance, wherein these weights are calculated on a dry weight basis.
In this embodiment, the amorphous solid of the first aerosol-generating material may have the following composition provided as percentages of the total dry weight, i.e., dry weight basis (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-former material in an amount of from about 10wt% to about 70wt%, or from about 20wt% to about 60wt%, or from about 25wt% to about 40wt% (all calculated on a dry weight basis), the active substance in an amount of from about 0.5 wt% to about 50 wt%, or from about 1 wt% to 40 wt%, or from about 2 wt% to about 30 wt%, or from about 5 wt% to about 20 wt %, or from about 2 wt% to about wt%. Suitably, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 20wt% to about 60wt%; and the active substance in an amount of from about 0.1 wt% to about 10 wt%. In some of these embodiments the amorphous solid of the first aerosol-generating material is free from the flavourant contained in the second aerosol-generating material and the acid. In alternative embodiments, the amorphous solid of the first aerosol-generating material also comprises the flavourant and/or the acid.
In this embodiment, the amorphous solid of the second aerosol-generating material, comprising the flavourant comprises:- 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and - 5-60 wt% of the flavourant,wherein these weights are calculated on a dry weight basis; WO 2021/105449 PCT/EP2020/083764 In this embodiment, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-form er material in an amount of from about 10wt% to about 70wt%, or from about 20wt% to about 60wt%, or from about 25wt% to about 40wt% (all calculated on a dry weight basis), flavourant in an amount of from about 10wt% to about 50wt%, or from about 20wt% to 40wt%, or from about 25wt% to about 30wt%. Suitably, the amorphous solid of the second aerosol- generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 10wt% to about 40wt%; and the flavourant in an amount of from about 20 wt% to about 50 wt%. In some embodiments the amorphous solid of the second aerosol-generating material is free from the active substance contained in the amorphous solid of the first aerosol-generating material, and the acid. In some embodiments, the amorphous solid of the second aerosol-generating material also comprises the active substance and/or the acid.
In a further embodiment, the amorphous solid of the first aerosol-generating material comprises the active substance and the amorphous solid of the second aerosol- generating material comprises the acid. In certain such embodiments the amorphous solid of the first aerosol-generating material is free from the flavourant and the acid. In some embodiments, the amorphous solid of the first aerosol-generating material does not comprise the acid contained in the second aerosol-generating material and does not comprise the flavourant. In other embodiments the amorphous solid of the first aerosol- generating material also comprises the acid and/or the flavourant. In certain such embodiments the amorphous solid of the second aerosol-generating material is free from the active substance and the flavourant. In some embodiments, the amorphous solid of the second aerosol-generating material does not comprise the active substance contained in the first aerosol-generating material and does not comprise the flavourant. In other embodiments the amorphous solid of the second aerosol-generating material also comprises the active substance and/or the flavourant.
WO 2021/105449 PCT/EP2020/083764 In this embodiment, the amorphous solid of the first aerosol-generating material, comprising the active substance comprises:- 0.5-60 wt% of a gelling agent;- 5-80 wt% of an aerosol-former material; and - 0.1 -60 wt% of at least one active substance, wherein these weights are calculated on a dry weight basis.
In this embodiment, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-former material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the active substance in an amount of from about 1 wt% to about 50 wt%, or from about 2 wt% to 40 wt%, or from about wt% to about 30 wt%. Suitably, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 20wt% to about 60wt%; and the active substance in an amount of from about 0.1 wt% to about 10 wt%. In some embodiments the amorphous solid of the first aerosol-generating material is free from the acid and the flavourant. In alternative embodiments, the amorphous solid of the first aerosol- generating material also comprises the flavourant and/or the acid.
In this embodiment, the amorphous solid of the second aerosol-generating material, comprising the acid, comprises:- 0.5-60 wt% of the gelling agent;- 5-80 wt% of the aerosol-former material; and- 0.1 -10 wt% of the acid,wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the second aerosol-generating material may have the following composition (calculated on a dry weight basis): the WO 2021/105449 PCT/EP2020/083764 gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-form er material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the acid in an amount of from about 0.1 wt% to about 8 wt%, or from about 0.5wt% to 7wt%, or from about lwt% to about 5wt%, or form about lwt% to about 3wt%. Suitably, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 40wt% to about 70wt%; the aerosol-former material in an amount of from about 20wt% to about 50wt%; and the acid in an amount of from about 0.1 wt% to about 5 wt%. In some embodiments the amorphous solid of the second aerosol- generating material is free from the active substance and the flavourant. In alternative embodiments, the amorphous solid of the second aerosol-generating material also comprises the active substance and/or the flavourant.
In a still further embodiment, the amorphous solid of the first aerosol-generating material comprises the flavourant and the amorphous solid of the second aerosol- generating material comprises the acid. In certain such embodiments, the amorphous solid of the first aerosol-generating material is free from the acid and the active substance. In some embodiments, the amorphous solid of the first aerosol-generating material does not comprise the acid contained in the second aerosol-generating material and does not comprise the active substance. In other embodiments the amorphous solid of the first aerosol-generating material also comprises the acid and/or the active substance. In certain embodiments, the amorphous solid of the second aerosol- generating material is free from the flavourant and the active substance. In some embodiments, the amorphous solid of the second aerosol-generating material does not comprise the flavourant contained in the first aerosol-generating material and does not comprise the active substance. In other embodiments the amorphous solid of the second aerosol-generating material also comprises the flavourant and/or the active substance In this embodiment, the amorphous solid of the first aerosol-generating material, comprising the flavourant comprises: WO 2021/105449 PCT/EP2020/083764 - 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and- 5-60 wt% of the flavourant, wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; aerosol-former material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), flavourant in an amount of from about 30wt% to about 60wt%, or from about 40wt% to 55wt%, or from about 45wt% to about 50wt%. Suitably, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 10wt% to about 40wt%; and the flavourant in an amount of from about wt% to about 50 wt%. In some embodiments the amorphous solid of the first aerosol-generating material is free from the acid and the active substance. In alternative embodiments, the amorphous solid of the first aerosol-generating material also comprises the acid and/or the active substance.
In this embodiment, the amorphous solid of the second aerosol-generating material, comprising the acid comprises:- 0.5-60 wt% of the gelling agent;- 5-80 wt% of the aerosol-former material; and- 0.1 -10 wt% of the acid, wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-form er material in an amount of WO 2021/105449 PCT/EP2020/083764 from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the acid in an amount of from about 0.1 wt% to about 8 wt%, or from about 0.5wt% to 7wt%, or from about lwt% to about 5wt%, or form about lwt% to about 3wt%. Suitably, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 40wt% to about 70wt%; the aerosol-former material in an amount of from about 20wt% to about 50wt%; and the acid in an amount of from about 0.1 wt% to about 5 wt%. In some embodiments the amorphous solid of the second aerosol- generating material is free from the active substance or the flavourant. In alternative embodiments, the amorphous solid of the second aerosol-generating material also comprises the active substance and/or the flavourant.
In further embodiments, the amorphous solid of one of the first or second aerosol-generating materials is free from the active substance, the flavourant and the acid. In some embodiments, the amorphous solid of the first aerosol generating material does not comprise the active substance, the flavourant or the acid. In this embodiment the aerosol-generating material which is free from the active substance, flavourant and acid is provided for the purposes of providing a source of aerosol-former material, e.g. a humectant. As such, in this embodiment, the amorphous solid of the aerosol- generating material which is free from the active substance, flavourant and acid comprises at least 5% by weight of aerosol-former material; for example, in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis). In an exemplary embodiment, the first aerosol-generating material comprises:- 0.5 - 60 wt % of a gelling agent;- 5 - 80 wt % of an aerosol-former material;a nd is free from an active substance, a flavourant and an acid;and the second aerosol-generating material comprises 0.1 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis.
WO 2021/105449 PCT/EP2020/083764 In some such embodiments, the consumable of the invention comprises such a first aerosol-generating material in combination with any other second aerosol- generating material described herein.
In some embodiments, the amorphous solid of the first and second aerosol- generating materials both comprise an active substance. In some such embodiments, the amorphous solid of the first and second aerosol-generating materials comprise the same active substance. In some such embodiments the active substance is present in different quantities. When used herein "quantity" can mean that the amorphous solid contains 0% of the active substance, in other words the amorphous solid of the first or second aerosol-generating material is free from the active substance present in the amorphous solid of the other aerosol-generating material.
In some embodiments the amorphous solid of the first and second aerosol- generating materials both comprise an active substance. In some such embodiments, the amorphous solid of the first and second aerosol-generating materials comprise the same active substance, wherein the amorphous solid of the first aerosol-generating material comprises a greater quantity of the active substance than the quantity of the active substance present in the amorphous solid of the second aerosol-generating material. In some embodiments, the amorphous solid of the first and second aerosol- generating materials comprise the same active substance, wherein the amorphous solid of the first aerosol-generating material comprises a lesser quantity of the active substance than the quantity of the active substance present in the amorphous solid of the second aerosol-generating material.
In some such embodiments, the amorphous solids of both the first and second aerosol-generating materials comprise a quantity of the active substance which is greater than 0.1% (all calculated on a dry weight basis); for example, the amorphous solids of both the first and second aerosol-generating materials comprise at least 0.2, 0.5, 1.0, 1.5 or 2% of the active substance. In an exemplary embodiment the amorphous solid of the first aerosol-generating material comprises from 0-30 wt% of the active substance present therein, and the amorphous solid of the second aerosol-generating WO 2021/105449 PCT/EP2020/083764 material comprises from 31-60 wt% of the active substance present therein. Suitably, the amorphous solid of the first aerosol-generating material comprises from 0-20 wt% of the active substance present therein (for example, 1-15 wt% or 5 - 10 wt%) and the amorphous solid of the second aerosol-generating material comprises from 30 - 60 wt% of the active substance present therein (for example, 30 - 50 wt%, or 40 - 60 wt%). In some such embodiments the amorphous solid of the first aerosol-generating material comprises the same active substance as the active substance present in the amorphous solid of the second aerosol-generating material. In some such embodiments the amorphous solid of the first aerosol-generating material comprises a different active substance from the active substance present in the amorphous solid of the second aerosol-generating material.
In such embodiments, two aerosol-generating materials may comprise substantially the same ingredients, except that the quantity of active substance present in each of the two aerosol-generating materials is different. In a non-limiting example, a consumable in accordance with the invention comprises a first aerosol-generating material; and a second aerosol-generating material,wherein the first aerosol-generating material comprises an amorphous solid, the amorphous solid comprising- 0.5 - 60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and- 0 - 5 wt% of an active substance, wherein these weights are calculated on a dry weight basis; and the second aerosol-generating material comprises an amorphous solid, the amorphous solid comprising- 0.5 - 60 wt% of a gelling agent;- 0 - 80 wt% of an aerosol-former material; and- 5 - 10 wt% of an active substance, wherein these weights are calculated on a dry weight basis. Suitably the amorphous solid of the first aerosol-generating material comprises from 0.1-2 wt% of the active substance contained therein and the WO 2021/105449 PCT/EP2020/083764 amorphous solid of the second aerosol-generating material comprises from 2-10 wt% of the active substance contained therein. Suitably the active substance is nicotine.
In such embodiments the first and second aerosol-generating material may further comprise flavourant and/or acid in variable quantities. In other embodiments the first and/or second aerosol-generating material is free from (does not comprise) flavourant and/or acid.
In the above embodiments, suitably, the active substance is nicotine and the amorphous solid of the first aerosol-generating material comprises 0.1-5 wt% of nicotine, for example 0.5-4 wt%, 1-3 wt% or 2 - 5 wt% of nicotine, and the amorphous solid of the second aerosol-generating material comprises 5-10 wt% of nicotine, for example 6-9 wt% or 7 - 8 wt% of nicotine, wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol- generating material comprises a different quantity of nicotine from the quantity of nicotine contained in the amorphous solid of the second aerosol-generating material.
In some embodiments the amorphous solid of the first aerosol-generating material comprises a different active substance from the active substance present in the amorphous solid of the second aerosol-generating material.
In some embodiments, the amorphous solid of the first aerosol-generating material comprises a different flavourant from the flavourant present in the amorphous solid of the second aerosol-generating material.
In some cases, the amorphous solid of at least one aerosol-generating material mentioned above comprises more than one of a flavourant, active substance and/or acid. For example, in some embodiments the amorphous solid of the first and or/second aerosol-generating material comprises the flavourant and the active substance, but is free from the acid. In other cases the amorphous solids of the first and/or second aerosol-generating materials comprises the acid and the active substance, but are free from the flavourant. In other cases, the amorphous solids of the first and/or second WO 2021/105449 PCT/EP2020/083764 aerosol-generating materials comprise the flavourant and the acid, but are free from the active substance.
It is also envisaged that the consumable of the invention comprises aerosol- generating materials as discussed above which differ from each other by type of flavourant. In such embodiments the amorphous solid of the first aerosol-generating material comprises a different flavourant from the flavourant contained in the amorphous solid of the second aerosol-generating material. In such embodiments, two aerosol-generating materials (for example the first and second aerosol-generating materials) may comprise substantially the same ingredients, except that the amorphous solid of the first aerosol-generating material comprises a flavourant which is different from a flavourant present in the amorphous solid of the second aerosol generating material. In a non-limiting example, the amorphous solids of two aerosol-generating materials comprise an active substance, acid and flavourant, wherein the flavourant in the amorphous solid of the first aerosol-generating material is different from the flavourant in the amorphous solid of the second aerosol-generating material. In some embodiments, the consumable of the invention may comprise more than two aerosol- generating materials, wherein the amorphous solid of each aerosol-generating material comprises a different flavourant from a flavourant present in at least one other amorphous solid of another aerosol-generating material in the consumable of the invention.
It is also envisaged that aerosol-generating materials in the consumable of the invention differ from each other by type of active substance. In such embodiments, the amorphous solids of two aerosol-generating materials may comprise substantially the same ingredients, except that the active substance present in the amorphous solid is different. In one embodiment, the amorphous solid of the first aerosol-generating material comprises a different active substance from the active substance present in the amorphous solid of the second aerosol-generating material. In some embodiments, the consumable of the invention comprises more than two aerosol-generating materials, wherein the amorphous solid of each aerosol-generating material comprises a different WO 2021/105449 PCT/EP2020/083764 active substance from the active substance present in the amorphous solid of at least one other aerosol-generating material in the consumable.
It is also envisaged that aerosol-generating materials in consumables of the invention differ from each other by quantity of flavourant, or acid. In some such embodiments the flavourant of the amorphous solid of the first aerosol-generating material is present in a different quantity from a quantity of the flavourant in the amorphous solid of the second aerosol-generating material. For example, the quantity of flavourant present in the amorphous solid of the first aerosol-generating material is greater than the quantity of the flavourant present in the second aerosol-generating material. In some such embodiments the acid of the amorphous solid of the first aerosol-generating material is present in a different quantity from a quantity of the acid in the amorphous solid of the second aerosol-generating material. For example, the quantity of acid present in the amorphous solid of the first aerosol-generating material is greater than the quantity of the acid present in the second aerosol-generating material.
It will be appreciated that there are very many combinations of aerosol- generating materials which can be included in a consumable of the present invention. All combinations of active substance, flavourant and acid are included within the scope of the invention.
In some embodiments the consumable comprises a third aerosol-generating material comprising an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid; wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the third aerosol-generating material has a different composition from a composition of the amorphous solid of the first aerosol-generating material and/or the second aerosol-generating material.
WO 2021/105449 PCT/EP2020/083764 In some embodiments the consumable comprises a fourth aerosol-generating material comprising an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid; wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the fourth aerosol-generating material has a different composition from a composition of the amorphous solid of at least one of the first, second or third aerosol- generating materials.
In some embodiments the consumable comprises more than four aerosol- generating materials having the features described above. Suitably, the amorphous solid of each additional aerosol-generating material has a different composition from the composition of the amorphous solid of at least one other aerosol-generating material contained in the consumable. Indeed, the consumable, in some embodiments, comprises five, six, seven, eight, nine or ten aerosol-generating materials, each of which comprises an amorphous solid having a different composition from an amorphous solid of at least one other aerosol-generating material contained in the consumable. In such embodiments each of the additional aerosol-generating materials comprises an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the fifth, sixth, seventh, eighth, ninth or tenth aerosol-generating materials has a composition different from the amorphous solid of at least one other aerosol-generating material contained in the consumable.
In some cases the amorphous solid of each aerosol-generating material comprises one of a flavourant, acid, active substance, or is free from flavourant, acid WO 2021/105449 PCT/EP2020/083764 and active substance, such that it contributes only humectant when subject to aerosolization.
In a non-limiting and exemplary embodiment, a consumable in accordance with the invention comprisesa first aerosol-generating material;a second aerosol-generating material;a third aerosol-generating material; anda fourth aerosol-generating materialwherein each of the first to fourth aerosol-generating materials comprises an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material is free from the active substance, the flavourant and the acid;the amorphous solid of the second aerosol-generating material comprises the flavourant, but is free from the active substance and the acid;the amorphous solid of the third aerosol-generating material comprises the active substance, but is free from the flavourant and the acid; andthe amorphous solid of the fourth aerosol-generating material comprises the acid, but is free from the active substance and the flavourant.
In this embodiment, the amorphous solid of the first aerosol-generating material, free from the flavourant, the active substance and the acid may comprise: - 0.5-60 wt% of a gelling agent; and- 5-80 wt% of an aerosol-former material;wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): gelling agent WO 2021/105449 PCT/EP2020/083764 in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-former material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis).
In this embodiment, the amorphous solid of the second aerosol-generating material, comprising the flavourant, but free from the active substance and the acid may comprise:- 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and- 5-60 wt% of the flavourant,wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; aerosol-form er material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), flavourant in an amount of from about 30wt% to about 60wt%, or from about 40wt% to 55wt%, or from about 45wt% to about 50wt%. Suitably, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 10wt% to about 40wt%; and the flavourant in an amount of from about 10 wt% to about 50 wt%.
In this embodiment, the amorphous solid of the third aerosol-generating material, comprising the active substance, and free from the flavourant and acid comprises:- 0.5-60 wt% of a gelling agent;- 5-80 wt% of an aerosol-former material; and- 5-60 wt% of at least one active substance, WO 2021/105449 PCT/EP2020/083764 wherein these weights are calculated on a dry weight basis.
In this embodiment, the amorphous solid of the third aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-form er material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the active substance in an amount of from about 30wt% to about 60wt%, or from about 40wt% to 55wt%, or from about 45wt% to about 50wt%. Suitably, the amorphous solid of the first aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 20wt% to about 60wt%; and the active substance in an amount of from about 0.1 wt% to about 10 wt%.
In this embodiment, the amorphous solid of the fourth aerosol-generating material, comprising the acid, but free from the active substance and the flavourant comprises:- 0.5-60 wt% of the gelling agent;- 5-80 wt% of the aerosol-former material; and- 0.1 -10 wt% of the acid,wherein these weights are calculated on a dry weight basis; In this embodiment, the amorphous solid of the fourth aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-form er material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the acid in an amount of from about 0.1 wt% to about 8 wt%, or from about 0.5wt% to 7wt%, or from about lwt% to about 5wt%, or form about lwt% to about 3wt%. Suitably, the amorphous solid of the fourth aerosol-generating material may have the following WO 2021/105449 PCT/EP2020/083764 composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 40wt% to about 70wt%; the aerosol-former material in an amount of from about 20wt% to about 50wt%; and the acid in an amount of from about 0.1 wt% to about 5 wt%.
FORMULATIONS The following formulations represent exemplary component amounts of each excipient in the aerosol-generating materials contained in consumables of the invention.
In embodiments wherein the amorphous solid of the aerosol-generating material in the consumable comprises an active substance, the amorphous solid, in some such embodiments comprises:- 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and - 0.1 -60 wt% of at least one active substance, wherein these weights are calculated on a dry weight basis.
In these embodiments, the amorphous solid of the aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-former material in an amount of from about 10wt% to about 70wt%, or from about 20wt% to about 60wt%, or from about 25wt% to about 40wt% (all calculated on a dry weight basis), the active substance in an amount of from about 0.5 wt% to about 50 wt%, or from about 1 wt% to 40 wt%, or from about wt% to about 30 wt%, or from about 5 wt% to about 20 wt %, or from about 2 wt% to about 10 wt%. Suitably, the amorphous solid of the aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 20wt% to about 60wt%; and the active substance in an amount of from about 0.1 wt% to about 10 wt%.
WO 2021/105449 PCT/EP2020/083764 In embodiments wherein the amorphous solid of the aerosol-generating material in the consumable comprises flavourant, in some such embodiments the amorphous solid comprises:- 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and- 5-60 wt% of the flavourant, wherein these weights are calculated on a dry weight basis; In these embodiments, the amorphous solid the aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about 25wt%; the aerosol-former material in an amount of from about 10wt% to about 70wt%, or from about 20wt% to about 60wt%, or from about 25wt% to about 40wt% (all calculated on a dry weight basis), flavourant in an amount of from about 10wt% to about 50wt%, or from about 20wt% to 40wt%, or from about 25wt% to about 30wt%. Suitably, the amorphous solid of the second aerosol-generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 30wt% to about 60wt%; the aerosol-former material in an amount of from about 10wt% to about 40wt%; and the flavourant in an amount of from about 20 wt% to about 50 wt%.
In embodiments wherein the amorphous solid of the aerosol-generating material in the consumable comprises an acid, in some such embodiments the amorphous solid comprises:- 0.5-60 wt% of the gelling agent;- 5-80 wt% of the aerosol-former material; and- 0.1 -10 wt% of the acid,wherein these weights are calculated on a dry weight basis; In these embodiments, the amorphous solid may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 5wt% to about 40wt%, or about 10wt% to 30wt%, or about 15wt% to about WO 2021/105449 PCT/EP2020/083764 25wt%; the aerosol-former material in an amount of from about 10wt% to about 50wt%, or from about 20wt% to about 40wt%, or from about 25wt% to about 35wt% (all calculated on a dry weight basis), the acid in an amount of from about 0.1 wt% to about wt%, or from about 0.5wt% to 7wt%, or from about lwt% to about 5wt%, or form about lwt% to about 3wt%. Suitably, the amorphous solid of the second aerosol- generating material may have the following composition (all calculated on a dry weight basis): the gelling agent in an amount of from about 40wt% to about 70wt%; the aerosol-former material in an amount of from about 20wt% to about 50wt%; and the acid in an amount of from about 0.1 wt% to about 5 wt%.
AMORPHOUS SOLID COMPOSITION The following discussion of the amorphous solid composition applies independently to the amorphous solid in each of the aerosol-generating materials present in the consumable of the invention.
In some cases, the amorphous solid may have a thickness of about 0.015mm to about 1.0mm. Suitably, the thickness may be in the range of about 0.05mm, 0.1mm or 0.15mm to about 0.5mm, 0.3mm or 0.2mm. The inventors have found that an amorphous solid having a thickness of 0.2mm is particularly suitable. In some embodiments the amorphous solid may have a thickness of about 0.1-0.2 mm. The amorphous solid may comprise more than one layer, and the thickness described herein refers to the aggregate thickness of those layers.
The inventors have established that if the amorphous solid is too thick, then heating efficiency is compromised. This adversely affects the power consumption in use. Conversely, if the amorphous solid is too thin, it is difficult to manufacture and handle; a very thin material is harder to cast and may be fragile, compromising aerosol formation in use.
The inventors have established that the amorphous solid thicknesses stipulated herein optimise the material properties in view of these competing considerations. The WO 2021/105449 PCT/EP2020/083764 thickness stipulated herein is a mean thickness for the material. In some cases, the amorphous solid thickness may vary by no more than 25%, 20%, 15%, 10%, 5% or 1%.
In some cases, the amorphous solids may be heated to generate aerosol once. In some cases, the amorphous solids may be heated to generate aerosol more than once, such as twice or three times.
Where an amorphous solid is to be heated more than once a thicker amorphous solid may be used. For example, in some embodiments the thickness may be 0.2-0.mm.
In some cases, the amorphous solid may comprise l-60wt% of a gelling agent wherein these weights are calculated on a dry weight basis.
In some embodiments, the gelling agent comprises a hydrocolloid. In some embodiments, the gelling agent comprises one or more compounds selected from the group comprising alginates, pectins, starches (and derivatives), celluloses (and derivatives such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose (CMC)), gums, silica or silicones compounds, clays, polyvinyl alcohol and combinations thereof. For example, in some embodiments, the gelling agent comprises one or more of alginates, pectins, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, pullulan, xanthan gum guar gum, carrageenan, agarose, acacia gum, fumed silica, PDMS, sodium silicate, kaolin and polyvinyl alcohol. In some cases, the gelling agent comprises alginate and/or pectin, and may be combined with a setting agent (such as a calcium source) during formation of the amorphous solid. In some cases, the amorphous solid may comprise a calcium-crosslinked alginate and/or a calcium-crosslinked pectin.
In some cases, the gelling agent may be combined with a setting agent (such as a calcium source) during formation of the amorphous solid.
WO 2021/105449 PCT/EP2020/083764 In examples, the setting agent comprises or consists of calcium acetate, calcium formate, calcium carbonate, calcium hydrogencarbonate, calcium chloride, calcium lactate, or a combination thereof. In some examples, the setting agent comprises or consists of calcium formate and/or calcium lactate. In particular examples, the setting agent comprises or consists of calcium formate. The inventors have identified that, typically, employing calcium formate as a setting agent results in an amorphous solid having a greater tensile strength and greater resistance to elongation.
The total amount of the setting agent, such as a calcium source, may be 0.5- 5wt% (calculated on a dry weight basis). Suitably, the total amount may be from about lwt%, 2.5wt% or 4wt% to about 4.8wt% or 4.5wt%. The inventors have found that the addition of too little setting agent may result in an amorphous solid which does not stabilise the amorphous solid components and results in these components dropping out of the amorphous solid. The inventors have found that the addition of too much setting agent results in an amorphous solid that is very tacky and consequently has poor handleability.
When the amorphous solid does not contain tobacco, a higher amount of setting agent may need to be applied. In some cases the total amount of setting agent may therefore be from 0.5-12wt% such as 5-10wt%, calculated on a dry weight basis. Suitably, the total amount may be from about 5wt%, 6wt% or 7wt% to about 12wt% or 10wt%. In this case the amorphous solid will not generally contain any tobacco.
In some embodiments, the gelling agent comprises alginate, and the alginate is present in the amorphous solid in an amount of from 10-30wt% of the amorphous solid (calculated on a dry weight basis). In some embodiments, alginate is the only gelling agent present in the amorphous solid. In other embodiments, the gelling agent comprises alginate and at least one further gelling agent, such as pectin.
In some embodiments the gelling agent comprises a mixture of alginate and carboxymethylcellulose (CMC). Suitably the gelling agent comprises a greater quantity of CMC than alginate; for example in some cases the ratio of CMC to alginate is about WO 2021/105449 PCT/EP2020/083764 : 1, about 3 : 1, about 2 : 1, or about 1.5 : 1; for example is in the range of 5 : 1 - 1.: 1.
In some embodiments the amorphous solid may include gelling agent comprising carrageenan.
In some embodiments, the gelling agent may comprise one or more compounds selected from cellulosic gelling agents, non-cellulosic gelling agents, guar gum, acacia gum and mixtures thereof.
In some embodiments, the cellulosic gelling agent is selected from the group consisting of: hydroxymethyl cellulose, hydroxy ethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), cellulose acetate propionate (CAP) and combinations thereof.
In some embodiments, the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose, guar gum, or acacia gum.
In some embodiments, the gelling agent comprises (or is) one or more non- cellulosic gelling agents, including, but not limited to, agar, xanthan gum, gum Arabic, guar gum, locust bean gum, pectin, carrageenan, starch, alginate, and combinations thereof. In preferred embodiments, the non-cellulose based gelling agent is alginate or agar.
Suitably, the amorphous solid may comprise from about 5wt%, 10wt%, 15wt%, or 20wt% to about 80wt%, 70wt%, 60wt%, 55wt%, 50wt%, 45wt% 40wt%, or 35wt% of an aerosol-former material (all calculated on a dry weight basis). The aerosol-former material may act as a plasticiser. For example, the amorphous solid may comprise 10- 60wt%, 15-50wt% or 20-40wt% of an aerosol-former material. In some cases, the aerosol-former material comprises one or more compound selected from erythritol, WO 2021/105449 PCT/EP2020/083764 propylene glycol, glycerol, triacetin, sorbitol and xylitol. In some cases, the aerosol- former material comprises, consists essentially of or consists of glycerol. The inventors have established that if the content of the aerosol-former material is too high, the amorphous solid may absorb water resulting in a material that does not create an appropriate consumption experience in use. The inventors have established that if the aerosol-former material content is too low, the amorphous solid may be brittle and easily broken.
In some embodiments, the aerosol former comprises one or more polyhydric alcohols, such as propylene glycol, triethylene glycol, 1,3-butanediol and glycerin; esters of polyhydric alcohols, such as glycerol mono-, di- or triacetate; and/or aliphatic esters of mono-, di- or polycarboxylic acids, such as dimethyl dodecanedioate and dimethyl tetradecanedioate.
In embodiments in which the amorphous solid comprises a flavourant, suitably, the amorphous solid comprises up to about 60wt%, 50wt%, 40wt%, 30wt%, 20wt%, 10wt% or 5wt% of the flavourant. In some cases, the amorphous solid may comprise at least about 0.5wt%, lwt%, 2wt%, 5wt% 10wt%, 20wt% or 30wt% of the flavourant (all calculated on a dry weight basis). For example, the amorphous solid may comprise 0.1-60wt%, l-60wt%, 5-60wt%, 10-60wt%, 20-50wt% or 30-40wt% of the flavourant. In some cases, the flavourant (if present) comprises, consists essentially of or consists of menthol. In some cases, the amorphous solid is free from flavourant.
In embodiments in which an aerosol-generating material of the invention comprises an active substance, in some cases, the amorphous solid comprises a tobacco material and/or nicotine. For example, the amorphous solid may comprise powdered tobacco and/or nicotine and/or a tobacco extract. In some cases, the amorphous solid may comprise from about lwt%, 5wt%, 10wt%, 15wt%, 20wt% or 25wt% to about 70wt%, 50wt%, 45wt% or 40wt% (calculated on a dry weight basis) of an active substance. In some cases, the amorphous solid may comprise from about lwt%, 5wt%, 10wt%, 15wt%, 20wt% or 25wt% to about 70wt%, 60wt%, 50wt%, 45wt% or 40wt% (calculated on a dry weight basis) of a tobacco material and/or nicotine.
WO 2021/105449 PCT/EP2020/083764 In embodiments in which the aerosol-generating material comprises an active substance such as tobacco extract; in some cases, the amorphous solid may comprise 5- 60wt% (calculated on a dry weight basis) of tobacco extract. In some cases, the amorphous solid may comprise from about 5wt%, 10wt%, 15wt%, 20wt% or 25wt% to about 55wt%, 50wt%, 45wt% or 40wt% (calculated on a dry weight basis) tobacco extract. For example, the amorphous solid may comprise 5-60wt%, 10-55wt% or 25- 55wt% of tobacco extract. The tobacco extract may comprise nicotine at a concentration such that the amorphous solid comprises 1 wt% 1.5wt%, 2wt% or 2.5wt% to about 6wt%, 5wt%, 4.5wt% or 4wt% (calculated on a dry weight basis) of nicotine. In some cases, there may be no nicotine in the amorphous solid other than that which results from the tobacco extract.
In some embodiments the amorphous solid comprises no tobacco material but does comprise nicotine. In some such cases, the amorphous solid may comprise from about lwt%, 2wt%, 3wt% or 4wt% to about 20wt%, 15wt%, 10wt% or 5wt% (calculated on a dry weight basis) of nicotine. For example, the amorphous solid may comprise l-20wt% or 2-5wt% of nicotine.
In embodiments where the amorphous solid comprises an acid, the amorphous solid may comprise l-20wt%, 5-15wt% or 8-12wt% (calculated on a dry weight basis) of acid, for example, lwt%, 2wt%, 3wt% or 4wt% to about 20wt%, 15wt%, 10wt% or 5wt% (calculated on a dry weight basis) of acid.
Without wishing to be bound by theory, it is believed that including an acid in the amorphous solid protonates the nicotine and results in an aerosol which some users of smoking devices find more satisfying.
The aerosol-generating material or amorphous solid may comprise an acid.
The inclusion of an acid is particularly preferred in embodiments in which the aerosol-generating material or amorphous solid comprises nicotine. In such WO 2021/105449 PCT/EP2020/083764 embodiments, the presence of an acid may stabilise dissolved species in the slurry from which the aerosol-generating material or amorphous solid is formed. The presence of the acid may reduce or substantially prevent evaporation of nicotine during drying of the slurry, thereby reducing loss of nicotine during manufacturing.
In some such embodiments, the acid may contain an acidic functional group which has a p/؛a value ranging from 2 to 6, for example ranging from 3 to 6 or ranging from 4 to 5, when measured at 25°C.
In some such embodiments, the acid may have a boiling point ranging from 70°C to 450°C, for example, ranging from 100°C to 320°C.
In some such embodiments, the amorphous solid comprises from 1 - 20wt% of acid, wherein the acid has a functional group which has a p/؛a value ranging from 2 to when measured at 25°C and wherein the acid has a boiling point ranging from 70°C to 350°C.
In some such embodiments, the acid may be an organic acid.
In some of these embodiments, the acid may be at least one of a monoprotic acid, diprotic acid and triprotic acid.
In some such embodiments, the acid may contain at least one carboxyl functional group.
In some such embodiments, the acid may be at least one of an alpha-hydroxy acid, carboxylic acid, dicarboxylic acid, tricarboxylic acid and keto acid.
In some such embodiments, the acid may be an alpha-keto acid.
WO 2021/105449 PCT/EP2020/083764 In some such embodiments, the acid may be at least one of succinic acid, lactic acid, benzoic acid, citric acid, tartaric acid, fumaric acid, levulinic acid, acetic acid, malic acid, formic acid, sorbic acid, benzoic acid, propanoic and pyruvic acid.
Suitably the acid is lactic acid. In other embodiments, the acid is benzoic acid.
In other embodiments the acid may be an inorganic acid. In some of these embodiments the acid may be a mineral acid. In some such embodiments, the acid may be at least one of sulphuric acid, hydrochloric acid, boric acid and phosphoric acid.
In some embodiments, the acid is levulinic acid.
In embodiments where the amorphous solid comprises an acid, the amorphous solid may comprise lwt%, 2wt%, 3wt% or 4wt% to about 20wt%, 15wt%, 10wt% or 5wt% (calculated on a dry weight basis) of an organic acid.
In embodiments where the amorphous solid comprises an acid, the amorphous solid may comprise lwt%, 2wt%, 3wt% or 4wt% to about 20wt%, 15wt%, 10wt% or 5wt% (calculated on a dry weight basis) of an acid comprising a carboxyl functional group.
In embodiments where the amorphous solid comprises an acid, the amorphous solid may comprise lwt%, 2wt%, 3wt% or 4wt% to about 20wt%, 15wt%, 10wt% or 5wt% (calculated on a dry weight basis) of an acid containing an acidic functional group which has a p/؛a value of between 2 and 6, when measured at 25°C.
In certain embodiments, the aerosol-generating material or amorphous solid comprises a gelling agent comprising a cellulosic gelling agent and/or a non-cellulosic gelling agent, an active substance and an acid.
The amorphous solid may, in some cases, be a hydrogel and comprises less than about 20wt%, 15wt%, 12wt% or 10wt% of water calculated on a wet weight basis WO 2021/105449 PCT/EP2020/083764 (WWB). In some cases, the amorphous solid may comprise at least about lwt%, 2wt% or 5wt% of water (WWB). The amorphous solid comprises from about lwt% to about 15wt% water, or from about 5wt% to about 15wt% calculated on a wet weight basis. Suitably, the water content of the amorphous solid may be from about 5wt%, 7wt% or 9wt% to about 15wt%, 13wt% or 1 lwt% (WWB), most suitably about 10wt%.
The amorphous solid may be made from a gel, and this gel may additionally comprise a solvent, included at 0.1-50wt%. However, the inventors have established that the inclusion of a solvent in which the flavourant is soluble may reduce the gel stability and the flavourant may crystallise out of the gel. As such, in some cases, the gel does not include a solvent in which the flavourant is soluble.
In some cases, the amorphous solid comprises from 1 - 60wt% of a filler, for example, 5 - 50wt%, 10 - 40 wt% or 15 - 30 wt% of a filler. In some such cases the amorphous solid comprises at least 1 wt% of a filler, for example, at least 5 wt%, at least 10wt%, at least 20wt% at least 30wt%, at least 40wt%, or at least 50wt% of a filler.
In some embodiments, the amorphous solid comprises less than 60wt% of a filler, such as from lwt% to 60wt%, or 5wt% to 50wt%, or 5wt% to 30wt%, or 10wt% to 20wt%.
In other embodiments, the amorphous solid comprises less than 20wt%, suitably less than 10wt% or less than 5wt% of a filler. In some cases, the amorphous solid comprises less than lwt% of a filler, and in some cases, is free from filler.
The filler, if present, may comprise one or more inorganic filler materials, such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulphate, magnesium carbonate, and suitable inorganic sorbents, such as molecular sieves. The filler may comprise one or more organic filler materials such as wood pulp, cellulose and cellulose derivatives (such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose (CMC)). In WO 2021/105449 PCT/EP2020/083764 some cases, the amorphous solid comprises less than lwt% of a filler, and in some cases, comprises no filler. In particular, in some cases, the amorphous solid comprises no calcium carbonate such as chalk.
In particular embodiments which include filler, the filler is fibrous. For example, the filler may be a fibrous organic filler material such as wood pulp, hemp fibre, cellulose or cellulose derivatives (such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose (CMC)). Without wishing to be bound by theory, it is believed that including fibrous filler in an amorphous solid may increase the tensile strength of the material.
In some embodiments, the amorphous solid does not comprise tobacco fibres. In particular embodiments, the amorphous solid does not comprise fibrous material.
In some embodiments, the aerosol-generating material does not comprise tobacco fibres. In particular embodiments, the aerosol-generating material does not comprise fibrous material.
In some embodiments, the aerosol-generating material does not comprise tobacco fibres. In particular embodiments, the aerosol-generating material does not comprise fibrous material.
In some embodiments, the consumable does not comprise tobacco fibres. In particular embodiments, the consumable does not comprise fibrous material.
The aerosol-generating material comprising the amorphous solid may have any suitable area density, such as from 30 g/m2 to 120 g/m2. In some embodiments, aerosol generating material may have an area density of from about 30 to 70 g/m2, or about to 60 g/m2. In some embodiments, the amorphous solid may have an area density of from about 80 to 120 g/m2, or from about 70 to 110 g/m2, or particularly from about to 110 g/m2.
WO 2021/105449 PCT/EP2020/083764 In some examples, the amorphous solid in sheet form may have a tensile strength of from around 200 N/m to around 900 N/m. In some examples, such as where the amorphous solid does not comprise a filler, the amorphous solid may have a tensile strength of from 200 N/m to 400 N/m, or 200 N/m to 300 N/m, or about 250 N/m. In some examples, such as where the amorphous solid comprises a filler, the amorphous solid may have a tensile strength of from 600 N/m to 900 N/m, or from 700 N/m to 9N/m, or around 800 N/m.
The amorphous solid may comprise a colourant. The addition of a colourant may alter the visual appearance of the amorphous solid. The presence of colourant in the amorphous solid may enhance the visual appearance of the amorphous solid and the aerosol-generating material. By adding a colourant to the amorphous solid, the amorphous solid may be colour-matched to other components of the aerosol-generating material or to other components of an article comprising the amorphous solid.
A variety of colourants may be used depending on the desired colour of the amorphous solid. The colour of amorphous solid may be, for example, white, green, red, purple, blue, brown or black. Other colours are also envisaged. Natural or synthetic colourants, such as natural or synthetic dyes, food-grade colourants and pharmaceutical-grade colourants may be used. In certain embodiments, the colourant is caramel, which may confer the amorphous solid with a brown appearance. In such embodiments, the colour of the amorphous solid may be similar to the colour of other components (such as tobacco material) in an aerosol- generating material comprising the amorphous solid. In some embodiments, the addition of a colourant to the amorphous solid renders it visually indistinguishable from other components in the aerosol-generating material.
The colourant may be incorporated during the formation of the amorphous solid (e.g. when forming a slurry comprising the materials that form the amorphous solid) or it may be applied to the amorphous solid after its formation (e.g. by spraying it onto the amorphous solid).
WO 2021/105449 PCT/EP2020/083764 METHOD OF MANUFACTURING A CONSUMABLE The invention also provides a method of manufacturing a consumable for use with a non-combustible aerosol provision device, the method comprising:providing a support;depositing on the support at least two discrete portions of slurry comprising a gelling agent, an aerosol former and at least one of an active substance, flavourant and an acid;drying the at least two discrete portions of slurry to provide a first aerosol- generating material and a second aerosol-generating material, wherein the first and second aerosol-generating materials are attached to the support;forming the consumable;wherein each of the first and second aerosol-generating materials comprise an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material has a composition different from a composition of the amorphous solid of the second aerosol-generating material.
The embodiments described throughout the application in relation to the consumable of the present invention also apply mutatis mutandis to the method of manufacturing a consumable.
The present invention also includes the use of a consumable as described throughout the present application in a non-combustible aerosol provision device, wherein the device is arranged to generate aerosol from the consumable when the consumable is used with the non-combustible aerosol provision device.
WO 2021/105449 PCT/EP2020/083764 The embodiments described throughout the application in relation to the consumable of the present invention also apply mutatis mutandis to the use of the consumable.
CONSUMABLE In some cases, the aerosol-generating materials (for example, the first and second aerosol-generating materials) are attached to a support. Advantageously, the support is a planar support. In some cases, the support may be substantially or wholly impermeable to gas and/or aerosol. This prevents aerosol or gas passage through the support, thereby controlling the flow and ensuring good delivery to the user. This can also be used to prevent condensation or other deposition in use of the gas/aerosol on, for example, the surface of a heater provided in non-combustible aerosol provision system. Thus, consumption efficiency and hygiene can be improved in some cases.
Thus, in certain embodiments the invention provides a consumable for use within a non-combustible aerosol provision system, the consumable comprising:a support;a first aerosol-generating material attached to the support; and a second aerosol-generating material attached to the support, wherein each aerosol-generating material comprises an amorphous solid, the amorphous solid comprising:- 0.5-60 wt% of a gelling agent;- 0-80 wt% of an aerosol-former material; and- 0-60 wt% of at least one of an active substance, flavourant and an acid; wherein these weights are calculated on a dry weight basis; andwherein the amorphous solid of the first aerosol-generating material has a composition different from the amorphous solid of the second aerosol-generating material.
The support may be at least partially porous in the region of a surface abutting the amorphous solid. The inventors have found that such a support is particularly suitable for the present invention; the porous section of the support abuts the amorphous WO 2021/105449 PCT/EP2020/083764 solid and forms a strong bond. The amorphous solid is formed by drying a gel and, without being limited by theory, it is thought that a slurry from which the amorphous solid is formed partially impregnates porous material of the support so that when the amorphous solid sets and forms cross-links, the support is partially bound into the amorphous solid. This provides a strong binding between the amorphous solid and the support.
Additionally, surface roughness may contribute to the strength of bond between the amorphous solid and the support. The inventors have found that the paper roughness (for the surface abutting the aerosol-generating material) may suitably be in the range of 50-1000 Bekk seconds, suitably 50-150 Bekk seconds, suitably 100 Bekk seconds (measured over an air pressure interval of 50.66-48.00 kPa). (A Bekk smoothness tester is an instrument used to determine the smoothness of a paper surface, in which air at a specified pressure is leaked between a smooth glass surface and a paper sample, and the time (in seconds) for a fixed volume of air to seep between these surfaces is the "Bekk smoothness".) Conversely, the surface of the support facing away from the amorphous solid may be arranged in contact with a heater, and a smoother surface may provide more efficient heat transfer. Thus, in some cases, the support is disposed so as to have a rougher side abutting the amorphous solid and a smoother side facing away from the amorphous solid.
In one particular case, the support may itself be a laminate structure. For example, it may comprise a cardboard-backed foil; a cardboard layer abuts the amorphous solid and the properties discussed in the previous paragraphs are afforded by this abutment. A foil backing is substantially impermeable, providing control of the aerosol flow path. A metal foil backing may also serve to conduct heat to the amorphous solid.
In another case, a foil layer of the cardboard-backed foil abuts the amorphous solid. The foil is substantially impermeable, thereby preventing water provided in the WO 2021/105449 PCT/EP2020/083764 amorphous solid to be absorbed into the paper which could weaken its structural integrity.
In some cases, the support is formed from or comprises metal foil, such as aluminium foil. A metallic support may allow for better conduction of thermal energy to the amorphous solid. Additionally, or alternatively, a metal foil may function as a susceptor in an induction heating system. In particular embodiments, the support comprises a metal foil layer and a support layer, such as cardboard. In these embodiments, the metal foil layer may have a thickness of less than 20pm, such as from about 1pm to about 10pm, suitably about 5pm.
The consumable may alternatively be referred to herein as a cartridge. The consumable may be adapted for use in a THP, a hybrid device or another aerosol generating device. In some cases, the consumable may be in the form of a rod. In some cases, the consumable may additionally comprise a filter and/or cooling element, as described previously. In some cases, the consumable may be circumscribed by a wrapping material such as paper.
The consumable may additionally comprise ventilation apertures. These may be provided in the sidewall of the consumable. In some cases, the ventilation apertures may be provided in the filter and/or cooling element. These apertures may allow cool air to be drawn into the consumable during use, which can mix with the heated volatilised components thereby cooling the aerosol.
The ventilation enhances the generation of visible heated volatilised components from the consumable when it is heated in use. The heated volatilised components are made visible by the process of cooling the heated volatilised components such that supersaturation of the heated volatilised components occurs. The heated volatilised components then undergo droplet formation, otherwise known as nucleation, and eventually the size of the aerosol particles of the heated volatilised components increases by further condensation of the heated volatilised components and by coagulation of newly formed droplets from the heated volatilised components.
WO 2021/105449 PCT/EP2020/083764 In some cases, the ratio of the cool air to the sum of the heated volatilised components and the cool air, known as the ventilation ratio, is at least 15%. A ventilation ratio of 15% enables the heated volatilised components to be made visible by the method described above. The visibility of the heated volatilised components enables the user to identify that the volatilised components have been generated and adds to the sensory experience of the smoking experience.
In another example, the ventilation ratio is between 50% and 85% to provide additional cooling to the heated volatilised components. In some cases, the ventilation ratio may be at least 60% or 65%.
Referring to Figures 1 and 2, there are shown a partially cut-away section view and a perspective view of an example of an aerosol-generating consumable 101. The consumable 101 is adapted for use with a device having a power source and a heater. The consumable 101 of this embodiment is particularly suitable for use with the device shown in Figures 5 to 7, described below. In use, the consumable 101 may be removably inserted into the device shown in Figure 5 at an insertion point 20 of the device 51.
The consumable 101 of one example is in the form of a substantially cylindrical rod that includes a body of aerosol-generating material 103 and a filter assembly 105 in the form of a rod. The aerosol-generating material comprises the amorphous solid material described herein. In some embodiments, it may be included in sheet form. In some embodiments it may be included in the form of a shredded sheet. In some embodiments, the aerosol-generating material described herein may be incorporated in sheet form and in shredded form.
The filter assembly 105 includes three segments, a cooling segment 107, a filter segment 109 and a mouth end segment 111. The consumable 101 has a first end 113, also known as a mouth end or a proximal end and a second end 115, also known as a distal end. The body of aerosol-generating material 103 is located towards the distal WO 2021/105449 PCT/EP2020/083764 end 115 of the consumable 101. In one example, the cooling segment 107 is located adjacent the body of aerosol-generating material 103 between the body of aerosol generating material 103 and the filter segment 109, such that the cooling segment 1is in an abutting relationship with the aerosol-generating material 103 and the filter segment 103. In other examples, there may be a separation between the body of aerosol- generating material 103 and the cooling segment 107 and between the body of aerosol- generating material 103 and the filter segment 109. The filter segment 109 is located in between the cooling segment 107 and the mouth end segment 111. The mouth end segment 111 is located towards the proximal end 113 of the consumable 101, adjacent the filter segment 109. In one example, the filter segment 109 is in an abutting relationship with the mouth end segment 111. In one embodiment, the total length of the filter assembly 105 is between 37mm and 45mm, more preferably, the total length of the filter assembly 105 is 41mm.
In one example, the rod of aerosol-generating material 103 is between 34mm and 50mm in length, suitably between 38mm and 46mm in length, suitably 42mm in length.
In one example, the total length of the consumable 101 is between 71mm and 95mm, suitably between 79mm and 87mm, suitably 83mm.
An axial end of the body of aerosol-generating material 103 is visible at the distal end 115 of the consumable 101. However, in other embodiments, the distal end 115 of the consumable 101 may comprise an end member (not shown) covering the axial end of the body of aerosol-generating material 103.
The body of aerosol-generating material 103 is joined to the filter assembly 1by annular tipping paper (not shown), which is located substantially around the circumference of the filter assembly 105 to surround the filter assembly 105 and extends partially along the length of the body of aerosol-generating material 103. In one example, the tipping paper is made of 58GSM standard tipping base paper. In one example the tipping paper has a length of between 42mm and 50mm, suitably of 46mm.
WO 2021/105449 PCT/EP2020/083764 In one example, the cooling segment 107 is an annular tube and is located around and defines an air gap within the cooling segment. The air gap provides a chamber for heated volatilised components generated from the body of aerosol- generating material 103 to flow. The cooling segment 107 is hollow to provide a chamber for aerosol accumulation yet rigid enough to withstand axial compressive forces and bending moments that might arise during manufacture and whilst the consumable 101 is in use during insertion into the device 51. In one example, the thickness of the wall of the cooling segment 107 is approximately 0.29mm.
The cooling segment 107 provides a physical displacement between the aerosol- generating material 103 and the filter segment 109. The physical displacement provided by the cooling segment 107 will provide a thermal gradient across the length of the cooling segment 107. In one example the cooling segment 107 is configured to provide a temperature differential of at least 40 degrees Celsius between a heated volatilised component entering a first end of the cooling segment 107 and a heated volatilised component exiting a second end of the cooling segment 107. In one example the cooling segment 107 is configured to provide a temperature differential of at least degrees Celsius between a heated volatilised component entering a first end of the cooling segment 107 and a heated volatilised component exiting a second end of the cooling segment 107. This temperature differential across the length of the cooling element 107 protects the temperature sensitive filter segment 109 from the high temperatures of the aerosol-generating material 103 when it is heated by the device 51. If the physical displacement was not provided between the filter segment 109 and the body of aerosol-generating material 103 and the heating elements of the device 51, then the temperature sensitive filter segment may 109 become damaged in use, so it would not perform its required functions as effectively.
In one example the length of the cooling segment 107 is at least 15mm. In one example, the length of the cooling segment 107 is between 20mm and 30mm, more particularly 23mm to 27mm, more particularly 25mm to 27mm, suitably 25mm.
WO 2021/105449 PCT/EP2020/083764 The cooling segment 107 is made of paper, which means that it is comprised of a material that does not generate compounds of concern, for example, toxic compounds when in use adj acent to the heater of the device 51. In one example, the cooling segment 107 is manufactured from a spirally wound paper tube which provides a hollow internal chamber yet maintains mechanical rigidity. Spirally wound paper tubes are able to meet the tight dimensional accuracy requirements of high-speed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.
In another example, the cooling segment 107 is a recess created from stiff plug wrap or tipping paper. The stiff plug wrap or tipping paper is manufactured to have a rigidity that is sufficient to withstand the axial compressive forces and bending moments that might arise during manufacture and whilst the consumable 101 is in use during insertion into the device 51.
The filter segment 109 may be formed of any filter material sufficient to remove one or more volatilised compounds from heated volatilised components from the aerosol-generating material. In one example the filter segment 109 is made of a mono- acetate material, such as cellulose acetate. The filter segment 109 provides cooling and irritation-reduction from the heated volatilised components without depleting the quantity of the heated volatilised components to an unsatisfactory level for a user.
In some embodiments, a capsule (not illustrated) may be provided in filter segment 109. It may be disposed substantially centrally in the filter segment 109, both across the filter segment 109 diameter and along the filter segment 109 length. In other cases, it may be offset in one or more dimension. The capsule may in some cases, where present, contain a volatile component such as a flavourant or aerosol generating agent.
The density of the cellulose acetate tow material of the filter segment 1controls the pressure drop across the filter segment 109, which in turn controls the draw resistance of the consumable 101. Therefore the selection of the material of the filter WO 2021/105449 PCT/EP2020/083764 segment 109 is important in controlling the resistance to draw of the consumable 101. In addition, the filter segment performs a filtration function in the consumable 101.
In one example, the filter segment 109 is made of a 8Y15 grade of filter tow material, which provides a filtration effect on the heated volatilised material, whilst also reducing the size of condensed aerosol droplets which result from the heated volatilised material.
The presence of the filter segment 109 provides an insulating effect by providing further cooling to the heated volatilised components that exit the cooling segment 107. This further cooling effect reduces the contact temperature of the user’s lips on the surface of the filter segment 109.
In one example, the filter segment 109 is between 6mm to 10mm in length, suitably 8mm.
The mouth end segment 111 is an annular tube and is located around and defines an air gap within the mouth end segment 111. The air gap provides a chamber for heated volatilised components that flow from the filter segment 109. The mouth end segment Illis hollow to provide a chamber for aerosol accumulation yet rigid enough to withstand axial compressive forces and bending moments that might arise during manufacture and whilst the consumable is in use during insertion into the device 51. In one example, the thickness of the wall of the mouth end segment Illis approximately 0.29mm. In one example, the length of the mouth end segment Illis between 6mm to 10mm, suitably 8mm.
The mouth end segment 111 may be manufactured from a spirally wound paper tube which provides a hollow internal chamber yet maintains critical mechanical rigidity. Spirally wound paper tubes are able to meet the tight dimensional accuracy requirements of high-speed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.
WO 2021/105449 PCT/EP2020/083764 The mouth end segment 111 provides the function of preventing any liquid condensate that accumulates at the exit of the filter segment 109 from coming into direct contact with a user.
It should be appreciated that, in one example, the mouth end segment 111 and the cooling segment 107 may be formed of a single tube and the filter segment 109 is located within that tube separating the mouth end segment 111 and the cooling segment 107.
Referring to Figures 3 and 4, there are shown a partially cut-away section and perspective views of an example of a consumable 301. The reference signs shown in Figures 3 and 4 are equivalent to the reference signs shown in Figures 1 and 2, but with an increment of 200.
In the example of the consumable 301 shown in Figures 3 and 4, a ventilation region 317 is provided in the consumable 301 to enable air to flow into the interior of the consumable 301 from the exterior of the consumable 301. In one example the ventilation region 317 takes the form of one or more ventilation holes 317 formed through the outer layer of the consumable 301. The ventilation holes may be located in the cooling segment 307 to aid with the cooling of the consumable 301. In one example, the ventilation region 317 comprises one or more rows of holes, and preferably, each row of holes is arranged circumferentially around the consumable 301 in a cross-section that is substantially perpendicular to a longitudinal axis of the consumable 301.
In one example, there are between one to four rows of ventilation holes to provide ventilation for the consumable 301. Each row of ventilation holes may have between 12 to 36 ventilation holes 317. The ventilation holes 317 may, for example, be between 100 to 500pm in diameter. In one example, an axial separation between rows of ventilation holes 317 is between 0.25mm and 0.75mm, suitably 0.5mm.
In one example, the ventilation holes 317 are of uniform size. In another example, the ventilation holes 317 vary in size. The ventilation holes can be made using WO 2021/105449 PCT/EP2020/083764 any suitable technique, for example, one or more of the following techniques: laser technology, mechanical perforation of the cooling segment 307 or pre-perforation of the cooling segment 307 before it is formed into the consumable 301. The ventilation holes 317 are positioned so as to provide effective cooling to the consumable 301.
In one example, the rows of ventilation holes 317 are located at least 11mm from the proximal end 313 of the consumable, suitably between 17mm and 20mm from the proximal end 313 of the consumable 301. The location of the ventilation holes 3is positioned such that user does not block the ventilation holes 317 when the consumable 301 is in use.
Providing the rows of ventilation holes between 17mm and 20mm from the proximal end 313 of the consumable 301 enables the ventilation holes 317 to be located outside of the device 51, when the consumable 301 is fully inserted in the device 51, as can be seen in Figures 6 and 7. By locating the ventilation holes outside of the device, non-heated air is able to enter the consumable 301 through the ventilation holes from outside the device 51 to aid with the cooling of the consumable 301.
The length of the cooling segment 307 is such that the cooling segment 307 will be partially inserted into the device 51, when the consumable 301 is fully inserted into the device 51. The length of the cooling segment 307 provides a first function of providing a physical gap between the heater arrangement of the device 51 and the heat sensitive filter arrangement 309, and a second function of enabling the ventilation holes 317 to be located in the cooling segment, whilst also being located outside of the device 51, when the consumable 301 is fully inserted into the device 51. As can be seen from Figures 6 and 7, the majority of the cooling element 307 is located within the device 51. However, there is a portion of the cooling element 307 that extends out of the device 51. It is in this portion of the cooling element 307 that extends out of the device 51 in which the ventilation holes 317 are located.
Referring now to Figures 5 to 7 in more detail, there is shown an example of a device 51 arranged to heat aerosol-generating material to volatilise at least one WO 2021/105449 PCT/EP2020/083764 component of said aerosol-generating material, typically to form an aerosol which can be inhaled. The device 51 is a heating device which releases compounds by heating, but not burning, the aerosol-generating material.
A first end 53 is sometimes referred to herein as the mouth or proximal end of the device 51 and a second end 55 is sometimes referred to herein as the distal end of the device 51. The device 51 has an on/off button 57 to allow the device 51 as a whole to be switched on and off as desired by a user.
The device 51 comprises a housing 59 for locating and protecting various internal components of the device 51. In the example shown, the housing 59 comprises a uni-body sleeve 11 that encompasses the perimeter of the device 51, capped with a top panel 17 which defines generally the ‘top’ of the device 51 and a bottom panel which defines generally the ‘bottom’ of the device 51. In another example the housing comprises a front panel, a rear panel and a pair of opposite side panels in addition to the top panel 17 and the bottom panel 19.
The top panel 17 and/or the bottom panel 19 may be removably fixed to the uni- body sleeve 11, to permit easy access to the interior of the device 51, or may be "permanently" fixed to the uni-body sleeve 11, for example to deter a user from accessing the interior of the device 51. In an example, the panels 17 and 19 are made of a plastics material, including for example glass-filled nylon formed by injection moulding, and the uni-body sleeve 11 is made of aluminium, though other materials and other manufacturing processes may be used.
The top panel 17 of the device 51 has an opening 20 at the mouth end 53 of the device 51 through which, in use, the consumable 101, 301 including the aerosol- generating material may be inserted into the device 51 and removed from the device by a user.
The housing 59 has located or fixed therein a heater arrangement 23, control circuitry 25 and a power source 27. In this example, the heater arrangement 23, the WO 2021/105449 PCT/EP2020/083764 control circuitry 25 and the power source 27 are laterally adjacent (that is, adjacent when viewed from an end), with the control circuitry 25 being located generally between the heater arrangement 23 and the power source 27, though other locations are possible.
The control circuitry 25 may include a controller, such as a microprocessor arrangement, configured and arranged to control the heating of the aerosol-generating material in the consumable 101, 301 as discussed further below.
The power source 27 may be for example a battery, which may be a rechargeable battery or a non-rechargeable battery. Examples of suitable batteries include for example a lithium-ion battery, a nickel battery (such as a nickel-cadmium battery), an alkaline battery and/ or the like. The battery 27 is electrically coupled to the heater arrangement 23 to supply electrical power when required and under control of the control circuitry 25 to heat the aerosol-generating material in the consumable (as discussed, to volatilise the aerosol-generating material without causing the aerosol- generating material to burn).
An advantage of locating the power source 27 laterally adjacent to the heater arrangement 23 is that a physically large power source 25 may be used without causing the device 51 as a whole to be unduly lengthy. As will be understood, in general a physically large power source 25 has a higher capacity (that is, the total electrical energy that can be supplied, often measured in Amp-hours or the like) and thus the battery life for the device 51 can be longer.
In one example, the heater arrangement 23 is generally in the form of a hollow cylindrical tube, having a hollow interior heating chamber 29 into which the consumable 101, 301 comprising the aerosol-generating material is inserted for heating in use. Different arrangements for the heater arrangement 23 are possible. For example, the heater arrangement 23 may comprise a single heating element or may be formed of plural heating elements aligned along the longitudinal axis of the heater arrangement 23. The or each heating element may be annular or tubular, or at least part-annular or WO 2021/105449 PCT/EP2020/083764 part-tubular around its circumference. In an example, the or each heating element may be a thin film heater. In another example, the or each heating element may be made of a ceramics material. Examples of suitable ceramics materials include alumina and aluminium nitride and silicon nitride ceramics, which may be laminated and sintered. Other heating arrangements are possible, including for example inductive heating, infrared heater elements, which heat by emitting infrared radiation, or resistive heating elements formed by for example a resistive electrical winding.
In one particular example, the heater arrangement 23 is supported by a stainless steel support tube and comprises a polyimide heating element. The heater arrangement is dimensioned so that substantially the whole of the body of aerosol-generating material 103, 303 of the consumable 101, 301 is inserted into the heater arrangement when the consumable 101, 301 is inserted into the device 51.
The or each heating element may be arranged so that selected zones of the aerosol-generating material can be independently heated, for example in turn (over time, as discussed above) or together (simultaneously) as desired.
The heater arrangement 23 in this example is surrounded along at least part of its length by a thermal insulator 31. The insulator 31 helps to reduce heat passing from the heater arrangement 23 to the exterior of the device 51. This helps to keep down the power requirements for the heater arrangement 23 as it reduces heat losses generally. The insulator 31 also helps to keep the exterior of the device 51 cool during operation of the heater arrangement 23. In one example, the insulator 31 may be a double-walled sleeve which provides a low pressure region between the two walls of the sleeve. That is, the insulator 31 may be for example a "vacuum" tube, i.e. a tube that has been at least partially evacuated so as to minimise heat transfer by conduction and/or convection. Other arrangements for the insulator 31 are possible, including using heat insulating materials, including for example a suitable foam-type material, in addition to or instead of a double-walled sleeve.
WO 2021/105449 PCT/EP2020/083764 The housing 59 may further comprises various internal support structures 37 for supporting all internal components, as well as the heating arrangement 23.
The device 51 further comprises a collar 33 which extends around and projects from the opening 20 into the interior of the housing 59 and a generally tubular chamber which is located between the collar 33 and one end of the vacuum sleeve 31. The chamber 35 further comprises a cooling structure 35f, which in this example, comprises a plurality of cooling fins 35f spaced apart along the outer surface of the chamber 35, and each arranged circumferentially around outer surface of the chamber 35. There is an air gap 36 between the hollow chamber 35 and the consumable 101, 301 when it is inserted in the device 51 over at least part of the length of the hollow chamber 35. The air gap 36 is around all of the circumference of the consumable 101, 301 over at least part of the cooling segment 307.
The collar 33 comprises a plurality of ridges 60 arranged circumferentially around the periphery of the opening 20 and which project into the opening 20. The ridges 60 take up space within the opening 20 such that the open span of the opening at the locations of the ridges 60 is less than the open span of the opening 20 at the locations without the ridges 60. The ridges 60 are configured to engage with a consumable 101, 301 inserted into the device to assist in securing it within the device 51. Open spaces (not shown in the Figures) defined by adjacent pairs of ridges 60 and the consumable 101, 301 form ventilation paths around the exterior of the consumable 101, 301. These ventilation paths allow hot vapours that have escaped from the consumable 101, 301 to exit the device 51 and allow cooling air to flow into the device around the consumable 101, 301 in the air gap 36.
In operation, the consumable 101, 301 is removably inserted into an insertion point 20 of the device 51, as shown in Figures 5 to 7. Referring particularly to Figure 6, in one example, the body of aerosol-generating material 103, 303, which is located towards the distal end 115, 315 of the consumable 101, 301, is entirely received within the heater arrangement 23 of the device 51. The proximal end 113, 313 of the WO 2021/105449 PCT/EP2020/083764 consumable 101, 301 extends from the device 51 and acts as a mouthpiece assembly for a user.
In operation, the heater arrangement 23 will heat the consumable 101, 301 to volatilise at least one component of the aerosol-generating material from the body of aerosol-generating material 103, 303.
The primary flow path for the heated volatilised components from the body of aerosol-generating material 103, 303 is axially through the consumable 101, 301, through the chamber inside the cooling segment 107, 307, through the filter segment 109, 309, through the mouth end segment 111, 313 to the user. In one example, the temperature of the heated volatilised components that are generated from the body of aerosol generating material is between 60°C and 250°C, which may be above the acceptable inhalation temperature for a user. As the heated volatilised component travels through the cooling segment 107, 307, it will cool and some volatilised components will condense on the inner surface of the cooling segment 107, 307.
In the examples of the consumable 301 shown in Figures 3 and 4, cool air will be able to enter the cooling segment 307 via the ventilation holes 317 formed in the cooling segment 307. This cool air will mix with the heated volatilised components to provide additional cooling to the heated volatilised components.
Advantageously, the consumable of the invention allows each of the first and second aerosol-generating materials to be aerosolized separately. In other words, the generation of aerosol from each aerosol-generating material may be under separate control, such that the generation of aerosol produced by each aerosol-generating material can be varied individually. In an embodiment in which a non-combustible aerosol provision system uses heat to generate aerosol, each aerosol-generating material in the consumable could be under the control of a separate heat generation arrangement. In such an embodiment, the temperature of each aerosol-generating material may be controlled separately to stimulate the release of a desired quantity of aerosol from each aerosol-generating material. In this way, the non-combustible aerosol provision system WO 2021/105449 PCT/EP2020/083764 is adapted to allow a user to aerosolize the first and/or second aerosol-generating material according to personal preference. As a non-limiting example provided to illustrate the invention; the amorphous solid of the first aerosol-generating material may comprise a flavourant, and no active substance, whilst the amorphous solid of the second aerosol-generating material may comprise active substance and no flavourant; if the user would like to inhale flavour only, then the non-combustible aerosol provision system could allow this; for example, the user could programme the non-combustible aerosol provision device to aerosolize the first aerosol-generating material (comprising the flavourant), but not aerosolize the second aerosol-generating material (comprising the active substance). It will be appreciated that such a system could be further configured to allow a user to obtain a wide variety of smoking experiences according to preference.
In some embodiments, the aerosol-generating materials are be arranged in the consumable such that they may be stimulated to generate aerosol under separate control from each other, when used within a non-combustible aerosol provision system.
An advantage of the consumable of the invention is that one production line or facility can produce a single type of consumable, which is capable of providing a variety of experiences according to user preference.
In some cases, a heater (for example a heater in the non-combustible aerosol provision system) may heat, without burning, the amorphous solids to between 120°C and 350°C in use. In some cases the heater, may heat, without burning, the amorphous solids to between 140°C and 250°C in use.
The heater may comprise one or more electrically resistive heaters, including for example one or more nichrome resistive heater(s) and/or one or more ceramic heater(s). The one or more heaters may comprise one or more induction heaters which includes an arrangement comprising one or more susceptors which may form a chamber into which an article comprising aerosol-generating material is inserted or otherwise WO 2021/105449 PCT/EP2020/083764 located in use. Alternatively or in addition, one or more susceptors may be provided in the aerosol-generating material. Other heating arrangements may also be used.
EXEMPLARY EMBODIMENTS The following embodiments are provided by way of example, to better explain how the present invention may be implemented.
In one embodiment, there is provided a consumable for use with a non- combustible aerosol provision device, the consumable comprising:a first aerosol-generating material; anda second aerosol-generating material,wherein the first aerosol-generating material comprises an amorphous solid, the amorphous solid comprising:- 30 - 60 wt% of a gelling agent;- 15 - 60 wt% of an aerosol-former material; and- 1 - 10 wt% of an active substance; andwherein the second aerosol-generating material comprises an amorphous solid, the amorphous solid comprising:- 30 - 60 wt% of a gelling agent;- 10-40 wt% of an aerosol-former material; and- 20 - 50 wt% of a flavourant;wherein these weights are calculated on a dry weight basis; andwherein the amorphous solid of the first aerosol-generating material has a composition different from the amorphous solid of the second aerosol-generating material.
In a further embodiment there is provided a consumable for use in a non- combustible aerosol provision device, the consumable comprising:a supporta first aerosol-generating material attached to the support; anda second aerosol-generating material attached to the support, WO 2021/105449 PCT/EP2020/083764 wherein each of the first and second aerosol-generating materials comprises an amorphous solid, the amorphous solid comprising:- 30 - 60 wt% of a gelling agent;- 15 - 60 wt% of an aerosol-former material; and- 0 - 60 wt% of at least one of nicotine, flavourant and acid, wherein the acid has a boiling point ranging from 100°C to 350°C and/or an acidic functional group which has a PKa value ranging from 3 to 7 when measured at 25°C;wherein these weights are calculated on a dry weight basis; andwherein the amorphous solid of the first aerosol-generating material has a composition different from the amorphous solid of the second aerosol-generating material.
In a further embodiment there is provided a consumable for use in a non- combustible aerosol provision device, the consumable comprising:a supporta first aerosol-generating material attached to the support; anda second aerosol-generating material attached to the support,wherein each of the first and second aerosol-generating materials comprises an amorphous solid, the amorphous solid comprising:- 30 - 60 wt% of a gelling agent;- 15 - 60 wt% of an aerosol-former material; and- 0 - 60 wt% of at least one of nicotine, flavourant and benzoic acid and/or lactic acid;wherein these weights are calculated on a dry weight basis; andwherein the amorphous solid of the first aerosol-generating material has a composition different from the amorphous solid of the second aerosol-generating material.
Exemplary and non-limiting formulations for four aerosol-generating materials comprising an amorphous solid, which may be included in a consumable of the invention are provided in the table below.
WO 2021/105449 PCT/EP2020/083764 First aerosol- generating material (Active substance) Second aerosol- generating material (Flavourant) Third aerosol- generating material (Aerosol- former material) Fourth aerosol- generating material (Acid) Total Gelling agent 43% 43% 43% 56%Alginate 12% 12% 72% 24% CMC 31% 31% 31% 32% Filler 0% 0% 0% 0% Calcium 1% 1% 1% 2% Flavourant 0% 37% 0% 0% Glycerol 48% 19% 56% 39% Nicotine 6% 0% 0% 0% Benzoic acid 2% 0% 0% 3%100% 100% 100% 100% WO 2021/105449 PCT/EP2020/083764 DEFINITIONS Delivery System As used herein, the term "delivery system" is intended to encompass systems that deliver at least one substance to a user, and includes:combustible aerosol provision systems, such as cigarettes, cigarillos, cigars, and tobacco for pipes or for roll-your-own or for make-your-own cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes or other smokable material);non-combustible aerosol provision systems that release compounds from an aerosol-generating material without combusting the aerosol-generating material, such as electronic cigarettes, tobacco heating products, and hybrid systems to generate aerosol using a combination of aerosol-generating materials; andaerosol-free delivery systems that deliver the at least one substance to a user orally, nasally, transdermally or in another way without forming an aerosol, including but not limited to, lozenges, gums, patches, articles comprising inhalable powders, and oral products such as oral tobacco which includes snus or moist snuff, wherein the at least one substance may or may not comprise nicotine.
Non-Combustible Aerosol Provision SystemAccording to the present disclosure, a "non-combustible" aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is not combusted or burned in order to facilitate delivery of at least one substance to a user.
In some embodiments, the delivery system is a non-combustible aerosol provision system, such as a powered non-combustible aerosol provision system.
In some embodiments, the non-combustible aerosol provision system is an electronic cigarette, also known as a vaping device or electronic nicotine delivery WO 2021/105449 PCT/EP2020/083764 system (END), although it is noted that the presence of nicotine in the aerosol- generating material is not a requirement.
In some embodiments, the non-combustible aerosol provision system is an aerosol-generating material heating system, also known as a heat-not-burn system. An example of such a system is a tobacco heating system.
In some embodiments, the non-combustible aerosol provision system is a hybrid system to generate aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated. Each of the aerosol- generating materials may be, for example, in the form of a solid, liquid or gel and may or may not contain nicotine. In some embodiments, the hybrid system comprises a liquid or gel aerosol-generating material and a solid aerosol-generating material. The solid aerosol-generating material may comprise, for example, tobacco or a non-tobacco product.
Typically, the non-combustible aerosol provision system may comprise a non-combustible aerosol provision device and a consumable for use with the non- combustible aerosol provision device.
In some embodiments, the disclosure relates to consumables comprising aerosol-generating material and configured to be used with non-combustible aerosol provision devices. These consumables are sometimes referred to as articles throughout the disclosure.
In some embodiments, the non-combustible aerosol provision system, such as a non-combustible aerosol provision device thereof, may comprise a power source and a controller. The power source may, for example, be an electric power source or an exothermic power source. In some embodiments, the exothermic power source comprises a carbon substrate which may be energised so as to distribute power in the form of heat to an aerosol-generating material or to a heat transfer material in proximity to the exothermic power source.
WO 2021/105449 PCT/EP2020/083764 In some embodiments, the non-combustible aerosol provision system may comprise an area for receiving the consumable, an aerosol generator, an aerosol generation area, a housing, a mouthpiece, a filter and/or an aerosol-modifying agent.
In some embodiments, the consumable for use with the non-combustible aerosol provision device may comprise aerosol-generating material, an aerosol- generating material storage area, an aerosol-generating material transfer component, an aerosol generator, an aerosol generation area, a housing, a wrapper, a filter, a mouthpiece, and/or an aerosol-modifying agent.
Active SubstanceIn some embodiments, the substance to be delivered comprises an active substance.
The active substance as used herein may be a physiologically active material, which is a material intended to achieve or enhance a physiological response. The active substance may for example be selected from nutraceuticals, nootropics, psychoactives. The active substance may be naturally occurring or synthetically obtained. The active substance may comprise for example nicotine, caffeine, taurine, theine, vitamins such as B6 or B12 or C, melatonin, cannabinoids, or constituents, derivatives, or combinations thereof. The active substance may comprise one or more constituents, derivatives or extracts of tobacco, cannabis or another botanical.
In some embodiments, the active substance comprises nicotine. In some embodiments, the active substance comprises caffeine, melatonin or vitamin B12.
In some embodiments, the active substance comprises one or more cannabinoid compounds selected from the group consisting of: cannabidiol (CBD), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic WO 2021/105449 PCT/EP2020/083764 acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM) and cannabielsoin (CBE), cannabicitran (CBT).
The active substance may comprise one or more cannabinoid compounds selected from the group consisting of cannabidiol (CBD) and THC (tetrahydrocannabinol).
The active substance may comprise cannabidiol (CBD).
The active substance may comprise nicotine and cannabidiol (CBD).
The active substance may comprise nicotine, cannabidiol (CBD), and THC (tetrahydrocannabinol).
B otani calsAs noted herein, the active substance may comprise or be derived from one or more botanicals or constituents, derivatives or extracts thereof. As used herein, the term "botanical" includes any material derived from plants including, but not limited to, extracts, leaves, bark, fibres, stems, roots, seeds, flowers, fruits, pollen, husk, shells or the like. Alternatively, the material may comprise an active compound naturally existing in a botanical, obtained synthetically. The material may be in the form of liquid, gas, solid, powder, dust, crushed particles, granules, pellets, shreds, strips, sheets, or the like. Example botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel, licorice (liquorice), matcha, mate, orange skin, papaya, rose, sage, tea such as green tea or black tea, thyme, clove, cinnamon, coffee, aniseed (anise), basil, bay leaves, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, beefsteak plant, curcuma, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, WO 2021/105449 PCT/EP2020/083764 cassis, valerian, pimento, mace, damien, marjoram, olive, lemon balm, lemon basil, chive, carvi, verbena, tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab or any combination thereof. The mint may be chosen from the following mint varieties: Mentha Arventis, Mentha c.v.,Mentha niliaca, Mentha piperita, Mentha piperita citrata c.v.,Mentha piperita c.v, Mentha spicata crispa, Mentha cardifolia, Memtha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata c.v. and Mentha suaveolens In some embodiments, the active substance comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is tobacco.
In some embodiments, the active substance comprises or derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is selected from eucalyptus, star anise, cocoa and hemp.
In some embodiments, the active substance comprises or derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is selected from rooibos and fennel.
FlavoursIn some embodiments, the substance to be delivered comprises a flavour.
As used herein, the terms "flavour" and "flavourant" refer to materials which, where local regulations permit, may be used to create a desired taste, aroma or other somatosensorial sensation in a product for adult consumers. They may include naturally occurring flavour materials, botanicals, extracts of botanicals, synthetically obtained materials, or combinations thereof (e.g., tobacco, cannabis, licorice (liquorice), hydrangea, eugenol, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, maple, matcha, menthol, Japanese mint, aniseed (anise), cinnamon, turmeric, Indian spices, Asian spices, herb, wintergreen, cherry, WO 2021/105449 PCT/EP2020/083764 berry, red berry, cranberry, peach, apple, orange, mango, clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruits, Drambuie, bourbon, scotch, whiskey, gin, tequila, rum, spearmint, peppermint, lavender, aloe vera, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, khat, naswar, betel, shisha, pine, honey essence, rose oil, vanilla, lemon oil, orange oil, orange blossom, cherry blossom, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, wasabi, piment, ginger, coriander, coffee, hemp, a mint oil from any species of the genus Mentha, eucalyptus, star anise, cocoa, lemongrass, rooibos, flax, ginkgo biloba, hazel, hibiscus, laurel, mate, orange skin, rose, tea such as green tea or black tea, thyme, juniper, elderflower, basil, bay leaves, cumin, oregano, paprika, rosemary, saffron, lemon peel, mint, beefsteak plant, curcuma, cilantro, myrtle, cassis, valerian, pimento, mace, damien, marjoram, olive, lemon balm, lemon basil, chive, carvi, verbena, tarragon, limonene, thymol, camphene), flavour enhancers, bitterness receptor site blockers, sensorial receptor site activators or stimulators, sugars and/or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals, or breath freshening agents. They may be imitation, synthetic or natural ingredients or blends thereof. They may be in any suitable form, for example, liquid such as an oil, solid such as a powder, or gas.
In some embodiments, the flavour comprises menthol, spearmint and/or peppermint. In some embodiments, the flavour comprises flavour components of cucumber, blueberry, citrus fruits and/or redberry. In some embodiments, the flavour comprises eugenol. In some embodiments, the flavour comprises flavour components extracted from tobacco. In some embodiments, the flavour comprises flavour components extracted from cannabis.
In some embodiments, the flavour may comprise a sensate, which is intended to achieve a somatosensorial sensation which are usually chemically induced and perceived by the stimulation of the fifth cranial nerve (trigeminal WO 2021/105449 PCT/EP2020/083764 nerve), in addition to or in place of aroma or taste nerves, and these may include agents providing heating, cooling, tingling, numbing effect. A suitable heat effect agent may be, but is not limited to, vanillyl ethyl ether and a suitable cooling agent may be, but not limited to eucolyptol, WS-3.
Aerosol-generating materialAerosol-generating material is a material that is capable of generating aerosol, for example when heated, irradiated or energized in any other way. Aerosol-generating material may, for example, be in the form of a solid, liquid or gel which may or may not contain an active substance and/or flavourants. In some embodiments, the aerosol-generating material may comprise an "amorphous solid", which may alternatively be referred to as a "monolithic solid" (i.e. non- fibrous). In some embodiments, the amorphous solid may be a dried gel. The amorphous solid is a solid material that may retain some fluid, such as liquid, within it. In some embodiments, the aerosol-generating material may for example comprise from about 50wt%, 60wt% or 70wt% of amorphous solid, to about 90wt%, 95wt% or 100wt% of amorphous solid.
The aerosol-generating material may comprise one or more active substances and/or flavours, one or more aerosol-former materials, and optionally one or more other functional materials.
Aerosol-former materialThe aerosol-former material may comprise one or more constituents capable of forming an aerosol. In some embodiments, the aerosol-former material may comprise one or more of glycerine, glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.
WO 2021/105449 PCT/EP2020/083764 In some embodiments, the aerosol former comprises one or more polyhydric alcohols, such as propylene glycol, triethylene glycol, 1,3-butanediand glycerin; esters of polyhydric alcohols, such as glycerol mono-, di- or triacetate; and/or aliphatic esters of mono-, di- or polycarboxylic acids, such as dimethyl dodecanedioate and dimethyl tetradecanedioate.
Functional materialThe one or more other functional materials may comprise one or more of pH regulators, colouring agents, preservatives, binders, fillers, stabilizers, and/or antioxidants.
SubstrateThe material may be present on or in a support, to form a substrate. The support may, for example, be or comprise paper, card, paperboard, cardboard, reconstituted material, a plastics material, a ceramic material, a composite material, glass, a metal, or a metal alloy. In some embodiments, the support comprises a susceptor. In some embodiments, the susceptor is embedded within the material. In some alternative embodiments, the susceptor is on one or either side of the material.
ConsumableA consumable is an article comprising or consisting of aerosol-generating material, part or all of which is intended to be consumed during use by a user. A consumable may comprise one or more other components, such as an aerosol- generating material storage area, an aerosol-generating material transfer component, an aerosol generation area, a housing, a wrapper, a mouthpiece, a filter and/or an aerosol-modifying agent. A consumable may also comprise an aerosol generator, such as a heater, that emits heat to cause the aerosol-generating material to generate aerosol in use. The heater may, for example, comprise combustible material, a material heatable by electrical conduction, or a susceptor.
WO 2021/105449 PCT/EP2020/083764 SusceptorA susceptor is a material that is heatable by penetration with a varying magnetic field, such as an alternating magnetic field. The susceptor may be an electrically-conductive material, so that penetration thereof with a varying magnetic field causes induction heating of the heating material. The heating material may be magnetic material, so that penetration thereof with a varying magnetic field causes magnetic hysteresis heating of the heating material. The susceptor may be both electrically-conductive and magnetic, so that the susceptor is heatable by both heating mechanisms. The device that is configured to generate the varying magnetic field is referred to as a magnetic field generator, herein.
Aerosol-modifying agentAn aerosol-modifying agent is a substance, typically located downstream of the aerosol generation area, that is configured to modify the aerosol generated, for example by changing the taste, flavour, acidity or another characteristic of the aerosol. The aerosol-modifying agent may be provided in an aerosol-modifying agent release component, that is operable to selectively release the aerosol- modifying agent The aerosol-modifying agent may, for example, be an additive or a sorbent. The aerosol-modifying agent may, for example, comprise one or more of a flavourant, a colourant, water, and a carbon adsorbent. The aerosol-modifying agent may, for example, be a solid, a liquid, or a gel. The aerosol-modifying agent may be in powder, thread or granule form. The aerosol-modifying agent may be free from filtration material.
Aerosol generatorAn aerosol generator is an apparatus configured to cause aerosol to be generated from the aerosol-generating material. In some embodiments, the aerosol generator is a heater configured to subject the aerosol-generating material to heat energy, so as to release one or more volatiles from the aerosol-generating material to form an aerosol. In some embodiments, the aerosol generator is configured to
Claims (29)
1. A consumable for use with a non-combustible aerosol provision device, the consumable comprising:a first aerosol-generating material; anda second aerosol-generating material,wherein each of the first and second aerosol-generating materials comprise an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid; wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the first aerosol-generating material has a composition different from a composition of the amorphous solid of the second aerosol- generating material.
2. The consumable according to claim 1 wherein the amorphous solid of the first aerosol-generating material comprises the active substance and wherein the amorphous solid of the second aerosol-generating material comprises the flavourant.
3. The consumable according to claim 1 or claim 2 wherein the amorphous solid of the first aerosol-generating material is free from the flavourant and the acid.
4. The consumable according to any one of claims 1 to 3 wherein the amorphous solid of the second aerosol-generating material is free from the active substance and the acid.
5. The consumable according to any one of claims 1 to 3 wherein the amorphous solid of the first aerosol-generating material comprises the active WO 2021/105449 PCT/EP2020/083764 substance and wherein the amorphous solid of the second aerosol-generating material comprises the acid.
6. The consumable according to claim 5 wherein the amorphous solid of the first aerosol-generating material is free from the acid and the flavourant.
7. The consumable according to claim 5 or claim 6 wherein the amorphous solid of the second aerosol-generating material is free from the flavourant and the active substance.
8. The consumable according to claim 1 wherein the amorphous solid of the first aerosol-generating material comprises the flavourant and wherein the amorphous solid of the second aerosol-generating material comprises the acid.
9. The consumable according to claim 8 wherein the amorphous solid of the first aerosol-generating material is free from the active substance and the acid.
10. The consumable according to claim 8 or claim 9 wherein the amorphous solid of the second aerosol-generating material is free from the flavourant and the active substance.
11. The consumable according to claim 1 wherein the first aerosol-generating material comprises- 0.5 - 60 wt % of a gelling agent;- 5 - 80 wt % of an aerosol-former material;a nd is free from an active substance, a flavourant and an acid;and the second aerosol-generating material comprises 0.1 - 60 wt % of at least one of an active substance, flavourant and an acid;wherein these weights are calculated on a dry weight basis. WO 2021/105449 PCT/EP2020/083764
12. The consumable according to any one of claims 1 to 11, wherein the active substance of the amorphous solid of the first aerosol-generating material is present in a different quantity from a quantity of the active substance in the amorphous solid of the second aerosol-generating material.
13. The consumable according to claim 12, wherein the active substance of the amorphous solid of the first aerosol-generating material is present in a lesser quantity than a quantity of the active substance in the amorphous solid of the second aerosol-generating material.
14. The consumable according to claim 13, wherein the amorphous solid of the first aerosol-generating material comprises from 0 - 10 wt % of the active substance present therein, and the amorphous solid of the second aerosol- generating material comprises from 10 - 60 wt % of the active substance present therein.
15. The consumable according to any one of claims 1, 2, 4, 5, 8, 9 or 12-14, wherein the amorphous solid of the first aerosol-generating material comprises a different flavourant from the flavourant of the amorphous solid of the second aerosol-generating material.
16. The consumable according to any one of claims 1 to 3, 5, 6, 8, or 12-wherein the amorphous solid of the first aerosol-generating material comprises a different active substance from the active substance of the amorphous solid of the second aerosol-generating material.
17. The consumable according to any one of claims 1 to 16 wherein the consumable comprises a support and the first and second aerosol- generating materials are attached to the support.
18. The consumable according to claim 17 wherein the support is a planar support. WO 2021/105449 PCT/EP2020/083764
19. The consumable according to any one of claims 1 to 18, comprising a third aerosol-generating material comprising an amorphous solid, the amorphous solid comprising:- 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid; wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the third aerosol-generating material has a different composition from a composition of the amorphous solid of the first aerosol- generating material and/or the second aerosol-generating material.
20. The consumable according claim 19, comprising a fourth aerosol-generating material comprising an amorphous solid, the amorphous solid comprising: - 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, flavourant and an acid; wherein these weights are calculated on a dry weight basis and wherein the amorphous solid of the fourth aerosol-generating material has a different composition from a composition of the amorphous solid of at least one of the first, second or third aerosol-generating materials.
21. The consumable according to claim 20, wherein the amorphous solid of the first aerosol-generating material comprises the active substance and is free from the flavourant and the acid;the amorphous solid of the second aerosol-generating material comprises the flavourant and is free from the active substance and the acid;the amorphous solid of the third aerosol-generating material comprises the acid and is free from the flavourant and the active substance; andthe amorphous solid of the fourth aerosol-generating material is free from the active substance, the flavourant and the acid. WO 2021/105449 PCT/EP2020/083764
22. The consumable according to any one of claims 1 to 21, wherein when the amorphous solid comprises acid, the acid has a boiling point ranging from 100°C to 350°C; and/orthe acid has an acidic functional group which has a PKa value ranging from to 7 when measured at 25°C.
23. The consumable according to any one of claims 1 to 22, wherein when the amorphous solid comprises acid, the acid is an organic acid.
24. The consumable according to any one of claims 1 to 23, wherein when the amorphous solid comprises acid, the acid is lactic acid and/or benzoic acid.
25. The consumable according to claim 24, wherein the acid is lactic acid.
26. A non-combustible aerosol provision system comprising a consumable according to any one of claims 1 to 25 and a non-combustible aerosol provision device, the non-combustible aerosol provision device comprising an aerosol-generation device arranged to generate aerosol from the consumable when the consumable is used with the non-combustible aerosol provision device.
27. A method of manufacturing a consumable for use with a non-combustible aerosol provision device, the method comprising: providing a support;depositing on the support at least two discrete portions of slurry comprising a gelling agent, an aerosol-former material and at least one of an active substance, a flavourant and an acid;drying the at least two discrete portions of slurry to provide a first aerosol- generating material and a second aerosol-generating material, wherein the first and second aerosol-generating materials are attached to the support; wherein each of the first and second aerosol-generating materials comprise an amorphous solid, the amorphous solid comprising:
28.WO 2021/105449 PCT/EP2020/083764 - 0.5 - 60 wt % of a gelling agent;- 0 - 80 wt % of an aerosol-former material; and- 0 - 60 wt % of at least one of an active substance, a flavourant and an acid, wherein these weights are calculated on a dry weight basis andwherein the amorphous solid of the first aerosol-generating material has acomposition different from a composition of the amorphous solid of the second aerosol-generating material; and forming the consumable. 10 28. The method according to claim 27, wherein the consumable is as describedin any one of claims 1-25.
29. Use of a consumable as described in any one of claims 1 to 25 in a non- combustible aerosol provision device, wherein the device is arranged togenerate aerosol from the consumable when the consumable is used withthe non-combustible aerosol provision device.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1917468.9A GB201917468D0 (en) | 2019-11-29 | 2019-11-29 | Aerosol generation |
GBGB2001312.4A GB202001312D0 (en) | 2020-01-30 | 2020-01-30 | Aerosol generation |
PCT/EP2020/083764 WO2021105449A1 (en) | 2019-11-29 | 2020-11-27 | Consumable comprising two different aerosol-generating materials for non-combustible aerosol provision device |
Publications (1)
Publication Number | Publication Date |
---|---|
IL293169A true IL293169A (en) | 2022-07-01 |
Family
ID=73654794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL293169A IL293169A (en) | 2019-11-29 | 2020-11-27 | Consumable comprising two different aerosol-generating materials for non-combustible aerosol provision device |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230037155A1 (en) |
EP (1) | EP4064865A1 (en) |
JP (1) | JP2023503504A (en) |
KR (1) | KR20220121786A (en) |
CN (1) | CN115397267A (en) |
AU (1) | AU2020392616A1 (en) |
BR (1) | BR112022010571A2 (en) |
CA (1) | CA3159877A1 (en) |
IL (1) | IL293169A (en) |
WO (1) | WO2021105449A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023135284A1 (en) | 2022-01-14 | 2023-07-20 | Jt International Sa | Aerosol generating article |
WO2023135285A1 (en) | 2022-01-14 | 2023-07-20 | Jt International Sa | Aerosol generating substrate and article containing the substrate |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7726320B2 (en) * | 2006-10-18 | 2010-06-01 | R. J. Reynolds Tobacco Company | Tobacco-containing smoking article |
TWI603682B (en) * | 2012-05-31 | 2017-11-01 | 菲利浦莫里斯製品股份有限公司 | Functional rods for use in aerosol-generating articles |
US11571017B2 (en) * | 2012-05-31 | 2023-02-07 | Philip Morris Products S.A. | Flavoured rods for use in aerosol-generating articles |
GB201505593D0 (en) * | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
US20170265517A1 (en) * | 2016-03-15 | 2017-09-21 | Rai Strategic Holdings, Inc. | Multi-Layered Micro-Beads for Electronic Cigarettes |
WO2019086462A1 (en) * | 2017-10-31 | 2019-05-09 | Philip Morris Products S.A. | Sheet of a material containing alkaloids and method for producing the same |
GB201812498D0 (en) * | 2018-07-31 | 2018-09-12 | Nicoventures Holdings Ltd | Aerosol generation |
JP7453967B2 (en) * | 2018-10-08 | 2024-03-21 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Clove-containing aerosol-generating substrate |
-
2020
- 2020-11-27 IL IL293169A patent/IL293169A/en unknown
- 2020-11-27 BR BR112022010571A patent/BR112022010571A2/en unknown
- 2020-11-27 EP EP20816935.9A patent/EP4064865A1/en active Pending
- 2020-11-27 KR KR1020227017899A patent/KR20220121786A/en active Search and Examination
- 2020-11-27 JP JP2022531390A patent/JP2023503504A/en active Pending
- 2020-11-27 CA CA3159877A patent/CA3159877A1/en active Pending
- 2020-11-27 US US17/780,209 patent/US20230037155A1/en active Pending
- 2020-11-27 CN CN202080094360.6A patent/CN115397267A/en active Pending
- 2020-11-27 AU AU2020392616A patent/AU2020392616A1/en active Pending
- 2020-11-27 WO PCT/EP2020/083764 patent/WO2021105449A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021105449A1 (en) | 2021-06-03 |
US20230037155A1 (en) | 2023-02-02 |
KR20220121786A (en) | 2022-09-01 |
AU2020392616A1 (en) | 2022-06-16 |
CA3159877A1 (en) | 2021-06-03 |
JP2023503504A (en) | 2023-01-30 |
BR112022010571A2 (en) | 2022-08-23 |
EP4064865A1 (en) | 2022-10-05 |
CN115397267A (en) | 2022-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP4064864A1 (en) | Method of manufacturing an amorphous solid comprising an aerosol-former material | |
EP4064870A1 (en) | A consumable for use with a non-combustible aerosol provision system | |
US20230037155A1 (en) | Consumable comprising two different aerosol-generating materials for non-combustible aerosol provision device | |
AU2020392630A1 (en) | Aerosol-generating comprising an amorphous solid with alginate and pectin as gelling agents | |
EP4064872A1 (en) | Method of making an amorphous solid using a stencil | |
AU2019314678B2 (en) | Method of making an aerosol forming substrate | |
EP4064876A1 (en) | Method of making an amorphous solid for use with a non-combustible aerosol provision system | |
WO2021105437A1 (en) | Aerosol-generating material comprising an amorphous solid with carrageenan | |
CA3226554A1 (en) | Aerosol generation | |
CA3159868A1 (en) | Aerosol generation | |
CA3226558A1 (en) | Aerosol generation | |
AU2021212295A1 (en) | Aerosol generation | |
EP4064877A1 (en) | Method of making an amorphous solid for use with a non-combustible aerosol provision system | |
EP4064867A1 (en) | Aerosol generation |